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Objective To compare the efficacy of dual-frequency dual-pulse laser lithotripsy under endoscopic retrograde cholangiopancreatography (ERCP) and traditional endoscopic mechanical lithotripsy in the treatment of patients with common bile duct stones, and summarize perioperative nursing measures. Methods From May 2018 to May 2022, the clinical data of 200 patients with common bile duct stones who underwent ERCP treatment and lithotripsy were retrospectively analyzed, of which 69 patients were treated with dual-frequency dual-pulse laser lithotripsy (Laser group) and 131 patients were treated with mechanical lithotripsy (Mechanical group), and the success rate of stone extraction, operation time, postoperative hospital stay time and complications of two groups of patients were compared. Results There was no significant difference in baseline data such as general conditions and preoperative clinical data between two groups (P＞0. 05). Neither neither Laser group nor Mechanical group had reported the perioperative death case. There were no significant difference in postoperative bleeding, postoperative pancreatitis and perforation complication rates in the two groups (P＞0. 05). The surgical time in the Laser group was significantly longer than that in the Mechanical group (P＜0. 05). The postoperative hospital stay was shorter in the Laser group than that in the Mechanical group(P＜0. 05), and the total complication rate and stone residue rate were lower in the Laser group than those in the Mechanical group (P＜0. 05). Conclusion The treatment of common bile duct stones by dual-frequency dual-pulse laser lithotripsy has better efficacy and lower complication rate than traditional surgical mechanical lithotripsy, but there is still room for improvement in the operation time. (目的 比较内镜逆行胰胆管造影术(ERCP)下双频双脉冲激光碎石与内镜下传统机械碎石治疗胆总管结石患者的效果, 总结护理经验。方法 回顾性分析2018年5月—2022年5月在北京中医药大学东方医院消化内镜中心行ERCP治疗并碎石的200例胆总管结石患者的临床资料, 其中69例患者采用双频双脉冲激光碎石术(激光组), 131例患者采用机械碎石(机械组)。比较两组患者的取石成功率、手术时间、术后住院时间、并发症等情况。结果 两组患者一般情况、术前临床资料等基线资料比较, 差异无统计学意义(P＞0. 05)。激光组和机械组均无围术期死亡患者。两组患者术后出血、术后胰腺炎、穿孔并发症率比较差异无统计学意义(P＞0. 05)。与机械组相比, 激光组的手术时间较长(P＜0. 05), 术后住院时间更短(P＜0. 05), 总并发症率和结石残留率更低(P＜0. 05)。结论 ERCP下双频双脉冲激光碎石治疗胆总管结石具有比传统手术机械碎石更好的效果及更低的并发症率, 但手术时间仍有改进的空间。)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

During the hydrolysis process of caprolactam to produce polyamide 6, a considerable number of cyclic oligomers are inevitably formed. Among these, the cyclic dimer, with its propensity for aggregation, poses significant challenges to both process safety and product quality. Thus, understanding the characteristics of cyclic oligomers is crucial for ensuring process safety and enhancing product quality. This paper employs a personification approach to vividly describe the properties of cyclic oligomers, elucidating the formation mechanism of cyclic dimers, delineating the behavior of crystal phase transitions, and highlighting the detrimental effects of cyclic dimers on industrial production. Moreover, it proposes methods for process optimization. [ABSTRACT FROM AUTHOR]

This paper summarizes the nursing experience of a patient who received endoscopic variceal ligation in the treatment of esophageal varices, including preoperative psychological care, instrument preparation, patient preparation, intraoperative care, postoperative general care, complication care and other targeted nursing measures. Through the comprehensive nursing mode, full preoperative preparation, close surgical cooperation, and meticulous postoperative care, the success of esophageal variceal ligation was guaranteed, the pain of patients was reduced, the patient's symptoms were improved. (本文总结1例内镜下食管静脉曲张套扎术治疗食管静脉曲张患者的护理体会, 包括术前的心理护理、器械准备、患者准备、术中护理、术后一般护理、并发症护理等针对性护理措施。充分的术前准备、密切的手术配合和细致的术后护理是保障食管静脉曲张套扎术成功的关键, 有助于减轻患者疼痛, 改善患者病症, 促进其康复。)

