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主方案试验设计作为一种新型试验设计方法，已被临床研究广泛应用。平台试验设计是主方案试验设计的重要组成部分，用于长期、动态地评价某种疾病的多种治疗方案。因其具有灵活、共享的特点，被越来越多的学者所认可和采用。本文将从背景、设计思路、重要问题、案例分析等方面对平台试验设计方法进行简要介绍。 Abstract: As a new experimental design method, the master protocol has been widely used in clinical research. The platform trial is an important part of the master protocol design, which is used to evaluate multiple treatment regimens for a single disease in a long-term and dynamic manner, and has been recognized and adopted by a growing number of scholars because of its flexibility and sharing. This paper will briefly introduce the method of platform trail from the aspects of background, design concepts, important issues, and case analyses.

在国内贯彻落实“双碳”目标和大规模推广可再生能源的背景下，电化学储能作为提高新能源利用率的重要技术手段，近年来快速发展。但目前尚缺乏完备的大容量电化学储能电站储能效果评价平台。首先剖析了储能电池组和储能变流器模型的运行特性，采用k-means聚类算法提取电化学储能电站的等值参数并建立等值模型。其次，基于现有储能并网运行架构，以四象限变流器为核心，开发了测试大容量储能电站故障电压穿越能力和电网适应性的评价平台，以实现对大容量电化学储能电站的并网检测及运行评价。测试结果显示，提出的储能电站等值模型和大容量电化学储能电站评价平台能够在较短的仿真时间内对电化学储能电站做出较准确的评价。

以预饲喂植物甾醇的小鼠为研究对象，采用脂多糖诱导小鼠产生炎症，研究不同剂量的植物甾醇对炎症发生的预防效果。结果表明：与脂多糖组相比，植物甾醇组小鼠血清中炎症因子白介素1β（IL-1β）、白介素6（IL-6）和肿瘤坏死因子α（TNF-α）含量显著（P

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Copyright of Journal of Frontiers of Computer Science & Technology is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective At present, the carbon storage technology mainly consists of geological structure storage, residual gas storage, dissolution storage and mineral storage. With the application of CO2 fracturing related technologies, It is necessary to carry out in-depth research on the mechanism and main controlling factors of CO2 storage after energized fracturing. Methods According to the factors affecting the pore space and conductivity in fractures, the optimal values of the influence of different factors on fracture retention carbon storage were selected by proppant (quartz sand and ceramsite) under different sand spreading concentrations (5.0 kg/m², 7.5 kg/m² and 10.0 kg/m²) and the effects of different factors on fracture retention carbon storage were analyzed by orthogonal experimental method. Results CO2 storage is mainly in the supercritical state; the storage rate of CO2 is more than 80% when in the supercritical state. The storage rate decreases rapidly as the formation pressure continues to decline, and the storage rate is only about 40% when the pressure drops to 6 MPa. The factors affecting the storage rate include closing pressure, flowback rate, proppant type, and sand spreading concentration, and the influencing order from large to small is closing pressure > flowback rate > proppant type > sand spreading concentration. The main controlling factor is the closing pressure, and the storage rate gradually decreases with the increase of the closing pressure. Conclusion The problem of unclear understanding of CO2 storage carbon in CO2 energized fracturing fractures was solved, and the influence of four fracturing fracture-related parameters on CO2 storage was clarified. While in the design of CO2 energized fracturing, CO2 storage can be predicted based on experimental results. [ABSTRACT FROM AUTHOR]

By using acrylamide (AM), sodium oxyalgae (OSA) and polydopamine-modified polypyrrole (PDA-PPy) as raw materials, a multifunctional hydrogel PAM/OSA/PDA-PPy (PODY) with adhesion, self-healing and conductivity was prepared. The aldehyde group of OSA reacts with the amino group of AM to form imine bond. Because PDA-PPy carries a large number of catechol groups and conductive groups, it endows hydrogels with good adhesion and conductivity. At the same time, more hydrogen bonds are created inside the hydrogel. The structures of OSA, PDA-PPy and PODY hydrogels were analyzed by Fourier transform infrared spectroscopy, hydrogen nuclear magnetic resonance spectroscopy (1H-NMR) and scanning electron microscopy. Their mechanical properties, adhesion properties, self-healing properties and electrical conductivity were characterized by universal electronic testing machine, rotary rheometer and four-probe tester. Results show that the elongation at break of PODY hydrogel is up to 928%, and the tensile strength is up to 194 kPa. The maximum adhesion strength of the hydrogel on pig skin, glass and plastic is 9.0, 17.6 kPa and 22.8 kPa, respectively, and good adhesion strength is still maintained after three cycles of adhesion. PODY hydrogel can form a stable three-dimensional network and has good self-healing performance. The maximum conductivity of PODY hydrogel is 0.248 S/m. It lays a good foundation for its application in the field of wearable sensing. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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遗传算法（GA）是无人艇路径规划系统中的一种有效方法，为了克服该算法易陷入局部最优早熟和收敛速度慢等缺陷，在不增加算法复杂度的前提下，基于数据驱动线性动态交叉策略提出了一种能够在最短时间内自适应动态调整控制参数的改进遗传算法（LCPGA）。与传统的遗传算法相比，LCPGA增加了种群多样性，能更有效地避免陷入局部最优，并提高了路径规划的精度、稳健性和收敛速度。仿真实验和无人艇现场试验验证了该算法具有更优良的性能，该算法可为无人艇路径规划提供一定的应用价值。

