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目的探究影响不同新生儿危重评分对超低出生体质量儿（ELBWI）死亡风险准确预测的相关因素。方法自2019年1月1日至2021年1月1日南京医科大学附属儿童医院和东南大学附属中大医院溧水分院新生儿科收治的ELBWI 186例，经纳入和排除标准筛选后最终纳入125名ELBWI。其中死亡组47例、存活组78例。收集围生期一般资料以及新生儿急性生理学评分-Ⅱ（SNAP-Ⅱ）、新生儿急性生理学评分围生期补充-Ⅱ（SNAPPE-Ⅱ）、新生儿临床危险指数（CRIB）、新生儿临床危险指数-Ⅱ（CRIB-Ⅱ）以及国内开发的新生儿危重病例评分（NCIS）其包含的所有评分条目内容进行单变量、多变量统计，并绘制列线图及受试者工作曲线（ROC）进行分析。结果生后收缩压、最大吸入氧浓度、BE值和出生体质量是影响ELBWI死亡风险准确评估的重要因素［收缩压OR值0.968，95%CI： 0.938-0.999，P =0.043；最大吸入氧浓度OR值1.020，95%CI：1.006-1.034，P =0.006；BE的OR值0.868，95%CI： 0.786-0.959，P =0.005；出生体质量OR值0.994，95%CI： 0.991-0.997，P =0.000］，ROC示以上四者的综合曲线下面积0.71、95%可信区间0.610-0.799，优于CRIB评分。结论较低收缩压、较高吸入氧浓度、较大BE值、较小出生体质量为影响ELBWI死亡风险准确评估的关键因素。在新评分的开发中，推荐将以上四者纳入评估条目可得到效率更优的ELBWI危重评分预测体系。

Based on the principle of blade tip timing（ BTT） and the vibration principle of one degree of freedom,the parameter identification algorithm of rotating blade asynchronous vibration is established by using all phase FFT（ apFFT） and least square method.The algorithm is verified by numerical simulation,and the test parameter and empirical value of the rationality for sensor layout are given.The tests of asynchronous vibration parameter identification were launched on a fan rotor,while high pressure nitrogen was used to shock the blades to produce single frequency absolute occupancy vibration.Results show that the method for asynchronous vibration identification could accurately identify blade vibration parameters,and the vibration frequencies of all blades obtained are exactly the same.Frequency identification accuracy is high with the maximum relative error of 1.12% using strain analysis frequency as a baseline.Results verify that the method of asynchronous vibration parameter identification is correct.

【目的】探讨登革病毒I型（DENV-1）感染时，机体B细胞和浆细胞随病程的动态变化及其与疾病严重性的关系，为重症登革热的早期预警或治疗提供可能依据。【方法】选择2014年9月至12月登革热住院病例62例，设轻症登革热组（DF，n=33）、重症登革热组（SD，n=29）及对照组（control，n=6）。采用多色流式细胞技术分析患者急性期及极期的外周血中B细胞及浆细胞随病程的动态变化及其在重症和轻症组的差异。进一步通过系列样品分析同一感染者（包括轻症和重症各3例）浆细胞随病程的变化，并且观察登革病毒初次及二次感染时，B细胞及其亚群即初始B细胞、记忆B细胞和浆细胞的变化。【结果】重症组B细胞扩增明显高于轻症组（=0.013），特别是在病程第5~6天（=0.017，0.002）。轻症组和重症组浆细胞与对照组相比均有明显的增殖（=0.011，0.032），但轻症和重症两组间相比差异无统计学意义。同一感染者系列样品分析显示，轻症病例浆细胞在病程第7~8天达高峰，第10天基本恢复正常。重症病例在病程第7~9天达高峰，但在病程10d后仍有一定量的增殖。对于轻症登革热，二次感染组表现出更明显的B细胞增殖、初始B细胞减少及记忆B细胞减少（=0.028，0.010，0.037），但浆细胞变化未体现出差异。而对于重症登革热，在二次感染时仅初始B细胞明显减少（=0.018）。【结论】DENV-1血清型感染时轻症和重症登革热组B细胞反应呈现不同的趋势。宿主在病程早期B细胞的明显扩增以及浆细胞延迟反应可能与疾病严重性相关。

