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Objective: To evaluate the effect of Nd-Fe-B magnets coated with Ni, Ti N and Ni-Ti N composite coatings on the bile corrosion through the in vitro immersion method, and provide a surface modification scheme for the clinical application of magnetic compression technique in biliary reconstruction. Methods: The bile of clinical patients was collected, and the magnets were immersed at38 ℃ in vitro. The weight of magnets was periodically weighed and the soaking solution was replaced to measure the iron ion concentration of the soaking solution. After 30 days of immersion, the weight loss rate of each group of magnets were calculated, and the surface structure of magnets were observed by scanning electron microscopy. Results: After 30 days of bile soaking, the weight loss rates of magnets of bare magnet, nickel plating, titanium nitride coating and nickel-titanium nitride composite coating were 0.57%, 0.35%,0.34%, and 0.19%, respectively. The concentration of iron in the soaking solution is different in each time points. Electron microscopy showed that the surface of each group of magnets showed different degrees of corrosion spots after immersion, and the coating appeared to fall off. Conclusions: The corrosion resistance of NdFeB magnets after surface modification of nickel-titanium nitride composite coating was significantly better than that of pure nickel coating and titanium nitride coating. [ABSTRACT FROM AUTHOR]

Objective: The structural design scheme of the parallel moving clamp which can be used for the clamping and fixing of the magnet in the magnetic pressing anastomosis operation is proposed. Methods: The shortcomings and deficiencies of the original magnetic compression anastomosis technology of our team were analyzed, the magnets that magnetic compression anastomosis operation need by hand alone or by using the existing vascular forceps clamping and fixing, and it is the main reason of inconvenience in operation.From the mechanics point of view, analyzed the reason of the conventional vascular forceps hold the magnet can lead to the slippage of the magnet. And pointed out that the design and processing of magnetic anastomosis dedicated forceps is an effective measure to solve the problem of the inconvenience during magnetic anastomosis. On this basis, the structural design scheme of using the parallel moving clamp to fix the magnet is proposed. The mechanics analysis of the magnet is made. The parallel moving clamp with the magnets for clamping and fixing in the magnetic compression anastomosis are designed. Results: The structural design of the parallel moving clamp can stably clamp the magnet and prevent the magnet from slipping off. Meanwhile, the parallel movement of the clamp head can be controlled by the gear transmission structure to better control the precise attract and separation of the magnet, thereby further simplifying the operation, avoiding the unnecessary damage and saving operation time. Conclusions: The parallel moving clamp can be a variety of shapes and sizes to meet the magnet clamping and fixing, it can effectively control the magnet pull and separation, facilitate the operation.The parallel moving clamp processing simple, easy to use, and will promote magnetic compression anastomosis technology widely carried out in the clinic. [ABSTRACT FROM AUTHOR]

Objective To evaluate the application effect of telemedicine robot on the postoperative followup of liver transplantation recipients from donation after cardiac death (DCD). Methods A total of 100 recipients undergoing liver transplantation from DCD in the First Affiliated Hospital of Xi 'an Jiaotong University from January 2014 to December 2017 were recruited in this investigation. According to differnt follow-up patterns, all recipients were divided into the research group (n=50, follow-up by telemedicine robot) and control group (n=50, follow-up by traditional telephone). The compliance (medication compliance, self-monitoring, life compliance and follow-up compliance), followup time and follow-up satisfaction at postoperative 3 months of all DCD liver transplantation recipients were analyzed and statistically compared between research group and control group. Results The scores of medication compliance, self-monitoring, life compliance, follow-up compliance and the total score of compliance in the research group were significantly higher than those in the control group (all P<0.05). The each follow-up time of liver transplantation recipients in the research group was (9±4) min, significantly shorter than (13±4) min in the control group (t=-4.452, P<0.001). The score of satisfaction during postoperative follow-up in the research group was 19.8±2.6, significantly higher than 16.2±3.1 in the control group (t=6.234, P<0.001). Conclusions The application effect of telemedicine robot on the postoperative follow-up of liver transplantation recipients from DCD is satisfactory, deserves widespread application in clinical practice. It is expected to become an indispensable part of the postoperative follow-up of liver transplantation recipients from DCD. [ABSTRACT FROM AUTHOR]