【摘要】 目的 分析公立医院高层次人才满意度调查，为提高人才满意度提出持续改进的策略。 方法 对北京市某三级甲等综合医院155名高层次人才进行问卷调查。采用Likert 5点量表赋分方法，从工作情况、职业发展、工作关系、薪酬福利和科研管理5个维度设计调查问卷。根据研究对象对各维度的满意度，进行对策研究。 结果 本研究获得有效问卷144份，问卷有效率92.90%。参与调查对象总体满意度评价得分为（77.86±11.3）分。5个维度满意度评分排序依次为：科研管理（82.16±11.56）分、工作关系（78.72±12.72）分、工作情况（77.30±15.02）分、职业发展（75.60±12.7）分和薪酬福利（75.56±13.72）分。 结论 提高公立医院高层次人才的薪酬福利、创造职业发展的平台可能是今后公立医院提高高层次人才满意度应当努力的方向。 【Abstract】 Objective To survey the satisfaction of high-level talents in a public hospital, and put forward the improvement strategy to increase the satisfaction of high-level talents. Methods A questionnaire survey was conducted in 155 high-level talents from a class 1, Grade 3 general hospital in Beijing. 5-point Likert scale was used to measure their satisfaction from 5 aspects, including working condition, career development, working relationship, salary and welfare and research management. Based on the survey results, an analysis was conducted to develop the improvement measures. Results 144 valid questionnaires (92.90%) were collected. The overall satisfaction score from the participants was 77.86±11.3. The satisfaction scores in 5 aspects were as follows: 82.16±11.56 for research management, 78.72±12.72 for working relationship, 77.30±15.02 for working condition, 75.60±12.7 for career development, and 75.56±13.72 for salary and welfare. Conclusions Improving the salary and welfare of high-level talents in public hospitals and creating a career development platform may be the direction for public hospitals to improve the satisfaction of high-level talents in the future.

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Oncogenic mutations are responsible for a majority of the malignancy of melanoma. Activating mutations of NRAS gene are found in 15%-20% melanoma cases, endowing the tumor cells with more aggressive phenotypes and greater difficulty to treat. The development of targeted inhibitor of mutant NRAS remains a big challenge since the mutation sites could hardly be druggable. Therefore, immune checkpoint inhibitors are currently recommended as the first-line therapy for NRAS mutant advanced melanoma albeit the response rate is still far from satisfaction. In recent years, the exploration of targeted therapy regimens has focused on the downstream pathway of NRAS, the mitogen-activated protein kinase (MAPK) pathway. A novel MEK1/2 inhibitor tunlametinib was reported to achieve an objective response rate (ORR) of 34.7% which is higher than the ORR of binimetinib in previous report. However, the phase Ⅰ trial of the pan-RAF inhibitor belvarafenib and the ERK inhibitor ulixertinib failed to show marked benefits. In the meanwhile, MEK inhibitor-based combination therapy has also achieved some progress: it was reported in the phase Ⅰb trial of the selective BRAF/CRAF inhibitor naporafenib (LXH254) combined with Trametinib in NRAS mutant melanoma that the ORR was 46.7%. The ORR of binetinib plus the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, ribociclib, was 32.5% in patients with NRAS mutation with concurrent alterations of CDKN2A, CDK4, or CCND1. The response rate of the combination of focal adhesion kinase (FAK) inhibitor, IN10018, and cobimetinib was 38.5%. On the other hand, only 27.2% of patients carrying NRAS mutation responded partially to the combined regimen of immune checkpoint inhibitor programmed death ligand-1 (PDL1) monoclonal antibody durvalumab+trametinib. In addition, some preclinical findings have also shown translational potentials: for example, heat shock protein 90 (HSP90) inhibitor XL888 and serine/threonine protein kinase 19 (STK19) inhibitors were found to inhibit the growth of NRAS mutant melanoma in animal models. This article reviewed the oncogenic roles of NRAS mutation in melanoma and the cutting-edge clinical trials for the treatment of NRAS mutant melanoma, aiming to provide alterative treatment options for clinical practice and inspire novel combination regimen. [ABSTRACT FROM AUTHOR]

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In order to facilitate studies on biological function of PUP family genes in Gossypium hirsutum, and provide candidate genes for subsequent studies on the function of PUP genes in stress resistance, in this study, 31 PUP genes were identified in Gossypium hirsutum(TM-1) genome using bioinformatics, and could be classified into 3 subfamilies according to polygenetic analysis. The results of chromosome location and gene replication analysis showed that 31 GhPUP genes were distributed on 19 chromosomes, and all PUP genes were generated by gene replication events, and the duplication type was fragment duplication. Gene structure analysis indicated that most PUP genes had only one intron, a few had two or three introns, and a few had no introns. Conserved domain analysis showed that both commonality and specificity existed between PUP proteins in different subfamilies. Cis-acting elements analysis showed that there were 18 elements in the GhPUP genes promoter region, which were classified into three categories: hormone response, stress/physical response, and plant growth and development related elements. At the same time, combined with evolutionary analysis and transcriptome data, PUP genes involved in stress response in Gossypium hirsutum were screened. [ABSTRACT FROM AUTHOR]