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Objective: To study the relationship between the angiomotin (Amot) and Yes-associated protein 1 (YAP1) expression and clinicopathological parameters and prognosis in type I endometrial cancer (EC) tissues. Methods: 75 type I EC patients who were diagnosed and treated in Affiliated Hospital of Xuzhou Medical University from January 2014 to June 2017 were selected as the study object (EC group), 30 patients with pathologically confirmed atypical hyperplasia endometrial tissue specimens diagnosed and treated during the same period were selected as the atypical hyperplasia endometrial group, and 30 patients with pathologically confirmed normal endometrial tissue specimens during the same period were selected as the normal endometrial group. The Amot and YAP1 protein expressions in each group were detected by immunohistochemistry. Spearman rank correlation was used to analyze the correlation between Amot and YAP1 protein expression in type I EC cancer tissues. The differences of Amot and YAP1 protein expression in cancer tissues of type I EC patients with different clinicopathological characteristics were compared. Kaplan-Meier analysis (Log-rank test) was used to analyze the relationship between the expression of Amot and YAP1 protein and the survival prognosis of type I EC patients. Univariate and multivariate COX regression analysis was used to analyze the factors affecting the survival prognosis of type I EC patients. Results: The positive rates of Amot and YAP1 protein expression in type I EC tissues were 80.00%(60/75) and 85.33%(64/75), respectively, which were significantly higher than those in atypical hyperplasia endometrial tissue 43.33% (13/30) and 46.67% (14/30), and the difference was statistically significant (all P＜0.05). The positive rates of Amot and YAP1 protein in atypical hyperplasia endometrial tissue were significantly higher than those in normal endometrial tissue with 16.67% (5/30) and 20.00% (6/30), and the difference was statistically significant (all P＜0.05). There was a significant positive correlation between Amot and YAP1 protein expression in type I EC cancer tissues(P＜0.05). The positive rates of Amot and YAP1 protein expression in EC type I patients with different International Federation of Gynecology and Obstetrics (FIGO) stages, histological grades and lymph node metastasis were statistically significant (P＜0.05). The cumulative survival time of Amot-positive expression typeⅠEC patients was significantly lower than that of Amot-negative expression typeⅠEC patients (P＜0.05). The cumulative survival time of patients with YAP1-positive expression of typeⅠEC was significantly lower than that of patients with YAP1-negative expression of typeⅠEC (P＜0.05). Amot-positive expression, YAP1 positive expression, FIGO stage Ⅲ and lymph node metastasis were independent risk factors for poor prognosis in patients with EC type I (P＜0.05). Conclusion: The Amot and YAP1 protein positive expression increased in type I EC cancer tissues, which are related to FIGO stage, histological grade and lymph node metastasis. The positive expression of Amot protein and YAP1 protein is one of the risk factors affecting the poor prognosis of patients with type I EC. [ABSTRACT FROM AUTHOR]

目的：观察子宫内膜异位症患者异位子宫内膜组织中Twist蛋白、E-钙黏蛋白（ E-cadherin ）及N-钙黏蛋白（ N-cadherin）的表达变化，探讨三者与子宫内膜异位症的关系。方法　采用免疫组化SP法检测30例子宫内膜异位症患者在位内膜组织（在位内膜组）、异位内膜组织（异位内膜组）及30例非子宫内膜异位症患者的正常内膜组织（正常对照组）中的Twist蛋白、E-cadherin、N-cadherin，计算各组蛋白高表达（强阳性表达）率；分析异位内膜组织中Twist蛋白、E-cadherin、N-cadherin表达的相关性。结果　异位内膜组、在位内膜组、正常对照组中Twist蛋白高表达率分别为70．0％、30．0％、6．7％，E-cadherin高表达率分别为6．7％、23．3％、73．3％，N-cadherin高表达率分别为66．7％、30．0％、3．3％，Twist蛋白及N-cadherin高表达率在异位内膜组、在位内膜组、正常对照组依次升高，E-cadherin高表达率依次减小（P均＜0．05）。异位内膜组织中Twist蛋白表达与E-cadherin表达呈负相关关系（r＝－0．463，P＜0．01），与N-cadherin表达呈正相关关系（r＝0．616，P＜0．01）；E-cadherin表达与N-cadherin表达呈负相关关系（r＝－0．502，P＜0．01）。结论　子宫内膜异位症患者的异位子宫内膜组织中Twist蛋白和N-cadherin表达上调，E-cadherin表达下调，三者相互作用，共同参与了子宫内膜异位症的发生发展。 [ABSTRACT FROM AUTHOR]