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Cell signaling pathway refers to the process that extracellular factors combine with membrane receptors and nuclear receptors to lead to the interaction and biochemical process of a series of proteins in cells so that the genes to be expressed in cells begin to form various biological effects.Hepatic stellate cell（HSC） is an important protective barrier of human liver.For example, when liver injury factors invade in the external environment, HSC will be activated immediately and quickly change from the original static state to the activated state.However, in the process of activation, the body participates in a large number of cells and cytokines, which interact and transform each other, resulting in further aggravation of fibrosis in hepatocytes.Many previous experimental studies have shown that the action mechanism of anti-hepatic fibrosis drugs is multi-level cross regulation, which is a very complex network system.It can inhibit the activation and proliferation of HSC from a variety of signal pathways, so as to inhibit hepatic fibrosis, and inhibit the overall process of liver cirrhosis.This paper summarized seven signaling pathways involved in the study of HSC activation.With the help of the study of HSC activation and proliferation, this paper explored the effect and treatment process of hepatic fibrosis caused by HSC activation and proliferation under the action of signaling pathway. [ABSTRACT FROM AUTHOR]