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Objective：To investigate the changes of follicular helper T lymphocytes (Tfh) in peripheral blood of the patients with systemic lupus erythematosus (SLE) during pregnancy, and to clarify the immune effects of Tfh cells duing pregnancy. Methods：The SLE patients from Qingdao Municipal Hospital and Qingdao Women and Children Hospital were divided into SLE with pregnancy group ( n=32) and SLE without pregnancy group (n=30)；at the same time, healthy pregnancy group (healthy pregnancy women，n = 30) and healthy non-pregnancy group (healthy non-pregnancy women，n=25) were used as control. According to the changes of lupus during pregnancy and after termination of pregnancy within 3 months, the 32 cases of SLE patients in SLE with pregnancy group (2 cases were lost during follow-up) were divided into poor prognosis group (n=8) and clinical stabilization group (n=22). The clinical data and laboratory examination indexes of the patients were collected. The percentages of CD4+inducible T-cell costimulatory factor (ICOS)+ chemokine C-X-C-motif receptor 5 (CXCR5)+Tfh cells in the CD4+ T lymphocytes in peripheral blood of the patients in various groups ( percentages of Tfh cells ) were detected by flow cytometry. The relationships between the percentages of Tfh cells in peripheral blood of the patients in SLE with pregnancy group and the laboratory examination indexes were analyzed by Spearman correlation analysis. The levels of interleukin-6 (IL-6), interleukin-21 ( IL-21) and interferon-γ ( IFN- γ) in peripheral blood of the subjects in various groups were detected by enzyme linked immunosorbent assay (ELISA)method. Results：Compared with healthy pregnancy group, the percentage of Tfh cells in peripheral blood of the patients in SLE with pregnancy group was significantly increased (P<0. 01), and the percentage of Tfh cells in peripheral blood of the subjects in healthy non-pregnancy group was significantly decreased (P<0. 05). Compared with SLE without pregnancy group, the percentage of Tfh cells in peripheral blood of the patients in SLE with pregnancy group was significantly increased (P<0. 05). During the follow-up, compared with clinical stabilization group, the percentage of Tfh cells in peripheral blood of the patients in poor prognosis group was significantly increased (P<0. 05). The percentage of Tfh cells in peripheral blood of the patients in SLE with pregnancy group was positively correlated with the levels of anticardiolipin antibody ( ACA) and anti-β2 glycoprotein Ⅰ (β2GPⅠ) antibody (r=0. 743 1，P<0. 05； r= 0. 830 7，P<0. 01). Compared with healthy pregnancy group, the levels of IL-6 and IL-21 in peripheral blood of the patients in SLE with pregnancy group were significantly increased (P<0. 05)；compared with SLE without pregnancy group，the level of IL-21 in peripheral blood of the patients in SLE with pregnancy group was significantly increased (P<0. 05). Conclusion：The increase of the percentage of Tfh cells in peripheral blood of the patients with SLE in early pregnancy may be related to the poor pregnancy prognosis in the patients with SLE. [ABSTRACT FROM AUTHOR]

Liver transplantation is an effective treatment for the end-stage liver disease. However, hepatic ischemiareperfusion injury (HIRI) will inevitably occur during liver transplantation, which might lead to early graft dysfunction or aggravate rejection. The underlying protective mechanism remains to be further elucidated. Programmed cell death is an important mechanism of HIRI, and multiple novel types of programmed cell death participate in the pathological process of HIRI. In-depth study of programmed cell death is expected to further improve the therapeutic effect of liver transplantation. In this article, research progresses on apoptosis, autophagy and autophagy-dependent cell death, ferroptosis, necroptosis, pyroptosis, pathanatos and other common programmed cell death patterns in HIRI were reviewed, aiming to provide reference for enhancing the success rate of liver transplantation and improving clinical prognosis of the recipients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between serum N-terminal brain natriuretic peptide precursor (NT-proBNP), human epididymal protein 4(HE4), β2 microglobulin(β2-MG), soluble ST2 (sST2) and ventricular remodeling in patients with dilated cardiomyopathy (DCM) and the predictive value of short-term prognosis after discharge. Methods: 74 patients with DCM who were admitted to Tongji Hospital Affiliated to Tongji Medical College of HUST from March 2019 to December 2020 were selected, and were recorded as DCM group. Another 80 healthy subjects in the same period were taken as the control group. The levels of serum NT-proBNP, HE4, β2-MG and sST2 and related indexes of ventricular remodeling were detected and compared between the two groups. Pearson correlation was used to analyze the correlation between serum NT-proBNP, HE4, β2-MG, sST2 levels and various ventricular remodeling parameters. In addition, all patients with DCM were divided into the poor prognosis group with 33 cases and the good prognosis group with 41 cases according to whether rehospitalization for heart failure and cardiovascular death events had occurred after discharge. The baseline data and the levels of serum NT-proBNP, HE4, β2-MG and sST2 were compared between the two groups. Multivariate Logistic regression was used to analyze the risk factors for short-term prognosis in patients with DCM after discharge. The efficacy of serum NT-proBNP, HE4, β2-MG and sST2 in predicting short-term prognosis of patients with DCM after discharge was analyzed by receiver operating characteristic (ROC) curve. Results: The levels of serum NT-proBNP, HE4, β2-MG and sST2 in DCM group were higher than those in control group (P<0. 05). The levels of left ventricular mass index (LVMI), left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV) in DCM group were higher than those in control group, while the level of left ventricular ejection fraction (LVEF) was lower than that in control group (P<0. 05). Pearson correlation analysis showed that the levels of serum NT-proBNP, HE4, β2-MG and sST2 were positively correlated with LVMI, LVEDV and LVESV, while negatively correlated with LVEF (P<0. 05). The age and the levels of serum NT-proBNP, HE4, β2-MG and sST2 in the poor prognosis group were higher than those in the good prognosis group (P <0. 05). Multivariate Logistic regression analysis showed that age and the levels of serum NT-proBNP, HE4, β2-MG and sST2 were risk factors for short-term prognosis in patients with DCM after discharge (P<0. 05). ROC curve analysis showed that the area under curve, sensitivity and specificity of combined detection of serum NT-proBNP, HE4, β2-MG and sST2 in predicting short-term prognosis of patients with DCM after discharge were higher than those of the above four indicators alone. Conclusions: Serum NT-proBNP, HE4, β2-MG and sST2 are closely related to ventricular remodeling in patients with DCM, and have high value in predicting short-term prognosis after discharge. [ABSTRACT FROM AUTHOR]

