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高大施工支架是大跨度复杂桥梁工程中常用的钢结构支撑系统。实际工程中由于受到高大施工支架加工安装误差、超限受力或不均匀受力等因素影响，因此钢结构施工支架存在节点连接不牢固、杆件弯曲变形等初始缺陷。为明确初始缺陷对桥梁高大施工支架整体稳定性能的影响规律，首先开展了桥梁高大施工支架的线性屈曲分析，进而探讨了节点半刚性、杆件初弯曲等初始缺陷对桥梁高大施工支架极限承载力的影响规律。为提高桥梁高大施工支架极限承载力的求解精度，引入刚度系数来衡量节点半刚性，综合考虑节点体对杆件计算长度的影响，并提出模拟节点三向六自由度的方法以简化计算。研究表明，结构的极限承载力与刚度系数相关，实际工程中应保障刚度系数在4以上。以第一阶整体屈曲模态作为结构初始几何缺陷时，缺陷对于结构的极限承载力和跨中平面外位移的影响更显著；以第二阶屈曲模态作为结构初始几何缺陷时，缺陷对于结构的边杆平面外位移的影响更显著。

传统Bootstrap抽样和Bagging集成学习通常以串行方式实现，计算效率低，且存在样本不可重用、扩展性差等问题，不适合高效的大规模Bagging集成学习。从大数据分布式计算的思维入手，提出新的Bootstrap样本划分（BSP）大数据模型和分布式集成学习方法。BSP数据模型通过分布式生成算法将训练数据表达成分布式Bootstrap样本集的集合，存储成HDFS分布式数据文件，为后续的分布式集成学习提供数据支持。分布式集成学习方法从BSP数据模型中随机选取多个BSP数据块，读入集群各个节点的虚拟机，用串行算法对选取的数据块并行计算统计量或训练建模，再将所有的计算子结果回传至主节点中，生成最终的集成学习结果，此过程中可加入对子结果的质量选择以进一步提高预测效果。BSP数据模型的生成和分布式集成学习采用非Map-Reduce计算范式进行，每个数据块的计算独立完成，减少了计算节点间的数据通信开销。提出的算法在Spark开源系统中以新的算子方式实现，供Spark应用程序调用。实验表明，新方法可以高效地生成训练数据的BSP数据模型，提高数据样本的可重用性，在基于有监督机器学习算法构建的大规模Bagging集成学习实验中，计算效率能提高50%以上，同时预测精度进一步提高约2%。

高大施工支架是大跨度复杂桥梁工程中常用的钢结构支撑系统。实际工程中由于高大施工支架加工安装误差、超限受力或不均匀受力等影响，会导致钢结构施工支架存在节点连接不牢固、杆件弯曲变形等初始缺陷。为明晰初始缺陷对桥梁高大施工支架整体稳定性能的影响规律，首先开展了桥梁高大施工支架的线性屈曲分析；进而探讨了节点半刚性、杆件初弯曲等初始缺陷对桥梁高大施工支架极限承载力的影响规律。为提高桥梁高大施工支架极限承载力的求解精度，引入刚度系数α来衡量节点半刚性值，综合考虑节点体对杆件计算长度的影响；并提出模拟节点三向六自由度的方法以简化计算。研究表明，结构的极限承载力与刚度系数α相关，实际工程中应保障α值在4以上。以第一阶整体屈曲模态作为结构初始几何缺陷时，缺陷对于结构的极限承载力和跨中平面外位移的影响更敏感；以第二阶屈曲模态作为结构初始几何缺陷时，缺陷对于结构的边杆平面外位移的影响更敏感。

旨在为进一步提高共轭亚油酸产量提供理论依据，总结概述了共轭亚油酸的生理活性与制备方法的研究进展。共轭亚油酸是一种天然存在于反刍动物体内的物质，具有降低胆固醇含量、抗癌、抗氧化、提高免疫力等重要生理功能，在减肥、癌症治疗、哮喘治疗等方面发挥了重要作用，在功能性膳食研发领域拥有巨大潜力。由于共轭亚油酸的天然含量与来源无法满足人们日常生活的需求，因此研究更高产率的共轭亚油酸的合成方法一直是热点内容。合成共轭亚油酸的方法主要有生物合成法和化学合成法，生物合成法中的微生物合成法和酶催化异构化合成法是近年来的研究热点。 The research progress on the physiological activity and preparation methods of conjugated linoleic acid were summarized and outlined to provide a theoretical basis for further improving the yield of conjugated linoleic acid. Conjugated linoleic acid is a substance naturally existing in ruminants and has important physiological functions such as reducing the contents of cholesterol in the body, anti-cancer, antioxidant and immune enhancement, and plays an important role in weight loss, cancer treatment and asthma disease treatment, and has great potential in the field of functional diet research and development. Since the natural content and source of conjugated linoleic acid can not meet the needs of people′s daily life, the research on the synthesis of conjugated linoleic acid with higher yield has been a hot topic. The main methods for the synthesis of conjugated linoleic acid includ biological synthesis and chemical synthesis. Among biological synthesis, microbial synthesis and enzymatic isomerization synthesis are the research focuses in recent years.

