Search

N6-methyladenosine (m6A) RNA methylation is the most common internal modification of messenger RNA in vivo and is involved in physiological and pathological processes in vivo. With the in-depth study of m6A modification, its importance in the pathogenesis of many diseases has been paid attention to. osteoarthritis (OA) is a degenerative disease of articular cartilage. Research on OA has increased rapidly in recent years, and the exploration of its pathogenesis is one of the main research directions. Current studies on m6A modification in the pathogenesis of OA mainly focus on five aspects：protection of ECM from degradation, inhibition of OA programmed cell death, regulation of fat mass and obesity-related proteins, interaction with non-coding RNA, and improvement of immune microenvironment. Therefore, this paper will focus on these aspects, in order to provide a certain basis for the in-depth study of m6A RNA methylation modification in the pathogenesis of OA and the treatment of orthopedic diseases based on epigenetic mechanism and theoretical reference. [ABSTRACT FROM AUTHOR]

Oleic acid is an important quality index that determines the oxidation stability and nutritional value of peanut oil. In recent years, scholars at home and abroad have taken increasing oleic acid content and reducing linoleic acid content as an important direction of quality improvement. Optimizing the composition and content of peanut fatty acids through molecular marker-assisted selection and traditional breeding techniques, and cultivating high oleic acid peanut varieties with high yield, strong disease resistance, and specialized properties is of great significance for promoting the development of the peanut industry and improving people's health. This paper reviewed the molecular mechanism of high oleic acid traits, the application of molecular marker-assisted selection in high oleic acid peanut breeding, and the identification technology of high oleic acid peanuts. It analyzed the current status of high oleic acid variety breeding, and pointed out the problems in high oleic acid peanut breeding in China to provide a reference for expanding the breeding objectives of high oleic acid peanut. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of separation exercise training of upper limb robot in improving upper limb motor function of stroke patients, and to explore the underlying mechanism by transcranial magnetic stimulation motor-evoked potential (MEP) evoked potentials. Method: Stroke patients were randomly divided into the experimental group (n=21) and the control group (n= 23). The experimental group was trained with a fixed trajectories (the separation movement of elbow flexion-extension and shoulder adduction-abduction), while the control group underwent upper limb robot training with random movement trajectories (a compound action that can reach for objects). Both groups received robot training once a day, 20min/time, 5 times/week for 3 weeks. The Fugl-Meyer assessment of upper extremity (FMAUE) and modified Barthel index (modified Barthel index, MBI) were used to evaluate motor function. The latency period and central motor conduction time (CMCT) of MEP were detected before and after treatment. Result: After 3 weeks of treatment, the FMA-UE, MBI and MEP were improved compared with before treatment in the experimental group (P<0.05), There was no significant difference between the FMA-UE, MBI and MEP of the control group and that before treatment (P>0.05); There were no significant differences in in FMA-UE, MBI and MEP between-group comparisons after 3 weeks of treatment. Conclusion: The separation exercise training of the upper limb robot can improve the upper limb motor function and enhance daily living activities in stroke patients, which may be related to enhanced remodeling of brain function in stroke patients. [ABSTRACT FROM AUTHOR]

