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During the construction of a dike, the riprap will drift due to the tidal current, which will seriously affect the quality of riprap and cause a lot of waste of riprap material. Based on the construction of a dike in Lianyungang Port Area, the hydrodynamic characteristics of the construction area of the dike and the adjacent sea area are studied based on mathematical modeling and theoretical formulae, the influence mechanism of the dike on the hydrodynamics is explored, and the migration mechanism of riprap under the action of tidal current is analyzed. At the same time, the riprap drift test and synchronous hydrological observation were carried out on the project site, and the calculation method of riprap drift was calibrated and verified. The research results may provide suggestions for riprap construction of similar dikes. [ABSTRACT FROM AUTHOR]

In order to maintain better recognition robustness in the EEG signals with noise data or missing value, and to reveal the interaction relationship between multiple channels of EEG signals, a series of studies have been carried out. This paper used the random forest algorithm to select the important channels with interaction and remove the irrelevant and redundant channels. It used the state space model to describe the internal motion law of multi-channel, reflecting the relationship between internal state and input or output. It used the EM algorithm to identify the parameters, as the identification features of the state space model. Moreover, this paper identified the extracted features by SE-GRU model, which increased the weight of important features. Generally, this method can effectively improve the classification accuracy on both the public datasets and virtual human guided EEG datasets. Compared with the methods without channel selection, it achieves better results. Meanwhile, through using the final trained model, it achieves the control of virtual human. [ABSTRACT FROM AUTHOR]

目的观察自制愈疮散外敷对轻型复发性阿弗他溃疡（MiRAU）的治疗效果。方法MiRAU患者80例， 随机分为自制愈疮散组、口炎清组，每组40例。自制愈疮散组每日两次予自制愈疮散外敷，口炎清组每日两次予口 炎清颗粒6 g口服，连续治疗至溃疡创面愈合。观察两组患者治疗前后疼痛程度（以VAS评分表示）、镇痛耗时、溃 疡愈合时间，计算总有效率。结果自制愈疮散组、口炎清组治疗前VAS评分分别为（6. 53 ± 0. 72）分、（6. 40 ± 0. 81）分，两组相比，P>0. 05。自制愈疮散组、口炎清组治疗后VAS评分分别为（1. 85 ± 0. 58）分、（4. 33 ± 0. 76）分， 两组相比，P<0. 05。自制愈疮散组镇痛耗时、溃疡愈合时间分别为（20. 23 ± 1. 79）s、（3. 93 ± 0. 70）d，口炎清组分别 为（57. 50 ± 4. 82）s、（7. 00 ± 0. 93）d，两组相比，P 均<0. 05。自制愈疮散组总有效率为97. 5%，口炎清组总有效率为 85. 0%，两组相比，P<0. 05。结论与口炎清颗粒相比，自制愈疮散外敷能有效缓解疼痛，镇痛迅速、溃疡愈合时间 短，总有效率高。 [ABSTRACT FROM AUTHOR]

Objective To investigate the influence of Tiaozhi Tongmai (Fat-regulating and Vessel-freeing) Granule (TZTMG) on blood fat，triglyceride-rich remnant-like particle (RLP) and cell adhesion molecule in ApoE-/- mice. Methods After established model of atherosclerosis (AS)，ApoE-/- mice (n = 30) were randomly divided into model group, fenofibrate group and TZTMG group (each n = 10). C57BL/6J mice (ti = 10) were chosen into normal group. All medicinal groups were fed with high-fat diet, meanwhile were intervened with TZTMG and fenofibrate. The indexes of triglyceride-rich RLP (RLP-C) and 4 items of blood fat were detected detector after 12 weeks. The levels of serum intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) were detected by using ELISA. The aortic root was collected to prepare paraffin sections for observing morphological changes after HE staining. Results Since the 4th week, mouse weight decreased in TZTMG group and fenofibrate group compared with model group. The levels of serum RLP-C，TC，TG, HDL-C and LDL-C increased in model group, fenofibrate group and TZTMG group compared with normal group (P < 0.05). The levels of serum RLP-C and TG decreased in fenofibrate group and TZTMG group compared with model group (P < 0. 05). The levels of ICAM-1 and VCAM-1 increased significantly in model group, fenofibrate group and TZTMG group compared with normal group (P <0. 05). The levels of serum ICAM-1 and VCAM-1 decreased in fenofibrate group and TZTMG group compared with model group (P <0. 05). Comparison in VCAM-1 among normal group, fenofibrate group and TZTMC group had no statistical significance. HE staining showed there were thickened aortic intima and vulnerable plaques in model group, and thickened aortic intima and stable plaques in TZTMG group. Conclusion TZTMG can decrease the expression of adhesion molecule and delay AS development through reducing RLP-C level. [ABSTRACT FROM AUTHOR]

