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当前，光伏、海上风电等新能源场站的直流汇流应用得到越来越多的关注，在新能源发电低压输入中高压汇流输出的场合，为了提升直流输电电压并进一步减小器件应力，多采用输入并联输出串联（IPOS）结构。虽然这种模块化串并联结构有着许多优势，但由于模块间器件参数误差，导致各模块存在电压电流不均衡的问题，影响整个功率变换系统的稳定运行。为此提出了面向直流汇流应用的IPOS多模块谐振变换器的改进下垂控制均衡方法，各模块间无需加入通信就实现各模块的输出电压和功率的完全均衡，改进了传统下垂控制电压与参考值不符的问题，并进一步提升了系统的动态响应性能。基于该控制方式，搭建了三路模块化IPOS谐振变换器原理样机，通过实验验证了所提改进下垂控制方法对IPOS系统的均衡效果。

【目的】检测健康女性、卵巢良性上皮性肿瘤患者及卵巢恶性上皮性癌患者（含各分期）外周血循环 肿瘤细胞（CTC）阳性率及数量差异，初步评估CTC检测在卵巢恶性上皮性癌筛查中的临床意义。【方法】选取中 山市博爱医院、中山大学附属中山医院2016年1月至2017年12月期间，151例健康女性体检者（正常组）、138例 卵巢上皮性良性肿瘤患者（良性组）、92例卵巢上皮性癌，含所有类型及临床分期的卵巢上皮性癌患者（恶性组） 为研究对象，卵巢肿瘤患者以病理组织学结果为金标准，采集患者术前和正常组静脉血液样本，采用免疫磁珠微 粒阴性富集法和免疫荧光原位杂交法检测研究对象的CTC，使用SPSS20.0比较3组外周血CTC阳性率及数量差 异；统计分析CTC检测诊断卵巢上皮性癌的灵敏度、特异度、符合率、阳性预测值和阴性预测值，综合评估CTC检 测诊断卵巢上皮性癌的价值。【结果】①正常组、良性组与恶性组CTC阳性率分别为0、 0和90.22%，总体差异具 有统计学意义（P

文章阐述了光模块突发接收误码测试的基本原理。根据吉比特无源光网络（GPON）系统上行数据的特点,提出了一种新的突发数据提取方法及其关键技术,并设计了实现突发测试的逻辑框图、逻辑时序图及电路。采用该测试系统对GPON光线路终端（OLT）光模块进行了测试,结果表明该系统操作简单,可靠性高,能够满足GPON OLT光模块性能测试的需要。

Copyright of Journal of Nanchang University (Engineering & Technology) is the property of Nanchang University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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In this paper, the formation of oxygen vacancy in the Al2O3 support was induced by urea doping. Through metal-support interaction, the dispersion of Ru-based active species on the surface of the Al2O3 support was improved. The electronic properties of Ru-based active centers was regulated, and then the catalytic performance of the Ru-based catalyst for Sabatier reaction was effectively improved. In this process, it was verified by nuclear magnetic resonance spectroscopy Al-NMR) that urea doping can effectively induce the formation of oxygen vacancy in the Al2O3 support. Transmission electron microscopy (TEM) showed that, the loaded Ru particles could be stabilized at about 3.7 nm on the surface of the Al2O3 support rich in oxygen vacancy, and the distribution of particle size was concentrated. By X-ray photoelectron spectroscopy (XPS) and H2 programmed temperature reduction (H2-TPR), it was found that the oxygen vacancy from the Al2O3 support can effectively regulate the electronic property of the Ru-based active sites. Sabatier reaction performance test showed that under the reaction condition of 300 °C, nco2 : = 1 : 4 and 6000 mL/(g • h), the conversion rate of CO2 could be reached at 61.25% and the selectivity of CH4 could be reached at 92.31 %. Moreover, the catalytic performance did not decrease within 20 hours of the reaction time. [ABSTRACT FROM AUTHOR]