Strengthening user relationship management is the important way for the high-quality development of university libraries, which has attracted the attention of university libraries in recent years. The current research and practice mainly focus on service strategy, and lack of systematic research and planning from the perspective of organizational strategy. In addition, there are also problems such as insufficient attention to the subjectivity and initiative of users in library work, and lack of empirical research results. The purpose of this study is to construct a suitable cognitive and practical framework for user relationship management in university libraries, and to introduce the successful experience based on this framework, so as to provide reference for other university libraries. Therefore, based on the essential characteristics and fundamental functions of all library services and resources to support user knowledge construction, this study defines four vertical dimensions of user relationship management in university libraries by applying knowledge construction theory and logical deduction method, including space construction, knowledge resource construction, interactive situation construction and user subject construction, which intersect with the horizontal process of reinterpretation of user relationship management, and together constitute the cognitive and practical framework of library user relationship management. Based on the above framework, this paper introduces the practice and effect of strengthening user relationship management in the library of North China University of Science and Technology, including the construction of physical space, to provide users with real situation; knowledge resource construction, to provide users with applicable learning materials; social interaction construction, to promote the exchange and cooperation of users; user subject construction, to enhance the subjective initiative of user knowledge construction. It also introduces the specific measures taken by the library in terms of organization construction, librarian team construction and external publicity and promotion. The cognitive and practical framework constructed in this study better deals with the relationship between theory introduction and localization reconstruction, defines the logical and behavioral boundaries of library user relationship management, and clarifies the content and focus of practice. It is the inheritance and development of the traditional "user-centered" concept and practice of libraries. It has become a strategic action guide for the industry to recognize and practice user relationship management, and helps to achieve good results in related work. [ABSTRACT FROM AUTHOR]

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Soochow Journal of Economics & Business is the property of Soochow Journal of Economics & Business and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Agriculturae Zhejiangensis is the property of Acta Agriculturae Zhejiangensis Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

An accurate detection can greatly contribute to the wheat ears in field environments. Traditional object detection models with horizontal bounding boxes cannot accurately detect the densely distributed wheat ears, particularly on the significant occlusion between ears and stalks. The high miss detection of wheat ears often occurs in the variation of illumination conditions, dense distribution, and small scales, due to the overlap of prediction bounding boxes. It is a high demand to orient the wheat ears with less noise and of large background for the high performance. In this study, an improved Oriented Region-based Convolution Neural Networks (R-CNN) model was proposed to detect and count rotated wheat ears. Firstly, the spatial pyramid pooling cross-stage partial networks (SPPCSPC) was added to the backbone network to generate the last layer of the output feature map. The sensing field was then enlarged to enhance the perceptual ability of the network; Secondly, the feature aggregation network and the efficient two convolutional block attention module (E2CBAM) hybrid attention mechanism module were introduced into the neck network to enrich the feature information in the feature map; Finally, the prediction bounding boxes were optimized using the flexible non-maximal inhibition algorithm soft-non maximum suppression (Soft-NMS), in order to optimize the predicted bounding boxes screening. The E2CBAM module was improved using the convolutional block attention module (CBAM) in the E2CA module, instead of the CAM channel attention module. The E2CA module was composed of two parallel ECA branch structures: the maximum and average pooling. Two adaptive convolution kernels were then obtained to sum. Finally, the channel assignment was weighted for the important channel information. The key feature was captured to improve the detection performance of the model. To verify the E2CBAM hybrid attention module, the path aggregation network (PANet) was introduced into the neck network to enrich the semantic and target location in the feature map. The detection accuracy of the model was then improved by 0.19 percentage points. Furthermore, the detection accuracy was improved by 0.16 and 0.31 percentage points, whereas, the number of parameters increased by 0.24 and 0.20 M. respectively, in the CBAM and E2CBAM hybrid attention mechanism module. The floating-point computation remained unchanged. Compared with the CBAM, the E2CBAM hybrid attention mechanism module improved the detection accuracy of the model by 0.15 percentage points, while reducing the number of parameters by 0.04 M with the unchanged computation. The experimental results show that the improved Oriented R-CNN model accurately represented the head direction of wheat ears, indicating better detection performance. The mean mAP of average accuracy was 2.02 percentage points higher than the original model, compared with the mainstream-oriented bounding boxes detection models. Moreover, the mAP values were improved by 4.99, 2.49, 3.94, 2.25, and 4.12 percentage points, respectively, compared with the mainstream rotating target detection models, Gliding vertex, R3det, Rotated Faster R-CNN, S2anet, and Rotated Retinanet. The Oriented RCNN was utilized to accurately represent the head direction of wheat ears. The background area was also reduced in the prediction bounding boxes. The model detection was more visually appealing. The finding can provide an effective way for the practical observation of the growth status of wheat ears and counting the number of ears. [ABSTRACT FROM AUTHOR]

