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Objective To investigate the efficacy of 48 weeks of rapid initiation of HIV antiviral therapy in Kunming, and analyze the influencing factors of Non-rapid initiation. Methods Data of patients initially receiving HIV antiviral treatment in The Third People's Hospital of Kunming from January 2018 to December 2022 were retrospectively collected. The time interval between diagnosis and treatment initiation was ≤7 days in the rapid ART group, and > 7 days in the non-rapid ART group. Chi-square test and T-test were used to compare the baseline demographic and clinical characteristics between the two groups and logistic regression analysis was used to analyze the influence factors. The chi-square test was used to compare the difference of CD4 count, viral inhibition rate, cohort retention rate and mortality between the two groups after 48 weeks of treatment. Results The Rapid ART rate was 32.70%, the Non-rapid ART group has higher loss rate in 48 week (χ² = 11.169, P = 0.001), higher mortality (χ² = 3.924, P = 0.048). The risk of Non-rapid initiation was 1.212 times higher in patients without a spouse (P = 0.040). The risk of Non-rapid initiation in patients transmitted by intravenous drug use was 2.987 times that of heterosexual transmission (P < 0.001). Patients with baseline CD4/CD8<0.5 had a 1.423 times greater risk of Non-rapid initiation than patients with CD4/CD8≥0.5 ( P = 0.001), patients with CD4 counts≤350/μL were at higher risk for Non-rapid initiation (P = 0.047). After 48 weeks of treatment, the virus inhibition rate in the Rapid ART group was higher than that in theNon-rapid ART group (P = 0.031), the proportion of patients with CD4/CD8≥ 0.5 was higher in theRapid ART group (P < 0.001). Conclusion Rapid initiation of antiviral therapy is beneficial to improve viral inhibition rate and cohort retention rate, and reduce mortality. For patients without spouses, with intravenous transmission and CD4/CD8<0.5, more interventions should be given to help patients receive antiviral therapy as soon as possible. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the efficacy and safety of the three-in-one single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide（BIC/FTC/TAF） in AIDS patients. Methods Newly treated patients who received a single tablet combination（BIC/FTC/TAF） between February 1，2022 and June 1，2022（the initial treatment group） and those who underwent treatment（ the treated group） were included. The virological， immunological and biochemical indexes were statistically analyzed by means of prospective observational study. Results 249 patients were included at baseline, with 220 in the treated group and 29 in the newly treated group. At 48 weeks， the analysis showed that the virus suppression rate was 93.10% for the newly treated group and 98.55% for the treated group. Compared to the baseline, both groups showed increased CD4+ T lymphocyte counts and CD4+ /CD8+ T cell ratios after 48 weeks of treatment（P < 0.001）. There were also significant increases in blood triglycerides, total cholesterol, total bilirubin, and blood creatinine compared to the baseline（P < 0.05）. Aspartate aminotransferase and alanine aminotransferase decreased compared to the baseline， with all differences being statistically significant except for alanine aminotransferase in the newly treated group（P > 0.05）. Additionally，the estimated glomerular filtration rate based on blood creatinine improved in the newly treated group compared to the baseline（P < 0.001），while there were no significant changes in the treated group. Conclusion BIC/FTC/TAF can effectively inhibit virus replication，improve the immune function of patients, and has good safety. Bic /FTC/TAF can be one of the preferred treatment options for some specific clinical populations. