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Objective: To summarize clinical experience of red man syndrome in anti-infective therapy after cardiac surgery. Methods: The data of red man syndrome in anti-infective therapy after cardiac surgery from January 2013 to August 2020 were retrospectively collected from Nanjing Drum Tower Hospital for study. Clinical characteristics and factors influencing the occurrence of red man syndrome were analyzed. Results: In anti-infecive therapy after cardiac surgery, there were totally 6 patients with red man syndrome, of whom 4 developed the syndrome during the treatment course of vancomycin or after application of the drug, one developed the syndrome induced by teicoplanin after using the drug for 23 days and 5 days after drug withdrawal, and one occurred following application of cephalosporins for 13 days. With effective treatment, all the 6 patients recovered and were discharged from hospital. Conclusion: Red man syndrome is quite common in the process of anti-infective therapy after cardiac surgery, which is mostly caused by vancomycin allergy. Early manifestations are local red rash, papule or maculopapular rash, with itching. If not actively treated, rash can spread to all parts of the body, or even cause shock with critical conditions. Early attention and active salvage measures could help patients to be out of danger. [ABSTRACT FROM AUTHOR]

Objective To explore the diagnostic value of serum fibroblast growth factor-23 (FCF23) and Fetuin-A detection for main adverse cardiovascular events (MACE) in patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) operation. Methods Totally 127 patients with STEMI who completed PCI operation within 24 hours were selected. The patients were divided into MACE group (n =38) and non-MACE group (n =89) according to whether or not they had MACE during hospitalization. Meanwhile, 50 healthy people in the same period were taken as the control group. The demographic data and laboratory indicators in each group were collected, and the serum FCF23 and Fetuin-A levels were measured by enzyme-linked immunosorbent assay. Logistic regression analysis was used to analyze the influencing factors of MACE in STEMI patients after PCI during hospitalization. The value of predicting MACE by FCF-23 and Fetuin-A was evaluated by receiver operating characteristic curve (ROC curve). Results Serum FCF23 level in STEMI patients was higher than that in the control group, and serum Fetuin-A level was lower than that in the control group (both P<0.05). Serum FCF23 level in the STEMI group was higher than that in the non-MACE group, and serum Fetuin-A level was lower than that in the non-MACE group (P<0.05). High Killip classification of cardiac function and elevated levels of amino-terminal pro-brain natriuretic peptide (NT-proBNP) and FCF23 were independent risk factors for MACE; the elevated levels of left ventricular ejection fraction (LVEF), cardiac index (CI), and Fe-tuin-A were protective factors for MACE. The area under the curve (AUC) of FCF23 in predicting MACE was 0.871, 95% CI: 0.808-0.934, the best cut-off was 10.89 pg/mL, the sensitivity and specificity were 0.86 and 0.82, respectively, and the accuracy was 0.85. The AUC of Fetuin in predicting MACE was 0.852, 95% CI: 0.785-0.198, and the best cut-off was 976.82 ng/mL, the sensitivity and specificity were 0.81 and 0.75, respectively, and the accuracy was 0.80. The ACU of FCF23 combined with Fetuin for MACE prediction was 0.934, 95% CI: 0.891-0.977, the sensitivity and specificity were 0.93 and 0.89, respectively, and the accuracy was 0.92. Conclusions The increased FCF23 and decreased Fetuin-A levels are independent influencing factors for MACE in STEMI patients after PCI operation, and the combined detection of FCF23 and Fetuin-A can be used as important markers for predicting the occurrence of MACE in STEMI patients. [ABSTRACT FROM AUTHOR]