光纤传输网具有独特的优势,但也有特殊的脆弱性。随着光纤通信技术的快速发展和广泛应用,光纤传输网的安全性显得越来越重要。文章按照分层的观点,介绍了光纤传输网的安全分层结构,分析了光纤传输网不同层面的脆弱性和所受攻击的类型及方法,并针对各层可能受到的安全威胁,研究了相关的安全对策。

BACKGROUND: Filamin B (FLNB) can crosslink the actin cytoskeleton into a dynamic structure that is essential for the directional movement of cells. It can regulate the proliferation, differentiation and apoptosis of chondrocytes. However, the effect of FLNB on osteoblast proliferation, migration and apoptosis has not been reported. OBJECTIVE: To investigate the effect of FLNB on the proliferation, migration and apoptosis of MC3T3-E1 cells. METHODS: The adenoviral vectors for knockdown of FLNB expression (sh-FLNB1, sh-FLNB2, sh-FLNB3) were constructed and infected with MC3T3-E1 cells. After screened by puromycin drug, the efficiency of FLNB knockdown was detected by western blot and RT-PCR. The MC3T3-E1 cell line with the best efficiency of FLNB knockdown was selected as the stable transient cell line of MC3T3-E1 for subsequent experiments. The cells were divided into blank group, mc3t3 group, sh-NC group (empty vector), and sh-FLNB group (sh-FLNB lentivirus). The blank group was cultured in cell-free α-MEM complete medium; the mc3t3 group was cultured in α-MEM complete medium alone; and the sh-NC and sh-FLNB groups were cultured with α-MEM medium containing 2.5 μg/mL puromycin. After 3 days of culture, cell counting kit-8 assay and cell scratch assay were used to detect the proliferation and migration ability of MC3T3-E1; flow cytometry was used to detect cell apoptosis; and RT-PCR was used to detect the expression of apoptosis-related genes. RESULTS AND CONCLUSION: Western blot and RT-PCR results showed that the efficiency of FLNB knockdown was the best in the sh-FLNB3 (P < 0.000 1), which was used as a stable cell line for subsequent experiments. Cell counting kit-8 data showed that the proliferative ability of MC3T3 cells was significantly weakened after knockdown of FLNB (P < 0.05). Cell scratch assay results showed that the migration ability of MC3T3 cells was significantly decreased after knockdown of FLNB. Flow cytometry and RT-PCR results showed that the apoptotic rate of MC3T3-E1 cells increased after knockdown of FLNB, the expression of pro-apoptotic factor Bax increased significantly, and the expression of anti-apoptotic factor Bcl-2 decreased significantly (P < 0.05). To conclude, knockdown of FLNB can reduce the proliferation ability of MC3T3-E1 cells, decrease the migration ability of the cells, and increase cell apoptosis. [ABSTRACT FROM AUTHOR]

