Search

Copyright of Journal of New Medicine is the property of Sun Yat Sen University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The density current of water and sediment in the reservoir is a special phenomenon caused by the sediment laden flow in the river channel diving under the clear water, which is of great significance to the sedimentation reduction and sediment removal of the reservoir. In view of the dramatic increase of sediment in Zipingpu Reservoir in recent years and the serious problem of reservoir siltation, this study built a one-dimensional water and sediment mathematical model of Zipingpu Reservoir by coupling the basic hydrodynamic sediment equation with the density current and studied the water and sediment movement process of the reservoir. The results show that the coupled model can predict the outflow discharge, outflow sediment concentration, thalweg and sedimentation distribution in the reservoir area with good accuracy. The model can provide theoretical basis for the simulation and prediction of different water and sediment scenarios of Zipingpu Reservoir in the future, and provide technical support for the study of water and sediment movement process of sediment laden reservoirs in southwest China and sediment discharge regulation. [ABSTRACT FROM AUTHOR]

Objective To investigate the curative effect and safety of haploidentical allogeneic cytokine-induced killer (CIK) in treatment of advanced hepatocellular carcinoma. Methods The peripheral blood mononuclear cell (PBMC) of the healthy immediate family members of 21 patients with advanced hepatocellular carcinoma (HCC) were collected, induced into haploidentical allogeneic CIK in vitro and transfused to the patients for 4 cycles. The curative effect and safety were assessed. Results The 21 patients were followed up for half a year. The survival rate was 81 % (17/21). Among the 21 patients, 11 cases were with stable disease and 10 cases were with progressive disease (including 4 dead cases). Six patients developed fever of different degrees during the treatment and one patient developed rash. The platelet counts of the patients at the fourth cycle after the treatment decreased compared with that before the treatment, with significance difference (P <0.05). The difference in leukocytes, neutrophils, lymphocytes, hemoglobin, liver function and renal function at the first and fourth cycle after the treatment had no statistical significance (all in P >0.05 ). Conclusions Haploidentical allogeneic CIK in treatment of advanced HCC may effectively improve the quality of life and the adverse reactions are tolerable, which is a relatively safe therapy. [ABSTRACT FROM AUTHOR]