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目的 探讨颞浅动脉-大脑中动脉端侧吻合术中不同临时阻断技术的效果及可靠性。 方法 回顾性分析2015年1月—2023年4月南方医科大学南方医院神经外科收治的接受直接搭桥术治疗的烟雾病患者资料，根据临时阻断策略的不同将患者分为3组：①有垫片、多阻断夹阻断组（multi-clips+rubber pad group，M+R组）；②无垫片、多阻断夹阻断组（multi-clips group，M组）；③无垫片、单阻断夹阻断组（single-clip group，S组）。比较组间临时阻断时间、受体动脉切开后有无渗血、术中穿支血管损伤以及术后新发脑梗死情况。 结果 共355例患者、360个大脑半球纳入分析，按大脑半球统计患者360例，其中男性188例，女性172例，平均年龄为（43.8±0.7）岁。其中M+R组45例，M组191例，S组124例。3组平均阻断时间：M+R组为（37.9±9.8）min，M组为（20.9±9.0）min，S组为（11.0±3.5）min，组间差异有统计学意义（P＜0.001）。阻断后受体动脉管腔内渗血以及术中穿支血管损伤发生率：M+R组为8.89%（阻断后受体动脉渗血4例），M组为14.66%（阻断后受体动脉渗血19例，术中穿支血管损伤8例，临时阻断部位有血栓形成1例），S组为5.65%（阻断后受体动脉渗血7例），组间差异无统计学意义（P>0.05）。术后新发脑梗死发生率差异无统计学意义（P>0.05）。 结论 单阻断夹阻断策略安全、有效，能显著缩短临时阻断时间，可以优先考虑作为颞浅动脉-大脑中动脉端侧吻合过程中的临时阻断策略。 Abstract: Objective To investigate the effects and reliability of different temporary occlusion techniques in end-to-side anastomosis of the superficial temporal artery-middle cerebral artery. Methods A retrospective analysis was conducted on the data of patients with Moyamoya disease who underwent direct bypass surgery in the Department of Neurosurgery, Nanfang Hospital, Southern Medical University, from January 2015 to April 2023. The patients were divided into three groups according to the different temporary occlusion strategies: ①multi-clips+rubber pad group (M+R group); ②multi-clips group (M group); and ③single-clip group (S group). Temporary occlusion time, presence of errhysis after recipient artery incision, intraoperative perforator vessel injury, and postoperative novel cerebral infarction were compared among the three groups. Results A total of 355 patients and 360 cerebral hemispheres were included in the analysis, and 360 patients were counted according to the number of cerebral hemispheres, including 188 males and 172 females, with an average age of (43.8±0.7) years. There were 45 cases in the M+R group, 191 cases in the M group, and 124 cases in the S group. The average occlusion time were (37.9±9.8) minutes in the M+R group, (20.9±9.0) minutes in the M group, and (11.0±3.5) minutes in the S group, with significant differences between the groups (P0.05). There was no significant difference in the incidence of novel cerebral infarctions postoperatively (P>0.05). Conclusions The single-clip occlusion strategy is safe and effective, which significantly shortens the temporary occlusion time, and should be prioritized as the temporary occlusion technique in end-to-side anastomosis of the superficial temporal artery-middle cerebral artery.

