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Objective: To investigate the relationship between cluster of differentiation 64 (CD64) index, systemic immune inflammation index (SII), C-reactive protein/albumin (CRP/Alb) ratio and postoperative infection in patients with partial hepatectomy (PR) for liver cancer. Methods: 300 patients with liver cancer who underwent PR in our hospital from January 2021 to October 2023 were selected and divided into infection group and non-infection group according to whether postoperative infection occurred, the CD64 index, SII and CRP/Alb ratio were calculated. The factors of postoperative infection in patients with liver cancer PR were analyzed by multivariate Logistic regression analysis, the predictive value of CD64 index, SII and CRP/Alb ratio for postoperative infection in patients with liver cancer PR were analyzed by receiver operating characteristic (ROC) curve. Results: The incidence of postoperative infection in 300 patients with liver cancer PR was 21.33% (64/300). Compared with non-infected group, the CD64 index, SII and CRP/Alb ratio in infected group increased (P<0.05). Multivariate Logistic regression analysis showed that diabetes mellitus, intraoperative blood transfusion, drainage tube placement time ≥ 7 d and elevated CD64 index, SII, CRP/Alb ratio were independent risk factors for postoperative infection in patients with liver cancer PR (P<0.05). The area under the curve of CD64 index, SII and CRP/Alb ratio in predicting postoperative infection of PR patients with liver cancer was 0.910, which was greater than 0.790, 0.778 and 0.776 predicted by CD64 index, SII and CRP/Alb ratio alone (P<0.05). Conclusions: The increase of CD64 index, SII and CRP/Alb ratio are independent risk factor for postoperative infection in PR patients with liver cancer, the combination of CD64 index, SII and CRP/Alb ratio has higher value in predicting postoperative infection in PR patients with liver cancer. [ABSTRACT FROM AUTHOR]