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Objective To construct an evaluation index for the post competency of case managers of diabetes foot, and to provide an objective and scientific theoretical basis for the selection, training and assessment of case managers of diabetes foot. Methods Based on the iceberg model of post competency, through literature review and semi-structured in-depth interview and consultation with 10 specialized nurses from different departments in the hospital, the primary index of post competency evaluation for case managers of diabetic foot was established, and 19 experts were consulted by Delphi expert letter method for three rounds, and the index system of post competency evaluation for case managers of diabetic foot was established in combination with the actual situation and expert opinions of the hospital. Results After three rounds of consultation, the questionnaire response rate was 100%, with Kendall′s harmony coefficients of 0. 136-0. 270, 0. 182-0. 235, 0. 184-0. 341, and expert authority coefficients of 0. 926, 0. 955, and 0. 961, respectively. Finally, a competency evaluation index system for diabetes foot case managers was formed with five first level indicators（nursing decision-making ability, interpersonal communication ability, quality supervision ability, education guidance ability, scientific research innovation ability), 13 second level indicators, and 69 third level indicators. Conclusion The competency evaluation index system of diabetes foot case managers constructed in this study is scientific, practical and reliable, which can provide quantifiable index reference for the selection, training, assessment and evaluation of diabetes foot case managers. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective] The identification of HaYABBY gene related to flower development in sunflower (Helianthus annuus L.) is conductive to exploring its biological function and regulatory mechanism in the floral development of sunflower, and to provide important molecular clues for sunflower variety breeding. [Method] Based on sunflower genome database and our transcriptome data, bioinformatics analysis was conducted to analyze the physicochemical properties, chromosome localization, phylogenetic relationship, gene structure, conserved motif, protein structure, promoter cis-action regulatory element, and tissue expression pattern, etc. RT-qPCR was used to analyze the differences of HaYABBY gene expression between WT sunflower and cb1 (crazy broccoli 1) mutant with the defection of meristem determinacy and floral organ differentiation at st2-st8. [Result] Twelve members of YABBY family were identified, belonging to 4 subfamilies, and located in 8 chromosomes; meanwhile, the members in the same subfamily shared similar gene structure and conserved motifs. Results of tissue expression pattern showed that 8 members presented high expressions during flower development in sunflower, including HaYABBY1a, HaYABBY1c, HaYABBY3, HaYABBY4b, HaYABBY5a, HaYABBY5b, HaCRABS CLAWa, and HaCRABS CLAWb, among which HaYABBY3, HaYABBYY5a, and HaYABBYY5d expressed with up-regulation at the late stages of flower development in cb1 mutant; while the expression of HaYABBYY4b and HaCRABS CLAWa was strongly inhibited in cb1 mutants, corresponding to their expressions at early floral developmental in WT plants. The analysis of cis-regulatory elements showed that all the HaYABBY members contained multiple promoter cis-acting elements, some acting elements only existing in specific genes. Among them, endosperm expression elements were presented in HaCRABS CLAWa and HaYABBY4a. Auxin responders were in HaCRABS CLAWa, HaCRABS CLAWb, HaYABBY4a, HaYABBY4b and HaYABBY5c. Meristem expression elements existed in HaYABBY1a, HaYABBY1c, HaYABBY4b, HaYABBY5a, and HaYABBY5d. Gibberellin response elements were included in HaCRABS CLAWa, HaYABBY5b, HaYABBY5c, and HaYABBY5d. Seed-specific regulatory elements presented in HaYABBY5a, HaYABBY5c, and HaYABBY5d. [Conclusion] Five HaYABBY genes of HaYABBY3, HaYABBY4b, HaYABBY5a, HaYABBY5d and HaCRABS CLAW play important roles in the process of floral meristem transformation and floral organ formation in sunflower, and they might depend on the regulation of auxin, gibberellin and meristem expression related regulators during meristem transformation and floral organogenesis, and need the involvement of the auxin response factor ARFs, gibberellin response factor MYBs and flower organ development regulator MADS-boxes. [ABSTRACT FROM AUTHOR]

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The mammalian target of rapamycin (mTOR) is a highly conserved kinase that regulates biological growth and homeostasis by sensing and integrating signals from the cellular environment, playing a crucial role in the growth processes of many cells. Autophagy is a highly conserved process of substance degradation and recycling in eukaryotes. Recent genetic and functional studies have shown that mTOR plays an important regulatory role in bone homeostasis through the autophagy pathway. As a key component of the PI3K/AKT/mTOR signaling pathway, the activation or inhibition of mTOR has both positive and negative regulatory effects on bone formation mediated by bone marrow mesenchymal stem cells/osteoclasts. Given the significant regulatory role of mTOR in autophagy in bone homeostasis, this article provides a comprehensive review of the relationship between mTOR, autophagy, and bone homeostasis, and explores the therapeutic potential of mTOR in osteoporosis, and hopes to provide new insights and approaches for the pathogenesis and treatment of osteoporosis. [ABSTRACT FROM AUTHOR]

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