It is a hot research topic to obtain user interest by analyzing user's UCC content. Identifying user interest changes in social networks is of great significance for providing high-quality personalized network services. For the cold - start' users with poor UGC, LDA topic model is not effective to obtain their interest, and it is more difficult to identify the interest changes of them. To solve this problem, LDA is firstly used to obtain network top ices, and by which the topic-tag model is constructed. Furthermore, the spatial vector similarity calculation method based on tag association is used to construct the user-topic model. Combined with the learning model, a user interest change recognition algorithm is proposed. The proposed algorithm is applied to the large-scale data set collected by the microblog website, and the network topic, the core users of the network topic and their probability distribution on the interest topic are obtained more accurately, thus the identification problem of user interest change in the model is solved. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of ropivacaine combined with hydromorphone on the PCEA in cesarean section of gestational diabetes mellitus. Methods: Eighty-one patients with gestational diabetes who underwent cesarean section in our hospital from January 2018 to June 2019 were selected and divided into two groups randomly. The control group used conventional intramuscular injection for analgesia to intervene. When the maternal could not bear the pain, intramuscular injection of pethidine 100 mg. The observation group was connected to a self-controlled analgesic pump after the end of cesarean section and used hydromorphone 0.3 mg+0.75 % ropivacaine 20 mL. The levels of ALD, Cor, Ang-Ⅱ, NE, VIP, MTL,CCK and GAS, serum levels of MCP-1, IL-6, HMGB-1 were compared before and after the intervention between the two groups. Results: After intervention, the VLD, Cor, Ang-Ⅱ and NE of the two groups were significantly higher than before treatment (P<0.05), and the VLD, Cor, Ang-Ⅱ and NE of the observation group were significantly lower than those of the control group (P<0.05). After intervention, the VIP and CCK of the two groups were significantly higher than before treatment (P<0.05), the MTL and GAS of the two groups were significantly lower than before treatment (P<0.05), the VIP and CCK of the observation group were significantly lower than those of the control group (P<0.05), the MTL and GAS were significantly higher than those of the control group (P<0.05). After 2 days of intervention, the levels of serum MCP-1, IL-6 and HMGB-1 in the two groups were significantly lower than before treatment (P<0.05), and the levels of serum MCP-1, IL-6 and HMGB-1 in the observation group were significantly lower than those in the control group (P<0.05). Conclusion: Ropivacaine combined with hydromorphone could improve gastrointestinal function and inhibit systemic inflammatory response in patients with gestational diabetes mellitus after cesarean section. [ABSTRACT FROM AUTHOR]

The mining and analysis of user - generated content is an effective way to obtain microblog topic. Aiming at the problem of cold start due to the lack of user tags, this author proposes a microblog topic generation method by integrating user tags and topic tags. Firsdy, the user tag was used as the feature item to compress the sparse vector and calculate the similarity of user tag. Secondly, LDA topic model was used to extract the topic of users microblog by which the topic tag was generated. Thirdly, the two kinds of tags were integrated to establish the similarity model of user tag topic and obtain the topic of microblog. The proposed method was applied to the microb¬log data set and the microblog topic represented by hot tags was obtained. While it is basically consistent with the results gotten with LDA topic model, it is more representative [ABSTRACT FROM AUTHOR]

Recommending friends with the same interest to a user is a hot issue of user relationship research. But it also has many problems, such as data sparseness and recommendation deviation in interest. To address such problems, this paper proposed a recommender approach considering node importance degree( NID). First, through the combination of co-occurrence and agglomerate approaches, it realized a tag clustering algorithm and divided user groups with similar interest. Second, it constructed user relationship network through social network analysis. Based on above, it calculated NID in PageRank to evaluate user recommended ability. Compared with several other approaches on real datasets, the approach achieved the best performance. It finally also presented visualized results to express user relationship. [ABSTRACT FROM AUTHOR]

In order to explore the thermodynamic mechanism of multicomponent gas adsorption on coal, the Grand Canonical Monte Carlo simulation method was used to study the adsorption behavior of CH4, CO2 and N2 in the coal molecular model at different temperatures from the perspective of thermodynamics. The simu-lation results show that CH4 shows a dotted distribution, CO2 shows a cluster distribution, and N2 shows a strip distribution in the unit cell. The relationship between the adsorption capacity, adsorption heat and adsorption entropy of the three gases is CO2> CH4> N2. And the relationship between the adsorption potential of the three gases is CO2

Abnormal power consumption detection aims to identify and locate customers in the power system that deviate significantly from regular power consumption behavior. Existing supervised detection methods based on machine learning or deep learning generally require a large amount of manually labeled data, and require transformation for discrete data, thus leading to the loss of important information. FRS theory provides an effective tool for tackling discrete data. Therefore, FRS can be directly applied to the knowledge classification of heterogeneous information that includes continuous and discrete data. This pa- per proposed an unsupervised anomaly detection method with multi-granularity fuzzy relative differences based on FRS theory, and applied it to detect anomalous power consumption users in smart grid. Specifically, it first used information entropy of fuzzy approximation space to measure the importance of attributes for knowledge classification, then constructed a fuzzy granule sequence based on the attribute set's importance, and defined the fuzzy relative difference of the samples on top of this sequence. Finally, it constructed the anomaly detection method based on multi-granularity fuzzy relative differences and conducted evaluation on public datasets. Experimental results demonstrate the effectiveness and efficiency of the proposed algorithm. The code and data for the experiments are publicly available online (http://www.github.com/chenbaiyang/FRAD). [ABSTRACT FROM AUTHOR]

In order to research the conveyor belt vibration law during the working process under the random load, the random forced vibration model of the conveyor belt is established by using the forced string theory. The initial mathematical boundary conditions of the conveyor belt is derived, and the forced stimulus resulted from eccentric condition of the conveyor belt rollers on the both sides and the vertical load stimulus resulted from the random distribution of the materials on the conveyor belt are established. The model analytical solution is derived by employing the superposition principle and the separation of variables. Finally, the numerical analysis of the vibration characteristics of the conveyor belt is performed, and the validity of the model analytical solution is validated by the analysis results. The research results provide the basis for the dynamic reliability design of the conveyor belt. [ABSTRACT FROM AUTHOR]

As one of the important ecological assets, ecosystems provide human with ecological products and services, which is the foundation of human survival and social-economic sustainable development. Gross ecosystem product (GEP) is the value of products and services provided by ecosystems, which is an important part of ecological asset. Taking Yunnan Province as a case study, we used an accounting system to analyze the connotation and relevance of ecological assets and GEP in 2010. The evaluation results showed that the condition of ecological asset was overall good in 2010. Forest, shrub and grassland were mainly of good quality level; farmland was mainly of poor quality, while biodiversity had excellent quality level. Total worth of GEP was 2 986.95 billion yuan in 2010, in which, direct products contributed 413.27 billion yuan, and indirect services value amounted to 2 573.68 billion yuan. The results showed that the ecological asset accounting system works well in reflecting the contribution of ecological asset to local social and economic development, and can be used to assess the ecological asset conditions. Thus, the ecological asset accounting system can be used in ecosystem management and governmental performance appraisal. [ABSTRACT FROM AUTHOR]