Objective To understand the prevalence situation of chronic diseases among adult residents and related risk factors in Pengzhou City of Sichuan to provide the reference for formulating and evaluating the prevention and treatment measures of chronic diseases. Methods The multistage stratified cluster sampling method was adopted to randomly extract 600 households from 12 monitoring villages (community) in Pengzhou. Then according to the KISH selection method, 1 resident aged 18 years old or more was randomly extracted. The questionnaire, physical examination and laboratory detection were carried out in survey. Results Totally 575 residents were surveyed,including 191 males and 384 females. The prevalence rates of hypertension,dys-lipidemia, diabetes, chronic obstructive pulmonary disease, myocardial infarction, stroke, asthma and malignant tumors in the surveyed population were 48.59% ,22.30% , 12.57% ,6.61% ,0.35% ,0.87%, 1.22% and 1.39% respectively. The total smoking rate among the investigated population was 26.26%,moreover male was higher than female with statistical difference(64.40% vs.l .29%, X2=241.811 ,P<0.001). The alcohol drinking rate was 24.70%, moreover male was significantly higher than female with statistical difference(56.54% vs. 8.85%, X2= 155.997 ,P<0.001). The over-weight rate was 35.68%, 11.32% in male and 35.79% in female, showing no statistically significant difference between the sexes(P>0.05). The obesity rate was 9.67%, 11.32% in female and 6.35% in male,female was higher than male with statistical difference (X2=3.566,P=0.038). The central obesity rate was 41.74% in total ,45.57% in female,which was higher than 34.03% in male,the difference was statistically significant(^2=6.506,P<0.005). Conclusion The chronic disease of hypertension, dyslipidemia, diabetes, etc. and their risk factors seriously affect the health of residents, therefore the health behavior education should be actively conducted to prevent the occurrence of chronic diseases. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the clinical efficacy of lour combinations of pantoprazole, amoxicillin, clarithromycin and bismuth pectin with different courses in treatment of gastric ulcer and its effects on recurrence rate. METHODS: 92 patients with gastric ulcer admitted into Ji’an Hospital of Shanghai Dongfang Hospital from May. 2015 to May. 2016 were selected and divided into control group and observation group via random number table method, with 46 cases in each group. Both groups were given combination treatment of pantoprazole, amoxicillin, clarithromycin and bismuth pectin, 1 month of continuous treatment was set as 1 course, the control group received 1 course of treatment, while the observation group was given 3 courses. Clinical efficacy, recurrence rate, levels of superoxide dismutase(SOD) and nitric oxide synthase(NOS) ol before and after treatment were compared. RESULTS: The total effective rate ol observation group(93. 48%, 43/46) was significantly higher than that of the control group (78. 26%, 36/46) ; after treatment, the SOD and NOS levels of observation group were significantly higher than those of the control group, with statistically significance differences (P < 0. 05). 1 year alter the end ol treatment, the positive rate of helicobacter pylori of observation group (32. 61 %, 15/46) was significantly lower than that of the control group (54. 35%, 25/46), the recurrence rate ol observation group (6. 52%, 3/46) was significantly lower than that of the control group (26.09%, 12/46), with statistically significance difference (P < 0.05). CONCLUSIONS: The efficacy ol four combinations ol pantoprazole, amoxicillin, clarithromycin and bismuth pectin with 3 courses in treatment of gastric ulcer is better than that of 1 course of treatment, with lower recurrence rale. [ABSTRACT FROM AUTHOR]

目的观察产后抑郁患者海马磁共振T2信号值变化。方法观察组为6例产后抑郁患者（产后12个月仍处于抑郁状态）,对照组为20例未发生产后抑郁的产妇。两组产前（入院待产即刻）及产后12个月均接受MR头颅检查,收集磁共振图像资料,分析两组左、右侧海马磁共振T2信号值,测算海马体积。结果产前观察组左、右侧海马磁共振T2信号值分别为569.51±15.36、568.70±15.22;产后12个月观察组左、右侧海马磁共振T2信号值分别为597.54±18.36、598.70±18.82,与产前左、右侧海马磁共振T2信号值相比,P均<0.05。产前对照组左、右侧磁共振T2信号值分别为556.42±15.12、555.90±15.14。对照组左、右侧海马磁共振T2信号值分别为561.42±14.53、569.90±15.72,与自身孕前左、右侧海马体积相比,P均>0.05。产后12个月观察组左、右侧海马磁共振T2信号值与对照组相比,P均<0.05。产后12个月观察组、对照组的左右侧海马体积与产前比较,P均>0.05。结论产后抑郁患者海马磁共振T2信号值高,海马体积无变化。 [ABSTRACT FROM AUTHOR]

Organic chemistry experiment is an important part of organic chemistry. It can support organic chemistry theory teaching by experimental verification. However, some organic chemistry experiment textbooks cannot clearly describe some experimental details or ambiguously introduce some experimental concept which cause some experiment cannot be carried out. For example, in the experiment of distillation, the temperature of the first drop of condensation is ambiguously expressed . In the experiment of recrystallization and the process of filtering insoluble substance, it can expand error by using filter paper. In the experiment of ethyl acetate synthesis, concentrated sulfuric acid as catalyst, it can easily appear carbonization black phenomenon. The above three problems are thoroughly analyzed and discussed in this paper. New methods and advice are put forward and thoroughly dissolved the above three problems. Great teaching result is achieved at last. [ABSTRACT FROM AUTHOR]