This paper summarized the clinical observation and nursing measures of a patient with acute mastitis during lactation treated by milk-ejection manipulation technique combined with external application of Rutong powder. On the basis of nursing assessment and basic care, the milk-ejection manipulation technique combined with external application of Rutong powder showed a positive effect on relief of pain and anxiety of the patient during lactation. This method has the advantages of few side effects, high safety and high patient acceptance. (本文总结1例哺乳期急性乳腺炎患者行手法排乳联合自制乳通散外敷治疗的效果及护理措施。在完善护理评估和常规护理的基础上, 手法排乳联合乳通散外敷治疗能够有效缓解患者疼痛和焦虑症状, 且该方法具有不良反应少、安全性高等优势, 患者易于接受。)

This paper reported the nursing experience of a patient undergoing Chinese herbal medicine enema treatment for gastrointestinal dysfunction after laparoscopy for adrenal mass. The patient was diagnosed with intestinal Qi stagnation according to the Traditional Chinese Medicine syndrome differentiation. The Chinese herbal medicine enema technique and coordinated integrated nursing measures were carried out after nursing evaluation. (本文报告中药灌肠技术干预1例右肾上腺肿物患者腹腔镜术后胃肠功能障碍的护理经验。患者经中医辨证属于腑气不通, 在完善护理评估的基础上, 遵医嘱实施中药灌肠技术进行干预, 并配合中西医结合护理。)

This paper reviewed the clinical data of an acute mastitis patient undergoing paracentesis of breast abscess, and summarized the effect and measures of milk-ejection manipulation technique combined with external application of Rutong powder in postoperative pain relief. Nursing assessment, manipulation technique, component analysis of Rutong powder, external application methods and cautions and routine nursing intervention were summarized. Based on the Traditional Chinese Medicine nursing by syndrome differentiation, application of milk-ejection manipulation technique combined with external application of Rutong powder is effective to relief the pain of the patient after paracentesis of breast abscess. It is an effective Traditional Chinese Medicine nursing technology which helps mothers to build confidence in breastfeeding and ensure the maternal and infant safety. (本文回顾1例哺乳期急性乳腺炎脓肿形成行穿刺引流患者的临床资料, 总结手法排乳联合乳通散中药外敷缓解术后疼痛的效果及护理措施, 包括护理评估、排乳手法、乳通散组方、外敷方法和注意事项以及常规护理等。基于中医辨证施护理论指导, 采取手法排乳联合乳通散外敷治疗能够有效缓解术后疼痛, 帮助患者重拾哺乳信心, 确保母婴健康。)

This paper summarized the nursing experience of a patient with Liver-Qi stagnation and phlegm stagnation type hyperplasia of mammary glands treated by Traditional Chinese Medicine (TCM) ointment rubbing combined with moxibustion. Nursing measures and efficacy observation of TCM ointment combined with moxibustion at Zusanli acupoint were performed. In addition to the targeted interventions by TCM syndrome differentiation, health education on dietary and emotion regulation was carried to achieve the effect of dredging milk collaterals, detumescence, relieving pain and improving gland hyperplasia. (本文总结了采用中药膏摩外敷联合艾灸足三里缓解乳腺增生症状的护理经验, 包括中药膏组方选择、膏摩操作方法、艾灸足三里的注意事项以及饮食指导、情绪疏导等常规护理方法, 全程基于中医辨证指导开展针对性措施, 从而达到疏通乳络、消肿散结、缓解疼痛、改善腺体增生状态的目的。)

