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To compare the effects of arthroscopic double-row anchor suture bridge technique and locking plate internal fixation on avulsion fracture of greater tuberosity of humerus. According to the different treatment methods, 74 patients with avulsion fracture of greater tuberosity of humerus were divided into group A (locking plate internal fixation, n=35) and group B (arthroscopic double-row anchor suture bridge technique, n=39). The American shoulder and elbow surgeon score (ASES), shoulder joint mobility, visual analogue scale (VAS), perioperative indicators, University of California Los Angeles functional score (UCLA) and postoperative complications were compared between two groups. There was no difference in fracture healing time and complication rate between two groups (P>0.05). The intraoperative blood loss in group B was less than that in group A, the hospitalization time was shorter than that in group A, and the operation time was longer than that in group A (P<0.05). The postoperative VAS score in group B was lower than that in group A, and the ASES and UCLA scores were higher than those in group A (P<0.05). The range of motion of extension, flexion, abduction and adduction in group B was greater than that in group A (P<0.05). Compared with locking plate internal fixation for the treatment of avulsion fracture of greater tuberosity of humerus, arthroscopic double-row anchor suture bridge technique has longer operation time, but it has more advantages in reducing postoperative pain, improving shoulder joint function and expanding shoulder joint mobility. [ABSTRACT FROM AUTHOR]