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Vascular endothelial injury is the initiating factor in atherosclerosis Currently, western medical treatment is ineffective and has many adverse effects. It has been found that flavonoids, the active ingredients of Chinese medicine, can regulate endothelial cell function by reducing inflammation, inhibiting oxidative stress, improving apoptosis and autophagy. They have the advantages of multiple pathways, links and targets in the prevention and treatment of atherosclerosis, and have great potential for development. This paper reviewed the recent studies on the mechanism of flavonoids in improving endothelial injury, and provided reference and theoretical basis to promote the discovery of new drug candidates for vascular endothelial injury and the wide application of flavonoids. [ABSTRACT FROM AUTHOR]