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Species of plant resources and community types of Sanmenxia reservoir wetland nature reserve were investigated by referring to relevant literatures and using the method of line transect combined with quadrat survey. The results showed that there were 598 species of vascular plants belonging to 285 genuses and 80 families in Sanmenxia wetland nature reserve, and the wetland vegetation was classified into 4 vegetation type groups, 10 vegetation types, 80 vegetation formations. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of metformin combined with oxaliplatin on the expression levels of vascular endothelial growth factor-C (VEGF-C), vascular endothelial growth factor receptor-3 (VEGFR-3), CD44v6 and β-catenin of lung cancer xenograft in nude mice. Methods We established human lung cancer xenograft models in the nude mice.The nude mice were randomly divided into metformin-treated, oxaliplatin-treated, metformin combined with oxaliplatin-treated and untreated control groups. Forty-two days after administration, all the nude mice were sacrificed and tumor tissues were sampled. The protein and mRNA expression of VEGF-C, VEGFR-3, CD44v6 and β-catenin in the tumor tissues was detected by immumohistochemical method and florescent real-time quantitative PCR, repectively. Results The respective tumor inhibition rates of metformin-treated group , oxaliplatin-treated group and metformin combined with oxaliplatin-treated group were 28.97%, 34.37% and 50.27%. The expression levels of VEGF-C, VEGFR-3, CD44v6 and β-catenin protein and mRNA in the oxaliplatin-treated and metformin combined with oxaliplatin-treated groups were lower than those in the control group, respectively (all P<0.05). Compared with the metformin-treated group and oxaliplatin-treated group, the expression levels of VEGF-C, VEGFR-3, CD44v6 and β-catenin protein and mRNA of the metformin combined with oxaliplatin-treated group were lower, respectively (all P<0.05). F values about comparison of VEGF-C, VEGFR-3, CD44v6 and β-catenin proteins within four groups were 79.281, 151.275, 171.294 and 164.149, respectively (all P<0.01); F values about comparison of VEGF-C, VEGFR-3, CD44v6 andβ-catenin mRNA within four groups were 78.897, 81.029, 64.100 and 83.892, respectively (all P<0.01). Conclusions Using oxaliplatin or metformin can inhibit the expression of VEGF-C,VEGFR-3, CD44v6 and β-catenin. The combination of metformin and oxaliplatin can en-hance the anti-tumor efficacy. [ABSTRACT FROM AUTHOR]