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The section K0 +785 -K0 +988 on the north shore of the Dalian Bay immersed tunnel, which is higher than the original seabed surface, is susceptible to ship collision risks and requires anti-collision measures. Taking into account factors such as construction difficulty, environmental protection, and cost, a permeable gravity pier foundation composed of circular caissons, column piles, and cast-in-place piers was proposed as the anti-collision structure, while meeting the requirements of the construction period. Combined with the structural form and main loads of the anti-collision pier, the overall stability of the anti-collision pier structure and the bearing capacity of the column piles were analyzed and calculated using finite element method and specification method. The results show that the permeable gravity pier anti-collision structure can meet the requirements of engineering use in all aspects, and can provide design reference for the construction of similar structures in the future. [ABSTRACT FROM AUTHOR]

The evolution of granite􀆳s mechanical characteristics with temperature is a contentious topic in the field of rock mechanics, and little research has been done on how its microstructures vary with temperature. The design of the constant amplitude temperature cycle and peak increasing temperature cycle loads was based on modern testing technology and experimental apparatus, with a particular emphasis on the generation and propagation law of granite microcracks under their action and a discussion of the influence of weathering degree. The results suggest that the peak temperature has a stronger influence on the formation of the fracture network than the total number of cycles. Temperature load can be slightly mitigated by weathering, but a thermal cycle with an increasing peak value can promote the growth of surface fracture. The understanding of the evolution of rock mechanical properties under temperature will be promoted in this study. [ABSTRACT FROM AUTHOR]

Objective To observe the clinical efficacy and complications of β receptor blockers for infantile hemangioma (IH) and observe the effect on growth and development during treatment. Methods From January 2017 to may 2022, 33 IH children were recruited. They were randomized into two groups of propranolol (n=22) and atenolol (n=11) according to parental wishes. No significant inter-group differences existed in age, gender, location or type (P>0.05). The former group received an oral dose of non-selective propranolol 1.5-2 mg·kg-1·d-1. And the latter group was prescribed with atenolol at 0.5 mg·kg-1·d-1 in the first week and then 1 mg·kg-1·d-1. During monthly follow-ups, the changes of clinical manifestations such as tumor color, size, texture and the complications were recorded. Color Doppler ultrasound was performed for measuring tumor volume and evaluating growth and development. Results There was nostatistically significant difference in the age, gender, Location, and type of initial diagnosis between the two groups of chidren(P > 0.05). The effective rate of both groups was 100%. No statistically significant reduction occurred in tumor volume in neither groups at Month 1, 5-6 and 10-12 post-treatment (P>0.05). Adverse reactions of drug dosing occurred in propranolol group (5/22, 22.7%) with respiratory symptoms, fretting or sleep disorder and atenolol group(2/11, 18.2%)with fretting or sleep disorder. No other serious adverse reactions occurred. No abnormality was found in physical development of neither groups during follow-ups. The developmental quotient of two groups did not differ significantly at Month 1/3/6/9 post-dosing (P>0.05). Conclusions The efficacies and complications of propranolol and atenolol are comparable for infantile hemangioma. No significant inter-group difference exists in growth and development during treatment. Regarding the impact of respiratory tract, atenolol may replace propranolol for infantile hemangiomas. [ABSTRACT FROM AUTHOR]

The mammalian navigation system comprises various kinds of neurons responsible for position perception and spatial path planning, involving the integration of multiple information sources. As a unified brain theory capable of providing explanations for complex cognitive functions like memory and decision-making, the theory of attractor dynamics can elucidate the firing dynamics of neurons and path integration in the navigation system. This review describes recent advances in attract。y dynamics in spatial cognition. First, it provides a brief overview of computational neuroscience and the general theory of attract oy dynamics. Subsequently, focusing on the continuous attractor dynamics, it delves into the dynamical characteristics and functional significance of head direction cells and grid cells. Finally, an extension and prospects of the attractort heory for spatial cognition are presented. [ABSTRACT FROM AUTHOR]