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Systems Engineering & Electronics is the property of Journal of Systems Engineering & Electronics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To investigate the quality of life of AIDS patients on different antiretroviral regimens in Kunming. Methods　From December 2021 to March 2022， questionnaire survey and Chinese version of WHOQOL-HIV-BREF scale were used in Kunming Third People’s Hospital to investigate the quality of life of AIDS patients taking different antiviral treatment regimes. Multiple linear regression analysis was used to analyze the factors influencing the total score of patients’ quality of life. The total score of quality of life is shown in mean ± standard deviation. Results　The results of one-way ANOVA showed that，total score for quality of life in male （ 67.67±9.86）， Han （ 67.22±9.74）， education level （ 69.12±10.07）， city of residence （ 67.66±9.74）， no drinking within 3 months （ 67.52±10.01）， under 30 years old （ 68.15±10.58） were higher than that of female （66.53±9.45），ethnic minorities （66.57±9.60），low education （64.43±8.51），rural （65.97±9.56），drinking within 3 months （65.81±7.76）, over 30 years old （64.25±6.77），the difference was statistically significant （P < 0.05）. The quality of life was higher in the unmarried than in the married and divorced/widowed. The total quality of life score of patients with high CD4 level （ CD4≥500） was higher than that of patients with low CD4 level. The quality of life score of MSM population was higher than that of heterosexual and drug abuse population， and the differences of the above factors were statistically significant （P < 0.05） . Quality of life scores of patients taking antiviral medication containing integrase inhibitors were higher than those taking antiviral therapy containing nonnucleoside analogues and protease inhibitors，and the difference was statistically significant （P < 0.05）. Multiple linear regression analysis showed that alcohol consumption，education，route of infection，and type of medication were correlated with the total quality of life score. Drinking habit （β = -1.670） was negatively correlated with the total score of quality of life；MSM transmission （β = 4.790）；university degree or above （β = 2.320）；patients taking integrase inhibitors such as DTG regimen （β = 7.014），FTC/TAF/EVG/c （β = 8.765），BIC/FTC/TAF （ β = 13.141） were positively correlated， and the differences were statistically significant （ P < 0.05） . Conclusion　The quality of life of AIDS patients with different antiretroviral treatment regimens in Kunming is mainly influenced by various factors such as the type of antiretroviral drugs taken， alcohol consumption， and education. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Chongqing University of Posts & Telecommunications (Natural Science Edition) is the property of Chongqing University of Posts & Telecommunications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Systems Engineering & Electronics is the property of Journal of Systems Engineering & Electronics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Plastics Science & Technology / Suliao Ke-Ji is the property of Plastics Science & Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Guihaia is the property of Guihaia Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Management & Technology Discussion is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Bulletin of the Chinese Ceramic Society is the property of Bulletin of the Chinese Ceramic Society Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Guihaia is the property of Guihaia Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ａｉｍｉｎｇ ａｔ ｔｈｅ ｐｒｏｂｌｅｍ ｏｆ ｄｉｆｆｉｃｕｌｔ ｔｏ ｂｕｉｌｄ ｔｈｅ ｄｙｎａｍｉｃｓ ｍｏｄｅｌ ｏｆ ｃａｂｌｅ￣ｄｒｉｖｅｎ ｍａｎｉｐｕｌａｔｏｒ ｂｅｃａｕｓｅ ｏｆ ｉｍｐｏｒｔｉｎｇ ｏｆ ｃａｂｌｅ. Ｓｉｎｇｌｅ ｗａｙ ｆｏｒｃｅ ｏｆ ｃａｂｌｅ ｗａｓ ｔａｋｅｎ ｉｎｔｏ ａｃｃｏｕｎｔ. Ｃａｂｌｅ￣ｄｒｉｖｅｎ ｍａｎｉｐｕｌａｔｏｒ ｗａｓ ｒｅｓｅａｒｃｈｅｄ ｏｎ ｉｎｆｌｕｅｎｃｅ ｏｆ ｃａｂｌｅ ｏｎ ｄｙｎａｍｉｃｓ ｍｏｄｅｌ, ｆｏｒｃｅ ｂｅｔｗｅｅｎ ｃａｂｌｅ ａｎｄ ｌｉｎｋａｇｅｓ, ｃｈａｎｇｅ ｏｆ ｆｏｒｃｅ ａｎｄ ｄｒｉｖｉｎｇ ｔｏｒｑｕｅ ｃａｕｓｅｄ ｂｙ ｐｒｅｌｏａｄ. Ｃｏｍｐｌｅｔｅ ｄｙｎａｍｉｃｓ ｍｏｄｅｌ ｏｆ ｃａｂｌｅ￣ｄｒｉｖｅｎ ｍａｎｉｐｕｌａｔｏｒ ｗａｓ ａｃ￣ ｑｕｉｒｅｄ ｏｎ ｔｈｅ ｂａｓｉｃ ｏｆ ｇｅｎｅｒａｌｉｚａｔｉｏｎ ｏｆ ｔｒａｄｉｔｉｏｎａｌ ｒｉｇｉｄ ｍａｎｉｐｕｌａｔｏｒ ｄｙｎａｍｉｃｓ ｍｏｄｅｌ, ｉｎｆｌｕｅｎｃｅｓ ｏｎ ｍａｎｉｐｕｌａｔｏｒ ｂｙ ｃａｂｌｅ ｗａｓ ａｎａｌｙｚｅｄ, ｉｔｅｒａ￣ ｔｉｏｎ Ｎｅｗｔｏｎ￣Ｅｕｌｅｒ ｍｅｔｈｏｄ ｗａｓ ｕｓｅｄ. Ｔｈｅ ｉｎｆｌｕｅｎｃｅ ｔｈａｔ ｃａｕｓｅｄ ｂｙ ｅｘｅｒｔｉｎｇ ｐｒｅｌｏａｄ ｏｎ ｌｉｎｋａｇｅｓ ｗａｓ ａｎａｌｙｚｅｄ ｏｎ ｔｈｅ ｂａｓｅ ｏｆ ｄｙｎａｍｉｃｓ ｍｏｄｅｌ. Ｄｙｎａｍｉｃｓ ｓｉｍｕｌａｔｉｏｎ ｏｆ ３ ＤＯＦ ｃａｂｌｅ￣ｄｒｉｖｅｎ ｍａｎｉｐｕｌａｔｏｒ ｗａｓ ａｃｈｉｅｖｅｄ ｔｈｒｏｕｇｈ ＡＤＡＭＳ. Ｔｈｅ ｓｉｍｕｌａｔｉｏｎ ｒｅｓｕｌｔｓ ｉｎｄｉｃａｔｅ ｔｈａｔ ｓｉｍｕｌａｔｉｏｎ ｔｏｒｑｕｅ ａｒｅ ａｃｃｏｒｄａｎｃｅ ｗｉｔｈ ｃａｌｃｕｌａｔｅｄ ｂａｓｉｃａｌｌｙ, ｗｈｉｃｈ ｓｈｏｗ ｔｈｅ ｃｏｒｒｅｃｔｎｅｓｓ ｏｆ ｄｙｎａｍｉｃｓ ｍｏｄｅｌ. Ｆｏｒｃｅｓ ｂｅｔｗｅｅｎ ｃａｂｌｅ ａｎｄ ｌｉｎｋａｇｅｓ ｗｉｌｌ ｃｈａｎｇｅ, ｈｏｗｅｖｅｒ, ｄｒｉｖｉｎｇ ｔｏｒｑｕｅ ｋｅｅｐ ｕｎｃｈａｎｇｅｄ ｗｈｅｎ ｐｒｅｌｏａｄ ｉｓ ｅｘｅｒｔｅｄ. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Signal Processing is the property of Journal of Signal Processing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)