尼古丁可导致雄性生殖系统生精细胞（精原细胞、精母细胞）ＤＮＡ 断裂，促进睾丸间质细胞、支持细胞凋 亡；降低精子顶体的完整性，导致精子出现形态异常，降低精子运动能力，阻碍受精过程；降低精子数量，促进精子 凋亡，降低精子活性。尼古丁还可导致孕鼠的雄性胎鼠精子质量降低、精子畸形率增加、精子运动参数降低、精子 的存活率降低，最终导致生育能力低下甚至不育。尼古丁可通过提高雄性大鼠血清ＬＨ、催乳素水平，降低睾酮、促 卵泡激素水平，导致精液中精子数量减少，抑制雄性生殖系统的成熟 [ABSTRACT FROM AUTHOR]

To study the relationship between the tissue pregradient protein 2 (AGR2) and microfiber associated protein2 (MFAP2) protein 2expression and clinicopathological features and prognosis of colorectal cancer (CRC). Methods: 84 patients with CRC who were admitted to the hospital from January 2015 to February 2016 were included in the study. CRC tissues and adjacent nor-mal tissues (2 ~ 5cm away from the tumor edge) were collected from all patients, and the AGR2 and MFAP2 protein expression in different tissues were detected and compared. The relationship between AGR2, MFAP2 protein expression and clinicopathological features and prognosis of patients with CRC were analyzed. Cox regression model was used to analyze the prognostic factors of patients with CRC. Results: The positive expression rates of AGR2 and MFAP2 protein in CRC tissues were all higher than those in adjacent normal tissues (P<0.05). The positive expression rates of AGR2 and MFAP2 protein in patients with CRC with low differentiation, TNM stage was Ⅲ and vascular invasion were higher than those in patients with CRC with medium and high differentiation, TNM stage was Ⅰ～Ⅱ, and no vascular invasion (P<0.05). 3-year survival rate and 5-year survival rate in AGR2, MFAP2 protein positive patients were significantly lower than those with negative expression patients (P<0.05). Cox regression model analysis showed that the degree of differentiation was low, TNM stage was stage III, vascular infiltration and the positive expression of AGR2 and MFAP2 protein were the risk factors of death in patients with CRC (P<0.05). Conclusion: The positive expression rate of AGR2 and MFAP2 protein in CRC increased, which are related to the degree of differentiation, TNM stage and vascular infiltration of patients. Detecting their expression is helpful to predict the prognosis of patients with CRC. [ABSTRACT FROM AUTHOR]

The experiment was to study the effect of fermented Chinese herbal medicine on growth performance and intestinal flora environment of weaned Songliao black pigs. 54 weaned Songliao black piglets of (35±1) d were randomly divided into three groups, with three replicates in each group and six pigs in each replicate. The piglets in control group were fed with basic diet, the piglets in group Ⅰ were fed a basal diet + 0.5% fermented Chinese herbal medicine additive, and piglets in group Ⅱ were fed with basal diet + 0.5% unfermented Chinese herbal medicine additive. The pre-experiment was 5 d, and the formal experiment was 30 d. The results showed that compared with the control group, the FW and ADG of group Ⅰ were significantly increased (P<0.05), and F/G was decreased (P>0.05). Compared with the control group, the apparent digestibility of DM, CP, EE and Ash in groupⅠincreased significantly (P<0.05). Compared with the control group, the number of lactic acid bacteria in the intestines of groupⅠincreased (P>0.05), and the number of Escherichia coli decreased on 1~15 d (P>0.05). Compared with the control group, the number of lactic acid bacteria increased significantly (P<0.05), and Escherichia coli decreased on 16~30 d (P>0.05). Compared with the control group, the content of total nitrogen in feces of group Ⅰ decreased significantly (P<0.05), and the content of total phosphorus decreased on 1~15 d (P>0.05). Compared with the control group, the content of total nitrogen and total phosphorus in feces of group Ⅰ decreased significantly on 16~30 d (P<0.05). The experiment indicates that fermented Chinese herbal medicine can improve growth performance and intestinal health of weaned piglets. [ABSTRACT FROM AUTHOR]