The organic matter content of melon and fruit waste is high, and the conventional landfill treatment method is easily to induce environmental pollution. Aiming at the problem of insufficient carbon sources for biological denitrification in urban sewage treatment, anaerobic fermentation technology can degrade such organic waste into organic acids as supplementary carbon sources to promote biological denitrification. Therefore, in this research, the effects of inoculation ratio (F/M=0. 5, 1.0 and 1.5) and the type of fermentation bacteria on the acid production of mesophilic anaerobic fermentation of melon and fruit waste were researched by batch experiments under the conditions of inoculation of lactic acid bacteria and anaerobic sludge. The results demonstrated that the volatile fatty acids (VFAs) yields were 9 145±781 mg COD/L and 7 916±1081 mg COD/L under the conditions of F/M=1.0 and 1.5, both of which were higher than that of VFAs yields at F/M=0.5, and the primary product was valeric acid. During anaerobic sludge fermentation, the VFAs production of fermentation broth under the condition of F/M=0. 5 reached the maximum at 11 d, which was 11 675±578 mg COD/L, and acetic acid accounted for 67% of the total VFAs. The anaerobic denitrification experiments of activated sludge were conducted out with the fermentation broth of lactic acid bacteria fermentation group under F/M=1.0 and 1.5 and the fermentation broth of anaerobic sludge fermentation group under F/M=0.5 as carbon sources. The denitrification rates of sludge were 5.75 mg NO-3-N/ (g MLSS·h), 3.68 mg NO-3-N/ (g MLSS·h) and 8.46 mg NO-3-N/ (g MLSS·h), while the control group utilized sodium acetate as carbon source. The denitrification rate was 6.44 mg NO-3-N/ (g MLSS·h). The results demonstrated that anaerobic sludge was utilized for the moderate temperature fermentation of melon and fruit waste. When the inoculation ratio F/M was 0.5, the acid output was the largest, and the fermentation broth had great utilization performance as an external carbon source for denitrification of activated sludge. The research results provide a theoretical reference for further exploration of the resource utilization of melon and fruit waste and the development of activated sludge denitrification carbon source. [ABSTRACT FROM AUTHOR]

Objective This study aimed to explore the predictive value of endoplasmic reticulum stress response （ERS）-related regulatory gene expression for the pathological grading, prognosis, and malignant progression phenotype of gliomas （excluding glioblastomas）. Methods After excluding duplicate and non-survival samples, clinical sequencing data of glioma samples from the American Cancer Genome Atlas and the Chinese Brain Glioma Genome Atlas were selected as the training and validation sets. A prognosis-related ERS risk regression model was constructed through differential gene enrichment and protein interaction analysis. The predictive value of ERS Cox model for glioma prognosis and malignant progression phenotype was validated using ROC curve analysis, real-time fluorescence quantitative PCR, and immunohistochemistry. Results The study findings reveal that the expression of 7 ERS-related risk factors increases with the rise in glioma grade and accurately predicts unfavorable patient prognosis （with accuracies higher than 0.7 for predictions at 1, 3, and 5 years）, all of which are statistically significant. Further validation demonstrates a positive correlation between ERS risk genes and the glioma malignant phenotype marker CD44, as well as a negative correlation with the clinically favorable prognosis marker GPR158, both of which have statistical differences （P < 0.05）. Finally, gene expression and immunohistochemistry analysis of clinical samples confirm that ERS-related risk factors are highly expressed in higher-grade gliomas, positively correlated with CD44 expression, with statistical significance （P < 0.05）.Conclusion The preliminary results of the study suggest that the risk regression model based on ERS response exhibits the capacity to predict pathological grading and prognosis. Moreover, it demonstrates a positive correlation with the malignant progression phenotype of gliomas. These findings offer insights for precise and targeted diagnosis and treatment of gliomas. [ABSTRACT FROM AUTHOR]