Objective To investigate the effect of external application of Rutong powder in the treatment of stagnation stage mastitis. Methods Totally 60 patients with stagnation stage mastitis were randomly divided into observation group and control group, with 30 cases in each group. Patients in both control group and observation group were treated with milk-ejection manipulation technique, and those in the observation group received the external application of Chinese herbal medicine Rutong powder. Results The overall effective rate was 96. 67%(29/30) in the observation group, which was higher than 83. 33%(25/30) in the control group (P＜0. 05). Conclusion Milk-ejection manipulation technique combined with external application of Rutong powder is effective in relief of symptoms and discomfort in patients with acute mastitis at stagnation stage. (目的 探讨乳通散外敷治疗郁滞期乳痈的临床疗效。方法 选取2021年5月—2022年1月收治的郁滞期乳痈患者60例, 随机分为观察组和对照组, 各30例。对照组采用单纯的手法排乳治疗, 观察组在对照组基础上实施乳通散外敷干预。对比2组临床疗效。结果 观察组有效率96. 67%(29/30), 高于对照组的83. 33%(25/30), 差异有统计学意义(P＜0. 05)。结论 手法排乳联合乳通散外敷治疗有助于缓解郁滞期乳痈患者不适症状。)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To investigate the effect of inhibiting the expression of RNA component of mitochondrial RNA processing endoribonuclease(RMRP) on the proliferation and invasion of human lung cancer cell line A549 in order to provide evidence to support the research on NSCLC mechanism. Methods A total of 122 cases of patients who underwent surgical treatment were selected in Jiaozuo People's Hospital from March 2016 to March 2021. In the same period, 50 healthy people from physical examination center were selected as the control group. RT-qPCR was used to detect the expressions of RMRP in blood and tissues. Human lung cancer cell line A549 was cultured and divided into si-RMRP group, siRNA-NC group and blank group. RT-qPCR, CCK-8 and Transwell assays were used to detect the expression of RMRP, proliferation activity and cell counting of invasive cells. Results The rel- ative expression level of RMRP in the blood of NSCLC patients was significantly higher than that of control group (P < 0.001) The relative expression level of RMRP in NSCLC tissues was significantly higher than the adjacent tissues (P<0.001). The relative expression level of RMRP in blood and tissues of patients with poorly differenti- ated, lymph node metastasis and TNM stage III compared with moderate to highly differentiated, no lymph node metastasis and TNM stage III were significantly increased (P < 0.05) The relative expression level of RMRP in the cells of the si-RMRP group was lower than that of blank and the siRNA-NC group (P < 0.001) . Compared with the blank group and the siRNA-NC group, the absorbance (A) value of cells at 24, 48, 72 and 96 h in the siRMRP -group was decreased (P < 0.05) The number of invasion cells in the si-RMRP group was lower than that in the blank group and the siRNA-NC group (F = 27.765) P < 0.001 ) . Conclusions The relative expression levels of RMRP in blood and tissues of NSCLC patients are increased. Down-regulation of the expres- sion of RMRP gene in A549 cells can inhibit cell proliferation and reduce cell invasion. [ABSTRACT FROM AUTHOR]

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Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

