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目的 探讨颅内动脉与颈动脉并存斑块分布特征对卒中复发风险的预测价值。 方法 连续纳入2周内发生缺血性卒中且至少一侧颈动脉存在粥样硬化斑块的患者，于基线期进行颅外颈动脉多对比度MR血管壁成像和颅内动脉MRA检查。随后对所有患者进行至少1年的随访研究，观察有无缺血性卒中复发。分析粥样硬化斑块在颅外颈动脉不同节段的分布特征，以及前循环颅内动脉狭窄并存颅外颈动脉不同节段斑块的发生率。采用Cox回归计算前循环颅内动脉狭窄并存颈动脉不同节段斑块对缺血性卒中复发的预测价值。 结果 共纳入117例患者，平均年龄为（62.6±11.8）岁，其中男性85例，中位随访时间为12.0（11.1～12.8）个月，有31例（26.5%）患者发生缺血性卒中复发。前循环颅内动脉狭窄并存颈动脉球部斑块与卒中复发显著相关（HR 2.535，95%CI 1.085～5.922，P=0.032），校正年龄、性别、BMI混杂因素后该相关性仍具有统计学意义（HR 2.903，95%CI 1.114～7.565，P=0.029）。前循环颅内动脉狭窄并存颈动脉其他节段斑块与卒中复发无相关（P>0.05）。 结论 在缺血性卒中且至少一侧颈动脉存在粥样硬化斑块的患者中，前循环颅内动脉狭窄并存颈动脉球部斑块与卒中复发独立相关。 Abstract: Objective To investigate the predictive value of intracranial and carotid arteries coexisting atherosclerotic plaque distribution characteristics for the risk of stroke recurrence. Methods Patients with ischemic stroke within 2 weeks and at least one carotid plaque were consecutively included and underwent multi-contrast MR vessel wall imaging for extracranial carotid arteries and MRA for intracranial arteries at baseline. All patients were followed up for at least 1 year to record stroke recurrence. The distribution characteristics of atherosclerotic plaque in different segments of the extracranial carotid artery and the incidence of coexisting intracranial artery stenosis in anterior circulation and extracranial carotid artery atherosclerotic plaques in different segments were analyzed. Univariate and multivariate Cox regressions were used to calculate the predictive value of coexisting intracranial artery stenosis in anterior circulation and carotid artery atherosclerotic plaques in different segments for stroke recurrence. Results A total of 117 patients were included, with a mean age of (62.6±11.8) years, including 85 males. The median follow-up time was 12.0(11.1-12.8) months, and 31(26.5%) patients experienced stroke recurrence. Coexisting intracranial artery stenosis in the anterior circulation and atherosclerotic plaques in the segment of the carotid bulb was significantly associated with stroke recurrence (HR 2.535, 95%CI 1.085-5.922, P=0.032). After adjusting for confounding factors (age, sex, and BMI), this association remained statistically significant (HR 2.903, 95%CI 1.114-7.565, P=0.029). No significant association was found between intracranial artery stenosis in anterior circulation coexistent with atherosclerotic plaque in other segments of the carotid artery and stroke recurrence (P>0.05). Conclusions In patients with ischemic stroke and at least one carotid plaque, coexisting intracranial artery stenosis in anterior circulation and atherosclerotic plaque in the segment of the carotid bulb was independently associated with stroke recurrence.