In view of the problems of chemical adsorption and chromatographic separation existing in the field application of polyacylamide and cross-linking agent, using N-hydroxymethylacrylamide(NHMAM), acrylamide (AM), acrylic acid (A A) and sodium 2-acrylamid o・ 2-methylpropanesulfonate (AMPSNa) as comonomers, and a quaternary copolymer was synthesized by aqueous solution copolymerization, and the structure of the copolymer was characterized・ The effects of pH, NHMAM content and polymer concentration on the crossrate of polymer solution were studied, and the aging-resistance and microscopic morphology of cross-linked gel were investigated ・ The results showed that the quaternary copolymer could spontaneously crosslinking in aqueous solution to form gel, and the gelling reaction was pH responsive・ If decrease the pH or increase the NHMAM content and polymer concentration the gelling time will be shorter. The viscosity retention rate of crosslinking copolymer at 90 °C for 90 d could reach 90%, reflecting an unusually good aging-resistance. [ABSTRACT FROM AUTHOR]

For the complex layout of large civil transport airports with multiple terminals and aprons, to scientifically determine the usage pattern of the multi-terminal area, based on the construction of multi-terminal area operation influence factors set, the adversarial interpretive structure modeling method(AISM) was improved by using the fuzzy theory, The horizontal intercept distribution was indepth analyzed by the fuzzy reachable matrix, and then the confrontation hierarchy model of multi-terminal area operation influence factors was obtained. Finally, the correlation and logic between the factors were analyzed by the topology diagram of the adversarial hierarchy and the fuzzy driver-dependency diagram, and the long-term planning of one of the trunk airports of the Guangdong-Hong Kong-Macao Greater Bay Area was used as an example to verify. The results show that the annual airline passenger traffic and the number of airline peak hour passengers have higher driving force and weaker dependence. The airline space allocation and utilization strategy and the accessibility of the decentralized inter-terminal mass rapid transit(MRT) system have lower driving force and higher dependence. Combining the surface, intermediate, and deep influencing factors revealed by the confrontation hierarchy topology diagram, it is clear that annual airline passenger traffic and peak hour passenger count are the most root and critical design influencing factors of zonal operation. [ABSTRACT FROM AUTHOR]

When conventional guanidine gum fracturing fluid is used for the construction of tight oil reservoir, there are some problems such as low flow-back rate. great damage to the reservoir and high treatment cost of flow-back fluid. Therefore, a new low damage non flowback guanidine gum fracturing fluid system suitable for tight oil reservoir is developed with multivariate modified guanidine gum HPG-GX, anionic surfactant YSN-1 and composite gel breaker FP-3 as the main treatment agents. It's comprehensive performance is evaluated. The results show that the fracturing fluid system has good temperature resistance, shear resist ance and filtration performance, and can meet the basic needs of fracturing operation; Moreover, when the dosage of compound breaker FP-3 is 0. 15%, the fracturing fluid system can break the gel rapidly. The viscosity and interfacial tension of the gel breaker are low, the residue content is less, and the damage rate of the gel breaker to the matrix permeability of the natural core is less than 15%, which has the characteristics of low damage; In addition, as an imbibition fluid, the imbibition recovery of natural core can reach 28.6%, and the imbibition oil displacement effect is obviously better than that of conventional hydroxypropyl guanidine gel fracturing fluid. After WQ-11 well is fractured with a new low damage non flow-back guanidine gum fracturing fluid system, the daily oil production and cumulative oil increase are significantly higher than that of WQ-03 well with conventional hydroxypropyl guanidine gum fracturing fluid in the same block, achieving good fracturing and stimulation effect. [ABSTRACT FROM AUTHOR]

The frequent leakage and large loss of drilling fluid during drilling in Bozi area of Tarim Oilfield have caused huge economic losses, which is a major difficulty in exploration and development in this area at present. The existing traditional fracture plugging simulation method is difficult to simulate the downhole fracture conditions, resulting in a large difference between the indoor experimental results and the field application. Taking the Bozi area as an example, through the analysis of its reservoir characteristics, it is clear that the reservoir leakage is caused by natural fracture leakage and weak formation fracture; Based on 3D scanning and printing technology, a simulation fracture plate with real fracture characteristics of the reservoir is made, and a new method of fracture plugging simulation is established with this as the core. The evaluation experiment of plugging formula under different fracture widths is carried out using self-developed plugging instrument. The experimental results show that the new method of fracture plugging simulation is applicable to the simulation and evaluation of the plugging formula in multi-scale fractured formations, and can provide strong support for the on-site testing of the plugging formula for fracture loss. [ABSTRACT FROM AUTHOR]