BACKGROUND: Seeking a relatively suitable animal model of intervertebral disc degeneration is of great significance for an in-depth study of the pathogenesis of intervertebral disc degeneration. OBJECTIVE: To seek a relatively suitable animal model of intervertebral disc degeneration, providing a new modeling option for basic research into degenerative disc disease. METHODS: Twenty male Sprague-Dawley rats were randomly divided into sham operation group and model group. The intervertebral disc degeneration model was prepared by castration of both upper limbs combined with intervertebral disc puncturing. MRI examination was performed on the day of modeling and at 4 and 8 weeks after modeling to observe the morphological changes of the intervertebral discs and evaluate the Pfirrmann grade before and after modeling. The L4-L5 and L5-L6 intervertebral discs were removed from the rats at 4 and 8 weeks after modeling. The pathological changes of the intervertebral discs were observed by hematoxylin-eosin and Masson staining and the expression of type II collagen was observed by immunohistochemistry. RESULTS AND CONCLUSION: The model group showed only slight degeneration on the day of modeling. Compared with the sham operation group, the T2- weighted signal on MRI was decreased in the model group, and there was a significant difference in the Pfirrmann grading at 4 weeks after modeling (P < 0.05). Compared with the sham operation group, the T2-weighted signal on MRI was significantly decreased and the boundary with the annulus fibrosa was blurred in the model group at 8 weeks after modeling. The nucleus pulposus in the model group was expanded in the posterior longitudinal ligament and there was a significant difference in the Pfirrmann grading between the two groups (P < 0.01). The results of pathological staining showed that compared with the sham operation group, the model group had a reduction in the number of nucleus pulposus cells, disordered annulus fibrosus, and decreased expression of type II collagen at the 4th week after modeling. While at the 8th week after modeling, the nucleus pulposus cells were shrunk, the matrix was condensed, the annulus fibrosus was ruptured, the structure was damaged and the boundary between the nucleus pulposus and the nucleus pulposus was blurred, and the expression of type II collagen in the nucleus pulposus was decreased more obviously in the model group compared with the sham operation group. To conclude, this method can successfully establish the rat model of intervertebral disc degeneration, and the animal model develops obvious degeneration, which provides a new idea for the study of intervertebral disc degeneration model. [ABSTRACT FROM AUTHOR]

Most of traditional fault diagnosis research ignored characteristics of local structure. For that problem under PMC model, this paper introduced the definition of node diagnosis. And through the study by nodes diagnosis, it obtained the sufficient condition of the node diagnosiability and got a newt-diagnosis algorithm called STFDA. Finally, it performed an analysis from the angle of node diagnosis of n-dimensional hypercube network and n-dimensional star network in order to test the validity of the sufficient conditions. This algorithm performed a fault diagnosis to the two kinds of network at last. Indeed, the implementation of the sufficient condition and algorithm got the help of a new structure called ST. And the algorithm's time complexity was proved to be 0 ( N δ ), with δ equal to the maximum degree of node in network, which was significantly reduced compared with others algorithm. [ABSTRACT FROM AUTHOR]

BACKGROUND: With the maturation of musculoskeletal ultrasound, it is widely used in orthopedic diagnosis. OBJECTIVE: To review the application status of musculoskeletal ultrasound in the diagnosis of muscle and tendon, bone and cartilage, joint and nerve in recent years, and to explain its principle, advantages and disadvantages. METHODS: “Musculoskeletal ultrasound, orthopedics” in Chinese and English, respectively were as keywords to retrieve in CNKI, PubMed databases, and Elsevier databases for the articles published from 2013 to 2018. Forty-four articles about the application of musculoskeletal ultrasound in orthopedic diagnosis were reviewed. RESULTS AND CONCLUSION: (1) In the diagnosis of soft tissue diseases such as muscle, tendon, fascia and other soft tissue diseases, as well as in the examination of occult fractures, early arthritis and other diseases of bone and joint, musculoskeletal ultrasound is superior to MRI and CT, because it is simple, cheap, has high sensitivity and no radiation. (2) It can be used as the first choice to judge the recovery of function and the injury of peripheral nerve after operation because it can dynamically analyze the movement of muscles and bones and observe the changes of peripheral nerve. (3) In the future, the application of musculoskeletal ultrasound in the diagnosis of delayed muscle soreness and quantification of tendon abnormalities will be a new research direction. [ABSTRACT FROM AUTHOR]

