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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the protective effect of BNP postcondition on rabbits acute myocardial infarction and the mechanism. Methods: Thirty rabbits were randomly divided into three groups (n=10): AMI group (saline), BNP group (BNP), BNP+GLY group (BNP+GLY). The myocardial ischemia-reperfusion models were induced by 30 min coronary artery ligature and 120 min reperfusion in rabbits. The rabbits were given intravenous infusion according to the above methods during 120 min reperfusion. Arrhythmias were observed during 120 min reperfusion; the concentration of SOD, MDA, cTnI and CK-MB in plasma were measured at the end of reperfusion; meanwhile, the myocardial tissue was observed in optics microscope. (1) Arrhythmia: In BNP group, the incidence of VT and VF were significantly lower than those in AMI group (both P<0.01); In BNP+GLY group, the above variables were significantly higer than those in BNP group (both P<0.01). (2) SOD, MDA, cTnI and CK-MB: In BNP group, the levels of MDA, cTnT and CK-MB were lower, but the activity of SOD was higer than those in AMI group (all P<0.01). Howerer, in BNP+GLY group, the above effects of BNP were blocked by GLY (P<0.01, P<0.05, P<0.01 and P<0.01 vs BNP group, respectively). (3) The myocardial tissue in optics microscope: the injuries of AMI and AMI+GLY group were worse than BNP group. These results suggest that BNP postcondition has cardioprotection effect on AMI in rabbits, which may be related to inhibition of KATP channel-GLY. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)