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Objective To investigate the correlation between the level of circulating placental growth factor (PLGF) and the severity of preeclampsia (PE), maternal and infant outcomes and placental pathology. Methods A total of 159 PE patients were selected as the study subjects and divided into the PE1 group (62 PE patients with termination of pregnancy < 34 weeks) and the PE2 group (97 PE patients with termination of pregnancy ≥ 34 weeks) according to the gestational age of pregnancy termination. A total of 107 non-PE patients who gave birth during the same period were selected as the control group. Patients were divided into two groups according to the gestational age of termination: the non-PE1 group (41 non-PE patients with termination of pregnancy at < 34 weeks) and the non-PE2 group (66 non-PE patients with termination of pregnancy at ≥34 weeks). General data were collected in each group of pregnant women, including age, body mass index (BMI), admission systolic blood pressure, diastolic blood pressure, 24 h urinary protein quantity, gestational times, presence of FGR and fetal embarrassment. General information of newborns during the operation were collected, for example, whether there was fecal contamination of amniotic fluid, neonatal asphyxia, and days of newborn stayed in NICU. PLGF in venous blood of pregnant women was detected on the day of delivery. The placenta was pathologically detected and scored. After delivery, blood gas of umbilical artery was analyzed, and PH (pH), base surplus (BE), lactic acid (LAC) were recorded. Results There were no significant differences in age, gestational times and delivery times between the PE1 group and the PE2 group and the corresponding the non-PE1 group and the non-PE2 group. BMI was higher in the PE1 group and the PE2 group than that in the non-PE1 group and the non-PE2 group. PLGF was lower in the PE1 group and the PE2 group than that in the non-PE1 group and the non-PE2 group, respectively, and PLGF was lower in the PE1 group than that in the PE2 group (P＜0.05). The 24 h urinary protein quantity, systolic blood pressure, diastolic blood pressure and pathological changes of placenta were higher in the PE1 group than those in the PE2 group (P＜0.05). There were no significant differences in fecal staining of amniotic fluid, fetal embarrassed condition and pH value of umbilical artery blood gas during delivery between the PE1 group and the PE2 group. Compared with the PE2 group, the proportion of neonatal asphyxia and FGR, the umbilical artery blood gas LAC were increased, the BE value was decreased, and the time of staying in NICU was prolonged in the PE1 group (P＜0.05). Conclusion The level of circulating PLGF is decreased in patients with preeclampsia. PLGF has certain value in evaluating PE and predicting adverse pregnancy outcome. [ABSTRACT FROM AUTHOR]

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Objective To study the clinical characteristics and perinatal outcomes of patients with premature preeclampsia (PE) and chronic hypertension complicated with PE, and to compare the difference of triglyceride-glucose index (TyG) between the two groups of patients. Methods A total of 158 cases of pregnancy terminated by cesarean section at 28-36+6 weeks of gestation due to "preeclampsia" were selected. According to whether they had chronic hypertension, patients were divided into the chronic hypertension PE group (53 cases) and the PE group (105 cases). The general data, blood routine, coagulation routine, biochemical indexes and TyG were compared between the two groups, and the difference in perinatal outcomes was analyzed. Results Compared with the PE group, patients in the chronic hypertension PE group had older age, higher gestational weight gain during pregnancy, and the gestational age of delivery is earlier, and the difference between the two groups was statistically significant (P＜0.05). Data of hematocrit, platelet, fibrinogen, creatine kinase isoenzyme, aspartate aminotransferase, total cholesterol, triglyceride, fasting blood glucose and 24-hour urinary protein were significantly increased in the chronic hypertension PE group, while uric acid was lower (P＜0.05). TyG index was also higher in the chronic hypertension PE group (9.89±0.30 vs. 9.76±0.26, P＜0.01). The neonatal birth weight and 1- minute Apgar score were lower in the chronic hypertension PE group, but the arterial blood alkaloid surplus was higher and the length of hospital stay in NICU was longer (P＜0.05). For both types of preterm PE, the preterm delivery near term (34- 36+6weeks of gestation) accounted for the largest proportion, but the early preterm birth (28-31+6weeks of gestation) was higher in the chronic hypertension PE group (28.3% vs. 10.5%, P＜0.01), and the proportion of small-gestational age babies (SGA) was also higher (60.4% vs. 42.9%, P＜0.05). Conclusion Compared with preterm PE, patients with preterm chronic hypertension PE have more significant insulin resistance, hypercoagulability, myocardial and kidney damage, and higher risk of early preterm delivery and SGA. Maternal and fetal monitoring should be more intensive. [ABSTRACT FROM AUTHOR]

Long QT syndrome (LQTS) is a genetic heart disease caused by mutations in genes that lead to abnormalities in the structure or function of ion channels, and is characterized by prolonged QT interval and T -wave changes in the electrocardiogram (ECG), and it is prone to palpitation, synocope, arrhythmia, cardiac arrest and even sudden death. The most common genetic subtypes of LQTS patients are LQT1, LQT2, and LQT3. Different Genetic subtypes of LQTS have different mutation genes, triggers, and even ECG changes, so clarifying the genetic subtypes of patients can help clinical diagnosis, treatment and prevention of cardiac events. Effective prevention of cardiac events is one of the most important measures for patients with LQTS. During pregnancy and puerperium, women with LQTS will experience a series of physiological changes such as hormonal levels and hemodynamic changes, which may affect the risk of cardiac events associated with LQTS; their clinical management is also different from that of non -LQTS women, and it is necessary to review the research progress of its pathogenesis, diagnostic criteria, treatment options and perinatal management. [ABSTRACT FROM AUTHOR]

Cardiovascular disease is an important cause of maternal death with non-obstetric factors. Noncompaction of the ventricular myocardium (NVM) is a rare congenital cardiomyopathy. The serious complications are heart failure, arrhythmia, and thromboembolism. Transthoracic echocardiography is the main diagnostic method. At present, the main treatment method of pregnancy combined with NVM is control symptom by medication. Meanwhile, the safety of mother and infant should be considered. It is considered appropriate to terminate pregnancy by cesarean section. This article analyzed the diagnosis and treatment of three cases of pregnancy with NVM and one case of twin pregnancy with NVM reported in our hospital, hoping to improve the clinical cognition and diagnosis of this disease during pregnancy. [ABSTRACT FROM AUTHOR]

Pre-eclampsia (PE) is a disease special to pregnancy. Its occurrence and development is an important reason for the increase of maternal and infant morbidity and mortality. Normal proliferation, migration and differentiation of trophoblasts in placenta are closely related to it. P27 acts as a cyclin dependent kinase inhibitors (CKIs), which regulates cell cycle by binding to cell cycle factors. Compared with normal pregnant women, the expression of P27 gene in placental trophoblasts of PE patients increased significantly, which may be related to the dysfunction of trophoblast proliferation and invasion. Nodal, as a member of transforming growth factor β (TGF-β), up-regulates the level of P27 mRNA and protein in trophoblast cells through various mechanisms, improves the stability of P27 protein and induces phosphorylation of P27 protein at S10, promotes the transfer of P27 protein and CDK2 to cytoplasm, and enhances the binding of P27/CDK2/CDK5/Stathmin, thus inhibiting cell proliferation and migration，transfer and invasion. P27 protein is phosphorylated at many siｔｅｓ, oxidative stress, protein kinase B (Akt), protein O-fucosyltransferase 1 (poFUT1), fructose-2-kinase/fructose-2, 6-diphosphatase (PFKFB1-4) affect the ubiquitinproteasome degradation pathway by phosphorylating P27 protein. [ABSTRACT FROM AUTHOR]