Objective: To analyze the risk factors affecting death in patients with acute severe pancreatitis, to provide evidences for clinical prevention and treatment. Methods: The clinical data of 101 patients with acute severe pancreatitis who were admitted to the hospital during the period from November 2014 to October 2018 were retrospectively analyzed. According to their treatment outcomes, they were divided into survival group (improved and discharged, n=82) and death group (died during hospitalization period, n=19). The risk factors affecting death in patients with acute severe pancreatitis were analyzed. Results: Univariate analysis showed there were significant differences in Ranson score, scores of Acute Physiology and Chronic Health Evaluation (APACHE-II), CT severity index (CTSI), cause of disease, serum calcium (Ca), serum albumin (ALB), blood glucose, serum creatinine (Cr), blood urea nitrogen (BUN), aspartate aminotransferase (AST), incidence of upper gastrointestinal haemorrhage, pleural effusion, sepsis, shock and multiple organ failure between survival group and death group (P<0.05). Multivariate Logistic regression analysis showed that APACHE-II scores, blood glucose, Cr, BUN, sepsis, shock, and multiple organ failure were independent risk factors for death in patients with acute severe pancreatitis (P<0.05), while Ca and ALB were protective factors (P<0.05). Conclusion: The risk factors affecting death in patients with acute severe pancreatitis include APACHE-II scores, FPG, Cr, BUN, AST, sepsis, shock, and multiple organ failure, while the protective factors include Ca and ALB. [ABSTRACT FROM AUTHOR]