[Objective] The aims of this study are to investigate the regularities of runoff and sediment yield on the slope of Dicranopteris pedata under different dead rates (100%, 50% and 0%）, and to reveal the effect of Dicranopteris pedata under different growth conditions on soil erosion control. [Methods] The variation characteristics of runoff and sediment yield on the slope with different dead rates of Dicranopteris pedata were quantitatively analyzed through artificial simulated rainfall experiments. [Results] (1) The runoff rate under different rainfall intensity and dead rate of Dicranopteris pedata increased slowly or rapidly in the early stage, and tended to be stable in the late stage. Under the light rainfall intensity, the erosion rate, except for bare slope, increased slowly in the early stage and tended to be stable in the later stage. Under the high rainfall intensity, the erosion rate increased rapidly in the early stage, and gradually decreased and stabilized in the middle and late stage. (2) Except for the cumulative runoff under 2 mm/min rainfall intensity, the cumulative runoff and sediment yield were significantly different under the other treatment conditions, and the sediment yield increased with the increase of the dead rate of Dicranopteris pedata. (3) The relationship between cumulative runoff and cumulative sediment yield on the slope under different rainfall intensities conformed to the power function model (R~2＞0.99）. [Conclusion] The runoff rate and erosion rate increased rapidly in the early stage and fluctuated steadily in the later stage with the change of rainfall duration under the different mortality rates of Dicranopteris pedata plantation with two kinds of rainfall intensities. A good regression effect is obtained by fitting the functional relationship between cumulative runoff and cumulative sediment yield under each treatment. It is proved that the dead Dicranopteris pedata can also play a good role in soil and water loss control in the red soil erosion area in southern China. [ABSTRACT FROM AUTHOR]

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Myeloid suppressor cells(MDSCs)are a kind of innate immune cells, which are characterized by the ability to control T cell response and inhibit inflammation. Although the role of MDSCs in cancer has been deeply studied, the reports of MDSCs during bacterial infection are still limited, and their association with immunoregulation of bacterial diseases is still being determined. Here, we summarize and discuss the current view of how MDSCs participate in bacterial infection. Understanding the similarities and differences between bacterial pathogen induced MDSCs and tumor derived MDSCs is very important for designing future immunotherapy methods. [ABSTRACT FROM AUTHOR]

This research investigated the response of D.pedata to drought stress using polyethylene glycol（PEG） 6 000.We examined several parameters such as superoxide dismutase（SOD）,peroxidase（POD）,catalase（CAT）,proline（Pro）,relative electrical conductivity（REC）,and malondialdehyde（MDA） of D.pedata under drought stress induced by PEG 6 000.Exposure to drought stress significantly increased SOD,Pro, PEC,and MDA levels in D.pedata.POD expression was remarkably upregulated at 10% PEG 6 000 concentration but decreased at higher concentrations.CAT activity decreased at first but increased later as the concentration of PEG 6 000 increased.Strong drought resistance was observed at 30% PEG 6000 concentration by principal component analysis and correlation analysis.Pro was shown to perform a critical role in the response of D.pedata to drought stress.The results suggest that the higher activities of SOD and CAT and higher Pro concentration, which work together to improve the drought resistance, are the main components that facilitate the survival of D.pedata under seasonal drought environment and play a vital role in soil and water conservation.Nevertheless, extremely severe drought still destroys the physiological activities of D.pedata further weakens its drought resistance. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and purpose: The response rate of gastric cancer patients to programmed death-1 (PD-1) inhibitor is relatively low. Establishing a useful efficacy prediction method to screen the superior gastric cancer patients receiving anti-PD-1 therapy could improve the prognosis of patients. This study aimed to explore the value of combined detection of lactate dehydrogenase (LDHA) and programmed death ligand-1 (PD-L1) expressions in predicting the efficacy and prognosis of gastric cancer patients treated with PD-1 inhibitor. Methods: The clinicopathological data of 50 advanced gastric cancer patients treated with PD-1 inhibitor in The First Affiliated Hospital of Wannan Medical College from January 2020 to March 2022 were retrospectively analyzed. The independent risk factors affecting the efficacy of PD-1 inhibitor were analyzed by multivariate logistic regression. The value of combined detection of LDHA and PD-L1 in predicting the efficacy of PD-1 inhibitors in gastric cancer was analyzed by receiver operating characteristic (ROC) curve analysis. Gastric cancer patient survival was analyzed by Kaplan-Meier method. Results: The objective response rate (ORR) of gastric cancer patients receiving PD-1 inhibitor therapy in LDHA low and high expression groups were 59% and 10%, respectively. The disease control rate (DCR) in LDHA low and high expression groups were 83% and 29%, respectively. The difference was statistically significant (P＜0.001). Multivariate logistic regression analysis showed that PD-L1 combined positive score (CPS)＜5 and LDHA high expression were independent risk factors affecting the efficacy of PD-1 inhibitor in gastric cancer (P＜0.05). ROC curve analysis showed that combined detection of LDHA and PD-L1 had good predictive value for the efficacy of PD-1 inhibitor in gastric cancer ［area under curve (AUC) was 0.951］. Kaplan-Meier survival analysis showed that gastric cancer patients with low LDHA expression and PD-L1 CPS≥5 had longer overall survival (OS, P=0.003) and progression-free survival (PFS, P＜0.001) after receiving PD-1 inhibitor therapy. Conclusion: Low LDHA expression and PD-L1 CPS≥5 were positively correlated with the efficacy of PD-1 inhibitor in gastric cancer. Gastric cancer patients with low LDHA expression and PD-L1 CPS≥5 significantly had prolonged OS and PFS after receiving PD-1 therapy. Therefore, the combined detection of LDHA and PD-L1 expressions has good value in predicting the efficacy and evaluating prognosis of advanced gastric cancer patients treated with PD-1 inhibitor. [ABSTRACT FROM AUTHOR]