BACKGROUND: The distribution of nitrogen isotopes has important significance in paleoclimate, paleosedimentary and evolutionary characteristics. Nitrogen is one of the important heteroatomic elements in crude oil. The nitrogen content of crude oil is generally 0.1% to 2%, mainly in the non-hydrocarbon and asphaltene fractions, and can be divided into basic and non-basic nitrogenous fractions according to polarity. Due to the high carbon/nitrogen ratio of crude oils, accurate nitrogen isotope analysis results cannot be obtained from direct testing for most crude oils. As a result, the research on nitrogen isotopes in crude oil has been developed slowly, and the available data are few, while not being well applied in practice. OBJECTIVES: To determine the nitrogen isotopic distribution characteristics of different nitrogen-containing components in crude oil, and to address the problem of low nitrogen content in crude oil, which makes the direct determination of nitrogen isotopes less stable and reproducible. METHODS: A two-stage separation pre-treatment method was utilized to successively separate the nonhydrocarbon and asphaltene fractions of crude oil, and the basic and neutral nitrogen fractions were separated from the non-hydrocarbon fraction. The characteristics of nitrogen isotope distribution in different nitrogenous components of crude oil were determined by the Dumas combustion method. Multiple stable nitrogen isotope standards (USGS61, USGS62, USGS63) were selected for quality control of nitrogen isotope results. RESULTS: The nitrogen isotope data obtained by this method for each component of crude oil were of good quality, with the uncertainties less than ±0.4‰. By separating and measuring crude oil samples from marine and continental sedimentary environments, the results showed that the nitrogen isotope of crude oil samples in continental sedimentary environment was heavier than that in a marine sedimentary environment. The distribution of nitrogen isotopes of asphaltene fractions was heavier than that of non-hydrocarbon fractions. The distribution characteristics of the nitrogen isotopes of the different polar nitrogen-containing compounds also differed significantly. CONCLUSIONS: The technical dilemma that crude oil samples cannot accurately produce stable nitrogen isotopes due to the disparity in carbon to nitrogen ratios is solved and technical support for the practical application of a crude oil nitrogen isotope index is also obtained. [ABSTRACT FROM AUTHOR]

To strengthen the research on sharing management mode and operational mechanism of large-scale instruments and equipment is an important guarantee to improve efficiency in the use of assets and capital investment, but also a driving force for improving the talent training quality and getting high level research achievements. The reasons for the low efficiency of use management, resource application and sharing degree of large-scale instruments and equipment in colleges and universities have been deeply analyzed. Combining with characteristics of university administration system, a shared management pattern of " overall planning, in charge of public, relatively concentrated, opening and sharing" has been put forward in order to construct shared platform of large-scale instruments and equipment. Research on running mechanism of the matching management mode is listed below ： proving mechanism of equipment purchase study, establishing information sharing network system, establishing and improving the daily security control, strengthening the team building, establishing incentive and restraining mechanism as well as the establishment of evaluation and supervision mechanism etc. [ABSTRACT FROM AUTHOR]

Struma ovarii is a highly specific and single endoderm differentiated mature teratoma and is composed predominantly of thyroid tissue. Malignant transformation of benign monodermal teratoma is a rare presentation of struma ovarii, reported that the rate is about 0.5%-5%. It is believed that malignant struma ovarii (MSO) has similar molecular mechanism such as BRAF, RAS mutation and RET/PCT rearrangements with the malignant tumors originating in the thyroid. Because of its clinical rare,currently there is still a lack of clear diagnostic criteria and principles of management. Some cancer experts advocated the use of primary thyroid carcinoma pathological criteria as the diagnostic basis of MSO. Complete surgical staging and adjuvant therapy such as total thyroidectomy, or thyroxine suppression, radioactive iodine ablation and external radiotherapy should be considered when the MSO has been diagnosed. It is observed that patients with MSO have an excellent disease-specific survival rate,postoperative adjuvant therapy can significantly improve the efficacy. Long-term follow-up after surgery were needed, thyroglobulin and total body 131I scan are useful as tumor marker for detection of metastases or tumor recurrence. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the awareness of primary prevention of stroke among patients in neurological department of Civil Aviation General Hospital (hereinafter referred to as "our hospital"), and to provide reference for the development of health education program by clinical pharmacists. METHODS: Patients admitted into neurological department from Dec. 13 to 18 in 2013 were investigated by questionnaire survey with simple random sampling. RESULTS: The average awareness rate of primary prevention of stroke was 52.5%. The awareness rate of the risk factors, preventive knowledge and first symptoms of stroke were respectively 39.5%, 56.4% and 71.4%. The awareness were statistically significantly different among patients with different age and educational background. CONCLUSIONS: There is a general lack of preventive and primary prevention knowledge of stroke among patients. It is urgent to popularize health education about the risk factors and primary prevention of stroke. [ABSTRACT FROM AUTHOR]

Objective To find a more suitable threshold of fracture risk assessment using in China by analyzing and evaluating the published literature on fracture risk assessment with FRAX tool. Methods Literature with specific FRAX calculation results, sample size ≥30, and Chinese as research subjects were retrieved from CNKI and Wanfang databases before April 2021 with the keyword FRAX. Two evaluators independently extracted the data, evaluated the literature quality, and extracted the relevant data. SPSS17.0 software was used for statistical analysis. Results A total of 216 related articles were retrieved. Among those, 19 articles met the criteria, including 20508 cases, with 11632 male cases and 8876 female cases. The 10-year risk of multisite fracture (PMOF) was assessed using FRAX tool. The incidence was 4.01%±1.57% in women and 2.94%±1.91% in men, respectively. The 10-year risk of hip fracture (PHF) was 1.25%±0.68% in women and 1.09%±0.75% in men using the FRAX tool. There were statistically significant differences in PMOF and PHF between males and females in 10 years (P<0.05). Conclusion The 10-year PMOF and PHF estimated by FRAX are different from foreign guidelines. It is recommended that PMOF is 3% in men and 4% in women, and PHF is 1% in men and 1.25% in women. [ABSTRACT FROM AUTHOR]

