The purpose of this study was to explore the effects of duck manure application on soil environmental quality and pear quality and to promote the scientific application of duck manure to partially replace chemical fertilizers in pear planting. Under the condition of equal nitrogen substitution, the duck manure alternative fertilizer program in this study was divided into five groups including the control group (CK), 30% (DM1), 40% (DM2), 50% (DM3), and 60% (DM4). The duck manure was applied to the pear tree soil in April and July. Soil and pear samples were collected in October. The soil environmental quality (soil pH, soil nutrients, heavy metals, antibiotics) and pear quality parameters (soluble solids, soluble sugars, vitamin C) were also analyzed. The results showed that all the duck manure replacement treatments (DM1-DM4) could significantly increase the soil pH (6%-21%) compared with the control group, and the organic matter of deeper soil (40-60cm) was improved. The most significant effect on increasing the content of available phosphorus and available potassium in the soil was also found in the DM3 group. Fortunately, the contents of heavy metals in different soil layers of each treatment fully meet the requirements of pollution-free and green food producing areas for soil environment. The results also indicated that the application of duck manure improved the pear quality, and the soluble solids, soluble sugars, and vitamin C of pear were increased by 5.21%-17.44%, 2.50%-8.45%, and 0.39%-11.01%, respectively. The results showed that 30% duck manure replacing had the best effect on improving pear quality, while 50% duck manure replacing had the best effect on improving soil environment quality. [ABSTRACT FROM AUTHOR]