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大跨度钢结构空间造型丰富，施工阶段结构的传力路径与最不利受力位置动态变化。为解决施工过程结构分析与安全复核时建模计算流程繁琐的问题，基于AutoCAD与ANSYS开发了大跨度钢结构一键式建模、计算与结果读取的插件。该插件采用C#语言调用AutoCAD .NET框架，读取并输出大跨度钢结构图纸文件中的模型信息，自动生成结构有限元建模、计算与结果读取的APDL命令流，可用于大跨度钢结构施工过程的数值模拟与安全评估。某单层球面网壳结构用来验证所开发大跨度钢结构建模分析插件的有效性，使用该插件快速建立有限元分析模型，并复核结构在施工阶段的内力和变形。研究结果表明，单层球面网壳结构在施工全过程中满足强度和稳定性要求，内力和变形控制在安全范围并满足设计要求。该插件能够高效、准确地将大跨度钢结构信息由CAD软件传递至CAE软件，完成施工过程的数值模拟与安全评估。

首先介绍了两类新型钢板阻尼墙技术（铅-黏滞复合阻尼墙和无屈曲钢板阻尼墙）。铅-黏滞复合阻尼墙由黏滞阻尼墙和铅阻尼器复合而成，主要用于解决高层钢结构的风振问题，其中黏滞阻尼墙用于提高舒适度性能，铅阻尼器用于减小风荷载下的层间位移角。无屈曲钢板阻尼墙则主要用于解决抗震问题，小震下其主要处于弹性状态，为结构提供抗侧刚度，中大震下则进入屈服状态消耗能量，使结构层间位移角满足规范要求。然后，基于上述两类阻尼墙技术，提出了适用于高层钢结构住宅的复合减震（振）设计方法。最后，通过在一幢高层钢结构住宅中采用上述两类新型阻尼墙技术，通过复合减震（振）设计，验证了两类阻尼墙技术对于减小高层钢结构风振和地震响应的有效性。

提出了一种短梁抗剪加强型钢框架-波纹钢板墙结构,通过对波纹钢板墙与框架柱之间的短梁进行抗剪加强,将边缘构件的轴力通过短梁抗剪有效传递至两边的框架柱,从而解决由于逐层累积作用导致边缘构件轴力过大的问题。同时,利用分析软件SAP2000,针对该类结构形式进行了基于Pushover的参数分析,考察了各种因素对边缘构件轴力、短梁剪力以及结构最大层间位移角的影响规律,其中,影响因素主要包括:宽跨比(波纹钢板墙宽度与柱距)、轴向刚度比(边缘构件与框架柱)和楼层层数。分析结果表明:边缘构件轴力随楼层层数和宽跨比的增大而增大,随刚度比的增大而减小;短梁剪力随宽跨比的增大而增大,随楼层层数的增加而减小,但与刚度比关系不大;结构最大层间位移角受宽跨比、刚度比的影响较小,随楼层层数的增加而略有增大。

随着工业化的发展,建筑结构逐渐轻量化,机械设备逐渐重型化、高效化,这使得机械设备高频扰力导致的结构振动问题越来越突出;为了减轻结构的高频受迫振动响应,可以在结构振动响应较大的位置安装高频高阻尼比的钢板夹层阻尼悬臂梁式调谐质量阻尼器(tuned mass damper,TMD)。由于TMD的弹性元件与阻尼元件相互耦合,因此根据TMD的目标参数进行TMD尺寸设计时需要反复迭代;为了提高设计效率,提出了解耦的TMD两阶段快速设计方法。首先根据模态应变能法推导得到了夹层阻尼悬臂梁的一阶模态阻尼比公式,根据截面弯矩转角关系推导了夹层阻尼悬臂梁的复合截面抗弯刚度公式,进而得到了夹层阻尼悬臂梁结构的动力特性计算公式,公式表明夹层阻尼悬臂梁的动力特性相互耦合。而后,利用推导的公式研究了几何参数对钢板夹层阻尼悬臂梁的一阶频率和模态阻尼比的影响,结果表明结构各部分尺寸的等比例缩放不影响构件的阻尼比,得出了阻尼比与频率可解耦的规律。据此规律提出了高频TMD的两阶段快速设计方法及流程:先根据TMD的目标阻尼比确定结构各部分之间的尺寸关系,然后根据目标频率确定构件尺寸。最后,运用所提出的方法,给出了微型化高频高阻尼比夹层阻尼悬臂梁集合式TMD的设计示例,并对示例模型进行了有限元分析,有限元计算结果与设计目标的偏差小于2%,进一步验证了所提方法的有效性。

介绍了无屈曲波纹钢板剪力墙在实际工程中的应用,分析了无屈曲波纹钢板剪力墙在加固设计中的刚度贡献和减震效果。通过对单片无屈曲波纹钢板剪力墙的数值模拟和试验研究,分析了无屈曲波纹钢板剪力墙的抗侧刚度及耗能能力,并进行构件参数化提取。整体弹性和弹塑性分析结果表明,无屈曲波纹钢板剪力墙在多遇地震下能够满足结构刚度需求,罕遇地震作用下能够发挥较好的耗能效果,提高整个结构的抗震性能。

