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n-3多不饱和脂肪酸（n-3 PUFA）具有多种生理活性，其主要有3种存在形式，其中甘油酯型n-3 PUFA因其生物利用度高和不易被氧化而优于游离型和乙酯型。然而，目前鲜有对甘油酯型n-3 PUFA进行高纯度富集的方法。为了对甘油酯型n-3 PUFA的高值化更加深入的研究提供参考，综述了富集甘油酯型n-3 PUFA的3种常见方法（物理一步法、两步法和酶一步法）及优缺点。物理一步法可以避免产物氧化，但得率较低；两步法工艺复杂，并有可能产生环境污染；而酶一步法具有简单、高效等优点，成为学者们关注的焦点。现有脂肪酶对甘油酯型n-3 PUFA的富集能力有限，还需进一步发掘富集能力更强的选择性脂肪酶 There are three main forms of n-3 polyunsaturated fatty acids (n-3 PUFA) with a variety of physiological activities, of which glyceride-type n-3 PUFA is superior to free and ethyl ester forms due to its high bioavailability and less susceptibility to oxidation. However, there is few method for the enrichment of glyceride-type n-3 PUFA with high purity. In order to provide a reference for a more in-depth study of the high value of glyceride-type n-3 PUFA, three common methods (physical one-step, two-step and enzymatic one-step), and their advantages and disadvantages of enriching glyceride-type n-3 PUFA were reviewed. The physical one-step method can avoid product oxidation, but the yield is low; the two-step method is complicated and may produce environmental pollution; while the enzymatic one-step method has the advantages of simplicity and high efficiency, which has become the focus of scholars attention. The existing lipases are limited in their ability to enrich glyceride-type n-3 PUFA, and there is a need to further explore selective lipases with higher enrichment capacity.

螺栓球节点是空间网格结构的常用节点型式,节点的安全可靠关系着结构的安全性,足够的螺栓拧入深度是螺栓节点受拉安全承载的保证。对3种螺栓直径、3种螺栓拧入深度、18个螺栓球节点试件进行了受拉试验。试验表明:当螺栓拧入深度分别为螺栓直径的0.8倍、0.9倍时,螺栓螺纹与螺栓球内螺纹间咬合破坏,螺栓从球内拔出;当拧入深度为螺栓直径的1.0倍时,发生螺栓断裂破坏。不同螺栓直径同一拧入深度的螺栓球节点承载力与螺栓极限承载力的比值基本相同。为保证螺栓球受拉节点的安全,螺栓拧入深度不得低于螺栓直径。

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view of the large amount of garbage and the fact that a picture contains multiple garbage objects, this study proposes a garbage detection and classification algorithm based on the improved MobileNet network, which integrates the MobileNet network into YOLOv5(You Only Look Oncev5) target detection algorithm. At the same time, the CBAM(Convolutional Block Attention Modul) module is introduced in the backbone to filter meaningful information, and the vision transformer is used to aggregate and form image features. In addition, the weighted bidirectional feature pyramid network is used to distinguish the contribution of different features. At the same time, the ECA(Efficient Channel Attention) module is introduced to combine the image features and transmit them to the prediction layer. Finally, in order to obtain better performance when there is occlusion between garbage targets, soft-NMS(soft-Non Maximum Suppression) method and Alpha-IoU(Alpha-Intersection over Union) loss function is used to predict the extracted features. The experimental results show that the method proposed in this study can realize the location and recognition of multi-target and multi-category garbage., and the mAP(mean Average Percision) value reaches 90.31%, which is 4.95% higher than that of YOLOv5 network, and the processing speed is shortened by about 2.4 seconds. Compared with the Faster R-CNN(Region-based Convolutional Neural Network) algorithm which integrates ResNet(Residual Network) network, the algorithm proposed in this study improves the processing efficiency on the premise of ensuring the accuracy. [ABSTRACT FROM AUTHOR]

