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Topology optimization technology was introduced into the design of nodes in cable-strut structures. Taking several typical nodes in a herringbone ribbed cable dome structure as research objects, the optimization program Altair Solidthinking Inspire was used to carry out static topology optimization under given load cases, where maximization of stiffness under volume constraint and minimization of mass under stress constraint were taken as optimization objectives. Key topology features were further extracted from the optimized results and new models were built by the usage of Evolve, leading to nodes with rational load-bearing behavior and design aesthetic perception. Finite element software ABAQUS was employed to analyze and compare the mechanical property of optimized nodes with initial designed ones in order to comment on the mechanical performance of the new designed nodes. For the nodes which are supposed to directly provide the stiffness，maximization of stiffness under volume constraint should be chosen as the primary optimization objective. For the nodes that serve as connecting components rather than providing stiffness, minimization of mass could be the optimization objective. Finally, additive manufacturing is utilized to realize practical manufacturing of the optimized nodes with complex and irregular geometry. [ABSTRACT FROM AUTHOR]