【Objective】In order to provide scientific basis for scientific and rational use of chlorantraniliprole and evaluate its risk after application, an analytical method was developed for the determination of chlorantraniliprole in tobacco plant and soil, and its residual dynamics in tobacco plant and soil were investigated through field trials. 【Method】 Residue and degradation dynamics of chlorantraniliprole were examined after its application to tobacco field. Chlorantraniliprole in tobacco plant and soil samples was extracted by acetonitrile, cleaned by Silica gel column and NH2 SPE-column, determined by HPLC. 【Result】 The results indicated that the average recovery of chlorantraniliprole at spiked levels of 0.05 to 10.00 mg/kg ranged from 80.8 % to 95.8 %, with relative standard deviations（RSD） from 2.4 % to 7.6 %.The limits of quantification（LOQ） were 0.10 mg/kg in tobacco plant and 0.05 mg/kg in soil. The degradation of chlorantraniliprole in tobacco plant and soil was proved to follow the first order kinetic equation, and the half-life of chlorantraniliprole in tobacco plant was 12-13.3 days, in soil was 24.8-27.7 days. Terminal residue studies in Yunnan and Shandong showed that the average residual amount of chlorfenamide in tobacco leaves was between 2.1 and 7.7 mg/kg 14 days after the last application. 【Conclusion】 The precision, accuracy and sensitivity of this method are consistent with the pesticide residue detection requirements. This method is easy to operate and is suitable for the determination of chlorantraniliprole in tobacco plants and soil. Based on the results of risk assessment, it is recommended that 5 % chlorantraniliprole SC used at a dose of 41.25 g（a.i）/hm2 in tobacco field up to 2 times with pre-harvest interval of 14 days. [ABSTRACT FROM AUTHOR]