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Objective To investigate the relationships between serum soluble signal peptide-CUB-epithelial growth factor domain-containing protein 1 (SCUBE1), lipoprotein phospholipase A2 (Lp-PLA2) and coronary artery high thrombus burden (HTB) in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods Totally 126 acute STEMI patients (acute STEMI group) were divided into the HTB group (57 cases) and non-HTB group (69 cases) according to thrombus grading, and 87 healthy people with physical examination in the same period were selected as the control group. Serum SCUBE1 and Lp-PLA2 levels were measured by enzyme-linked immunosorbent assay. Multifactorial logistic regression was used to analyze the influencing factors for coronary HTB in patients with acute STEMI, and receiver operating characteristic (ROC) curve was used to evaluate the the predictive value of serum SCUBE1 and Lp-PLA2 levels on coronary HTB in patients with acute STEMI. Results Serum SCUBE1 and Lp-PLA2 levels were higher in the acute STEMI group than the control group (both P<0. 05). The age, smoking proportion, low-density lipoprotein cholesterol, white blood cell count, SCUBE1, and Lp-PLA2 levels of patients with HTB were higher than those of patients without HTB (all P<0. 05), and there were no significant differences in gender, underlying diseases, culprit vessels, Gensini scores, or left ventricular ejection fractions between the two groups (all P>0. 05). Multifactorial Logistic regression analysis showed that increased age, smoking, and elevated SCUBE1 and Lp-PLA2 were independent risk factors for coronary HTB in patients with acute STEMI (all P<0. 05). ROC curve analysis showed that the area under the curve of serum SCUBE1 and Lp-PLA2 levels in predicting the coronary HTB in patients with acute STEMI was 0. 874, which was greater than that of serum SCUBE1 and Lp-PLA2 levels individually (0. 794 and 0. 791) (both P<0. 05). Conclusion Elevated serum SCUBE1 and Lp-PLA2 levels in patients with acute STEMI are closely associated with coronary HTB, and the combined detection of serum SCUBE1 and Lp-PLA2 levels has high predictive value for coronary HTB in patients with acute STEMI. [ABSTRACT FROM AUTHOR]

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