Copyright of Acta Sedimentologica Sinica is the property of Acta Sedimentologica Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nuclear Safety is the property of Nuclear & Radiation Safety Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Agricultural Outlook (1673-3908) is the property of Institute of Agricultural Information, Chinese Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Architectural Design & Research is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Automobile Technology is the property of Automobile Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electroplating & Finishing is the property of Electroplating & Finishing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shenyang Agricultural University is the property of Journal of Shenyang Agricultural University Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Telecommunications Science is the property of Beijing Xintong Media Co., Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Machine Tool & Hydraulics is the property of Guangzhou Mechanical Engineering Research Institute (GMERI) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Zhejiang Electric Power is the property of Zhejiang Electric Power Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The principle and method of mechanical activation, the influence of mechanical activation on the change of physical properties, crystal structure and chemical properties of tailings, the preparation of gel materials and metal leaching after mechanical grinding of tailings are systematically reviewed. The results show that mechanical activation can reduce the particle size of tailings, increase the specific surface area, decrease the degree of crystal crystallization, and increase the degree of lattice distortion and disorder, thus increasing the activation performance of tailings, reducing the reaction conditions, and greatly improving the utilization efficiency of tailings. It is hoped that this paper can play a certain reference role in the research and utilization of tailings. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Mechanical Engineering is the property of Editorial Board of China Mechanical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Systems Engineering & Electronics is the property of Journal of Systems Engineering & Electronics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nuclear Safety is the property of Nuclear & Radiation Safety Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Geodesy & Geodynamics (1671-5942) is the property of Editorial Board Journal of Geodesy & Geodynamics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Guangxi Normal University - Natural Science Edition is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Geodesy & Geodynamics (1671-5942) is the property of Editorial Board Journal of Geodesy & Geodynamics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

合成了以氧氟沙星(ofloxacin，ofo)为配体的锌（Ⅱ)配合物Zn(ofo)2 (H2O) • 2H2O，报道了锌配合物的单晶结构：三斜晶系，P-1空间群，晶胞参数为a=9.306(1)Å，b=11.331(1)Å，c=17.787 (2) Å，α= 92.667(1)°，β = 94.898(2)°, γ= 92.071(2)°，V= 1865.1(3)Å3，Z=2，Dc = 1.496 mg • m-3，畸变的四方锥形配位几何构型，其中锥顶上的氧原子来自水分子，锥底的4个氧原子来自两个氧氟沙星的羧酸根和酮基；探讨了该配合物的红外光谱、紫外-可见光谱、固体荧光光谱性质，对配合物的热稳定性进行了研究；并利用液体稀释法测定了药物配体和配合物对两种革兰氏阳性菌和两种革兰氏阴性菌的体外抑制活性.结果表明配合物与药物配体的抗菌活性相近.

合成了以氧氟沙星为配体的镍（Ⅱ )配合物Ni(ofo)2 • 4H2O，通过红外光谱和热分析等方法对配合物的结构进行了表征，推测了配合物的可能结构，并利用液体稀释法测定了药物配体和配合物对两种革兰氏阳性菌和两种革兰氏阴性菌的体外抑制活性.结果表明配合物与药物配体的抗菌活性和抗菌谱相同.采用MTT比色法测定了配体及配合物对HL-60（人急性早幼粒白血病）细胞的抑制作用，采用SRB蛋白染色法测定了配体及配合物对BEL-7402（人肝细胞性肝癌）细胞的抑制作用.结果表明Ni(ofo)2 • 4H2O对BEL-7402细胞没有抑制作用，对HL-60细胞在较高浓度时有一定的抑制作用.

Copyright of Chinese Journal of Aesthetic & Plastic Surgery is the property of Chinese Journal of Aesthetic & Plastic Surgery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan University of Science & Technology, Natural Science is the property of Editorial Office of Journal of Henan University of Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)