钢管桩码头外加电流阴极保护系统处于严苛海洋腐蚀环境并面临台风侵袭, 系统设计在确保满足阴极保护 规范要求的同时, 还需重点关注各系统组件的长期耐久性能。基于湛江港某码头钢管桩外加电流阴极保护系统设计, 详细介绍了关键参数的决策过程, 包括电流计算中涂层破损率的取值、阴极保护电源的设计选型和布置以及布线系 统设计。5 a 的运行结果表明, 阴极保护系统设计整体上是成功的, 系统运行状态与设计意图基本符合。 [ABSTRACT FROM AUTHOR]

A gold mine, operating with the short-hole shrinkage method for a long time, leaves a large number of goafs. According to the steady state of the current goaf, 12 factors including uniaxial compressive strength, integrity coefficient, the exposed area of goafs, and span/height ratio were selected as the predictive index system, and the unascertained measurement model was constructed. A weight calculation method based on AHP-information entropy combination weighting is proposed, and the expert scoring method and linear formula method are used as the measurement function of the qualitative index and quantitative index, finally, the evaluation results are obtained according to the confidence recognition criterion. The research shows that the prediction results are consistent with the actual performance of the onsite goafs, verifying the feasibility of this method and diversifying the safety assessment method of goafs. [ABSTRACT FROM AUTHOR]

Copyright of Refractories / Naihuo Cailiao is the property of Naihuo Cailia (Refractories) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Nonferrous Metals (Mineral Processing Section) is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nonferrous Metals (Mineral Processing Section) is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Plant functional traits can reflect response strategies of plants to environmental changes. In this study, we used a one-way ANOVA and redundancy(RDA)to compare the differences in leaf functional characters of Dicranopteris pedata in three micro-topographies(ridge, slope and valley of the ephemeral gully)and to analyze the response and adaptation strategy of D. pedata to shallow trench micro-topography. The results were as follows:(1)The overall variation degree of leaf functional characters of D. pedata was between 0.05 and 0.47. Both leaf thickness and leaf area were showed as the order of valley > slope > ridge(P<0.05). The leaf N content at the slope was significantly higher than that at the ridge and valley. The leaf P content was significantly lower at the ridge than those at the slope and valley. There was no significant differences in specific leaf area and leaf C content among three micro-topographies.(2)D. pedata at the ridge reduced water loss to protecte itself by reducing leaf area. D. pedata at the slope increased the photosynthetic rate of leaves to promote growth by increasing the N content of leaves. D. pedata at the valley improved light capture ability to promote growth by increasing the leaf area. The above results indicate that due to the differences of soil nutrients, temperature and humidity conditions, D. pedata can achieve better adaption to the environment by adjusting nutrient content and changing leaf morphology. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Guangxi Normal University - Natural Science Edition is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Complex fracture technology is one of the keys to the successful development of unconventional oil and gas reservoirs such as shale. At present, most studies focus on how to improve the complexity of fracture network. It is still unclear whether proppant can enter branch fractures at all levels after the complex fractures are formed. Numerical simulation and indoor experiments provide some qualitative results, but there are still lack of quantitative models. Thus, the liquid distribution model and the proppant turning law were proposed to predict the proppant transportation behavior in the complex fractures. The results show that the prediction accuracy of this model is higher than that of previous ones. In addition, the influence of branch fracture angle on the liquid distribution is discussed. Finally, an engineering case is studied with this model, and some suggestions are provided for the fracturing parameter optimization. [ABSTRACT FROM AUTHOR]

