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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To investigate the predictive value of preoperative serum transforming growth factor-β1 (TGF-β1), high mobility group protein B1 (HMGB1) and NOD-like receptor thermal protein domain associated protein 3 (NLRP3) on the prognosis of patients with spinal fracture combine with spinal cord injury (SCI). 134 patients with spinal fracture combine with SCI who underwent surgical treatment in Guizhou Orthopaedic Hospital from May 2021 to June 2022 were selected, patients were divided into good prognosis group (83 cases) and poor prognosis group (51 cases) according to the 12 months prognosis after surgery. The preoperative serum levels of TGF-β1, HMGB1 and NLRP3 were detected by enzyme-linked immunosorbent assay. Multifactorial logistic regression was used to analyze the factors of poor prognosis in patients with spinal fracture combine with SCI, and the predictive value of preoperative serum TGF-β1, HMGB1, and NLRP3 levels in patients with spinal fracture combine with SCI was analyzed by receiver operating characteristics (ROC) curves. The incidence of poor prognosis in 134 patients with spinal fracture combine with SCI was 38.06% (51/134) at 12 months after surgery. Compared with good prognosis group, HMGB1 and NLRP3 were higher and TGF-β1 was lower in poor prognosis group (P<0.05). Multivariate logistic regression analysis showed that diabetes, injury to treatment time≥ 8 h, spinal canal encroachment rate ≥ 50%, elevated HMGB1 and elevated NLRP3 were independent risk factors for poor prognosis in patients with spinal fracture combine with SCI, increased ASIA grade and elevated TGF-β1 were independent protective factors (P<0.05). The area under the curve (AUC) of preoperative serum TGF-β1, HMGB1, and NLRP3 combined to predict poor prognosis in patients with spinal fracture combine with SCI was 0.924, which was greater than that predicted by each of the indicators alone (P<0.05). The decrease of preoperative serum TGF-β1 level and the increase of HMGB1 and NLRP3 levels are closely relate to the poor prognosis of patients with spinal fracture combine with SCI, the combination of preoperative serum TGF-β1, HMGB1 and NLRP3 levels has a high predictive value for the poor prognosis of patients with spinal fracture combine with SCI. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe and study the changes of P1NP and β-CTX in patients after cervical spinal injury，in order to improve the knowledge of osteoporosis bone turnover markers，and to guide clinical work. Methods In our hospital，69 patients with cervical spinal cord injury were treated from October 2012 to December 2014. Venous blood of all the patients were collected after admission and 2，4，8，and 12 weeks after the admission. Serum P1NP and β-CTX levels were detected using luminescence immunoassay，and the result were analyzed and compared. Results P1NP in patients at admission was 31.7 ± 8.9 ng/mL. It decreased to 22.3 ± 8.3 ng/mL after 12 weeks，with statistical significance (P<0.05).β-CTX in patients at the admission was 0.41 ± 0.039 ng/mL. It increased to 0.72 ± 0.045 ng/mL after 12 weeks，with statistical significance (P<0.05).P1NP value was higher 2 weeks after the admission but β-CTX was lower than that at the admission. P1NP was 31.7 ± 8.9 ng/mL at admission，and it was 30.3 ± 8.1 ng/mL at 4 weeks after admission，with no significant difference (P>0.05).β-CTX in patients at the admission was 0.41 ± 0.039 ng/mL，and it was 0.40 ± 0.052 ng/mL 4 weeks after the admission，with no significant difference (P>0.05).P1NP decreased in 2 weeks，and it was more obvious in patients with smaller BM I. β-CTX increased gradually in 2 weeks，and it was more obvious in patients with smaller BM I. The difference was statistically significant (P<0.05).Conclusion Detection of P1NP and β-CTX after cervical spinal cord injury can reflect accurately the bone metabolism and can prevent osteoporosis in the patients. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)