旨在为米糠油的精准适度加工及其在食品工业中的应用提供科学指导，研究了常压和充氮加热（60~260 ℃）处理0~12 h条件下米糠油中谷维素及其4种主要组分〔环木菠萝烯醇阿魏酸酯（CAFA）、24-亚甲基环木菠萝烯醇阿魏酸酯（24-MCAFA）、菜油甾醇阿魏酸酯（CampFA）及 β-谷甾醇阿魏酸酯（SitoFA）〕的损失规律。结果表明：两种加热方式下谷维素及其4种主要组分的损失率随加热时间的延长均呈线性上升趋势（R2>0.90），损失速率随着加热温度升高而升高；在常压加热条件下，当温度达到220 ℃时谷维素开始快速损失，260 ℃下加热12 h时谷维素总量损失率最高（74.14%）；谷维素4种主要组分在两种热处理过程中热稳定性相似，即不高于140 ℃时各组分之间热稳定性总体无显著差异，不低于180 ℃时各组分热稳定性大小顺序为CampFA>CAFA>24-MCAFA>SitoFA；充氮加热下谷维素损失率变化趋势与常压加热下相似，但其损失率显著低于常压加热（除140 ℃和60 ℃），在220 ℃下加热12 h时两者相差最大（32.34百分点）。综上，米糠油应采用适度加工工艺及在食品工业应用中应合理控制加热条件以减少谷维素的损失，提高米糠油的营养品质。Aiming to provide scientific guidance for the precise and moderate processing of rice bran oil and its application in the food industry, the loss law of oryzanol and its four main components 〔cycloartenyl ferulate (CAFA),24-methylene cycloartenyl ferulate（24-MCAFA）,campesterol ferulate（CampFA）,β-sitosterol ferulate（SitoFA）〕 in rice bran oil heated by atmospheric pressure heating and nitrogen-filled heating respectively under the conditions of heating temperature 60-260 ℃ and heating time 0-12 h was studied. The results showed that the loss rate of oryzanol and its four main components showed a linear increasing trend with the extension of heating time (R2>0.90) under the two heating methods, and the loss rate was positively correlated with the heating temperature. Under the conditions of atmospheric pressure heating, oryzanol began to lose rapidly when the temperature reached 220 ℃, and the loss rate of oryzanol reached the highest (74.14%) when the temperature reached at 260 ℃ for 12 h. The thermal stability of the four main components of oryzanol was similar during the two heat treatment processes. There was overall no significant difference in the stability among the four components when the temperature was not higher than 140 ℃, whereas their stability was order as CampFA>CAFA>24-MCAFA>SitoFA when the temperature was not lower than 180 ℃. The variation trend of oryzanol loss rate under nitrogen-filled heating was similar to that under atmospheric pressure heating, whereas the loss rate under nitrogen-filled heating was significantly lower than that under atmospheric pressure heating(except for 140 ℃ and 60 ℃), and the difference was the highest (32.34 percentage) at 220 ℃ for 12 h. To sum up, rice bran oil should use moderate processing techniques and reasonable control heating conditions in food industry applications to reduce the loss of oryzanol, thereby enhancing the nutritional quality of rice bran oil.

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Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Accurate classification and detection have posed a great challenge on benthic organisms, due to the excessive parameters, computational overhead, and complex underwater environments. In this study, a lightweight target algorithm (named YOLOv7-RFPCW) was proposed to improve the detection accuracy of underwater benthic organisms. 1) The original YOLOv7 network architecture was reconstructed into the feature extraction, in order to significantly reduce the parameters and computational complexity. The overall footprint was effectively shrunk to simultaneously enhance the adaptability in the underwater scenes. This modification served as the lightweight solution. The deployment also remained computationally feasible in the resource-constrained underwater or real-time applications where processing speed was paramount. Progressive Efficient Lightweight Attention Network (P-ELAN) and its variant, P-ELAN-W, were integrated into the architecture to further lighten the network. The existing components were replaced or augmented to streamline the information flow, and then prune unnecessary computations for the essential feature representations. P-ELAN and P-ELAN-W contributed to a substantial reduction in the overall complexity. While the discriminatory power was preserved for the accurate detection of benthic organisms. A convolutional Block Attention Module (CBAM) was employed to recognize the color distortion and spatial localization in the underwater imagery. This attention mechanism was seamlessly integrated into the network to reinforce the feature fusion. The crucial visual cues were discerned in the context of the visually degraded underwater, in order to mitigate the information loss. The attention of CBAM networks was focused on the major features relevant to benthic organisms in the environmental factors of water turbidity and light scattering. 2) The default CIOU loss function was substituted with the Weighted Intersection over Union-Version 3 (WIOU-V3) loss function. The reason was that the shape deformation was commonly encountered with the underwater targets. WIOU-V3 was also tailored to handle the varying shapes and orientations of underwater benthic organisms, in order to provide the adaptive measure of bounding box prediction accuracy. The advanced loss function was incorporated to better cope with the underwater object shapes, thereby reducing the false negatives or positives from the shape-related misinterpretations. Extensive experiment was carried out to evaluate the efficacy of the YOLOv7-RFPCW. The results demonstrate that the parameters were significantly reduced by 75.9%, while there was a substantial decrease of 30.7% in the computational requirements. Moreover, the size of the model was compressed by 75.3%, indicating the profound impact of lightweight strategies. Notably, this efficiency was achieved in the high detection accuracy, which was improved by 1.9 percentage points, indicating successfully balanced compactness with high detection performance. In summary, the YOLOv7-RFPCW algorithm presented as the effective solution to detect underwater benthic organisms. The complexity and computational demands were fully met in the underwater environment, including color distortion, spatial localization errors, and target shape deformations. The improved model can be expected to serve as a robust and efficient tool in the practical deployment for the accurate detection of benthic organisms in underwater scenarios, where the model size and computational overhead were coupled with a tangible increase in detection precision. This finding can offer a reliable means to monitor these vital components of aquatic ecosystems with enhanced efficiency and reliability. [ABSTRACT FROM AUTHOR]

