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Copyright of Drilling Fluid & Completion Fluid is the property of Drilling Fluid & Completion Fluid Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To investigate the application of sex hormone drugs in patients with menopausal syndrome in outpatient department of obstetrics and gynecology hospital,so as to provide relevant data for health care of menopausal women. METHODS: Retrospective analysis was performed on the application of sex hormone drugs drugs in prescriptions clinically diagnosed as “menopause”or “climacterium”in outpatient department of Obstetrics and Gynecology Hospital of Fudan University（ hereinafter referred to as“our Hospital”） in 2019,and the age and drug types of patients were sorted out and analyzed. RESULTS: A total of 12 268 prescriptions were enrolled,of which5 808 prescriptions（ 47. 34%） were for the application of sex hormone drugs,including 5 808 patients. The mean age of patients with sex hormone drugs was（ 48. 85 ± 5. 39） years,including 3 299 patients aged from 40 to < 50 years,2 216 patients aged from 50 to < 60 years,189 patients aged ≥60 years,and 104 patients aged from 35 to < 40 years. There were 14 kinds of sex hormone drugs prescribed in 5 808 prescriptions（ with total number of drug use case-times of 6 102）,and the top 3 prescriptions were complex packing estradiol tablets/estradiol and dydrogesterone tablets（ 2 521 case-times）,tibolon tablets（ 1 832 case-times） and diprogesterone tablets（ 499 case-times）. The application of sex hormone drugs in different age groups had its own characteristics. Among patients aged from 40 to < 50 years,the use of complex packing estradiol tablets/estradiol and dydrogesterone tablets was the most（ 1 954 case-times,accounting for77. 51% of the total number of drug use case-times）. Among patients aged from 50 to < 60 years,the use of tibolon tablets was the most（ 1 151 case-times,accounting for 62. 83% of the total number of drug use case-times）,in addition,topical vaginal estrogen preparations were used most frequently in this age group. The application of sex hormone drugs in patients aged ≥60 years was based on tibolone tablets and topical estrogen preparations for vaginal application. Complex packing estradiol tablets/estradiol and dydrogesterone tablets and tibolon tablets were used as the main drugs in patients aged from 35 to < 40 years. There were statistically significant differences in the application of sex hormone drugs in different age groups（ Fisher exact probability test,P <0. 001）. CONCLUSIONS: Different age groups of patients with menopausal syndrome in our hospital have their own characteristics in the application of sex hormone therapy,which can provide reference for the individualized treatment of menopausal hormone. [ABSTRACT FROM AUTHOR]

Objective: To analyze the occurrence of hepatic dysfunction induced by tigecycline, so as to provide reference for rational use of tigecycline and reduce related adverse drug reactions (ADRs). Methods: Medical history data of 115 patients with hepatic dysfunction after treatment with tigecycline for over 2 days in Ruijin Hospital North Branch Affiliated to School of Medicine, Shanghai Jiao Tong University from 2013 to 2017 were collected by using the hospital information system. One hundred and fifteen patients with hepatic dysfunction were enrolled for study. Changes in symptoms, vital signs and laboratory indexes after taking tigecycline were summarized and analyzed. Results: Of the 115 patients with hepatic dysfunction after treat - ment with tigecycline，45 (39.13%) were diagnosed as lung infection, 15 (13.04%) were diagnosed as blood stream infection, 15 (13.04%) were diagnosed as septic shock and 11 (9.57%) were diagnosed as unknown site infection. The results of bacterial culture showed that Klebsiella pneumoniae (25.78%) and A cinetobacter baumannii (19.53%) were primary pathogens .Cefoperazone sodium and sulbactam sodium, meropenem, imipenem and cilastatin sodium were primary drugs used in combined medication • The seriousness of hepatic dysfunction in the patients varied quite considerably, with the main manifestations of the elevation of hepatic enzyme and bilirubin levels Abnormal indexes appeared in patients during 5-31 days of medication .The time for the occurrence of ADRs was on the average (12.16±6.94) days of medication. Those patients with hepatic dysfunction all received symptomatic treatment with different regimens of enzyme reduction and liver protection. Only 48 patients were advised to have medical follow-ups in view of good outcome data. After treatment, the time for recovery of liver function was 2-37 days, and the time for obvious symptom improvement was (13.31 ± 9.27) days on the average. Conclusion: Great attention should be paid to ADRs associated with hepatic damage when using tigecycline. At the same time, efforts should be made to intensify drug monitoring, and such biochemical indexes as liver enzyme should be closely followed up, so as to ensure the safety of clinical medication. [ABSTRACT FROM AUTHOR]

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To probe into the effectiveness of clinical pharmacists' real-time intervention of antibiotics application in obstetrics and gynecology hospital. METHODS: The clinical pharmacists settled in key inpatient ward to check doctor's advice of antibiotics everyday, and fund out the irrational phenomenon; and then took face to face or leave a tip modes to communicate with physicians about the key irrational problems per month. RESULTS: The clinical pharmacists reported the inspection results and related indicators at a fixed time to the dean who is in charge of the matters, and formulated rectification measures under the help of medical department and quality control department. Via the intervention of the clinical pharmacists, the application rate, use intensity of inpatient antibiotics , and the proportion of antibiotics in type I incision patients were all decreased significantly.The application rate of type I incision in two wards of department of gynaecology decreased from (28.82 ±4.99)% before intervention to (14.14 ±7.06)% after intervention, application rate of antibiotics decreased from (65.59 ±3.91)% to (57.68 ± 6.52 )%, and use intensify decreased from (61.03 ±19.18 ) DDDs/( 100 people ・d ) to (42.27 ±23.54 ) DDDs/(100 people ・ d), with statistically significant difference (P<0.05). The application rate, use intensify of antibiotics for special use and antibiotics in neonatology department were decreased to different extent. CONCLUSIONS: The intervention in application of antibiotics by clinical pharmacists in ward is effective and practicable, which play important roles in promoting safe, effective and economic application of antibiotics, and provide valuable reference for exploring the work mode of clinical pharmacists . [ABSTRACT FROM AUTHOR]

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)