AIM: To investigate the potential impact of mitoNEET ［mitochondrial protein containing Asn-GluGlu-Thr (NEET) sequence］ on mitochondrial metabolism in brown adipocytes, and to elucidate its underlying mechanism. METHODS: An in vitro model of primary mouse brown adipocytes was established. Western blot were utilized to detect relevant proteins, and iron ion and ATP content was measured using kits. Mitochondrial membrane potential and reactive oxygen species (ROS) were assessed by fluorescence microscopy and flow cytometry. RESULTS: The expression of the ferroptosis-related protein ACSL4 increased by 1. 13 times in ferroptosis inducer erastin treatment group, whereas the expression of SLC7A11 and GPX4 decreased by 27. 33% and 25. 33%, respectively, compared with control group (P< 0. 05). The expression of Nrf1, PGC-1α, MFN2 and UCP1 proteins, related to mitochondrial energy metabolism, decreased by 20. 98%, 15. 17%, 15. 03% and 34. 22%, respectively (P<0. 05). Additionally, the mitoNEET protein content was significantly reduced by 42. 14% (P<0. 05). The iron ion content in erastin group was substantially increased by 1. 80 times compared with control group. However, a notable decrease in ATP content of 14. 95% was seen (P<0. 05). The results obtained from fluorescence microscopy and flow cytometry demonstrated a significant decrease in the mitochondrial membrane potential of brown adipocytes in erastin group, with reductions of 52. 18% and 61. 31% (P<0. 05), respectively. A substantial increase in mitochondrial ROS content of 80. 97% was seen (P<0. 05). Western blot analysis of overexpressed stable strains revealed a significant elevation in mitoNEET levels in brown adipocytes following lentivirus transfection, exhibiting an increase of 11. 19 times (P<0. 05), thus confirming successful transfection. The LV-mitoNEET group exhibited a significant decrease of 37. 95% in the expression of ferroptosis-related protein ACSL4 in brown adipose cells compared with control group. Additionally, there was a notable increase of 77. 82% and 66. 3% in the expression of SLC7A11 and GPX4, respectively (P<0. 05). Up-regulation was observed in the expression of MFN2 (79. 06%), PGC1α (72. 89%), Nrf1 (40. 14%), and UCP1 (31. 68%) (P<0. 05). The test results demonstrated that the LV-mitoNEET group experienced a reduction of 43. 5% in iron ion content compared with control group while exhibiting an increase of 33. 5% in ATP content (P<0. 05). The results obtained from fluorescence microscopy and flow cytometry demonstrated that mitoNEET overexpression led to a significant increase in the mitochondrial membrane potential of erastin-induced brown adipocytes, with increments of 17. 61% and 96. 05%, respectively. Additionally, mitoNEET overexpression effectively reduced the production of mitochondrial ROS by 24. 48% (P<0. 05). CONCLUSION: Our findings suggest that mitoNEET overexpression can effectively inhibit the disruption of mitochondrial energy metabolism caused by ferroptosisinduced death of brown adipocytes. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Functional Materials / Gongneng Cailiao is the property of Chongqing Functional Materials Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Food & Machinery is the property of Food & Machinery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the health damage caused by long-term exposure to low-intensity laser among female workers and provide a basis for the development of corresponding preventive measures. Methods Totally 96 female workers exposed to low -intensity laser in a large -scale communication equipment manufacturing company were selected as the exposed group, while another 96 female office staff without any exposure to occupational hazards in the same company were studied as the control group. Occupational health examinations were conducted for all study participants, and the relative results were analyzed. Results The prevalences of self-reported ophthalmic symptoms such as eye pain, foreign body-like irritation of the eye, photophobia, tearing, conjunctival congestion, and decreased visual acuity were higher in the exposed group than in the control group (P < 0.05). The prevalences of abnormalities in cornea, conjunctiva, lens, and fundus examinations were higher in the exposed group than in the control group (P < 0.05). The prevalences of self -reported dizziness, nausea, palpitation, insomnia, appetite loss, muscular stiffness, hypomnesis, hidrosis, feeling fatigued, and dysphoria were all significantly increased in the exposed group compared with the control group (P < 0.05). Rates of sinus arrhythmia and T -wave elevation in the exposed group were higher than those in the control group (P < 0.05). The menstrual abnormality in the exposed group was higher than that in the control group (P < 0.05). There was no statistically significant difference in abnormalities of blood pressure, blood routine examination, liver function, urine routine examination, and blood lipids between the exposed group and the control group (P > 0.05). Conclusions Long-term exposure to lowintensity laser could at least cause damage to the eyes, nervous system, cardiovascular system, and reproductive system of female workers. Workers occupationally exposed to lase should pay attention to strengthening personal eye and skin protection. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate the feasibility of producing selenium-rich chicken products by long-term feeding of high selenium and herbal rations. Three hundred and sixty 299- day-old Zhengda brown laying hens were divided into four groups: group A was a blank group with 0.30 mg/kg (low selenium) in the diet; groups B, C and D were experimental groups with 0.80 (medium selenium) and 1.30 (high selenium) mg/kg of selenium in groups B and C, respectively; group D was supplemented with 0.2% Chinese herbal medicine on top of group C. After 170 d of the experiment, tissue and blood samples were collected to determine the selenium content and antioxidant index. The results showed that: the egg weight of group C was significantly lower than that of groups A and B (P<0.05), and there were no significant differences in other productive indexes among all groups. The selenium poles of pectoral muscle and kidney were significantly higher in groups B, C and D than in group A (P<0.01), the selenium poles of liver were significantly higher in groups C and D than in groups A and B (P<0.01), and the selenium poles of liver and kidney were significantly higher in group D than in group C (P<0.01); the blood glutathione peroxidase (GSHPx) and total superoxide dismutase (T-SOD) activities in groups B, C and D were extremely significantly higher than those in group A (P<0.01), groups C and D were extremely significantly higher than those in group B (P<0.01), and glutathione peroxidase in group D was extremely significantly higher than that in group C (P<0.01); blood malondialdehyde levels in groups B, C and D were extremely significantly lower than those in group A (P<0.01). It indicated that long-term feeding of high selenium (0.80-1.30 mg/kg) rations without selenium enrichment effect, and can produce selenium-rich chicken meat products. [ABSTRACT FROM AUTHOR]

The MQTT protocol is widely used in the Internet of Things for message transmission, and its security issues have received much attention. Currently, security analysis of the MQTT protocol mainly focuses on protocol implementation platforms, lacking security testing based on protocol standards, which makes it difficult to detect security vulnerabilities in the protocol standards themselves. To address this issue, this paper proposed a formal analysis method for MQTT protocol security based on Tamarin. The method firstly constructed a protocol state machine based on the MQTT protocol 3. 1. 1 standard, and completed formal description based on Tamarin syntax rules. Then, for confidentiality and authentication properties, the security properties that MQTT protocol needed to satisfy were given in the form of lemma descriptions. Finally, it completed the verification of 47 protocol security attributes based on the Dolev-Yao threat model in Tamarin. The results show that there are 9 confidentiality attribute violations and 29 authentication attribute violations. It conducted an attack test on the results, and the test results verify the effectiveness of the proposed method for MQTT protocol security analysis. It also proposed an optimized and improved scheme based on identity reauthentication. [ABSTRACT FROM AUTHOR]