To realize the high-quality processing of wooden windows, it is necessary to study the dynamic characteristics of the spindle system of the double-ended composite finishing milling machine tool, which can provide a theoretical basis for its structure optimization and vibration reduction. A simplified three-dimensional model of the spindle system was established using the software Adams, and the cutting force and the stiffness of the spindle system supporting bearings were calculated when the milling machine processed wooden windows, and combined the software Ansys and Adams to establish a rigid-flexible coupling model of the flexible spindle, and simulated the rigid body model and the rigid-flexible coupling model of the spindle system. The X, Y, and Z vibration curves at the centroid of the spindle, cutting force action point and the pulley connection point were extracted. The simulation results showed that the X and Z direction amplitudes of the cutting force action point were the largest, and the amplitude of the centroid and the cutting force action point when the spindle was a flexible body was much smaller than when the spindle was rigid. The results of this study showed that the dynamic characteristics of the spindle as a flexible body are more in line with the actual working conditions, and the vibration curve of the three points provides a certain theoretical basis for the structural optimization of the spindle system. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of different corneal surface treatments in full femtosecond SMILE surgery. Methods: Fifty patients who came to our hospital from October 2021 to September 2022 for full femtosecond SMILE surgery were selected.According to the principle of operation first on the right and then on the left, the left and right eyes were not fixed in the observation eye and the control eye. The observation eye was selected for 25 cases, the left eye was selected for 25 cases, and the other eye was selected for the control eye. After eyelid opening, clean the corneal surface with triangle sponge. The eyelid was opened with a blepharoscope after eye self-purification（blinking) in control eyes. The corneal optical density, corneal surface particulate matter count, corneal surface moisture, intraoperative negative pressure suction completion time, desorption ratio and OBL incidence were compared between the observation eyes and the control eyes, and the comfort level of 50 patients was analyzed. Results: The corneal optical density of the observation eye was 16.33±2.12 and that of the control group was 16.85±2.58, with no statistical significance between groups（t=-1.101,P=0.274). The count of particulate matter on the surface of the control eyes was lower than that of the observation eyes, and the surface moisture of the cornea was higher than that of the observation eyes（P＜0.05). The time of negative pressure suction and the time between the control eyes and the observation group（P＞0.05). The incidence of OBL in observation eyes was 6.00 %, and that in control eyes was2.00 %. Tthere was no statistical significance between groups（P=0.617＞0.05). Among the 50 patients, 32.00%（16/50) felt afraid of wiping the cornea with triangle sponge, 20.00 %（10/50) of patients affected the green spot of fixation after wiping the cornea with triangle sponge, and 20 patients chose to wipe the cornea with triangle sponge during the operation, accounting for 40.00 %（20/50). 30 cases of eye self-purification（blinking) were selected, accounting for 60.00 %（30/50). Conclusion: Eye self-purification（blink) can replace the triangular sponge to wipe the cornea, and be used for full femtosecond SMILE surgery to improve patient comfort. [ABSTRACT FROM AUTHOR]

Liver cancer is an important public health issue worldwide. With the improvements in high-throughput sequencing and gene editing techniques in recent years, studies have further revealed the biological mechanism of intestinal microflora in the development, progression, and metastasis of liver cancer via the gut-liver axis, and in particular, it has been found that lipopolysaccharide, a component of the outer membrane of gram-negative bacteria, can cause downstream immune cascade reactions. This article reviews the possible mechanism of action of intestinal microflora lipopolysaccharide in the development and progression of liver cancer from the aspects of the association between intestinal environmental changes and liver cancer, immunoregulation by lipopolysaccharide, and preclinical treatment. [ABSTRACT FROM AUTHOR]