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Objective To investigate the recurrence rate, the efficacy and safety of auxiliary hepatic arterial chemoembolization after the treatment of microvascular invasion (MIV) of hepatocellular carcinoma. Methods A total of 104 patients with hepatocellular carcinoma clinical staging of early metaphase were collected from the First Affiliated Hospital of Xi'an Jiaotong University in Jan．2010 to Dec.2016, all treated with liver resection and follow-ups. Adopting the method of retrospective analysis, univariate and multivariate analyses were performed to investigate the risk factors for recurrence-free survival(RFS)and overall survival(OS). Multiple logistic regression was used to identify the clinicopathological characteristics associated with MVI. The rates of RFS and OS were compared among patients with or without MVI treated with liver resection alone or followed by PA-TACE. Results In HCC patients, the gender HBsAg, total bilirubin, and prothrombin time, AFP, HBV - DNA, the size of largest tumor, capsule, operation type, hepatic door block, Child - Pugh grade, classification comparison differences had no statistical significance between the two groups of with or without TACE(P>0.05); Age, nodules, tumor cell resection, and BCLC were statistically significant in the non-MIV infiltration group (P<0.05).Hypersplenism and recurrence rate were statistically significant in MIV group (P<0.05). Univariate and multivariate analyses demonstrated that AFP (> 400 ng/mL), tumor diameter, membrane integrity, MVI， and most liver resection were significantly associated with overall survival rates (P<0.05), the AFP (>400 ng/mL), Child - Pugh, grade B, tumor diameter, hepatocellular carcinoma (HCC) and other abnormal degree, membrane integrity, MVI have significant correlation with disease-free survival rate (P< 0.05). Multiple logistic regression identified serum AFP level > 400 ng/L, tumor size > 5cm, and incomplete tumor envelope was independent correlation factor (P>0.05). In the HCC patients with MIV, both OS and DFS were significantly improved in patients who received PA-TACE as compared to those who underwent liver resection alone (P> 0.05), but no significant effect in HCC patients wieh no MIV invasion (P> 0.05). Conclusions There is a certain correlation between microvascular infiltration and the recurrence rate and survival rate of hepatocellular carcinoma, and the method of using adjuvant hepatic arterial chemoembolization is helpful to reduce the recurrence rate and prolong the survival period. [ABSTRACT FROM AUTHOR]

Objective To develop a pulling device using magnetic positioning to optimize the procedures of repairment of donor liver from organ donation . Methods The pig liver specimens were used to measure the pull force of repairment of donor liver, magnetic spiderman was developed based on the measurement results. The magnetic spiderman was applied to simulate the repairment of donor liver from organ donation on the pig liver specimens. The effectiveness of magnetic spiderman was also evaluated. Results The pulling force was required all less than 2 N during the repairment of donor liver. The magnetic spiderman was successfully manufactured. The magnets of magnetic spiderman could generate 3 N magnetic forces with paramagnetic basin of hepatic repairment. The self-retraction pull wire of the magnetic spiderman could provide 2.5 N pulling forces. The magnetic spiderman was successfully applied to the simulated experiment of repairment of donor liver from organ donation in 6 cases. The operation time was (54±5) min. No clip slippage, displacement and slippage of the base occurred during the operation. With the cooperation of multiple magnetic spidermen, the remaining surgical procedures were performed by one single surgeon except for the vascular ligation. Conclusions The magnetic spiderman has small volume and implements flexible positioning, can perform pulling operation and not take up operational space. It can effectively optimize the procedures of repairment of donor liver from organ donation and reduce the quantity of surgeons. [ABSTRACT FROM AUTHOR]

Objective To analyze the characteristics of papers published in Organ Transplantation in the past ten years. Methods The academic papers published in Organ Transplantation from January 2010 to December 2019 were retrieved from China National Knowledge Infrastructure (CNKI). The publication volume, the funded paper ratio, authors, research institutions and keywords were analyzed by information visualization software CiteSpace 5.3 and VOSviewer 1.6. Results From 2010 to 2019, a total of 919 academic papers were published in Organ Transplantation, with an average annual publication volume of 92, showing an overall stable trend. The funded paper ratio and the ratio of papers with funding support at the provincial level or above increased year by year, reaching 100% in 2019. High-yield authors mainly formed two research teams led by Shi Bingyi and Chen Guihua respectively. The first authors were distributed across China. In recent years, as many as 58 programmatic papers were published by national academic institutions, especially signed by Branch of Organ Transplantation of Chinese Medical Association. The average number of authors per paper was 4.94 in Organ Transplantation, and the proportion of papers contributed by two or more authors remained above 90% in recent years. According to the analysis of research institutions, the average number of institutions per paper was 1.60 in Organ Transplantation. Keyword co-occurrence network analysis demonstrated that liver transplantation, renal transplantation and organ transplantation were the research hotspots in the field of organ transplantation. Keyword cluster analysis showed that research mainly focused on 9 fields, such as liver transplantation, renal transplantation, organ transplantation, organ donation, posttransplantation complications, transplantation immunity, end-stage liver disease, xenotransplantation and stem cell transplantation. Keyword burst analysis showed that xenotransplantation, α-1,3-galactose, transplantation immunity, apoptosis, donor specific antibody (DSA), antibody-mediated rejection (AMR) and flow cytometry were the research hotspots. Conclusions The authors that publish academic papers in Organ Transplantation come from major transplantation centers all over the country. The papers of Organ Transplantation cover the research hotspots of each branch in the field of organ transplantation, and include a large quantity of programmatic papers signed and published by national academic institutions, which show the frontier hotspots and the highest level of research in the field of organ transplantation in China, making Organ Transplantation an excellent academic journal. [ABSTRACT FROM AUTHOR]