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Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effects of preoperative interstitial chemotherapy on the COX -2 expression and lymphatic vessel density (LVD) in well-differentiated oral squamous cell carcinoma (OSCC). Methods Sixty specimens of OSCC were selected, in which 15 specimens were treated by preoperative interstitial chemotherapy with slow-released 5-FU (interstitial chemotherapy group), 15 specimens underwent preoperative intravenous chemotherapy with pingyangmycin (intravenous chemotherapy group) and 30 specimens were not treated with chemotherapy (non-chemotherapy group ). The carcinomatous tissues and the tissues 3 cm from the carcinoma edge were embedded by paraffin. The expression of COX-2 and LVD marked with D2-40 in OSCC was detected by immunohistochemistry. Results The positive expression rates of COX-2 were respectively 40.0%, 66.6% and 83.3% in the interstitial chemotherapy group, intravenous chemotherapy group and non-chemotherapy group, and the difference among each group was significant (all P<0.05). The average LVD around the carcinoma were respectively (4.02 ±0.88), (8.12 ±0.79) and (12.22 ±2.25) vessels/mm2 in the interstitial chemotherapy group, intravenous chemotherapy group and non-chemotherapy group, and the difference among each group was significant (all P<0.05). In the non-chemotherapy group, 25 specimens with positive and 5 specimens with negative expression of COX-2, the average LVD around the carcinoma were respectively (12.91 ±1.66) and (8.75 ± 1.40) vessels/mm2, and significant difference was found between them (P<0.01). In the interstitial chemotherapy group and intravenous chemotherapy group, 16 specimens with positive and 14 specimens with negative expression of COX-2, the average LVD around the carcinoma were respectively (6.66 ±2.11) and (4.88 ±2.10) vessels/mm2, and significant difference was found between them (P<0.05). In the non-chemotherapy group, 14 specimens with lymph node metastasis and 16 specimens without lymph node metastasis, the average LVD around the carcinoma were respectively ( 13 .79 ± 1.76), (10.84 ±1.66) vessels/mm2, the positive expression rates of COX-2 in the carcinomatous tissues were respectively 100.0%and 68.8%, and significant difference was found in LVD around the carcinoma and the positive expression rate of COX-2 in the carcinomatous tissues between these two groups (all P<0.01). Conclusion Preoperative interstitial chemotherapy could reduce the expression of COX-2 and inhibit the lymphangiogenesis in well-differentiated oral squamous cell carcinoma. [ABSTRACT FROM AUTHOR]