Search

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Research has demonstrated a close association between ferroptosis and vascular dementia. Tongmai Kaiqiao Pill has a certain effect on improving the cognitive function of vascular dementia patients, but its mechanism is unclear. OBJECTIVE: To explore the interventional effects and molecular mechanisms of Tongmai Kaiqiao Pill for vascular dementia based on the regulation of ferroptosis by the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/glutathione peroxidase 4 (GPX4) signaling pathway. METHODS: Among eighty-four SD male rats, 12 rats were used as the sham-operated group, and the rest of them were prepared as a model of vascular dementia by the modified 2-VO method, and then randomly divided into the model group, the Tongmai Kaiqiao Pills high-, moderate-, and low-dosage (27. 6, 13. 8, and 6. 9 g/kg) groups, the combined group (Tongmai Kaiqiao Pill high-dosage+ML385, 20 mg/kg), and the donepezil hydrochloride group (0. 45 mg/kg). The drug was given once a day by intragastric administration. The combined group was also intraperitoneally injected Nrf2 inhibitor ML385, once a day, for 4 weeks. Morris water maze was used to detect the learning memory ability of rats. Hematoxylin-eosin staining was used to observe the histopathological changes in the hippocampus of rats in each group. Colorimetric assay was used to detect the content of reduced glutathione, ferrous ion (Fe2+), and malondialdehyde in the serum of rats. Prussian blue staining was used to detect the iron deposition in the hippocampal tissue of rats. Transmission electron microscopy was used to observe the ultrastructural changes of mitochondria in rat hippocampal tissues. Western blot assay was used to detect the protein expression levels of Nrf2, HO-1, GPX4, XCT, and ferritin heavy chain 1 (FTH1) in rat hippocampal tissues. RESULTS AND CONCLUSION: In comparison to the sham operation, rats in the model group exhibited a significantly prolonged latency period (P＜0. 05) and a reduced number of platform crossings (P＜0. 05). Additionally, the hippocampal tissues of these rats displayed loosely organized structure, deeply stained cell nuclei, and solidified or lysed chromatin. Ferri ions aggregated in CA1 region. There were atrophied mitochondria with dissolved cristae and thickened mitochondrial membranes. Fe2+, malondialdehyde, and reduced glutathione levels in rat serum were found to be elevated (P＜0. 05). A significant reduction in the expression of GPX4, HO-1, XCT, Nrf2, and FTH1 proteins was detected in the hippocampus (P＜0. 05). Compared to the model group, the average escape latency of the rats was significantly reduced following intervention with Tongmai Kaiqiao Pills and donepezil hydrochloride (P＜0. 05), with an increased number of platform crossings (P＜0. 05). Hippocampal neurons showed significant recovery. Notably, iron aggregation in the CA1 region was significantly reduced, and mitochondrial structure and function were improved. There were significant reductions in Fe2+and malondialdehyde levels, while the levels of GPX4, HO-1, XCT, Nrf2, and FTH1 in rat hippocampal tissues, and reduced glutathione in serum were significantly increased (P＜0. 05). The high-dose Tongmai Kaiqiao Pills exhibited a treatment effect comparable to that of donepezil hydrochloride (P＞0. 05), with a significant prolongation of water maze escape latency (P＜0. 05), a reduced number of platform crossings (P＜0. 05), and insignificant neuronal pathological changes in the CA1 area. However, the combined group showed increased iron deposition, elevated malondialdehyde and Fe2+levels in blood serum (P＜0. 05), reduced glutathione content (P＜0. 05), hippocampal tissue mitochondrial atrophy, and reduced expression of Nrf2, XCT, HO-1, GPX4, and FTH1 proteins (P＜0. 05). Within a certain range, higher doses of Tongmai Kaiqiao Pills demonstrated a more pronounced effect, comparable to the efficacy of high-dose donepezil hydrochloride. It is concluded that Tongmai Kaiqiao Pills have been shown to mitigate histopathological changes in the rat hippocampus and enhance cognitive function in rats with vascular dementia. The mechanism of action is likely associated with the suppression of ferroptosis through the activation of the Nrf2/HO-1/GPX4 signaling pathway. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article explores the construction plan and innovative operation mode of Peripherally Inserted Central Catheter (PICC) nursing clinics in a certain Traditional Chinese Medicine(TCM) hospital, and to evaluate its practical effects. The PICC nursing clinic had a reasonable layout, and the work was carried out through the formation of intravenous treatment teams, establishment of rules and regulations, nursing expert preparation system, multi-disciplinary team cooperation system, special quality control of outpatient clinics, application of characteristic Chinese Medicine technology, and networked nursing guidance, etc. (本文探讨了中医医院PICC护理门诊的建设方案和创新运行模式, 并评价其实践效果。PICC护理门诊设置布局合理, 通过组建静脉治疗团队, 通过建章立制、护理专家备班制、多学科团队合作制、门诊专项质量控制、应用中医特色技术及网络化护理指导等形式开展工作。)

