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The deformation feature and dynamic processes of the lithosphere in the southeastern margin of Qinghai-Tibet Plateau are significantly different from the principal part of the plateau, where forward collision is taking as the main form. The deformation patterns of the lithosphere in southeastern margin of Qinghai-Tibet Plateau are mainly characterized by lateral slip on the shallow crust, and accompanied by a series of deep processes to be revealed. Undoubtedly, the exploration and study of lithospheric structure in the southeastern margin of Qinghai-Tibet Plateau are indispensable to understand the deep dynamic process and collisional orogeny of Qinghai-Tibet Plateau. It is crucial to reveal the three-dimensional structure of the lithosphere and deep dynamic background of metallogenic zone associated with the deep process of lateral collision deformation for the integrity of the theoretical framework of continental collision orogeny and mineralization. The research results and basic knowledge of crust-upper mantle structure detection in the southeastern margin of Qinghai-Tibet Plateau are systematically sorted out, the recent progress and new understanding of deep structural seismic exploration in the southeastern margin of Qinghai-Tibet Plateau and its adjacent areas during recent decades are emphatically introduced, mainly in natural seismic imaging, artificial seismic profile and deep dynamics of the crust-upper mantle structure, which can be used as a reference for researchers interested in geosciences of Qinghai-Tibet Plateau. [ABSTRACT FROM AUTHOR]