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脑小血管病（small vessel disease,SVD）是衰老过程中的常见疾病，可出现卒中、认知障碍、神经心理症状或其他功能损害表现。脑小血管病国际影像标准1（standards for reporting vascular changes on neuroimaging 1，STRIVE-1）对结构MRI上所见的SVD不同影像特征，包括脑白质高信号、血管周围间隙、微出血、近期皮质下小梗死、假定血管源性腔隙和脑萎缩，进行了分类和标准化。随着对SVD影像特征认识的逐渐清晰，以及机器学习方法的迅速兴起，新的SVD研究的神经影像学标准——STRIVE-2已发布。为更全面地反映SVD对大脑的影响，STRIVE-2新增加了脑皮质的微梗死、偶发DWI阳性病灶等影像学特征，同时提出了当前SVD相关研究的困境和未来科研发展的希望。 Abstract: Cerebral small vessel disease (SVD) is a common disease in the aging process that would result in stroke, cognitive impairment, neuropsychological disorders or symptoms, and other functional impairments. Standards for reporting vascular changes on neuroimaging-1 (STRIVE-1) categorised and standardised the diverse features of SVD that are visible on structural MRI, including white matter hyperintensity, perivascular space, cerebral microbleed, recent small subcortical infarcts, lacune (of presumed vascular origin) and brain atrophy. With the understanding of the influence of SVD image features becoming clearer, combined with the rapidly emerging machine learning methods, a new neuroimaging standard for the study of small cerebral vascular disease has been updated which is STRIVE-2. In order to capture the effect of SVD on the brain more comprehensively, STRIVE-2 newly added imaging features such as cortical cerebral microinfarct and incidental DWI+ lesion. In addition, the STRIVE-2 presents the dilemmas of current researches and the hopes for future research development.

目的 探讨以问题为导向的教学法（problem-based learning，PBL）联合翻转课堂教学法在卒中临床教育中的应用价值。 方法 纳入于2022年9—11月在吉林大学第一医院卒中中心进行住院医师规范化培训的70名研究生，将其随机分为对照组和研究组，每组各35人。对照组采用传统教学方法，研究组采用PBL联合翻转课堂教学法，经过为期8个课时的培训，对两组分别进行理论和实践考核，比较考核结果，采用问卷调查的形式对受试者自我综合能力提升效果进行评价。 结果 研究组的实践考核分数[（41.66±1.57）分 vs.（36.29±2.02）分]、理论与实践考核总分数[（88.26±2.06）分 vs.（82.17±2.48）分]以及包括学习兴趣[（3.9±0.4）分 vs.（3.2±0.4）分]、自学能力[（3.7±0.4）分 vs.（3.1±0.9）分]、临床问诊能力[（3.7±0.6）分 vs.（3.2±0.4）分]、创新能力[（3.6±0.5）分 vs.（2.9±0.5）分]和人际交往及团队协作能力[（3.9±0.3）分 vs.（3.0±0.9）分]在内的评分均高于对照组，差异均有统计学意义（P

阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea syndrome，OSAS）是最常见的慢性疾病之一，也是导致发生卒中、卒中后功能恢复不良及卒中再发的独立危险因素。60%～70%的卒中患者在急性期出现睡眠呼吸暂停，其中以OSAS最常见。目前多导睡眠监测是OSAS诊断的“金标准”，但其操作过程烦琐，需要大量的医务人员，检查费用较高，易致OSAS患者诊疗延迟。目前已经研发出一些OSAS的院外筛查设备，但其准确性仍有待提高。因此，寻求一种操作简便、快捷有效的诊断方法，定期筛查潜在OSAS患者仍具有重要的临床意义。目前OSAS血清诊断标志物筛查可能成为一个理想的筛查OSAS的方法并为预测卒中预后提供参考依据。本文对OSAS在卒中发病病理生理机制中生物标志物的研究进展进行综述，希望有助于指导卒中伴OSAS的诊断、治疗、预防和预后。 Abstract: Obstructive sleep apnea syndrome (OSAS) is one of the most common chronic disorders, with an independent risk factor for stroke, poor recovery after stroke, and recurrent stroke. 60%-70% of patients with stroke have sleep apnea in the acute stage, of which OSAS is the most common. The current diagnostic criteria for OSAS is polysomnography, but the operation process is cumbersome, requires a large number of medical staff, and the examination is expensive, which delays the diagnosis and treatment of OSAS. Some out-of-hospital screening devices for OSAS have been developed, but their accuracy needs to be improved. Therefore, it is of great significance to find a simple, fast and effective diagnostic method and regularly screen potential OSAS. At present, biomarkers of OSAS may become an ideal method for screening OSAS and provide a reference for predicting stroke prognosis. This paper reviews the research progress of biomarkers of OSAS in the pathogenesis and physiology of stroke, hoping to help clinicians improve the diagnosis, treatment, disease prevention and prognosis of patients with stroke with OSAS.