Objective To explore the mechanism of long non-coding RNA (LncRNA) growth arrest-specific 5 (GAS5) targeting microRNA (miR) -103 to reduce 3T3L1 adipocyte insulin resistance (IR). Methods The 3T3L1 mouse preadipocytes were cultured and induced to differentiation, and oil red O staining was used to identify cell differentiation. The 3T3L1 adipocyte IR model was established. Cells were divided into the control group, the model group, the empty vector group (transfected with pEGFP-C1 empty vector), the GAS5 over-expression group (transfected with pEGFP-C1-GAS5 vector), the GAS5 over-expression + mimic NC group (transfected with pEGFP-C1-GAS5+mimic NC) and the GAS5 overexpression+miR-103 mimic group (transfected with pEGFP-C1-GAS5+miR-103 mimic). Real-time fluorescent quantitative PCR was used to detect the levels of GAS5 mRNA and miR-103 in cells. liquid scintillation method was used to detect glucose uptake capacity. Western blot assay was used to detect the expression levels of insulin receptor substrate-1 (IRS-1), p-IRS-1, peroxisome proliferator-activated receptor γ (PPARγ), glucose transporter 4 (GLUT4), and protein kinase B (AKT) and p-AKT proteins. Dual luciferase was used to identify the targeting sites of miR-103 and GAS5. Results After induction, the cells were round, the cell body enlarged, the cytoplasm was rich and contained a large number of lipid droplets. The oil red staining was obvious, showing‘finger-ring-like’structure. The model was successfully constructed. Compared with the control group, the GAS5 mRNA level, glucose uptake capacity, p-IRS-1/IRS-1, PPARγ, GLUT4 and p)AKT/AKT protein levels decreased in the model group, the empty vector group and the GAS5 over-expression+miR-103 mimic group (P＜0.05), the miR-103 mRNA level in cells increased (P＜0.05). Compared with the model group and the empty vector group, the GAS5 mRNA level, glucose uptake capacity, p-IRS-1/IRS-1, PPARγ, GLUT4 and p-AKT/AKT protein levels increased in the GAS5 over-expression group and the GAS5 over-expression+mimic NC group (P＜0.05), while the miR-103 mRNA level in cells decreased (P＜0.05). Compared with the GAS5 over-expression group and the GAS5 over-expression + mimic NC group, the GAS5 mRNA level, glucose uptake capacity, p-IRS-1/IRS-1, PPARγ, GLUT4 and p-AKT/AKT protein levels decreased in the GAS5 over-expression + miR-103 mimic group (P＜0.05), the miR-103 mRNA level increased (P＜0.05). The complementary binding sites of MiR-103 and GAS5 were verified by the dual luciferase targeting relationship. Conclusion Targeted down-regulation of miR-103 expression after over-expression of GAS5 can reduce IR of 3T3L1 adipocytes. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of S100A9 knockdown on cerebral ischemia-reperfusion (I/R) injury and inflammation in rats and to explore the related mechanism. Methods SD rats were randomly divided into the sham operation group, model group, Lsh-NC group, and Lsh-S100A9 group, respectively. The middle cerebral artery occlusion (MCAO) models were prepared by intraluminal suture method in the model group, Lsh-NC group, and LshS100A9 group; the rats in the sham operation group only received the carotid artery exposure and wire embedding; in the Lsh-S100A9 group and Lsh-NC group, rats received S100A9 knockdown lentivirus or empty vector intracerebral injection at 24 h after modeling. RT-qPCR was used to detect S100A9 mRNA expression in the brain tissues of rats; neurological severity score (NSS) score was used to evaluate the degree of neurological impairment; infarct volume of brain tissue was measured by 2, 3, 5-triphenyltetrazolium chloride (TTC) staining; and IL-1β, IL-6 and tumor necrosis factor-α(TNF-α) were detected by ELISA. The protein expression levels of p65, phosphorylated p65(p-p65) and MyD88 in the brain tissues of rats in the Lsh-NC group and Lsh-S100A9 group were detected by Western blotting. Results S100A9 mRNA expression level was as follows: the model group, Lsh-NC group > sham operation group > Lsh-S100A9 group; the neurological impairment score, ischemic cerebral infarction volume and IL-1β, IL-6, TNF-α expression levels in the brain tissues were in the following order: the model group, Lsh-NC group > Lsh-S100A9 group > sham operation group (both P<0. 05). The expression levels of p-p65 and MyD88 protein in the Lsh-S100A9 group were lower than those in the Lsh-NC group (all P<0. 01). Conclusion S100A9 knockdown can alleviate the cerebral I/R injury and inhibit brain inflammation in MCAO rats. The mechanism may be related to the regulation of NF-κB signaling pathway to affect the inflammatory response. [ABSTRACT FROM AUTHOR]

AI for Science "(AI4S) is a new scientific research paradigm that deeply integrates AI technology with scientific research to promote the discovery of new knowledge and the solution of scientific problems. As the application of AI4S in the natural sciences and humanities and social sciences advances, its development line, opportunities and challenges, needs and tasks, and ways of realization deserve further discussion. In order to advance AI4S research, promote scientific and technological (S&T) innovation and progress, and facilitate the effective strengthening of the discipline of information resources management, our journal has invited seven experts to organize this academic conversation on AI4S. 1) Supporting knowledge services for AI4S: In the current landscape of intelligent knowledge services, the requirements for supporting AI4S have increased, including the need for multi-level knowledge discovery and acquisition, cross-disciplinary research and innovation, and user-friendly participatory services. In addition, knowledge service scenarios are moving towards diversification, complexity, depth, specialization, and personalization in ubiquitous knowledge discovery, generative content services, and multi-round interactive service exploration. In response, professional science and technology information organizations need to reassess the role of knowledge services in the AI4Science environment and their significance in comprehensively supporting the S&T innovation process. This involves establishing a broad literature perspective, deepening full-text knowledge elements, balancing universal and specialized depth, autonomously developing core products, and deeply engaging with professional fields to support interdisciplinary innovation. 2) Building the knowledge base of AI4S: The essence of artificial intelligence (AI) lies in the acquisition and use of knowledge, and scientific and technological (S&T) literature is the primary carrier of human knowledge. Fully recognizing the paradigm shift in scientific research brought about by AI, the Document Information Center of the China Academy of Sciences has proposed the concept of building a S&T literature knowledge base for AI4S. It is actively exploring the scientific knowledge and high-quality data contained in the S&T literature, strives to build a domain intelligent knowledge base for AI4S, and transforms the "S&T literature database" into a "scientific knowledge engine" that supports intelligent services such as query evidence, situational awareness, inference prediction, and generation of insights required by AI4S. 3) Powering AI4S with scientific data: Effective aggregation of scientific data is the foundation for unleashing the powerful capabilities of AI4S. This is essential for libraries to adapt their roles and functions in the AI era and is a crucial prerequisite for catalyzing the transformation of scientific research services, deepening scientific research support, and accelerating S&T innovation. Currently, libraries face various macro and meso challenges in effectively aggregating valuable scientific data to provide support for AI4S. To address these challenges, the following ways can be pursued: defining the roles and functions of libraries in scientific data management; promoting a conducive environment for scientific data management; establishing a collaborative network for scientific data management; and enhancing the service capacity of scientific data management. 4) AI4S and intelligent language modeling for classical literature: AI4S technology can be used to analyze documents and texts, enabling a faster and more comprehensive understanding of a vast amount of historical documents and cultural materials. The development of intelligent language modeling for classical literature represents a significant breakthrough in the field of ancient literature research, bringing new opportunities and challenges. With the increasing popularity of multimodal and generative GPT models in the context of AI4S, the intelligent language modeling of classical literature will focus on integrating diverse information, enhancing adaptability, improving knowledge representation, and addressing a wider range of application scenarios. 5) Library Digital Scholarly Services for AI4S: The concept of using LLM-based AI4S and AIGC to drive the development of smart libraries is consistent with the vision for digital scholarly services in libraries, and presents both opportunities and challenges. Given the trends towards AI4S platformization and the characteristics of "middle-end" digital scholarly service, as well as the longstanding tradition of libraries in serving scholarly research, the reengineering path for the library's digital scholarly services platform includes three approaches: building an AI4S service platform independently, purchasing and utilizing third-party AI4S platforms, and promoting embedded knowledge services as a component of scientific intelligence. This innovative approach addresses the dilemmas of financial resources, human resources, cognitive and practical gaps, and emphasizes the importance of user needs in the AI4S environment. It also focuses on knowledge organization and service delivery to meet user needs in the AI4S landscape. 6) Historical evolution and logical structure of the scientific intelligence paradigm (AI4S): AI4S is a scientific paradigm change dominated by the full application of AI technology to various disciplines, and its logical structure includes "data+model"-driven, knowledge ecology created by machine conjecture, and application scenarios expanded by algorithmic thinking. In the era of digital civilization, AI4S-driven scientific progress and social development must carry forward the value of science and technology for the good, effectively select the theoretical arguments and proposals for extending AI4S to the field of social sciences and humanities, and improve the series of mechanisms for integrating human decision-making and machine intelligence. 7) Development opportunities and prospects of AI4S in the era of generative AI: With the advances in generative AI, pre-training algorithms and large-scale pre-trained models have provided significant opportunities for AI4S in various disciplinary domains. These technologies have shown immense potential and value for applications in diverse fields such as industrial inspection, robotics, and medicine. Additionally, it is crucial to emphasize the importance of key factors such as the constraints of technical implementation conditions for large pre-trained models, the sustainability of data/computing resources, and the transparency, fairness, and accessibility of the technology. [ABSTRACT FROM AUTHOR]

