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Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Hericium erinaceus is a valuable medicinal and edible macrofungus, which has anti-inflammatory, anti-tumor, and immunity-increasing effects. Gas chromatography-mass spectrometer (GC-MS) metabolomics was used to investigate the anti-fatigue effect and mechanism interpretation of Hericium erinaceus polysaccharide on rat negative gravity exhaustion swimming model. The rats were randomly divided into 6 groups (blank group, model group, 3 experimental groups with low, medium and high doses of Hericium erinaceus polysaccharides, and positive control group), with 6 rats in each group. After continuous gastric gavage for 21 days, GC-MS technology was used to analyze metabolites in the serum of rats in each group, and the differential metabolite information was obtained by multivariate statistical analysis, and the anti-fatigue effect of metabolic pathway was constructed to explain. The results show that the swimming time of rats in the high-dose group of Hericium erinaceus polysaccharide is significantly longer than that in the model group. The metabolic profile of rats in the dosing group is close to that of the blank group, showing certain anti-fatigue effects. The differential metabolites in serum 24 are identified as related to the negative gravity exhaustion swimming model, involving three major metabolic pathways: linoleic acid metabolism, glycerol metabolism, phenylalanine, tyrosine and tryptophan biosynthesis. It is hypothesized that Hericium erinaceus polysaccharides may exert anti-fatigue effects on negative gravity-exhausted swimming model rats by regulating lipid metabolism. [ABSTRACT FROM AUTHOR]

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Yupingfeng Powder, a classical prescription in ancient times, is commonly used for the treatment of chronic cough and chronic nephritis in children. It has anti-inflammatory, antioxidant and anti-fatigue effects. Gas chromatography-mass spectrometry (GC-MS) metabolomics was used to investigate the antifatigue effects and mechanistic explanation of Yupingfeng powder on the weightloaded exhaustion swimming model of mice. The mice were randomly divided into 5 groups ( normal group, model group, and low-, medium-, and high doses experimental groups of Yupingfeng powder),with six mice in each group. After 14 days of intragastric administration, the serum of mice was analyzed with GC-MS technique to obtain the differential metabolite information,and multivariate statistical analysis was performed to acquire differential metabolite information to construct metabolic pathways to explain the cause of antifatigue. The time span of weight-loaded exhaustion swimming in the Yupingfeng powder group is significantly prolonged than that in the the model group, and the metabolic profiles of mice in the dosing group are found to be closer to those of the normal group, indicating that Yupingfeng powder has certain antifatigue ability. Eighteen differential metabolites in serum are identified to be associated with the weight-bearing fatigue swimming model, three main metabolic pathways involved to be the linoleic acid metabolism, the glycerol metabolism and the phosphoinositide metabolism, the antifatigue mechanism of Yupingfeng powder may be achieved by regulating lipid metabolism. [ABSTRACT FROM AUTHOR]

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)