为提高蛋白基Pickering乳液稳定性，采用美拉德反应制备乳清分离蛋白（WPI）-葡聚糖（Dex）接枝物，然后利用该接枝物制得蛋白基固体颗粒，再与中链甘油三酯制备Pickering乳液，考察WPI-Dex接枝物对蛋白基固体颗粒乳化活性、乳化稳定性和蛋白基Pickering乳液乳析指数的影响，以及Pickering乳液在不同pH、加热温度、贮藏时间下粒径的变化。结果表明：扫描电镜观察到共价接枝Dex将WPI形貌结构由球状转变为片状，十二烷基硫酸钠-聚丙烯酰胺凝胶电泳证实干法美拉德反应成功制备了WPI-Dex接枝物；与WPI相比，WPI-Dex接枝物的乳化活性和乳化稳定性分别增加了57.8%和138.5%；WPI和WPI-Dex接枝物Pickering乳液贮藏30 d时的乳析指数分别为52.3%和36.0%，WPI-Dex接枝物使Pickering乳液的乳析稳定性提高了31.2%；WPI-Dex接枝物Pickering乳液具有良好的pH稳定性、热稳定性和贮藏稳定性。综上，蛋白质糖基化接枝修饰是提高天然蛋白质Pickering乳液稳定性的有效方法。In order to improve the stability of protein-based Pickering emulsion, Maillard reaction was used to prepare the whey protein isolate(WPI)-dextran(Dex) conjugate. The WPI-Dex conjugate was used to prepare protein-based solid particles, and then Pickering emulsion was prepared with medium-chain triglyceride. The effects of the WPI-Dex conjugate on the emulsification activity, emulsion stability of protein-base solid particles and creaming index of Pickering emulsion were investigated, as well as the change of diameter of Pickering emulsion under different pH, heating temperature and storage time. The results showed that scanning electron microscopy (SEM) observed the covalently grafted Dex transformed the morphologic structure of WPI from globular to flake. The WPI-Dex conjugate was successfully prepared by the dry state Maillard reaction, which was confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Compared with WPI, the emulsification activity and emulsion stability of WPI-Dex conjugate increased by 57.8% and 138.5%, respectively. The creaming indexes of WPI and WPI-Dex conjugate Pickering emulsion stored for 30 d were 52.3% and 36.0%, respectively, and the creaming stability of WPI-Dex conjugate Pickering emulsion increased by 31.2%. WPI-Dex conjugate Pickering emulsion had good pH stability, thermal stability and storage stability. In conclusion, the glycosylation graft modification of protein is an effective method to improve the stability of natural protein Pickering emulsions.

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Objective To develop a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for simultaneous determination of five flavonoids in Ganmao’an granules (GMA). Methods Chromatographic separation was achieved on a Kromasil C18 Column (150 mm× 4.6 mm,5 μm,100 Å), which was eluted with methanol (A) -0.1% formic acid (B) at the flow rate of 1.0 ml/min. The gradient condition was as follows: 0-20 min, 35% A, and 20-40 min, 45% A. The column temperature was 25 °C. Analytes were detected using a triple quadrupole tandem mass spectrometer equipped with an electrospray ionization source in the negative ion scanning. The multiple reaction monitoring mode was used for qualitative analysis. For each flavonoid, two precursor ion/product ion transitions were chosen: lutin m/z 609.1→300.1, hyperin and isoquercitrin m/z 463.0→300.1, quercetin m/z 301.0→151.0, luteolin m/z 285.0→132.9. Results Five flavonoids showed the good relationships within their own concentration ranges (correlation coefficient r>0.999 1), whose average recoveries were in the range of 100.63%-102.81% with RSDs of 0.67%-2.07%. The content results of rutin, hyperoside, isoquercetin, quercetin, and luteolin in 10 batches of GMA were 32.23-479.83, 0.291-1.825, 11.44-20.54, 6.32-18.41, 3.46-6.51 μg/g, respectively. Conclusion The results indicated that the developed method was sensitive, accurate and could provide excellent specificity for simultaneous determination of five flavonoids in GMA. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Soil & Water Conservation (1009-2242) is the property of Institute of Soil & Water Conservation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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在钢结构桥梁的施工设计中,钢梁安装受诸多因素的影响,为确保成桥阶段钢梁性能的充分发挥,对钢梁安装施工进行分析有其意义所在。以阜阳颖柳路泉河桥项目为背景,研究钢箱梁分块方案选择及其在滑道梁拖拉施工工序中的应力表现。通过采用ABAQUS中壳单元模拟板件、桁架单元模拟临时支撑,建立有限元模型,计算分析钢箱梁分块吊装及拖拉施工过程中的各项性能,以求验证该安装方案在实际施工过程中的安全性与可行性。

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Aim To explore the application value of a predictive model constructed based on superb microvascular imaging (SMI) blood flow grading indicators and serological indicators in evaluating the risk of carotid plaque shedding. Methods A total of 122 patients diagnosed with carotid plaque in Lishui Central Hospital from February 2019 to February 2021 were selected. SMI was used to observe the blood flow grading and plaque characteristics in carotid plaque, and baseline clinical data of the patients were recorded. All patients were followed up for a period of 2 years, with the occurrence of transient ischemic attack (TIA) or acute ischemic stroke (AIS) as the endpoint event, and were divided into plaque shedding group and non-shedding group. Clinical data of the two groups were compared and analyzed, and multiple regression analysis was conducted to identify the relevant factors affecting carotid plaque shedding. According to the SMI ultrasound characteristics and serological indicators, R software was adopted to establish the nomogram model and evaluate effectiveness of the model. Results During the 2-year follow-up period, 21 TIA cases and 14 AIS cases were found in the remaining 112 patients excluding 10 lost to follow up. The SMI blood flow grading, neutrophil to lymphocyte ratio (NLR), matrix metalloproteinase-9 (MMP-9), and low density lipoprotein cholesterol (LDLC) levels in the plaque shedding group were higher than those in the non-shedding group, and the differences were statistically significant (P< 0. 05). Multivariate Logistic regression analysis showed that SMI blood flow grade 3 (OR = 38. 095), LDLC (OR = 19. 730), NLR (OR=34. 525) and MMP-9 (OR=1. 225) were independent risk factors for carotid plaque shedding (P< 0. 05). The R software established a column chart model and applied it to the ROC curve analysis. The AUC of the column chart model in early prediction of plaque shedding was 0. 917, with a sensitivity of 82. 86% and a specificity of 90. 91%. Conclusion The predictive model constructed by combining blood flow grading within carotid artery plaques and serological indicators through SMI can provide early warning of plaque shedding and guide clinical early intervention to reduce the risk of TIA and AIS. [ABSTRACT FROM AUTHOR]

