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Fatigue has become one of the most common manifestation of human sub-health in contemporary society. This "invisible killer" seldom attracts human attention, in the meantime, however, affects the quality of existence and work efficiency significantly. The concern of finding ways to combat this disease has aroused broadly in the world of medicine. The earliest explicit recordation about fatigue of traditional Chinese medicine traces back to Eastern Han Dynasty, and TCM therapies have been enriched and developed through continuous practice. In this paper, the authors focused on TCM treatments of fatigue, investigated the theory and syndrome differentiation of TCM related to the characteristics of fatigue and concluded the internal and external TCM treatments of fatigue. The ideas for further research into TCM treatments of fatigue were provided. [ABSTRACT FROM AUTHOR]