In the present research, the extremely severe cyclonic storm Fani (2019) is studied by using the recently developed Coupled Ocean-Atmosphere-Wave-Sediment Transport (COAWST) model. Fani was originally formed from low depression over the Indian Ocean on April 26, and rapidly intensified into a severe tropical cyclone. It made landfall in India on May 3, causing severe damage. Using COAWST, we configure a regional numerical experiment to simulate the development and landfall process of Fani (April 30 12: 00—May 3 12: 00 UTC), and investigate the atmospheric and oceanic parameters as well as significant wave height. The results are compared with the measured storm track and intensity data from the International Best Track Archive for Climate Stewardship (IBTrACS) and the ERA5 reanalysis data. The results show that the movement path of Fani simulated by the model is close to the observation, but the simulated intensity is weaker. The simulated 2m temperature, latent heat and sensible heat flux are slightly different from the ERA5 reanalysis data, but the simulated intensity and characteristics of the sea surface temperature field are close to ERA5 reanalysis data. Significant wave height of 10m is obvious during the whole process of Fani, and this strong tropical cyclone-ocean interaction has been well modeled, which reveals the large potential of COAWST to model tropical cyclones over the Indian Ocean. [ABSTRACT FROM AUTHOR]

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Copyright of Computer Engineering & Science / Jisuanji Gongcheng yu Kexue is the property of Computer Engineering & Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and purpose: Gastric cancer is one of the most common malignant tumors of digestive system. Previous study demonstrated that circSMARCA5 was downregulated and could function as a tumor suppressor in gastric cancer. However, the molecular mechanism has not yet been documented. This study aimed to investigate the effects of circSMARCA5 on the proliferation and invasion of gastric cancer cells and their molecular mechanisms. Methods: Cell counting kit-8 (CCK-8) assays and transwell assays were performed to examine the cell proliferative and invasive abilities, respectively. The effect of circSMARCA5 on gastric cancer cell glycolysis was assessed by detecting the extracellular acidification rate, glucose uptake level and lactate production. Real-time fluorescent quantitative polymerase chain reaction (RTFQ-PCR) assay was performed to detect the expression levels of circSMARCA5, miR-4295 and PTEN. The levels of GLUT1 and LDHA were measured by Western blot assay. The transplanted xenograft model in nude mice was established, and the effects of circSMARCA5 on the tumor growth were observed. Immunohistochemistry assays were performed to examine the expression levels of GLUT1, LDHA and Ki-67 proliferation index in xenograft tumors. Dual luciferase reporter gene assays, Pearson's correlation analysis and RNA immunoprecipitation (RIP) assays were used to confirm the targeting relationship of circSMARCA5 and miR-4295 as well as miR-4295 and PTEN. Results: CircSMARCA5 overexpression inhibited the proliferation and invasion of gastric cancer cells. Compared to the control group, the glycolysis rate, glycolysis capacity, glucose uptake and lactate production in the circSMARCA5-overexpresing group were significantly decreased. In addition, nude mouse transplanted xenograft assays showed that the volume and the weight of the tumors in the circSMARCA5-overexpressing group were lower compared with the control group. Further studies indicated that circSMARCA5 acted as a molecular sponge to inhibit the expression of miR-4295. Besides, miR-4295 could inhibit the expression of PTEN by binding with the 3'-UTR of PTEN mRNA. Rescue experiments by upregulating miR-4295 or downregulating PTEN expression in the circSMARCA5-overexpressing gastric cancer cells were performed, and the results showed that upregulation of miR-4295 or PTEN knockdown could abolish the inhibitory effects of circSMARCA5 overexpression on cell proliferation, invasion and glycolysis. Conclusion: CircSMARCA5 suppresses the proliferation and invasion of gastric cancer cells by targeting miR-4295, increasing the expression level of PTEN and subsequently regulating glycolysis. [ABSTRACT FROM AUTHOR]

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