To estimate temporal change of regional tree diversity in Xishuangbanna, Southwest China, for this, we selected sampling plots from four forest vegetation types through field survey, including tropical rainforest(TRF), tropical seasonal moist forest(TSMF), tropical lower montane evergreen broad-leaved forest(TEBF)and tropical coniferous forest(COF). We used remote sensing imageries to map the distribution of four forest vegetation types for four different time periods 1992, 2000, 2009, 2016. Evenness indices of Simpson, Shannon-Wiener and Scaling were used to compare the tree evenness difference among the four forest vegetation types. Scaling index and grey correlational evaluation model were used to measure the biodiversity change in Xishuangbanna in four periods. The results were as follows:(1)Forest area showed a decreasing trend during 1992 to 2009 and then increasing to 2016, proportion of changing forest area found to be 65.5% in 1992 decreasing to 53.42% in 2000, then kept 52.49% in 2009 and increasing to 54.73% in 2016, but TRF area showed a decreasing trend during 1992 to 2016.(2)Four forest vegetation types had a significant difference that contributes to biodiversity, the tree evenness of four forest vegetation types were in the order TRF> TEBF> COF> TSMF, the richness of four forest vegetation types were in the order TRF> TEBF> TSMF> COF, this sorting of vegetation's contributions to Xishuangbanna tree diversity was TRF> TEBF> TSMF> COF.(3)Tree diversity of TRF and TSMF showed a decreasing trend from 1992 to 2016, the tree diversity of Xishuangbanna forest vegetation in different time periods were sorted as 1992>2009>2016>2000. The present study indicates that economic activity is an important factor to affect the regional diversity in Xishuangbanna, and the conservation of tropical rainforest has a great significance in maintaining biodiversity in Xishuangbanna. [ABSTRACT FROM AUTHOR]

Oil based drilling fluid is often used in shale gas drilling to solve the complex situations such as wellbore collapses but oil-based drilling fluid has many disadvantages such as high cost and environmental pollution. With the promulgation of new environmental protection law and increasing awareness of environmental protection, therefore, it is urgent to develop a water-based drilling fluid which is suitable for shale gas drilling. Yanchang Oilfield is the first national continental shale gas demonstration area in China , Therefore, taking it as an examples this paper analyzes comprehensively the mineral composition and microstructure of extended shale in Yanchang Oilfield, and reveals the mechanism of wellbore instability and the idea of drilling fluid construction in this area. On the basis of this, the key additives of drilling fluid system are optimized and the formula is tested. A new water-based drilling fluid system has been developed. The performance of it is equivalent to the oil-based drilling fluid. The loss of water at high temperature and pressure is only 4. 6 mL, the rolling recovery is over 95%, and the lubrication coefficient of extreme pressure is 0.103. The field application results show that new water-based drilling fluid can meet the performance requirements of drilling fluid for the extended shale gas horizontal well and guarantee effectively the safety of downhole. At the same time* it has certain reference value for the research and development of the shale gas water-based drilling fluid in China. [ABSTRACT FROM AUTHOR]

[Purpose/Significance] Recently artificial intelligence generated content (AIGC) has become an important tool for the digital development of industry in the digital intelligence integration environment. Clarifying the applicability and application scenarios of AIGC-driven innovation for galleries, libraries, archives and museums (GLAMs) as well as exploring GLAM development challenges will go far towards accelerating the transformation of GLAM digital intelligence and promoting GLAM to realize more value. As the previous research is fragmented and most of the related research only focuses on the impacts brought by a specific emerging technology such as ChatGPT or the application scenarios of a certain type of institution, especially libraries, we aim to explore the applicability, application scenarios and emerging challenges of various AIGC technologies to all GLAM institutions to ensure the systematicity of our research. [Method/Process] Based on the study of previous literature, this paper first elaborates on the applicability of AIGC to the development of GLAM digital intelligence integration from five aspects: policy, academia, industry, data, and users. Then, it analyzes the changes of GLAM digital intelligence scenarios driven by AIGC through the perspectives of technology, business, users and organizational management. Finally a discussion of the challenges faced by GLAM and the expectations for its future of digital intelligence integration is provided. In the section of applicability, policy documents are listed to illustrate the overlapping effect, and a review is provided on the development of the Semantic Web to metaverse, Web 3.0, then to AIGC to show the possibility of continuous research from an academic perspective for the GLAM to utilize AIGC. We demonstrate through several examples such as Hunan Museum that AIGC can be effective in the industry as it can create digital content and help develop the IP industry. It is also found that AIGC can help GLAM, which has a large amount of cultural data, to utilize the data, and AIGC can promote user immersive experience by specific user behavior examples. In terms of scenario change, we exemplify that the introduction of AIGC into GLAM as a collection of new technologies will first cause a huge change in technology, so that the diverse information in GLAM can produce more connections and fusion, and realize a large-scale digital twin. Second, it brings changes to the GLAM business such as AI digital human instead of real person doing inquiry service, and virtual pavilion expanding realistic exhibition hall. It also causes changes in user experience, which becomes strongly interactive, immersive and intelligent and it brings various changes to office style, cooperation mode, management mode and user information management. [Results/Conclusions] AIGC can efficiently promote the innovative development of GLAM under multiple application scenarios. In the future, GLAM institutions should actively address challenges including digital ownership protection and development, technology application benefit input-output ratio, and user conversion and evaluation, continuously promote digital talent training, expand digital technology research, and establish a complete AIGC application evaluation system based on existing resources. [ABSTRACT FROM AUTHOR]