目的 将以问题为基础的教学（problem-based learning，PBL）模式联合虚拟现实技术（virtual reality，VR）引入神经病学理论及实习教学，探究其对卒中后睡眠障碍临床教学质量的改善作用。 方法 纳入2022年9月—2023年1月在吉林大学第一医院神经内科进行学习的70名研究生，随机分为对照组和试验组，每组各35人，对照组采用PBL教学模式，试验组采用PBL联合VR教学模式，教学内容为卒中后睡眠障碍的解剖学基础。课程结束后，对两组学生进行试卷考核和问卷调查，比较两组学生试卷考核成绩及问卷调查结果。 结果 试验组学生基础理论成绩[（46.03±1.76）分 vs.（43.69±1.91）分]、病例分析成绩[（42.11±2.19）分 vs.（39.57±2.56）分]及总成绩[（88.14±2.55）分 vs.（83.26±3.55）分]均高于对照组，差异有统计学意义（P＜0.001）。试验组学生对于本次课程在激发学习积极性[（2.63±0.49）分 vs.（2.11±0.47）分]、提高学习效率[（2.57±0.50）分 vs.（1.97±0.57）分]、提高自学能力[（2.54±0.51）分 vs.（2.00±0.42）分]、培养临床思维 [（2.51±0.51）分 vs.（1.94±0.42）分] 的作用评价均高于对照组，差异有统计学意义（P＜0.001）。 结论 PBL联合VR教学模式引入神经病学临床教学可提高卒中后睡眠障碍临床教育的教学质量。 Abstract: Objective To explore the effect of problem-based learning (PBL) combined with virtual reality (VR) into neurology clinical teaching on post-stroke sleep disorder. Methods A total of 70 postgraduates who underwent training in the Department of Neurology of the First Hospital of Jilin University from September 2022 to January 2023 were included and randomly divided into the experimental group and the control group, 35 in each group. The control group adopted PBL teaching method, and the experimental group adopted PBL combined with VR teaching method. The teaching content was about the anatomical basis of post-stroke sleep disorder. After the course, two groups were assessed with test papers and questionnaires, and the assessment results were compared. Results Students in the experimental group had higher scores in basic theory (46.03±1.76 vs. 43.69±1.91), case analysis (42.11±2.19 vs. 39.57±2.56) and total score (88.14±2.55 vs. 83.26±3.55)than the control group, and the difference was statistically significant (P

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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Aiming at the problem of "fast and precise" in the optimization of joint fire strike scheme， a cross-entropy-quantum particle swarm optimization algorithm is designed， and an intelligent optimization method of joint fire strike scheme based on this algorithm is proposed. The algorithm fully combines the good global optimization ability of the cross-entropy algorithm and the efficient operation of the quantum particle swarm algorithm. By constructing a discrete probability matrix， the uncertain motion of the particles is more directional and the cooperative optimization ability of the particles is improved. The experimental results show that the intelligent optimization method of the joint fire strike scheme based on this algorithm can effectively improve the optimization effect and optimization efficiency of the joint fire strike scheme， and has obvious advantages compared with the standard cross-entropy algorithm and the standard quantum particle swarm optimization algorithm. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Cluster well drilling is an important method for the development of onshore and offshore oil and gas resources. The optimization of drilling platform location is the key prerequisite for reducing cluster well drilling investment and operational risks. By analyzing the principle of platform location optimization of cluster wells, this paper constructs the platform location optimization model by using the entropy weight method. According to the data difference degree of each evaluation index, the weight and scheme score are calculated, and the factors affecting the platform location selection are comprehensively analyzed and quantitatively evaluated. Through the application of a cluster well platform to the Bohai oilfield, the results show that the evaluation model is feasible and consistent with the conclusions of the qualitative analysis, thus providing a new guideline for platform location optimization. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The KBaY（BO3)2:Sm3+phosphors were synthesized by the solid-state method. The prepared samples were characterized by X-ray diffraction（XRD）and Photoluminescence spectrometer. The results revealed that the obtained samples have pure phase, and the Sm3+ions enter the lattice preferentially occupying the Y3+sites. Under the excitation of near-ultraviolet light（404 nm）, the main emission peaks were located at 573 nm, 610 nm and 657 nm, respectively. The optimal doping concentration of Sm3+ ions is 0.04, and the main mode of energy transfer between Sm3+ions is the dipole-dipole interaction in multipolar interactions. Under the optimum doping concentration, the correlated color temperature of the phosphors is 2 765.07 K, which is in the best color temperature region and makes up for the disadvantage of high color temperature of traditional yellow phosphors. [ABSTRACT FROM AUTHOR]