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AIM: To investigate the effect of vaccarin (VAC) on endothelial dysfunction in type 2 diabetes mellitus (T2DM), and to uncover the underlying mechanisms. METHODS: (1) C57BL/6 mice received intraperitoneal injection of streptozotocin and were fed with a high-fat diet (21. 8 kJ/kg, 60% of the energy source was fat) to construct a T2DM mouse model. Thirty mice were randomly divided into control, T2DM and T2DM+VAC groups, with 10 mice in each group. The mice in T2DM+VAC group were given 1 mg/kg VAC via oral gavage for 6 weeks, while those in control and T2DM groups were given the same volume of PBS. The mRNA and protein expression levels of BCL2-interacting protein 3(BNIP3), PTEN-induced kinase 1(PINK1) and parkin in the thoracic aorta were detected by RT-qPCR and Western blot. (2) Human umbilical vein endothelial cells (HUVECs) were stimulated by high glucose (HG；35 mmol/L glucose). Mitochondrial membrane potential, autophagy and mitochondrial superoxide levels were detected using JC-1, acridine orange (AO) and MitoSOX staining, respectively. RESULTS: Compared with control group, the mRNA and protein levels of BNIP3, PINK1 and parkin were significantly increased in the thoracic aorta of T2DM mice (P<0. 05). Compared with T2DM group, the mRNA and protein levels of BNIP3, PINK1 and parkin in the thoracic aorta were significantly reduced in T2DM+VAC group (P<0. 05). The results of JC-1, AO and MitoSOX staining showed that VAC attenuated the decrease in mitochondrial membrane potential and the increase in autophagy and mitochondrial superoxide levels in HG-induced HUVECs. Treatment with VAC also inhibited HG-mediated mitochondrial damage in HUVECs after BNIP3 overexpression. The effect of miR-570-3p mimic on mitochondrial damage was similar to VAC. RT-qPCR and Western blot showed that both miR-570-3p mimic and VAC significantly reduced the mRNA and protein levels of BNIP3, PINK1 and parkin. In contrast, inhibition of miR-570-3p exhibited the opposite effects. CONCLUSION: Treatment with VAC alleviated endothelial dysfunction in T2DM by inhibiting HG-induced mitochondrial dysfunction through miR-570-3p/BNIP3. [ABSTRACT FROM AUTHOR]

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急性胰腺炎是临床常见的急腹症之一，高甘油三酯血症是其重要病因。高甘油三酯血症性急性胰腺炎 （HTG-AP）有急性胰腺炎的临床表现，如持续剧烈的上腹部疼痛，可向背部放射，血清胰酶水平升高，CT或MRI上有 急性胰腺炎典型的影像学改变。除此之外，还会有血清甘油三酯水平显著升高。HTG-AP发病年轻化，合并症多， 并且病情进展迅速，有重症化倾向。由于HTG-AP早期手术治疗可增加多器官功能障碍综合征的发生风险，故在急 性期以非手术治疗为主。目前，HTG-AP的非手术治疗策略主要有常规治疗和病因治疗。常规治疗包括禁食、胃肠 减压、液体复苏、抑制胰酶分泌和胰酶活性、营养支持等。病因治疗主要包括常规调脂治疗、胰岛素治疗、肝素治疗、 血液净化治疗。HTG-AP的治疗核心在于快速降低血清甘油三酯水平，并且与其他类型急性胰腺炎相同，需要防治 局部或全身并发症，从而减少重症急性胰腺炎的发生。 [ABSTRACT FROM AUTHOR]

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Aiming at the air power hysteresis and ground shutdown faults of an aero-piston engine, a fault diagnosis method based on the combination of flight dynamic model restoration, data reasoning and comparison method was proposed. Taking the flight data of American Lycoming engine and GARMIN 1000 as the research object, using Google Earth and FLIGHTDATA to restore the track of aircraft fault segment by segment coordinates and attitude data, and combining with EGVIEW engine data software to analyze various data collected during engine operation, the typical fault data characteristics of fault engine were studied, and the actual working conditions of fault engine were judged based on the calculation results of engine residual gas coefficient during fault period. The results show that when engine failure occurs, it is seriously rich in oil. By analyzing the structure principle of fuel regulator and testing its performance on the ground test bench, it is confirmed that the two engine faults are homologous and related to flight control, excessive slow performance parameters of fuel regulator and structural design of idle valve. At the same time, the effectiveness and accuracy of fault diagnosis by state monitoring data were verified. [ABSTRACT FROM AUTHOR]