A new low temperature early-strength agent ES-22 has been developed through dispersion-coprecipitation method to solve the slow strength development of cement slurries in shallow and low temperature well cementing. In laboratory experiment, the particle size distribution and micro-structure of ES-22 were analyzed, the effects of ES-22 and other inorganic early-strength agents on the strength development of cement slurries at low temperatures were compared. The effects of ES-22 of different concentrations on the properties of cement slurries were also studied. It was found that ES-22 has particle sizes distributed between 15 μm and 25 μm. Compared with other early-strength agents, ES-22 is the best early-strength agent for the development of the early compressive strength of set cement. At low temperatures, ES-22 has even greater contribution to the development of the mechanical property of the set cement. ES-22 has little, if any, effects on the rheology of the cement slurry, the thickening time of the cement slurry becomes only a little short, and the volume of filter loss is reduced. In laboratory experiment, a set cement containing 4% ES-22 had its compressive strength and flexural strength increased by 204% and 136% respectively over the compressive strength and flexural trength of the blank set cement after aging at 20 ℃ for 24 hours. These results indicate that the early-strength agent ES-22 performs very well in oil well cement slurries. [ABSTRACT FROM AUTHOR]

In terms of both phenotype and function, macrophages have remarkable heterogeneity. Macrophages can maintain the integrity of tissue by eliminating/repairing damaged cells and matrices. In respond to various environmental cues or under different pathophysiologic conditions, macrophages can be polarized into different phenotypes that is M1 phenotypes (classical activated macrophage)or M2 phenotypes (alternative activated macrophages). The protective and pathogenic functions of the different macrophage subsets in antimicrobial defence, anti-parasitic immunity, asthma, atherosclerosis, and tumorigenesis and the mechanisms regulating macrophage polarization are summarized in this article. Awareness of the function that macrophage polarization played in different diseases as well as the mechanisms that control these events may lead to the development of novel strategies for preventing, diagnosing and treating diseases and drug development. [ABSTRACT FROM AUTHOR]

To improve its efficiency of using and benefit of investment funds, it is necessary to establish an effective evaluation system of large-scale equipment. Four principles arc put forward, namely: scientific, pertinence, authenticity and comparability. The evaluation system of benefit evaluation is built, and the effective practice is carried out. Through effective use of the above evaluation results, we can improve management measures and management level, enhance the ability of Large-scale Equipment on teaching scientific research and external services, and further improve the use of assets. [ABSTRACT FROM AUTHOR]

Wnt/GSK-3β/β-catenin pathway is a widely acting classical signaling pathway that plays an important role in various processes such as bone growth and development and bone marrow stem cell transformation. In this paper, we studied the literature on the effects of different traditional Chinese medicines on bone remodeling through this pathway, and learned that single herbs such as bitter herbs Duhuo, Veratrum, Curcuma longa, Coptis chinensis, and Scutellaria baicalensis, tonifying kidney drugs Tortoise Plate, Herba Epimedii, Rhizoma Drynariae, invigorating qi drugs Astragalus membranaceus, and tonifying kidney Chinese medicine compounds such as Zuogui pills, Yougui pills, and Jingui Shenqi pills inhibited the expression of GSK-3β by regulating the Wnt/GSK-3β/β-catenin pathway, promoted more β-catenin to transfer into the nucleus, and then induced bone marrow stem cells to differentiate into osteoblasts and inhibited bone fragmentation, in order to achieve the effects of increasing bone mineral density. By observing the effect of traditional Chinese medicine on the expression of various proteins of Wnt/GSK-3β/β-catenin pathway, the regulatory effect of traditional Chinese medicine on bone metabolism was elucidated, providing ideas for the research and development of traditional Chinese medicine compound in the treatment of osteoporosis. [ABSTRACT FROM AUTHOR]

目的：探讨转化生长因子β1( TGF-β1)在三阴型乳腺癌发生、发展中的作用。方法选择三阴型乳腺癌患者80例、非三阴型乳腺癌患者40例，采用ELISA法检测血清TGF-β1水平，采用免疫组化法检测乳腺癌组织TGF-β1表达，分析TGF-β1表达与三阴型乳腺癌患者临床病理参数及预后的关系。结果三阴型及非三阴型乳腺癌患者血清TGF-β1水平分别为(108．43±10．55)、(84．09±11．52)ng／L，二者比较P<0．05。三阴型乳腺癌患者中TGF-β1高表达42例、低表达38例，TGF-β1高表达者较低表达者腋下淋巴结转移率高、组织学分级程度低( P均<0．01)，二者年龄、绝经状态、肿瘤直径、乳腺癌家族史比较差异均无统计学意义(P均>0．05)；TGF-β1高表达者5年无瘤生存率为54．76%(23／42)、低表达者为71．05%(27／38)，二者比较P<0．05。结论三阴型乳腺癌患者TGF-β1高表达，TGF-β1的表达变化与肿瘤组织学分级及腋下淋巴结转移相关，并影响患者预后。 [ABSTRACT FROM AUTHOR]