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Based on the overall data of inter-bank assets and inter-bank liabilities of China’s commercial banks, the inter-bank borrowing-lending correlation network is inferred indirectly by the maximum entropy method, and the distress propagation process under a single shock or common shocks is investigated based on the DebtRank algorithm. The systemic impact and vulnerability of banks and their influencing factors are also investigated. The empirical results show that under certain circumstances, the negative results brought by bank distress are more severe than those brought by bank default. China’s commercial banks are not located in the area of “high vulnerability/strong impact”, indicating that China’s banking system is relatively safe. In terms of influencing factors, the average return on assets has a significant negative effect on banks’ systemic impact, while the loan reserve ratio, the tier-one leverage capital ratio and the inter-bank lending volume have significant positive effect on banks’ systemic impact. The tier-one leverage capital ratio and asset size have significant negative effect on the systemic vulnerability and the inter-bank lending volume has significant positive effect on the systemic vulnerability. The results not only help banks to understand their own situations, but also provide a basis for financial regulation. [ABSTRACT FROM AUTHOR]

Objective To explore the profile of serum lipid metabolism in children with severe asthma and mild-to-moderate asthma, and investigate the potential plasma markers of children with severe asthma. Methods Children with asthma from database of Children’s Hospital, Fudan University were enrolled and divided into severe asthma group (n=50) and mild-to-moderate asthma group (n=54) during Sept 1, 2019 to Apr 30, 2021. Plasma from the children was collected to detect lipid molecules by the liquid chromatography-mass spectrometry (LC-MS) technique. Multivariate statistical analysis was used to compare the differences in lipid molecules between the two groups. The main disturbed metabolic pathways were analyzed by the KEGG database. The diagnostic value of significantly different lipid molecules for severe asthma was analyzed by the receiver operating characteristic (ROC) curve. Results The average ages of severe asthma group and mild-to-moderate asthma group were (8.8±2.6) years and (8.4±2.8) years, respectively. There were no significant differences between the two groups in age and gender (P= 0.075 and 0.422). Eosinophil percentage and eosinophil count were higher in the severe asthma group than in the mild-to-moderate asthma group. FEV1/FVC, % predicted FEF50, % predicted FEF75, % predicted MMEF were lower in the severe asthma group than those in the mild-to-moderate asthma group (P=0.003, 0.005, 0.005, 0.003 respectively). There were 39 different kinds of lipid molecules between the two groups. phosphatidylethanolamine (PE)（47∶ 10) and phosphatidylserine (PS)（40∶ 2) were the only two molecules with fold change (FC)>1.5. KEGG metabolic pathway analysis showed that the differential metabolites participated in five metabolic pathways, including choline metabolism and glycerophospholipid metabolism. ROC curve showed the AUC values of clinical baseline variables combined with PE (47∶10) or with PS (40∶2) were 0.928（95%CI：0.851-1.000) and 0.923（95%CI：0.863-0.983), respectively, both higher than those of baseline module, which was 0.737（95%CI：0.640-0.834). Conclusion Lipid metabolism was significantly altered in children with severe asthma, and 39 differential lipid molecules were identified, with the most significant disturbance in the choline metabolic pathway; PE（47∶10) and PS (40∶2) may be potential biomarkers for the diagnosis of severe asthma. [ABSTRACT FROM AUTHOR]

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The purity, microstructure and uniformity of ceramic powders will affect the final performance of ceramic products. Therefore, achieving the controlled synthesis of SiC powders is the current research focus of silicon carbide preparation. Herein, SiC is used as the main material to summarize its main preparation methods. Under the normal pressure sintering system, the specific effects of temperature, raw materials, catalysts, gas supersaturation and other factors on SiC products are discussed based on the growth mechanism of Vapor-Liquid-Solid (VLS) mechanism and the Vapor-Solid (VS) mechanism. The controllable synthesis of SiC ceramic powder has important theoretical value and guiding significance for the large-scale production, application and subsequent preparation of ceramic products. [ABSTRACT FROM AUTHOR]

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