Objective: To study the effect of flunarizine combined with nerve growth factor(NGF) on NIHSS in patients with cerebral hemorrhage, ADL score and volume of hematoma. Methods: 98 cases of cerebral hemorrhage admitted to our hospital from September 2015 to October 2016 were selected as the study subjects, and divided into 2 groups by random number method, 49 cases in each group. Patients in the control group received conventional basic treatment, and patients in the study group received oral sibiline combined with intramuscular injection of NGF on the basis of this treatment. Compare two groups of patients with total effective rate of treatment, at the same time comparative hematoma, edema zone volume, neural function defect scale(NIHSS) scores, daily life ability scale(ADL)score, neurogenic nutrition factor(BDNF), monocyte chemotactic protein 1(MCP 1), neuron specific enolization enzyme(NSE) level changes and adverse reactions occur. Results: After treatment, the total effective rate between the two groups was significantly different(P<0.05). Before treatment, there were no significant differences in hematoma volume and edema zone volume between the study group and the control group. After treatment, the volume of hematoma and edema zone in the study group and the control group decreased with time, and the difference was significant(P<0.05). Before treatment, there were no significant differences in NIHSS and ADL scores between the study group and the control group. After treatment, the NIHSS of the study group and the control group decreased over time, and the ADL score of the study group was higher than that of the control group, and the difference was significant(P<0.05). Before treatment, there were no significant differences in BDNF, MCP-1 and NSE between the study group and the control group. After treatment,MCP-1 and NSE of the study group and control group decreased with time, and both of the study group were lower than the control group, while BDNF increased with time, and the study group was higher than the control group, the difference was significant(P<0.05).There was no significant difference in ADR between the two groups (P>0.05). Conclusion: The effect of sibilin combined with NGF in patients with intracerebral hemorrhage is reliable, which can significantly reduce the secondary injury, and the treatment is safe and worthy of clinical promotion. [ABSTRACT FROM AUTHOR]