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AIM: This study was performed to investigate the impact of neutrophil extracellular traps （NETs） on scar formation following urethral trauma. METHODS: （1） Clinical samples were derived from patients of Department of Urology, The First Affiliated Hospital of Fujian Medical University, from June 2021 to December 2022. Levels of NETs in the blood and urine were compared between patients with urethral trauma （n=20） and those without urethral trauma （controls, n=20）. The relationship between NETs and scar formation was analyzed.（ 2） Urethral fibroblasts were isolated from urethral scar tissues, and neutrophils were induced to produce NETs in vitro. The urethral fibroblasts were treated with normal saline, 0. 5 mg/L NETs, or 1. 5 mg/L NETs to investigate the effects of NETs on activation and collagen synthesis of urethral fibroblasts. Additionally, a rabbit model of urethral trauma was established and the animals were dioided into four groups to explore the therapeutic potential of deoxyribonuclease I （DNase I） in preventing urethral scar formation: control, operation + transforming growth factor-β1 （TGF-β1）, operation + normal saline, and operation+DNase I. RESULTS: The level of NETs in urine increased after urethral trauma （P<0. 05）, but the level of NETs in blood did not change（ P>0. 05）. In the animal models, the urethral scar became more severe as the level of NETs in the urine increased （P<0. 05）. At the cellular level, NETs promoted the viability, migration, and collagen synthesis of urethral fibroblasts （P <0. 05）. Additionally, urethral injection of DNase I after trauma reduced the level of NETs and inhibited the formation of urethral scar tissue in the animal models （P<0. 05）. CONCLUSION: Infiltration of NETs promotes activation of urethral fibroblasts and scar formation after urethral trauma. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

High -grade neuroendocrine carcinoma of the uterus is a rare malignant tumor of the uterus with high malignancy and poor prognosis. Due to its low incidence rate, there is no standard treatment at present. Therefore, this paper reports the diagnosis and treatment of a 56 -year -old patient with stage Ⅳ uterine high -grade neuroendocrine carcinoma accompanied by endometrioid adenocarcinoma. The patient has undergone surgery, followed by 1 intraperitoneal chemotherapy and 6 courses of systemic chemotherapy (paclitaxel + platinum), then the patient′s outcome was close to complete response. Subsequently, 2 courses of consolidation chemotherapy were performed, and the patient′s condition was evaluated as stable. Currently followed up for 2 years and 10 months, the patient recovered well and did not show obvious signs of recurrence on imaging examination. With retrospective analysis of the clinical characteristics, diagnosis, and treatment of this case as well as relevant literature analysis, this paper aim to improve clinician′s understanding of this type of disease [ABSTRACT FROM AUTHOR]

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Copyright of University Chemistry is the property of Peking University, College of Chemistry & Molecular Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mass traffic stations are key nodes in integrated traffic networks. The scientific definition of station types is of great significance for the refined management of stations and network operations. Using the Xiamen BRT track double-mode network system as the research object, this study analyzed the characteristics and hierarchical relationships of the station network and used complex network analysis to classify stations within the network. By constructing a Space-L-directed weighted complex network model based on station passenger flows, this study proposes four indicators: node strength, weighted betweenness centrality, weighted closeness centrality, and weighted PageRank. A system-clustering method was used to classify the stations. The results are as follows: (1) In the complex network model, the network sites can be divided into six types: core-hub type, local connection, network transition, strong network conduction, weak network conduction, and network-end. The important sites of the network are gathered at the center of Xiamin island, and the secondary sites of the network are distributed on the periphery of the regular spatial network. The important sites of the network outside the island are distributed in mature urban construction areas, and the secondary sites are scattered in preliminary urban construction development areas. (2) All transfer station types have different characteristics. Single-mode transfer stations have the ability to adjust network passenger flow and accommodate the transfer capacity of passenger flow between various regions of the city, whereas double-mode transfer stations have the ability to attract network passenger flow, and the station and other stations on the network. It is closely connected and has high accessibility; single-mode and double-mode combined transfer stations have the ability to promote network passenger flow, and have high passenger flow connection strength and global passenger flow influence ability. (3) Among the single-mode stations in the BRT-metro transit network, the BRT stations perform better than the metro stations. This feature is more obvious in the island area owing to the unbalanced development of the east and west areas of the island. The station classification index and method proposed in this study can reveal the characteristics of station networks, which can improve the operational efficiency of urban BRT-rail network systems. [ABSTRACT FROM AUTHOR]