以单颗粒半粒花生为研究对象，利用原位观测结合质构仪测试的方式对花生进行挤压实验，研究花生在不同的压距、压速、保压时间及温度条件下的结构-力学-出油特性，并且建立相关的曲线拟合模型。结果表明：压距逐渐增大，花生所受峰值力也逐渐增大，花生表面被挤压开始变形，逐渐产生裂纹，压力较大时，花生变成饼状，裂纹布满整个表面；峰值力随着温度的升高先缓慢升高后急剧降低，再趋于稳定；压速及保压时间对峰值力无明显影响。递增的压距和保压时间皆能促进花生出油，而压速增加则会抑制花生出油；花生出油量随着温度的升高先缓慢增大后急剧减小，然后趋于稳定。花生颗粒挤压出油的最优条件为压距5 mm、压速0.5 mm/s、保压时间360 s和温度75 ℃。 Taking half of the single-grain peanuts as the research object, the in-situ observation combined texture analyzer was used to carry out the extrusion test to study the mechanics-oil output characteristics of the peanuts under conditions of different extrusion distance, extrusion speed, pressure holding time and temperature, and the relevant curve fitting model was established. The results showed that the peak force of peanuts increased with the increase of extrusion distance. The peanut surface was extruded and began to deform, gradually cracks occurred. When the pressure was higher, the peanut became a cake shape, and the cracks covered the whole surface. With the increase of temperature, the peak force first increased slowly, then decreased sharply, and then tended to be stable. The extrusion speed and pressure holding time had no obvious effect on the peak force. Increasing extrusion distance and pressure holding time could promote the oil output of peanuts, and the increasing extrusion speed could inhibit the oil output of peanuts. The oil output of peanuts increased slowly, then decreased sharply, and then tended to be stable with the increase of temperature. The optimal conditions for extruding oil from peanut pellets were obtained as follows: extrusion distance 5 mm, extrusion speed 0.5 mm/s, pressure holding time 360 s and temperature 75 ℃.

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In recent years, unitized logistics is developing rapidly. As a core instrument, standardized pallet is gradually implemented in military logistics and commercial logistics. This paper expounds the concepts of unitized military logistics system and analyses the key elements. Then it summarizes three fundamental conditions to guarantee the system working fluently and three key problems, basing on the actual situation, about the work efficiency in support operation. Moreover, it analyzes the process of support pattern on three levels, from ‘supplier’, ‘battle warehouse, reserving and supplying base’ and ‘demand forces’ in this system. Finally, this paper analyzes the value from three angles, ‘military’, ‘economy’ and ‘society’, of this system. [ABSTRACT FROM AUTHOR]

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Objective To explore the heterogeneity of non-small-cell lung cancer ( NSCLC) cell line HCC827, and to analyze its relationship with gefitinib sensitivity. Methods We took HCC827 cells in the logarithmic growth phase as the research object, used the limiting dilution method to obtain the monoclonal HCC827 progeny cells, and divided them into groups A, B, C, D, E, and F. In addition, HCC827 cells in the logarithmic growth phase were used as the parental cell group. The plate clone formation experiment was used to observe the number of plate colonies formed in cells of each group. Cell proliferation multiples of each group were detected through cell growth curve experiment and the heterogeneity of cell proliferation ability was observed. The cell drug sensitivity test was used to observe the heterogeneity of the sensitivity of cells to gefitinib in each group. Sanger sequencing method was used to detect the EGFR gene of each group. The fluorescence in situ hybridization was used to detect the MET, HER2 genes of each group, and the genetic heterogeneity of each group was observed. Cell clone mixing experiment was used to observe the dynamic effect of gefitinib on cell heterogeneity. Results The number of clone formation in the group B was higher than that of the parental cell group ( P < 0. 01), and the number of clone formation in the groups A, D, and E was lower than that of the parental cell group (all P < 0. 05). Significant difference was found in the proliferation folds of cells between groups A-F and parental cell group at 48, 72, 96, and 120 h (all P < 0. 05); the the proliferation fold of group B was the highest, and the proliferation fold of group D was the lowest. The cells of group B were the most sensitive cells to gefitinib. Compared with the parent cell group, the IC50 values of cells to gefitinib in the other groups were significantly different (all P < 0. 05), and group D was the cell group with the highest IC50 value for gefitinib. Both the parental cell group and the groups A-F had EGFR gene 19 Del mutation. The amplification of HER2 gene in the group D cells was positive and the amplification of MET gene was negative, while the amplification of HER2 gene and MET gene in the parental cell group and groups A, B, C, E, F were all negative. Under the pressure of gefitinib, gefitinib-sensitive cells in the group B and drug-resistant cells in the group D were mixed in equal proportions and then the drug-resistant cells with absolute growth advantage after 2 weeks, gefitinib-sensitive cells in the group B and parental cells were mixed in equal proportions and then the parental cells had a relative advantage in a small amount of residual cells after 2 weeks, group D cells and parental cells were mixed in equal proportions and then the two cells grew evenly after 2 weeks. Conclusion HCC827 cells had clonal heterogeneity at the phenotypic level such as proliferation ability, drug sensitivity, and at genetic background level such as driver genes, and their clonal heterogeneity was related to gefitinib sensitivity. [ABSTRACT FROM AUTHOR]

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聚焦超声(FUS)具有良好的组织穿透性和定位性,能透过表层组织聚焦于特定深度的靶点而产生生物学效应,达到治疗疾病的目的。FUS在神经调控方面具有精确性高、安全性好等特点,可无创、精准地对外周神经和中枢神经进行调控,在神经调控方面有较大开发潜力。但FUS神经调控广泛应用于临床仍需较长时间,还存在着操作风险高、不良反应尚不明确等问题。 [ABSTRACT FROM AUTHOR]

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