To improve the clustering of the clustering algorithm, the bionic optimization algorithm and the kmeans clustering algorithm are combined to realize data clustering (BFOA-K). In the clustering process, the fruit fly optimization algorithm is used to determine the centroid of the k-means clustering algorithm, and the k-means clustering algorithm is used for data clustering. To solve the problem that k-means is sensitive to the initial centroid and easy to fall into the local optimum, and the influence of the fruit fly optimization algorithm on the flight step length, the F distribution is used to dynamically change the step length which improves the global search ability of the algorithm. The elite retention strategy is adopted to increase the diversity of the fruit fly population, expand the scope of the search and improve the search efficiency. Four UCI standard datasets are used to test the algorithm. The experiment shows that the algorithm is better than other comparison algorithms in all clustering evaluation indicators. The BFOA-K improves the convergence of the algorithm with effectiveness and feasibility. [ABSTRACT FROM AUTHOR]

BACKGROUND: The tortoise plastron-deer horn couplet medicine has been widely used as a classic drug matching formula for treatment of osteoporosis, but the pharmacology molecular mechanism remains unclear. OBJECTIVE: To investigate the pharmacological molecular mechanism of tortoise plastron-deer horn couplet medicine for treatment of osteoporosis. METHODS: The active compounds and targets of tortoise plastron-deer horn couplet medicine were obtained by using BATMAN-TCM, TCM-MESH and Chemistry Databases, as well as manual literature retrieval. The disease targets corresponding to osteoporosis were obtained by using Comparative Toxicogenomics Database and GeneCards databases. The protein-protein interaction network was constructed by STRING online database, analyzed and showed by the Cytoscape software. Gene ontology analysis of the targets was conducted by DAVID online tools. Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis was conducted by KOBAS. The enrichment results were obtained with a significant difference (P < 0.05). SwissDock was used for molecular docking verification of hub targets and active compounds. RESULTS AND CONCLUSION: A total of 21 active ingredients (including aspartic acid and phenylalanine) and 183 targets of tortoise plastron-deer horn couplet medicine for treatment of osteoporosis were obtained. There was a close interaction among herb pairs, active compounds and targets. Ten hub targets, such as INS, ALB and TNF, were sorted. Hub targets were mainly enriched in 66 gene ontology processes, such as aging and drug reaction. KEGG analysis showed 27 enrichment pathways of the targets with significant difference. Molecular docking results showed that HUB gene INS and ALB could be effectively combined with their corresponding active compounds (INS: alanine, androgens; ALB: alanine). These findings preliminarily validate the major compounds, targets and pathways of tortoise plastron-deer horn couplet medicine for treatment of osteoporosis. The medicine-compounds-targets network is complicated. The mechanism may happen through multiple closed pathways including cell differentiation, inflammatory response and sex hormone regulation as well as regulating dynamic balance of bone repair and remodeling. It is worth further investigating for the mechanism of Chinese medicine treating diseases. [ABSTRACT FROM AUTHOR]

Objective: To discuss the clinical efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with stereotactic X- knife in the treatment of liver cancer. Methods: 120 patients with primary liver cancer were selected from December 2015 to August 2017 in our hospital. The patients were randomly divided into X- group. TACE group and combined group, each group had a total of 40 patients. X- knife group patients were treated with X- knife. TACE group was treated with TACE alone, and the combination group was treated with X- knife combined with TACE. The clinical effect, survival time, liver function before and after treatment and the occurrence of toxic side effects were compared among the three groups. Results: The total effective rate of combined group was 47.5%. which was significantly higher than that of the X-knife group and the TACE group Q'<0.05). The total effective rate of X- knife group was 27. 5%. which was significantly higher than that of TACE group (l'<0.05). The survival time of the combined group was (0.73± 0.18) years. (0.48± 0.18) years. (1.10± 0.22) years, and the survival time of the combined group was significantly longer than that in the X - knife group and TACE group (P<0.0S), the survival time of the X-knife group was longer than that in TACE group (p<0.05). The level of Serum alanine aminotransferase (ALT), aspaitate aminotransferase (AST). Gamma - glutamyl transpeptidase (-γ-GT) and total bilirubin (TBil) were significantly lower than those before treatment (P<0.05). The level of serum ALT and AST after treatment in the combined group were no significant difference with TACE group or X-knife group (p>0.05). but the level of serum γGT and TBil was significantly lower than that of TACE group and X-knife group (P<0.05). There was no significant difference in the toxic and side effects among the three groups (P>0.05)- Conclusion: The clinical efficacy of TACE combined with stereotactic X- knife is superior to TACE or X- knife alone in the treatment of liver cancer, and the safety of three treatments is equal. [ABSTRACT FROM AUTHOR]