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Objective To investigate the association between time in range (TIR) and diabetic retinopathy (DR) among patients with type 2 diabetes mellitus (T2DM). Methods This study was designed as a prospective cohort study. A total of 1 057 patients with T2DM were prospectively recruited from April 2005 to May 2019 from Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital. TIR was measured with continuous glucose monitoring (CGM) at baseline. Cox proportion hazard regression analysis was used to determine the association between TIR and the risk of DR. Results During a median follow-up of 7.7 years, 266 patients developed DR. The incidence rates of DR were 26.0 (63/2 419.7), 28.0 (57/2 032.9), 40.5 (79/1 950.8) and 42.0 (67/1 594.1) per 1 000 person-years in TIR>85%, 71%-85%, 51%-70%, and ≤50%, respectively (log-rank P=0.013). Cox proportion hazard regression analysis showed that after adjusting for sex, age, diabetes duration, smoking, body mass index, blood pressure, blood lipids, and estimated glomerular filtration rate, hazard ratios (HR) for DR across different levels of TIR (>85%, 71%-85%, 51%-70%, and ≤50%) were 1.00, 1.02 [95% confidence interval (CI) 0.71-1.46], 1.42 (95%CI 1.01-1.99) and 1.46 (95%CI 1.02-2.07), which had statistically significant differences (P for trend=0.01), respectively. When TIR was considered as a continuous variable, the multivariable-adjusted HR for DR associated with each 10% decrease in TIR was 1.07 (95%CI 1.02-1.13). Conclusion The current prospective cohort study indicated an association of lower TIR with an increased risk of DR among patients with T2DM, supporting the validity of TIR as an optimal marker of glucose control. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

糖化血红蛋白（HbA1c）是评估糖尿病患者血糖控制水平的重要指标，但具有一定的局限 性。随着持续葡萄糖监测（CGM）技术的发展，葡萄糖在目标范围内时间（TIR）等新指标，近年来逐渐 引起重视。最新的研究证据表明TIR与糖尿病微血管并发症之间具有良好的相关性，并肯定了其在 临床试验评估以及治疗方案制定等方面的重要意义。随着更多循证证据的积累，以及CGM研发的推 进，未来TIR有望超越HbA1c成为血糖控制与管理的重要指标之一. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)