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Copyright of Bulletin of the Chinese Ceramic Society is the property of Bulletin of the Chinese Ceramic Society Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective］ During construction of PBA (pile-beam-arch) method stations, land subsidence is greatly affected by the guiding hole excavation sequence. In order to effectively control land subsidence, it is necessary to study the influence law of the guiding hole construction sequence. ［Method］ Based on the engineering background of Tiancun Station, a three-dimensional guiding hole construction model for the tunnel of 3-pillar 4-span PBA method station is established, and a reasonable guiding hole excavation sequence is obtained. Based on the above result, in order to shorten the construction period, a staggered synchronous excavation method for the guiding hole construction is proposed, and its effect on land subsidence control is studied based on the on-site measured data.［Result & Conclusion］ The land subsidence is smaller when the lower layer guiding hole is excavated first. When the guiding holes are close to each other, simultaneous excavation will produce group hole effect. In order to effectively control land subsidence in actual construction, separate excavation or staggered excavation should be used. The staggered synchronous excavation method for guiding hole construction has a good effect on land subsidence control, and significantly shortens the construction period. The above method can provide a reference for the similar large-span tunnel station construction. [ABSTRACT FROM AUTHOR]

Objective To explore the potential relationship between ubiquitination of transforming growth factor kinase 1 (TAK1)/nuclear factor-κB (NF-κB) signaling pathway mediated by ring finger protein 99 (RNF99) and septic acute respiratory distress syndrome (ARDS). Methods Plasmid and siRNA transfection were conducted to overexpress or knock down RNF99 in MLE12, and expressions of p65 phosphate and p65 protein were analyzed. The protein interaction between RNF99 and TRAF6 or TAK1 was analyzed by immunoprecipitation assay. Forty mice were randomly divided into WT plus PBS, WT plus LPS, RNF99 specific expression (TG) plus PBS, and TG plus LPS groups, with 10 mice in each group. Sepsis was induced by intraperitoneal injection of 30 mg/kg LPS. Results As compared with vector group, protein expression levels of TRAF6 and TAK1 in MLE12 cells decreased significantly in RNF99 group (P < 0.05). Ubiquitinated TRAF6 protein increased in MLE12 cells with RNF99 knockdown. As compared with LPS plus vector group, phosphorylation level of p65 in MLE12 cells was significantly lower in LPS plus RNF99 group (P < 0.05). As compared with si-NC group, protein expression levels of RNF99 and IκBα in si-RNF99 group decreased significantly (P < 0.05). As compared with LPS plus si-NC group, phosphorylation level of p65 in LPS plus si-RNF99 group increased significantly (P < 0.05). The staining percentage of CD68 macrophages in lung tissues was significantly lower in TG plus LPS group than in WT plus LPS group (P < 0.05). Phosphorylation level of p65 in lung tissues was significantly lower in TG plus LPS group than in WT plus LPS group (P < 0.05). Conclusion RNF99 regulates NF-κB signaling pathway by interacting with the key regulator of NF-κB signaling pathway (TRAF6/TAK1), and improves lung injury after intraperitoneal injection of LPS in mice. [ABSTRACT FROM AUTHOR]

Copyright of Atomic Energy Science & Technology is the property of Editorial Board of Atomic Energy Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Sedimentologica Sinica is the property of Acta Sedimentologica Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the expression discordances of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor2 (HER-2) and Ki-67 in primary and metastatic breast cancer specimens and explore the clinical significances. Methods Biopsies of metastatic lesions were performed in 203 patients with breast cancer recurrence and metastasis indicated by physical examination and/or imaging examination. We confirmed pathological properties and assessed the expressions of ER, PR, HER-2 and Ki-67 in primary and metastatic lesions, their relationships with prognosis were also analyzed. Results Biopsy failed in 3 patients, the pathology and immunohistochemitry results of metastatic lesions were not obtained. One person was diagnosed as tuberculosis and another was primary lung cancer. Among the 198 cases of primary and metastatic lesions, the discordance rates of ER, PR, HER-2 and Ki-67 were 27.3%, 34.3%, 11.8% and 15.1%, respectively.The expressions of ER, HER-2 and Ki-67 were not significantly different between the primary and metastatic lesions, however, the expressions of PR were more likely to turn negative in the metastases (P<0.001). The disease-free survival (DFS) of patients with ER, PR positive, HER-2 negative and low expression of Ki-67 in metastatic lesion was much longer (P<0.05). Conclusions The expressions of ER, PR, HER-2 and Ki-67 in metastatic lesions are associated with the prognosis of breast cancer patients.Their expression discordances between primary and metastatic lesions can guide the treatment and evaluate the risks of recurrence and prognosis. [ABSTRACT FROM AUTHOR]

The quality of earth-rock clam directly affects the safety of the dam. Most of the traditional methods for the evaluation of the quality of the earth-rock dam are mainly controlled by the rolling parameters and the physical parameters of the compaction and eannot quantitatively reflect the safety of the dam. In order to solve this problem, taking Jiulongtan Clay Rockflll Dam in Sichuan Province as an example, this paper put forward a method to evaluate the quality of earth-rock dam based on dam slope stability, in the situation of plenty physical properties and laek of mechanical properties, which took the indicators of mechanical shear strength (cohesion and internal friction angle) and physical indicators (the rate of water content and dry density) of non-linear regression equation to give a detailed physical and mechanical properties of each filling layer and then accordingly the safety factor of anti-sliding stability of the dam slope was cheeked and compared with the original design value and standard value, so as to judge the construction quality. The results show that the method is feasible and can reflect the safety of the dam quantitatively, which has significance of the quality evaluation of similar projects. [ABSTRACT FROM AUTHOR]

Copyright of Acta Automatica Sinica is the property of Chinese Academy of Sciences, Institute of Automation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Based on the JWL equation of state of detonation products and Taylor fracture criteria, a model considered the expansion details about energy conversion and fragment initial velocity is derived from conversation of energy. The cylinder tests of three materials, including copper, 45# steel and 6061 aluminum alloy, driven by TNT explosive are made, and the inflation track and velocity are analyzed. The experimental results show that, by comparing with Gurney formula which is considered only to express the driving ability of the explosion parameter, the proposed model considers the driving factors, inflation process and mechanics function of meta. The result is of pertinence and applicability. [ABSTRACT FROM AUTHOR]