无屈曲波纹钢板剪力墙是一种兼具承载和消能双功能的新型钢板剪力墙,它通过钢板波折的方法来提高自身的面外刚度,避免了普通钢板墙面外刚度小、易屈曲,屈曲约束钢板墙需额外设置面外约束部件的缺点,因此在工程中得到了越来越广泛的应用。根据无屈曲波纹钢板剪力墙的力学性能,在弹性设计阶段提出了等向交叉支撑模型和正交异性平面壳单元模型,在弹塑性验算阶段提出了基于Bouc-Wen模型的水平轴向弹簧模型和基于三线性本构关系的水平剪切板模型。然后,将上述模型与有限元ABAQUS模型进行了对比,验证了上述弹性和弹塑性简化分析模型的准确性。最后,通过设计算例给出了无屈曲波纹钢板剪力墙的设计流程,包括其在弹性设计和弹塑性验算阶段的模拟,以供设计人员参考。

开缝钢板墙是一种用于高层建筑的钢结构抗侧力构件。为便于其在实际工程中建模和分析,本文提出了3折线轴力-变形关系的简化交叉支撑模型,用于模拟两边连接开缝钢板墙的受力变形性能。对6个两边连接开缝钢板墙试件进行了数值模拟,验证了该简化模型的合理性;在一个设置有开缝钢板墙的5层框架结构体系中使用交叉支撑模型,并进行拟静力推覆计算,验证了该简化模型的可行性;还在该体系中使用了单斜撑简化模型,得到的结构体系的基本周期、破坏模式、结构塑性铰出现位置等结果与交叉支撑模型一致,而交叉支撑模型能更合理地反映框架梁的弯矩分布。

A multidisciplinary team (MDT) is a professional group of surgeons, oncologists and other medical and nursing experts who makes decisions about a specific subject in a collective manner, and best course of treatment and nursing plan will be implemented by the multidisciplinary team. This paper summarized the experience of adopting a MDT-based model of palliative treatment and nursing for a patient with end-stage cancer. Based on the nursing risk assessment, comprehensive interventions including wound management, nutrition support and psychological support were carried out to improve the quality of palliative care. (多学科协作(MDT)模式是由来自外科、肿瘤内科、放疗科、影像科、病理科等科室专家组成的工作组, 针对某一疾病, 通过定期会诊形式, 提出适合肿瘤终末期患者的最佳治疗方案, 继而由相关学科或多学科联合执行该治疗方案。 本文总结多学科协作模式下1例肿瘤终末期患者的姑息治疗和护理经验。在完善护理评估的基础上, 基于MDT模式加强患者伤口管理、营养干预、心理支持等, 提升缓和医疗服务质量。)

Copyright of Journal of Xi'an Jiaotong University is the property of Editorial Office of Journal of Xi'an Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The fluorescence components of dissolved organic matter (DOM) is a crucial controlling factor in mobilizing antimony in groundwater. However, the effect of molecular composition of DOM on Sb behaviors is still unclear. A total of 10 samples were collected from high-and low-Sb groundwater in the Xikuangshan mine to compare the molecular composition of DOM and to determine the roles of DOM in Sb mobility. The results show that the DOM content in high-and low-Sb groundwater was 2. 24 ~ 10. 45 mg / L (mean 5. 19 mg / L) and 3. 22 ~ 3. 23 mg / L (mean 3. 23 mg / L), respectively. Compared with low-Sb groundwater, high-Sb groundwater has more highly unsaturated and phenolic compounds and polyphenols, and lower aliphatic compounds, saturated compounds and polycyclic aromatics. Sb positively associated with high O/ C ratio (O/ C > 0. 5) and low H/ C ratio molecules (H/ C < 1. 2), which mainly grouped as highly unsaturated and phenolic compounds and polyphenols. Complexing agents with Fe and Sb (V), competitive adsorption with Sb (V), and accelerating the rate of Sb (Ⅲ) and Fe (Ⅱ) co-oxidation were considered as the formation mechanisms for DOM on Sb migration at a molecular level. [ABSTRACT FROM AUTHOR]

In order to understand the types of parasitic fungi in cicadas, we isolated and identified entomophytic fungi in cicadas, then observed their main characteristics, sequenced and analyzed ITS sequences of the strains. Several pathogenic fungi were isolated and purified from the cicada infected with fungi, named Y1, Y3, and Y6, and their morphology was observed, ribosomal DNA sequencing and analysis were performed to identify and analyze them. Morphologically, it can be inferred that the colonies of fungi Y1 and Y3 are yellow brown in color, with white hyphae and yellow brown spores. They are round and uniform in size. After ITS sequence alignment and combined with morphological characteristics, they belong to the Scopulariopsis alboflavescen genus of fungi. The color of Y6 colony is white, and the hyphae on PDA medium are short and dense, growing slowly. When observed under a microscope, the hyphae are colorless, and the spores are round or elliptical, with uniform sizes. After ITS sequence alignment and combined with morphological characteristics, it is classified as a Scoporariopsis fungus. [ABSTRACT FROM AUTHOR]