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[Objective] The study aimed to investigate the influence of applying orgauic fertilizers with varying degrees of maturation on soil properties within a wheat-com rotation system and to evaluate the role of orgauic fertilizers in regulating soil fertility. [Method] A two-year field experiment was conducted, combining composting and fertilization processes. Treatments included single chemical fertilizer application (CK-H) as a control, as well as two different degrees of maturation organic fertilizers: 70% maturation orgauic fertilizer (GI70) and 100% maturation organic fertilizer (GI100). Variations in nutrient content among organic fertilizers with different maturation levels were measured. Following orgauic fertilizer application, soil organic matter, total nitrogen, available phosphorus, exchangeable potassium, wheat and maize yields were determined. The impact of fertilization on soil fertility and crop yields was assessed using a structural equation model. [Result] After composting, the GI100 organic fertilizer treatment outperformed the GI70 treatment in several key aspects (P < 0. 05). Specifically, the GI100 treatment exhibited significantly higher levels of organic matter, total nitrogen, total potassium and moisture content. The GI100 organic matter content was 2. 90 times that of GI70, total nitrogen content was 1. 37 times higher, total potassium content was 1. 77 times higher, and moisture content was 1. 68 times higher. Additionally, the GI100 organic fertilizer demonstrated superior cleanliness compared to GI70. In the initial wheat season, organic fertilizer treatments showed increased soil organic matter and available phosphorus levels compared to the CK-H treatment. During the first maize season, they exhibited higher levels of organic matter, total nitrogen and available phosphorus relative to CK-H. Soil available potassium content decreased during the harvest periods of wheat and maize in the first season. In the second wheat and maize season, both organic fertilizer treatments yielded more than CK-H; However, soil available potassium content was lower in the organic fertilizer treatments. In the first year of wheat-com rotation, the GI100 and GI70 treatments increased wheat yields by 17. 00% and 9. 90%, respectively, and com yields by 11. 97% and 1. 41 %, respectively. In the second year of wheat-com rotation, during the wheat season, the GI100 and GI70 treatments boosted yields by 12. 89% and 9. 59%, respectively, and during the com season, they raised yields by 19.44% and 17.17%, respectively. The structural equation model indicated path coefficients of 0. 75 (0.94), 0.13 (0.40), and -0. 32 (- 0. 61) for organic fertilizer's fertility indicators, technical parameters, and heavy metal content concerning soil and crop yields in the wheat-com rotation system, respectively. [Conclusion] The application of organic fertilizer with a higher degree of maturation positively influences soil fertility and the yields of wheat and maize. Fertility indicators, technical parameters, and heavy metal content in organic fertilizers are crucial factors affecting soil fertility and crop yields. The study provides a scientific foundation and technical guidance for soil fertility management. [ABSTRACT FROM AUTHOR]

