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In order to expedite the transition of the Yellow River Simulator into the operational phase and quickly make use of its positive role in the difficulties of water resources shortage, economic imbalance and ecological fragility in the Yellow River Basin, an intelligent calculation method system for the Yellow River Simulator had been thoroughly sorted out and implemented. Drawing upon the concept of intelligent computing, the vital importance of the Yellow River Simulator’s intelligent computing was articulated from the perspectives of data storage and preprocessing, simulation computing power, and swift responsiveness, as well as its significance in ecological conservation and management, efficient water resources utilization and disaster evaluation and mitigation. Based on the architectural framework of the Yellow River Simulator, four branches of intelligent computing methods, namely biomimetic intelligent computing, machine learning, fuzzy computing and intelligent computation were summarized in detail. Envisioning the transformative potential of intelligent computation methodologies for the Yellow River Simulator, this paper explored its huge application prospects in development planning, disaster management and resources allocation. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (HCC) is a major health problem around the world. The incidence rate of HCC is gradually increasing, but its early diagnostic rate remains at a low level. Most patients who present with apparent clinical symptoms have reached the advanced stage, which greatly influences the treatment outcome. In recent years, immunotherapy for HCC has attracted more and more attention, and the change in immune status during the development and progression of HCC has gradually become a research hotspot. This article elaborates on the role of immunosuppressive cells in the development and progression of HCC and points out that in-depth studies on immunosuppressive cells will provide a new direction for immunotherapy for HCC in clinical practice. [ABSTRACT FROM AUTHOR]