OBJECTIVE: To investigate the characteristics and regularity of adverse drug reactions (ADR) in Xiamen Xianyue Hospital (hereinafter referred to as "our hospital"), so as to promote clinical rational medication and improve medication safety. METHODS: With the help of the Nationwide Adverse Drug Reaction Monitoring Network, 588 cases of ADR reports in our hospital from Jul. 2014 to Jun. 2016 were retrospectively analyzed in terms of patients' age and gender, categories of drugs, ADR involved organs and (or) systems, and clinical manifestations. RESULTS: Among the 588 cases of ADR, 577 cases were common ADR (98. 13%), with 89 cases of new ADR (15. 14%) and 11 cases of severe ADR (1. 87%), no death reports. 311 cases were male patients (52. 89%) with mostly aged 21-40 years, and 277 cases were females (47. 11%) with mostly aged 41-50 years. 539 cases of ADR (91. 67%) were caused by psychotropic drugs, of the rest 49 cases, 4 cases were caused by antibacterial drugs. Among the top 20 ADR-reducing drugs, all of them were psychotropic drugs except for propofol; the top 3 were respectively olanzapine, risperidone and clozapine, all three were atypical antipsychotic drugs. 408 cases of ADR (69. 39%) were caused by antipsychotic drugs, with 7 cases were severe ADR, mostly involved peripheral nervous system. Typical antipsychotic drugs, antidepressant and psychotropic drugs caused less ADR. CONCLUSIONS: Psychiatric hospitals should pay more attention to ADR, reinforce rational drug application and ensure patients' safe medication. [ABSTRACT FROM AUTHOR]