Objective: To investigate the current situation of pregnancy distress and related factors in the third trimester of pregnancy, and explore its association with self-compassion and emotional inhibition. Methods: A total of 214 women in the third trimester of pregnancy were selected and measured the pregnancy pain, self-compassion and emotional depression levels of pregnant women in the third trimester with the Tilburg Pregnancy Pain Scale (TPDS), Self-Compassion Scale (SCS), and Emotional Suppression Scale (EIS). Results: The average score of pregnancy distress of 214 pregnant women in the third trimester was (26.7±4.9), with a medium level of pregnancy distress. Multiple linear regression analysis showed that the total scores of pregnancy distress in the third trimester of pregnancy were negatively associated with the accompanying situation of the lover (β = 0. 15, P < 0.05), the number of accompanying prenatal examinations (β = 0. 24, P<0.05) and the total scores of self-compassion (β = 0. 12, P<0.05), while positively correlated with gestational age (β = 0. 14, P<0.05), complications (β = 0. 15, P <0.05), and the total score of emotional suppression (β = 0. 17, P <0.05). Conclusion: Pregnancy distress is common in pregnant women in the third trimester, which may be related to gestational age and complications, companionship of loved ones, number of accompanying prenatal examinations, self-compassion level and emotional inhibition. [ABSTRACT FROM AUTHOR]