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BACKGROUND: Although arthroscopically assisted Latarjet procedure is the “gold standard” for the treatment of recurrent anterior dislocation of shoulder with obvious glenoid bone defect, it has high complications such as shoulder joint degeneration and progression. The clinical effect of the arthroscopically modified elastic fixation Latarjet procedure has been good in recent years, but most of them are case reports. Modified elastic fixation Latarjet procedure in the treatment of recurrent anterior dislocation of shoulder with obvious glenoid bone defect is necessary to be further evaluated. OBJECTIVE: To investigate the short-term clinical effect of modified elastic fixation Latarjet procedure in the treatment of recurrent anterior dislocation of shoulder with glenoid bone defect. METHODS: Totally 42 patients with recurrent anterior dislocation of shoulder with obvious glenoid bone defect diagnosed and treated in Affiliated Hospital of Zunyi Medical University from January 2017 to October 2019 were collected into our study. They were treated with modified elastic fixation Latarjet procedure. Visual analogue scale score, university of California at Los Angeles shoulder rating scale, American shoulder and elbow surgeons, Rowe score and Walsh-Duplay score were compared before and after surgery. Postoperative CT and 3D reconstruction of shoulder joint and plain radiograph of shoulder joint were performed to evaluate the position of bone fragments, the degree of correction of glenoid defect, the degeneration of shoulder joint, and the healing and absorption of transposition coracoid process. RESULTS AND CONCLUSION: (1) The operation process of 42 patients was successful, and there were no serious complications such as nerve or vascular injury after operation. All patients completed the follow-up of 20-34 months. (2) The visual analogue scale score, university of California at Los Angeles shoulder rating scale score, American shoulder and elbow surgeons score, Rowe score, Walsh-Duplay score were significantly improved at 10 days after surgery compared with before operation, and no dislocation or subluxation occurred again in all patients. (3) At the last follow-up, all patients underwent shoulder CT, which showed that the shoulder glenoid reached the normal level, without transposition, coracoid process absorption or bone nonunion. (4) The modified elastic fixation Latarjet procedure can obtain satisfactory clinical effect in the treatment of recurrent anterior dislocation of shoulder with obvious glenoid bone defect. The operation time is short, with minimally invasive and fine arthroscopic operation. The position of coracoid process is satisfactory. There is no recurrent dislocation or subluxation after operation. It can significantly improve the function of shoulder joint. [ABSTRACT FROM AUTHOR]

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Malignant tumors are major diseases that threaten human health. The development of safe and efficient antitumor drugs and their delivery systems is an important guarantee for improving the efficacy of antitumor drugs. In recent years, cyclodextrin-based antitumor drug host-guest delivery systems have received much attention. Cyclodextrins are cyclic oligosaccharides obtained by amylolytic enzymes with an external hydrophilic internal hydrophobic structure, and have been widely used in gene therapy, immune cell therapy, immune-targeted therapy, and chemotherapy. This review summarizes the advances related to cyclodextrins as antitumor drug delivery carriers, and also provides a perspective and discussion on the opportunities and challenges of host-guest delivery systems in oncology therapy. [ABSTRACT FROM AUTHOR]

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BACKGROUND: Posterolateral knee complex injury can lead to external rotation of the tibia, affecting lower extremity function and quality of life. The reconstruction with partial peroneus longus tendon can restore the stability of the lateral knee joint, but its mechanism is less reported. OBJECTIVE: To observe the effect of partial peroneus longus tendon reconstruction in the treatment of posterolateral knee complex injury. METHODS: From January 2017 to January 2021, 56 patients with posterolateral knee complex injury were treated in Affiliated Hospital of Zunyi Medical University. They were randomly divided into control group and observation group (n=28 per group). Patients in the control group were treated with autogenous hamstring tendon and bone-patellar tendon-bone reconstruction under arthroscopy, while patients in the observation group were treated with partial peroneus longus tendon reconstruction. Knee stability, knee function, and quadriceps femoris muscle strength were evaluated and compared in both groups before and after surgery. General indexes, complications and ankle function were compared between the two groups after surgery. RESULTS AND CONCLUSION: (1) Length of hospital stay and postoperative visual analogue scale score were lower in the observation group than those in the control group (P < 0.05). Medical cost was less in the observation group than that in the control group (P < 0.05). (2) Hospital for Special Surgery knee score and Lysholm score were higher in the observation group than those in the control group at 1 and 2 months after surgery (P < 0.05). (3) The peak torque and total work of quadriceps femoris were lower in the observation group than those in the control group at 7 days after surgery (P < 0.05). (4) The complication rate of observation group was lower than that of control group after surgery (P < 0.05). (5) Baird-Jackson ankle scoring system at 2 months after surgery showed that motion range, pain score, running ability score, walking ability score, and ankle stability score were higher in the observation group than those in the control group (P < 0.05). (6) It is concluded that application of reconstruction with partial peroneus longus tendon in patients with posterolateral knee complex injuries can effectively improve the knee stability and function, alleviate the pain, promote the recovery of its quadriceps femoris muscle strength and shorten the length of hospital stay. [ABSTRACT FROM AUTHOR]

Copyright of Geography & Geographic Information Science is the property of Geography & Geo-Information Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mining & Metallurgy (10057854) is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)