[Objective] This study reveals the contribution of multi-system comprehensive evaluation of water and soil suitability of water and soil resources to regional development, clarifies the suitability evolution of coordinated development of water and soil resources in Ningxia, and identifies the influence factors of regional carrying capacity of water and soil resources. [Methods] A comprehensive evaluation system of resources, ecology, and social economy in Ningxia was built up. An entropy weight TOPSIS model, a coupling coordination degree model and a gray correlation degree model were used to evaluate the dynamic changes and coordinated development of water and soil resources in Ningxia in the past 20 years (2001—2020) and analyze the change rules of influencing factors. [Results] The suitability of water and soil resources in Ningxia had a trend from poor to good level and is currently at a high-quality level (0.883) . The degrees of coupling and coordination between the sub-systems had increased from a serious imbalance (0.159) in 2001 to a high-quality coordination (0.946) in 2020. The resource evaluation system (0.729) had a higher correlation in the evaluation of the suitability of water and soil resources among the sub-systems and social evaluation system (0.721) . [Conclusion] The coordinated development of sub-systems reflects the overall suitability of soil and water resources in Ningxia. In the future, more attention should be paid to the key factors in the social system, and the development and utilization of soil and water resources should be rationally allocated. [ABSTRACT FROM AUTHOR]

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Macrophages are highly heterogeneous and related to a variety of diseases such as tumors and autoimmune diseases. Therefore, the application of macrophages as a potential target for treatment of these diseases has received more and more attention. Although genetic engineering is widely used to modify cells, it is still difficult for efficient transfection of macrophages by existing methods. Recently, through continuous attempts and improvements, the efficiency of genetically engineered macrophages has been significantly improved. We herein introduce several transfection methods which are currently used in macrophages and discussed their advantages and disadvantages. In addition, potential applications of genetically engineered macrophages in treatment of tumors, autoimmune diseases and anti-graft rejection are emphasized. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Atomic Energy Science & Technology is the property of Editorial Board of Atomic Energy Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Surgical operation is one of the significant parts of the comprehensive therapeutic methods of lung cancer. In the history of the development of lung cancer operation, scholars and predecessors at home and abroad have gradually established the current status of lung cancer operation and the framework of comprehensive treatment after continuous understanding of local anatomy of lung, continuous innovation of surgical equipment and continuous reform of surgical methods. In the continuous development and improvement of lung cancer surgical diagnosis and treatment procedures, a set of standardized diagnosis and treatment process of lung cancer screening, early diagnosis and treatment, standardized surgery process, rapid perioperative recovery, postoperative adjuvant treatment and follow-up has been formed. The achievements of lung cancer operation are achieved by scholars standing on the shoulders of giants. In the process of pioneering and innovating, we should go back and review the road that our predecessors have taken, and draw energy from it to continue to create new brilliance in lung cancer operation. In this paper, the evolution history of lung cancer surgery is summarized in order to improve the clinician′s understanding of the history of lung cancer surgery. [ABSTRACT FROM AUTHOR]

Ground fissures on the Beijing Plain are highly concealed and displaced, causing significant economic losses and environmental damage. However, there have been few evaluations of the economic losses caused by ground fissures. In this study, the Songzhuang ground fracture (Shuangbutou Village–Dapang Village section) was selected as the research area and combined with the field investigation of ground fracture data in 2016 and 2022, as well as the housing appraisal data in 2018. A direct economic loss evaluation model for ground fracture disasters was established for the first time, and the current and predicted losses were quantitatively evaluated. According to the statistical analysis, the damage caused by ground fractures in this section was mainly to civil buildings, and the number of disaster-affected objects increased by 137.26% during the six years (2016-2022). By the end of 2016, 2018 and 2022, the total value of direct economic losses due to disasters was 46.23 million yuan, 70.33 million yuan and 107.51 million yuan, respectively, with an average annual growth of approximately 10.21 million yuan per year. The total direct economic losses in the region are expected to be approximately 150 million yuan and 410 million yuan by 2025 and 2035, respectively. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Railway Science & Engineering is the property of Journal of Railway Science & Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)