Copyright of China Petroleum Machinery is the property of China Petroleum Machinery Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Sedimentologica Sinica is the property of Acta Sedimentologica Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Mechanics is the property of Chinese Journal of Applied Mechanics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electric Power Engineering Technology is the property of Editorial Department of Electric Power Engineering Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Having adult healthy Jianzhou big-ear goat as experimental animals, RT-PCR technology was used to clone the goat ZNF32 gene. The bioinformatics analysis was used to analyze the expression characteristics, and real-time quantitative PCR（qPCR）was used to detect the expressions of ZNF32 in goat tissues and inducing differentiation of subcutaneous fat cells at different stages. Meanwhile, the overexpression vector was constructed and qPCR was to detect the effects of overexpression or interference of ZNF32 on the expressions of genes related to proliferation inhibition, and its effect on the proliferation of subcutaneous precursor adipocytes was explored. The results showed that the length of the cloned goats ZNF32 nucleotide sequence was 1 049 bp, of which the CDS area length was 822 bp and 273 amino acids were encoded. ZNF32 molecular weight was 30 983.03 Da, the theoretical isoelectric point was 9.52, and the average hydrophilic value was -0.813. In the composition of amino acid sequences, serine content was 9.2%, accounting for the highest proportion. The secondary structure prediction of proteins demonstrated that 149 amino acids formed irregular curls and the highest content. The results of amino acid homology alignment revealed that the Jianzhou big-ear goat shared the highest similarity with sheep, and they were in the closest genetic relationship. Tissue expression spectrum showed that the ZNF32 gene was widely expressed in various tissues of the goat. Among them, the expression in the large intestine was the highest（P<0.01). The timing expression spectrum showed that the expression level of the ZNF32 gene was on the rise, reached the highest expression at 96 h, which was significantly higher than that before differentiation（P<0.01). The detection results of qPCR technology suggested that the overexpression of the ZNF32 gene inhibited the expression of proliferative inhibition-related genes p27 and p57, while the interference of ZNF32 promoted the expression of p21, p27, p53 and p57. The above results show that the ZNF32 gene may be a positive regulatory factor for subcutaneous fat cell differentiation and proliferation. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cotton Textile Technology is the property of Cotton Textile Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

报道上海交通大学医学院附属同仁医院内分泌科1例新诊断2型糖尿病患者应用胰岛 素短期强化治疗后转换为司美格鲁肽单药治疗，并达到糖尿病逆转的治疗经过。患者为 34岁男性， 因“口干、多饮、多尿1个月”入院，入院后完善各项检查，明确诊断为2型糖尿病。予胰岛素泵控制血 糖5 d，入院后第3天加用司美格鲁肽，出院后予司美格鲁肽1 mg，每周1次皮下注射单药治疗，用药半 年后停药，停药3个月后测患者糖化血红蛋白为5.6%，达到糖尿病逆转标准。司美格鲁肽是一种可以 平稳控制血糖及减轻体重的新型胰高糖素样肽‑1类似物，可单独应用或与其他降糖药物联合应用于 肥胖及2型糖尿病肥胖患者，在糖尿病逆转治疗中有积极意义。 [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Chinese Institute of Food Science & Technology / Zhongguo Shipin Xuebao is the property of Journal of Chinese Institute of Food Science & Technology Periodical Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cotton Textile Technology is the property of Cotton Textile Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tropical Geography is the property of Tropical Geography Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan Agricultural Sciences is the property of Editorial Board of Journal of Henan Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Applied Chemical Industry is the property of Shaanxi Research Design Insitute of Petroleum & Chemical Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cotton Textile Technology is the property of Cotton Textile Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Applied Chemical Industry is the property of Shaanxi Research Design Insitute of Petroleum & Chemical Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)