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Objective To investigate the potential causal relationship between seven common unhealthy lifestyles (smoking, alcohol, sugar intake, salt intake, fat intake, sleep, and prolonged sedentary behaviors) and chronic kidney disease (CKD) using Mendelian randomization (MR) method. Methods The instrumental variables were obtained from genome-wide association study (GW AS) databases. Inverse-variance weighted (IVW) method was used as the primary analysis method, and MR-Egger and weighted-median (WM) as supplementary metliods to analyze the potential causal association between exposure and outcome. Sensitivity analyses were also conducted. Results The IVW analysis showed a causal relationship between fat intake (O/-=1.09, 95%CZ: 1.01-1.19, P=0.027) and CKD. Sensitivity analysis results did not reveal notable heterogeneity (-=18.00, P=0.12) or pleiotropy (P=0.27). Smoking, alcohol, sugar intake, salt intake, sleep, and prolonged sedentary behaviors showed no causal relationship with CKD in the IVW analysis. Conclusion There is a positive relationship between fat intake and CKD risk. It is suggested to control fat intake to reduce the risk of CKD. [ABSTRACT FROM AUTHOR]

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