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Objective: To investigate the clinical effect of Ni-Ti shape memory alloy embracing internal fixator in the treatment of patients with multiple rib fractures. Methods: A total of 97 patients with multiple rib fractures, who were admitted to Second People’s Hospital of Anhui Province from January 2016 to January 2018 were selected. The patients were divided into control group(n=47) and study group(n=50) according to the different treatment methods. The control group was treated with the external fixation of the chest protective plate, and the study group was treated with Ni-Ti shape memory alloy embracing internal fixator. The clinical effects of 7 d after operation were compared between the two groups, the pain and respiratory function were compared between the two groups before operation and 7 d after operation, and the occurrence of postoperative complications were recorded in the two groups. Results: The total effective rate[92.00%(46/50)] in the study group, which was higher than that[76.60%(36/47)] in the control group(P<0.05). The visual ana-logue pain scale(VAS) scores in the two groups 7 d after operation were lower than those before operation, and the study group was lower than the control group(P<0.05). The maximum voluntary ventilation percent(MVV%) 7 d after operation in the two groups was higher than that before operation, and the study group was higher than the control group(P<0.05). There was no significant difference in the forced expiratory vital capacity at the 1 st second percent(FEV1%) 7 d after operation between the two groups(P>0.05). The total incidence of postoperative complications [8.00%(4/50)] in the study group was lower than that [23.40%(11/47)] in the control group(P<0.05). Conclusion: Ni-Ti shape memory alloy embracing internal fixator for multiple rib fractures is safe and effective, it can reduce the postoperative pain and improve the respiratory function of the patients, with higher clinical application value. [ABSTRACT FROM AUTHOR]