Objective To evaluate the efficacy and safety of five live attenuated dengue vaccines and one inactivated dengue vaccine using Bayesian network meta-analysis, providing a scientific basis for dengue epidemic prevention and control as well as vaccine development. Methods A systematic search was conducted in various Chinese and English databases, including PubMedL, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wan fang Database, based on predefined inclusion and exclusion criteria. Randomized controlled trials (RCTs) assessing the efficacy and safety of six dengue vaccines were selected. The quality of the literature was evaluated using RevMan 54 software, and Bayesian network meta-analysis of relevant outcome indicators from the included RCTs was performed using R 43.1 software. Results A total of 20 studies involving 120 909 participants were included. The results of the Bayesian network meta-analysis indicated that the efficacy of three live attenuated vaccines was notable and the ranking from highest to lowest efficacy was as follows: Butantan-DV > TAK-003 > CYD-TDV, Among these, the dengue vaccine combining serotype 4 non-structural genes and serotype 2 structural genes (Butantan-DV) showed the best preventive effect, with a risk probability of dengue infection post-vaccination lower than that of other vaccines (Oi=0.22, 95%CI: 0.09-0.45). In terms of safety, the six vaccines showed varying risks of adverse events and ranked as follows: V180 > CYD-TDV > TV003 > TV005 > Butantan-DV > TAK-003. Notably, the inactivated vaccine (V180) presented a higher risk of adverse events (OR =2,2& 95%Cf: 1.02-5.15). Conclusion Based on the quantity and quality of the included studies, Butantan-DV exhibited the best efficacy among the three live attenuated vaccines, while CYD-TDV demonstrated the weakest efficacy, TAK-003 showed relatively better safety. The literature on the efficacy of the VI80, TV003, and TV005 vaccines is quite limited, suggesting potential directions for future research. [ABSTRACT FROM AUTHOR]

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AIM: To explore the mechanism by which Qingshen granules (QSG) intervene in the microRNA4516 (miR-4516) targeted regulation of the SIAH3/PINK1 axis, enhancing mitophagy and inhibiting renal fibrosis. METHODS: Male SD rats were randomly divided into three groups: control, model, and QSG groups. The QSG aqueous solution was administered via gavage once daily, 4 mL each time, for 8 consecutive weeks. Blood creatinine levels were measured in each group. Hematoxylin-eosin (HE) and Masson staining were utilized to assess the degree of renal pathological damage. Western blot analysis was performed to determine the expression levels of β-actin, PINK1, Parkin, SIAH3, VDAC1, Mfn1, Mfn2, OPA1, LC3B, and P62 proteins in renal tissue. RT-qPCR was used to detect the mRNA expression level of SIAH3 in rat kidney tissue, and transmission electron microscopy was employed to observe mitochondrial damage in renal tissue. QSG-containing serum and transforming growth factor-β1 (TGF-β1) were used to induce an HK-2 cell fibrosis model. The cells were divided into the following groups: normal cell (NC) group, model cell (MC) group, MC+ miR-4516 mimics group, MC+miR-4516 NC+QSG group, MC+miR-4516 mimics+QSG group, and MC+QSG group. Cell activity in each group was detected using the CCK-8 method, and Western blot analysis was performed to determine E-cadherin and α-SMA protein expression levels. The regulation of SIAH3 by miR-4516 was verified using a dual luciferase reporter assay. RT-qPCR was used to detect the mRNA expression of miR-4516, SIAH3 mRNA, and PINK1. RESULTS: The results indicated that QSG intervention reduced fibrosis in rat renal tissue and HK-2 cells, decreased SIAH3 mRNA expression, increased PINK1 expression, and activated mitophagy in renal tissue. In vitro results confirmed that QSG can elevate miR-4516 expression, inhibit SIAH3 mRNA expression, promote PINK1 expression in HK-2 cells, and reduce the expression of the fibrosis marker protein α-SMA. CONCLUSION: In summary, this study preliminarily clarified the mechanism by which QSG intervention targets miR-4516 to regulate the SIAH3/PINK1 axis, thereby enhancing mitophagy and inhibiting renal fibrosis. [ABSTRACT FROM AUTHOR]

The adsorption mechanism of CO on pristine graphene and B-, N-, Al-, P-doped finite size graphene sheets were investigated using first principle method. The results show that the sensing performance of graphene as a CO sensor strongly depends on the dopants. And the lower adsorption energies for CO molecule adsorption on the pristine, B-and N-doped graphene sheets indicate physisorption mechanism. The adsorption energies of the Al-and P-doped graphene were found to be significantly increased, about one order of magnitude higher than those of pristine, B-and N-doped graphene, and Al and P atoms protrude out of the graphene sheet and make locally buckled. The Al-doped graphene enhances the interaction between graphene and CO molecule, improves the gas sensitivity speed and adsorption capacity of graphene and can be the optimal candidate for CO sensing. [ABSTRACT FROM AUTHOR]

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