Objective To evaluate the capability of metagenomic next-generation sequencing （mNGS）in the pathogen diagnosis of periprosthetic joint infection（PJI）in order to provide clinical experience of choosing diagnostic methods. Methods From Jan 2017 to Dec 2019，patients with borderline symptoms were involved in this study.Intraoperative synovial fluid and periprosthetic tissues were both collected for microbial culture and mNGS.The pathogens were identified by symptoms, therapy and positive results. Results According to the criteria of Musculoskeletal Infection Society（MSIS）13 patients were diagnosed as PJI.The positive rate of mNGS was 84.62%, which was higher than that of culture method （76.92%). aphylococcus aureus, Enterococcus faecium, Candida albicans and Mycoplasma hominis were the main detected pathogens of PJI.The detection time of mNGS was 48 h, which was significantly shorter than culture method（14 d） . Conclusion With higher speed of detection in PJI, mNGS can provide vital etiological evidence for early accurate diagnosis of PJI.mNGS is an effectivecomplementtomicrobialculturemethod，especiallyinculture-negative PJI. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effectiveness of dezocine application in analgesia after laparoscopic radical gastric cancer surgery and its effect on patients' hemodynamics. Methods: October 2018 2 019 years. 5 admitted to our hospital for an acceptance of 120 cases of laparoscopic gastric cancer patients, according to the number table randomly divided into two groups, intraoperative application Bhutto Fino After analgesia, the research group used butofino combined with dezocine for postoperative analgesia, analyzed the analgesic effect, inflammatory response and postoperative hemodynamic changes of the two groups of patients, and compared the analgesic safety of the two groups. Results: The Visual Analogue Scale/Score (VAS) score of the study group was lower than that of the control group (P<0.05) at 24 and 48 hours after the operation. Score, BCS) was lower than the control group (P<0.05); the interleukin-6 (IL-6) of the study group was lower than the control group (P<0.05) at 24 h and 48 h after surgery. The levels of IL-2 at 24 h and 48 h after surgery in the study group were higher than those in the control group (P<0.05); the scores of the Mini Mental State Scale (MMSE) at 6 h, 12 h, and 24 h in the study group were higher than those in the control group (P <0.05), there was no significant difference between the study group and the control group before and 48 hours after operation (P>0.05); the study group's diastolic blood pressure (DBP), systolic blood pressure (SBP) and heart rate (heart rate) rate, HR) levels before anesthesia, 5 minutes and 10 minutes after tracheal extubation have no significant difference (P>0.05), the control group HR, SBP and DBP levels at 5 minutes and 10 minutes after tracheal extubation are higher than anesthesia Before (P<0.05), the levels of HR, SBP and DBP in the study group were lower than those in the control group at 5 and 10 minutes after tracheal extubation (P<0.05); adverse reactions in the study group were lower than those in the control group (P<0.05). Conclusion: In the postoperative analgesic intervention for patients undergoing laparoscopic radical gastrectomy, the combined use of Dezocine on the basis of Butofino can effectively reduce the impact on the patient's hemodynamics and improve the analgesic effect. [ABSTRACT FROM AUTHOR]

In order to better study the effect of moisture content on gas emission characteristics and laws of coal samples, this paper used the independently developed experimental device for determining the gas emission characteristics of coal samples to test the gas emission of coal samples under different moisture content. The kinetic equation can intuitively reflect the relationship between the moisture content and the gas emission efficiency of the coal sample. Therefore, four kinds of kinetic models, pseudo-first-class, pseudo-secondary, Elovich, and parabolic, are used to fit gas discharge at different water cuts. Investigate the law of moisture content on the dynamic characteristics of coal-like gas diffusion. The results show that the gas discharge rate of coal samples increases with the increase of time under different moisture content, and the presence of water will reduce the gas emission of coal samples. The water content is positively correlated with the quasi-first-order rate constant k1, the second-order rate constant k2, and the Elovich rate constant β, and is negatively correlated with the rate constant k3 of the parabola model. Quasi-first-order and quasi-second-order kinetics. The equilibrium liberation quantity q1, q2 in the model gradually decreases with the increase of the moisture content, that is, it has a negative correlation. Comparing with the four dynamic models, the best fitting effect is the Elovich dynamic model. That is to say, the Elovich dynamic model can better describe the dynamic characteristics between the water content and the bleeder, in order to further study its law of gas dispersion. [ABSTRACT FROM AUTHOR]

To study the force characteristics of support boots of a shearer under the conditions of large span and over constraint,the static model of the shearer under 18 loads was established by considering the factors including the roll and pitch angles.Aiming at the uncertainty of model coefficient matrix,an improved aggregation function was proposed to deal with the absolute coefficient matrix of the shearer static equations,and the modified smooth nonlinear equations were obtained.The three-axis forces of the drum obtained by the cutting experiment were input into the static equations as the excitation,the Levenberg-Marguardt method was used to solve the equations,and the theoretical values of boots were calculated and compared with the actual measured values.According to the error range less than 10%,the correctness of the theoretical model was verified.By applying the control variable method,the roll and pitch angles of the shearer were changed respectively to research the force characteristics variation of the shearer boots.The results show that the influences of the roll angle variation to the lateral forces of the front and rear guiding sliding boots were bigger,and to the support forces of the front and rear sliding boots and the flat sliding boots were smaller.The forces of all boots were influenced by the shearer roll angle variation,and the force variations were approximately linear. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression changes and significance of fork box protein C1 (FOXC1) in human epithelial ovarian cancer (EOC). Methods The expression of FOXC1, E-cadherin and Vimentin in 30 cases of benign EOC tissues, 30 cases of borderline ECO tissues and 70 cases of ECO tissues was detected by immunohistochemical SP staining. The ovarian cancer patients were followed up for 3 years, and the 3-year cumulative survival rate was compared between ovarian cancer patients with positive and negative FOXC1, E-cadherin and Vimentin. Results(1)The positive expression rates of FOXC1 and E-cadherin in the borderline ECO tissues were decreased,and the positive expression rate of Vimentin was increased as compared with those of the benigh ECO tissues (P < 0. 05). (2) The positive expression rate of E-cadherin was 28. 6% (20/70), the positive expression rate of Vimentin was 15. 7% (11/70) in ovarian cancer tissues with positive expression of FOXC1, the expression of FOXC1 was positively correlated with the expression of E-cadherin (r= 0. 446, P = 0. 000), and was correlated with Vimentin expression (r =-0. 295, P = 0. 014). (3) The expression of FOXC1 protein in EOC tissues was negatively correlated with lymph node metastasis, dualistic type and grading, and the protein expression of E-cadherin and Vimentin was correlated with lymph node metastasis, clinical classification,dualistic type and grading (all P < 0. 05). (4) The 3-year cumulative survival rates of EOC patients with positive expression of FOXC1 and E-cadherin was 82. 1% and 80. 6%, respectively,which were higher than those in patients with negative expression of FOXC1 and E-cadherin (69. 0% and 69. 2%). The 3-year cumulative survival rates of EOC patients with positive expression of Vimentin was 70%, which was significantly lower than that in patients with negative Vimentin (80%) (all P < 0. 05). Conclusions The expression of FOXC1 is decreased in ovarian cancer tissues, and the loss expression of FOXC1 may be a role in the process of EMT. Meanwhile, FOXC1 expression may be involved in the occurrence and development of ovarian cancer and can be used as an indicator to evaluate prognosis. [ABSTRACT FROM AUTHOR]

