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The degradation of cultivated-layer quality of sloping farmland shows the agro-ecological process of cultivated-layer profile damaged, soil nutrient depletion and the regulation ability of crops-ecological environment declined or even completed loss on the slope scale by the combining effects of nature and human factors. In order to analyze the characteristics of soil degradation and main factors affecting degradation of cultivated layer for slope farmland in southern red soil hilly area, taking the cultivated-layer soil (0-20cm) of red soil from a small watershed as research object, we analyzed the degradation characteristics of cultivated-layer quality by cultivated-layer degradation index (CLDI), identified the dominant factors and main driving factors of cultivated-layer degradation by principal component analysis and regression analysis, analyzed the variation characteristics of soil property parameters of different degradation degrees of cultivated-layer quality, and defined the main obstacle factors and obstacle amount of the cultivated-layer quality by the obstacle factor diagnostic model for red soil sloping farmland. The results showed that the distribution area of cultivated-layer quality was mainly medium and in a mildly degraded level (accounting for 70.4% of the total samples), severely degraded samples was 11.1%, and the samples of non-degraded cultivated-layer accounting for 18.5% in red soil small watershed. The main nature driving factors leading to cultivated-layer quality degradation were rainfall, slope and soil mother material, meanwhile, agricultural input per unit of sloping farmland, tillage measure, total mechanical power per unit of sloping farmland and amount of fertilizer applied per unit of sloping farmland were the main human-driving factors. In comparison with the no degraded soil, the cultivated-layer soil properties parameters in red soil sloping farmland showed characteristics in different degradation degree. The cultivated-layer thickness was gradually thinned. The pH value first decreased significantly and then tended to be stable, and the cultivated layer of degraded level was 9.8%, and lower than that of non-degraded cultivated layer. The thinning rate of severely degraded cultivated layer was 8.9%, compared with that of non-degradation cultivated layer, which was related to the water erosion and farmer’s improper tillage methods in daily farming. The soil clay content and soil shear strength increased gradually with the deterioration of cultivated layer soil. The main obstacles of the cultivated layer quality of red soil sloping farmland with highly soil clay content, lowly pH value, thinning cultivated layer and lowly soil shear strength, and their average obstacle amount were 0.15, 0.14, 0.13 and 0.10, respectively. However, the average obstacle amount of other soil property parameters was relatively low. The obstacle amount of soil clay content, pH value and cultivated layer thickness significantly increased with the degradation degree intensifying. However, the obstacle amount of soil shear strength decreased gradually, and other soil property parameters did not change significantly, which indicated that moderately sub-soiling about 30-48 cm and reasonable fertilization were effective measures to improve the cultivated layer quality of red soil sloping farmland. Our results could provide a theoretical basis and some parameter support to scientifically understand the degradation characteristics of cultivated layer quality, define the effective measures to improve the cultivated-layer quality and construct rational cultivated-layers for red soil sloping farmland. [ABSTRACT FROM AUTHOR]