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Objective: To investigate the differences of serum neuropeptide Y (NPY), heat shock protein 70 (HSP-70) and γ-aminobutyric acid (GABA) levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) with different conditions, and to analyze their correlation with sleep structure parameters and the risk factors of cognitive dysfunction in patients with OSAHS. Methods: 122 patients with OSAHS who were admitted to Nanjing Jiangbei Hospital Affiliated to Nantong University and Jiangsu Provincial People's Hospital from March 2019 to March 2022 were selected. According to the sleep apnea hypopnea index (AHI) and the lowest oxygen saturation (SPO2) at night, patients with OSAHS were divided into mild group with 32 cases, moderate group with 54 cases and severe group with 36 cases. According to the Montreal Cognitive Assessment Scale (MoCA), they were divided into cognitive dysfunction group (less than 26 scores, 71 cases) and normal cognitive function group (greater than or equal to 26 scores, 51 cases). The serum NPY, HSP-70, GABA levels were detected. Pearson correlation analysis was performed to analyze the correlation between serum NPY, HSP-70, GABA and sleep structure parameters in patients with OSAHS. Univariate and multivariate Logistic regression analysis were used to analyze the risk factors of cognitive dysfunction in OSAHS. Results: The serum NPY, HSP-70 levels, times of fast wave sleep, times of awakening after falling asleep and percentage of fast wave sleep in the severe group were higher than those in the moderate group and mild group (P＜0.05), while the serum GABA level, times of slow wave sleep and percentage of slow wave sleep were lower than those in the moderate group and mild group (P＜0.05). The serum NPY and HSP-70 levels in patients with OSAHS were positively correlated with the times of fast wave sleep, the times of awakening after falling asleep and the percentage of fast wave sleep (P＜0.05), and negatively correlated with the times of slow wave sleep and the percentage of slow wave sleep (P＜0.05). The serum GABA level was negatively correlated with the times of fast wave sleep, the times of awakening after falling asleep and the percentage of fast wave sleep (P＜0.05), and positively correlated with the times of slow wave sleep and the percentage of slow wave sleep (P＜0.05). Severe OSAHS, increased times of awakening after falling asleep, NPY (increased) and HSP-70 (increased) were risk factors for cognitive dysfunction in patients with OSAHS (P＜0.05), while GABA (increased) was a protective factor (P＜0.05). Conclusion: The increased serum NPY and HSP-70 levels and the decreased GABA level are associated with sleep structure disorder and cognitive dysfunction in patients with OSAHS. The detection of serum NPY, HSP-70 and GABA can assist in evaluating sleep and cognitive function of patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the differences of serum neuropeptide Y (NPY), heat shock protein 70 (HSP-70) andγ-aminobutyric acid (GABA) levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) with different conditions, and to analyze their correlation with sleep structure parameters and the risk factors of cognitive dysfunction in patients with OSAHS. Methods: 122 patients with OSAHS who were admitted to Nanjing Jiangbei Hospital Affiliated to Nantong University and Jiangsu Provincial People's Hospital from March 2019 to March 2022 were selected. According to the sleep apnea hypopnea index (AHI) and the lowest oxygen saturation (SPO2) at night, patients with OSAHS were divided into mild group with 32 cases, moderate group with 54 cases and severe group with 36 cases. According to the Montreal Cognitive Assessment Scale (MoCA), they were divided into cognitive dysfunction group (less than 26 scores, 71 cases) and normal cognitive function group (greater than or equal to 26 scores, 51 cases). The serum NPY,HSP-70, GABA levels were detected. Pearson correlation analysis was performed to analyze the correlation between serum NPY,HSP-70, GABA and sleep structure parameters in patients with OSAHS. Univariate and multivariate Logistic regression analysis were used to analyze the risk factors of cognitive dysfunction in OSAHS. Results: The serum NPY, HSP-70 levels, times of fast wave sleep,times of awakening after falling asleep and percentage of fast wave sleep in the severe group were higher than those in the moderate group and mild group (P＜0.05), while the serum GABA level, times of slow wave sleep and percentage of slow wave sleep were lower than those in the moderate group and mild group (P＜0.05). The serum NPY and HSP-70 levels in patients with OSAHS were positively correlated with the times of fast wave sleep, the times of awakening after falling asleep and the percentage of fast wave sleep (P＜0.05), and negatively correlated with the times of slow wave sleep and the percentage of slow wave sleep (P＜0.05). The serum GABA level was negatively correlated with the times of fast wave sleep, the times of awakening after falling asleep and the percentage of fast wave sleep (P＜0.05), and positively correlated with the times of slow wave sleep and the percentage of slow wave sleep (P＜0.05). Severe OSAHS,increased times of awakening after falling asleep, NPY (increased) and HSP-70 (increased) were risk factors for cognitive dysfunction in patients with OSAHS (P＜0.05), while GABA (increased) was a protective factor (P＜0.05). Conclusion: The increased serum NPY and HSP-70 levels and the decreased GABA level are associated with sleep structure disorder and cognitive dysfunction in patients with OSAHS. The detection of serum NPY, HSP-70 and GABA can assist in evaluating sleep and cognitive function of patients. [ABSTRACT FROM AUTHOR]

Centrifuge shaking table tests about the bridge pile groups with embedded cap and elevated cap were earned out to investigate the effect of bridge group foundation with massive cap and exposed piles on the dynamic pile-soil interaction. Clayey silt was chosen as the test soil, the superstructure was simplified as mass point and connecting column and the foundation types included both the single pile and pile group. To simulate the soil movement under earthquake shear wave excitations, the laminar shear box was adopted for the free shear motion of layer soil and corresponding reflection at its boundary was further eliminated by using the rubber film on the inner wall of shear box. In the 50g centrifugal acceleration environment, the Chi-Chi seismic wave was selected as the input motion, and the seismic responses of structure-pile group were analyzed at different input peak acceleration of waves. The results show that, compared with the embedded cap pile groups, the exposure of the bridge pile groups with elevated cap increases the inertia effect of superstructure and cap, and the distribution of peak bending moments along the pile shaft are also changed, i. e., the peak bending moment is significantly decreased at the connection of pile and cap, while the values of maximum peak bending moments along the pile shaft only have a small change. [ABSTRACT FROM AUTHOR]