Efficient, water-saving irrigation modes are commonly used in the sugarcane fields of latosolic red soils in the Guangxi Zhuang Autonomous Region, China. This research studied the effects of different irrigation treatments on photosynthetic characteristics of sugarcane. Because photosynthesis is an important process in plant dry matter accumulation, this research has implications for the development of high-efficiency cultivation methods that produce high yields of sugarcane. We planted the sugarcane cultivar Liucheng 05-136 under 6 types of irrigation modes: no irrigation, subsurface drip irrigation, surface drip irrigation, pipe irrigation, sprinkler irrigation, and micro sprinkler irrigation. Field measurements of net photosynthetic rate and related environmental factors(soil water content, soil temperature, air temperature, relative air humidity, soil organic matter, soil available nitrogen, soil available phosphorus, and soil available potassium content) were conducted at the Sugarcane Efficient Water-saving Irrigation Test Base in Chongzuo City from March to December, 2015 for different growth phases of sugarcane(tillering stage, early, peak and late stages of elongation, and maturation stage). Additionally, the differences in net photosynthetic rate of sugarcane under different irrigation modes were investigated with a multiple comparison method, and the relationship between environmental factors and net photosynthetic rate was analyzed using stepwise regression and path analysis. Results showed that the mean net photosynthetic rates of sugarcane under no irrigation, subsurface drip irrigation, surface drip irrigation, pipe irrigation, sprinkler irrigation, and micro sprinkler irrigation were 18.53, 29.23, 28.50, 26.65, 25.94 and 23.66 μmol/(m2·s), respectively. Net photosynthetic rate was the lowest under the no irrigation mode, while the highest value appeared under the subsurface drip irrigation mode, which was 57.74%, 23.54%, 12.68%, 9.68% and 2.56% higher than that of no irrigation, pipe irrigation, sprinkler irrigation, micro sprinkler irrigation and surface drip irrigation, respectively. Therefore, irrigation can significantly improve sugarcane photosynthetic rate(P<0.05). Path analysis results showed that soil water content, air temperature and soil fertility were the main environmental factors influencing sugarcane net photosynthetic rate on the whole, but some differences existed between irrigation modes. Soil fertility was a key variable for photosynthetic rate under no irrigation and subsurface drip irrigation, while soil water content and soil available nitrogen content had significant effects on photosynthetic rate under surface drip irrigation. In the case of pipe irrigation, soil available potassium and air temperature were the major factors. For sprinkler and micro sprinkler irrigation, the main factors were soil water content and air temperature. It may adjust the influence of irrigation treatments on photosynthesis through the regulation of environmental factors(air temperature and humidity, and soil physical and chemical properties). In addition, each factor mutually acts to promote or restrain the photosynthesis process, showing a comprehensive effect. In terms of soil water content, its influence on photosynthesis was reflected in the effect on absorption of nitrogen, phosphorus and potassium nutrient elements for sugarcane under no irrigation, subsurface and surface drip irrigation modes. Comprehensive analysis showed that the subsurface drip irrigation treatment effectively improved sugarcane photosynthesis. Subsurface drip irrigation will be more suitable for the cultivation of sugarcane in the latosolic red soils in the Guangxi Zhuang Autonomous Region. Furthermore, according to the different irrigation modes, ensuring favorable control of soil water content in combination with other main influencing factors, can further improve sugarcane net photosynthetic rate, and consequently increase the yield of sugarcane. [ABSTRACT FROM AUTHOR]

To study the mechanics and permeability characteristics of similar material of solid-gas coupling, orthogonal test is used to make up similar material which using river sand as aggregate, paraffin as cementing agent and hydraulic oil as regulator. Adopting range analysis and multivariate regression analysis, the influence of impact number, aggregate size, oil content and cement-sand ratio on the compressive strength, elasticity modulus, Poisson's ratio and permeability of similar material are investigated. The test results show that the size order that factors against compressive strength is oil content, impact number, aggregate size, and cement-sand ratio. The size order that factors against elasticity modulus is oil content,impact number, cement-sand ratio and aggregate size. The size order against permeability is impact number, cement-sand ratio, oil content and aggregate size.The factors have less influence on Poisson's ratio. The compressive strength and elasticity modulus of similar material is positively related to impact number and aggregate size, and is negatively related to oil content and cement-sand ratio. The permeability is negatively related to impact number, aggregate size, oil content, and is positively related to cement-sand ratio. Poisson's ratio has no obvious relationship with the factors. The comprehensive model of characteristic parameters of similar material is obtained under the influence of four factors in test. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of short term and intensive insulin pump on the blood lipid and glucose levels of patients with type 2 diabetes. Methods: 76 patients with type 2 diabetes were selected and divided into two groups according to different administration. The control group (38 cases) was given routine insulin as part treatment.The observation group (38 cases) was treated by insulin pump.The blood and lipid indexes and ADL score before treatment, at 1 week and 2 weeks after treatment were compared between two groups. Results: After treatment, the levels of FPG, HbAlc,TC,TG and LDL-C were lower than those before treatment and the level of HDL-C was increased in both groups.The levels of FPG, HbAlc, TC, TG, LDL-C of observation group were lower than those of the control group,and the level of HDL-C of observation group was higher than that of control group (P＜0.05). At 1 week, 2 weeks after treatment, the ADL scores of both groups were significantly improved,and the ADL score of observation group was higher than that of the control group (P＜0.05). Conclusion: Short term intensive insulin pump could significantly improve the blood glucose and lipid metabolism disorders in patients with type 2 diabetes, and improve the ability of daily life. [ABSTRACT FROM AUTHOR]

Objective To study the correlation among transcriptional expression and promoter methylation of FOXC 1 gene in epithelial ovarian tumors and its clinical characteristics. Methods Methylation-specific PCR was used to detect the methylation of FOXC1 gene promoter CpG island in 65 patients who underwent operation for epithelial ovarian tumors, reverse transcription PCR was performed to detect the expression of FOXC 1 mRNA. Result FOXC1 mRNA was showed in all epithelial ovarian tumor samples. The relative level of FOXC1 mRNA was 1.19 ±0.17 in benign tumors, 0.61 ±0.18 in borderline tumors and 0.38 ±0.16 in malignant tumors respectively. It was significantly lower in ovarian cancer than that in benign tumor specimens, and was significantly lower in borderline tumor than that in benign tumor too (P<0.05). The expression of FOXC1 was not correlated with clinical characteristics, such as clinical stage , histological differentiation. However there were lower expression level of FOXC 1 mRNA in patients with lymph node metastasis than that of patients without lymph node metastasis. The methylation rate of the FOXC1 gene promoter CpG island in ovarian cancer was higher than those in borderline tumor and the benign tumor, P<0.05. Conclution The expression of FOXC1 is closely correlated with the oncogenesis and progress of ovarian cancer. Promoter methylation may contribute to the low level of mRNA expression. [ABSTRACT FROM AUTHOR]