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Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the influence of paracrine function of recurring and metastatic cervical cancer tissues on the spread of cancer cells. Methods Surgical specimens（ cancerous and para-cancerous tissues） were obtained from 22 patients with metastatic cervical squamous cancer. Serum specimens were collected from 22 patients with metastatic cervical squamous cancer and 22 healthy volunteers， respectively. The expression levels of miR-21-5p in the cancerous and para-cancerous tissues were determined by quantitative real-time PCR （RT-qPCR）. SiHa cell were transferred with miR-21-5p mimics/inhibitors， respectively. The differences between two groups were analyzed by RT-qPCR， colony formation test， Transwell migration test， MTT， western blotting and dual luciferase reporter assay. Serum exosomes were extracted by high-speed centrifugation. The exosome characterization was performed by nanoparticle tracking analysis （NTA）， western blotting and transmission electron microscopy （TEM）. The differences in the expression levels of miR-21-5p in serum exosomes between cervical squamous cancer patients and healthy volunteers were assessed by RT-qPCR. The diagnostic efficiency of miR-21-5p in serum exosomes was evaluated by the receiver operating characteristic（ ROC） curve. Results The expression level of miR-21-5p was up-regulated in cervical cancerous tissues compared with para-cancerous tissues. And over-expressed miR-21-5p could significantly promote SiHa cell colony formation， cell proliferation and migration（ all P < 0.01）. Dual luciferase reporter assay showed that miR-21-5p could target SPYR2 and regulate the expression level of SPYR2. In SiHa cells transfected with miR-21-5p mimics， the expression levels of p-MSK， p-90RSK， p-C-RAF， p-MEK and p-MAPK proteins were significantly up-regulated（ all P < 0.05）. The expression level of miR-21-5p was significantly up-regulated in serum exosomes of patients with cervical squamous cancer （P < 0.05）. The area under the ROC curve （AUC） of serum exosomes for the assessment of cervical cancer metastasis was 0.9375. Conclusions The transfer of miR-21-5p to exosomes in the tissues of patients with metastatic cervical squamous cancer promotes the spread of cancer cells. The mechanism may be related to the targeting of the SPRY2/ERK/ MAPK signaling pathway. [ABSTRACT FROM AUTHOR]

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of China Surfactant Detergent & Cosmetics (1001-1803) is the property of China Surfactant Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Oil Drilling & Production Technology / Shiyou Zuancai Gongyi is the property of Shiyou Zuancai Gongyi Bianjibu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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目的 观察2型糖尿病肾病患者血浆肠源性内毒素(LPS)水平变化, 并探讨其意义。方法 2型糖尿病患 者108例, 其中2型糖尿病肾病患者34例(糖尿病肾病组)、单纯糖尿病患者74例(糖尿病组), 另选32例健康体检者 作对照(健康对照组), 比较各组血浆LPS、超敏Ｃ反应蛋白(hs-CRP)及空腹血糖(FPG)、肾小球滤过率(eGFR)、全血 糖化血红蛋白(HbA1C )和血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇 (HDL-C), 分析血浆LPS与其他临床指标的相关性, 并分析2型糖尿病肾病发病的影响因素和危险因素。结果 与 健康对照组比较, 糖尿病肾病组及糖尿病组血浆 LPS、血清 FPG、血清 TG、全血 HbA1C水平升高, 血清 HDL-C 水平、 eGFR降低(P均<0. 05);与糖尿病组比较, 糖尿病肾病组血浆LPS、血浆hs-CRP水平升高及eGFR降低(P均<0. 05)。 血浆LPS水平与年龄、病程、血浆hs-CRP呈正相关(r=0. 216、0. 267、0. 501, P均<0. 05), 与eGFR呈负相关(r=-0. 318, P<0. 05)。单因素分析显示, 病程、eGFR、血浆hs-CRP、LPS是2型糖尿病肾病发病的影响因素(P均<0. 05);多因素 分析显示, LPS、血浆hs-CRP是2型糖尿病肾病发病的危险因素(P均<0. 05)。结论 2型糖尿病肾病患者血浆LPS 水平升高, 其与糖尿病肾病的发生、发展相关, 有可能为早期干预糖尿病肾病提供治疗靶点。 [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Pesticide Science / Nongyaoxue Xuebao is the property of Chinese Journal of Pesticide Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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This paper elaborates the problems in American education derived by the "scientism", then the leading role of the "scientism"at the stage of undergraduate education for the follow-up education is analyzed. The reform in current university education can be regarded as the "experimental ideology", this paper analyzes the problems existing in the reform of innovation experiment in universities. This paper also puts forward a multi-level and multidisciplinary scientific experiment reforming program in the training of laboratory teachers, the upgrading of the laboratory hardware conditions and the experimental design. These may open up a new research area for the experimental reform in universities. [ABSTRACT FROM AUTHOR]

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