[Objective] The present paper aimed to investigate the effects of rearing material nutrients and juvenile hormone Ⅲ (JHIII) on the growth and development of Hepialus menyuanicus larvae, and to clarify the direct and indirect relationships between rearing material nutrients and JHIII on the growth and development of larvae using through path analysis. [Method] The newly molted 3rd instar larvae were studied with coconut flour as the rearing substrate, and a two-factor experimental design was used with four rearing materials[J: (Potentilla anserina), H: (Daucus carota), Z: (Polygonum viviparum) and D: (Rheum palmatum) ]and three JHIII titer levels (B1: 13.32 μg/g, B2: 16.56 μg/g and B3: 22.76 μg/g) were reared on larvae, and the reared materials were analyzed for crude protein, crude fiber, soluble sugar, crude ash, water content, carbohydrate and JHIII on larval growth and development (head width, body length, body weight and survival rate) were analyzed by regression analysis and path analysis. [Result] Both rearing materials and JHIII significantly affected the growth and development of larvae with a significant interaction effect (P＜0.05) .Path analysis showed that JHIII had the greatest direct effect on larval head width, body length, body weight and survival rate (P=-2.56, P=-1.89, P=-3.66, P=2.36) .Crude protein had the greatest indirect promoting effect on head width and body length (P=3.99, P=3.79), soluble sugar had the greatest indirect promoting effect on body weight (P=5.40), and crude ash had the greatest indirect inhibitory effect on survival (P=-5.14), and crude protein, soluble sugar, and crude ash all had the greatest indirect effects on head width and body length, body weight, and survival through JHIII (P=2.23, P=1.64, P=2.93, P=-2.86) . [Conclusion] The paper preliminarily finds the simple mechanism of feeding materials affecting the growth and development of larvae.JHIII is a direct factor affecting the growth and development of larvae, while nutrients in rearing materials are an indirect factor and affect larval growth and development through changes in JHIII titer.The nutrients of rearing materials lead to inconsistent growth and development of larvae by affecting the JHIII titer of the larvae.Among them, crude protein, soluble sugar and crude ash promote the growth of head width and body length of larvae, promote the development of body weight and reduce the survival rate of larvae by inhibiting the JHIII titer.The study provides a scientific reference for the artificial domestication and succession rearing of H.menyuanicus. [ABSTRACT FROM AUTHOR]

Feeding antimicrobial peptides have a special physical membrane breaking bactericidal mechanism and are not easy to produce drug resistance. However, naturally occurring or self-designed antimicrobial peptides are faced with the problem of low environmental stability in vivo. Therefore, it is of great significance to optimize the related properties of antimicrobial peptides by adopting various strategies to alleviate the above problems. The paper reviews various strategies to improve the stability of antimicrobial peptides salts and proteases by molecular genetic methods in recent years, analyzes the advantages and limitations of molecular genetic methods in improving the stability of antimicrobial peptides, to provide ideas for the design of antimicrobial peptides in the future. [ABSTRACT FROM AUTHOR]

S-adenosylmethionine synthase (SAMS) is the only enzyme that catalyzes the synthesis of S-adenosylmethionine (SAM) from methionine and ATP. Research shows that SAMS participates in lignin biosynthesis. In this study, we analyzed the expression patterns and protein interaction networks of the SAMS gene family identified from ’Huangdan’ tea plant (Camellia sinensis) to explore candidate genes of CsSAMS that may be involved in lignin synthesis. Then we identified the members of CsSAMS gene family by bioinformatics based on the genome of ’Huangdan’, and further analyzed their protein physicochemical properties, phylogenetic tree, chromosome location, gene structure,protein structure and expression pattern. We also studied the protein interaction network by yeast two-hybrid technology (Y2H). Finally, we determined the lignin contents of the first bud and the two leaves of ’Haungdan’, ’Tieguanyin’, ’Jinguanyin’ and ’Fuding Dahao’ by UV spectrophotometer. The results of bioinformatics analysis showed that 4 CsSAMS gene family members were identified in ’Huangdan’.The number of encoded amino acids was 345-519, and the isoelectric point ranged from 6.12 to 6.47. The prediction results of subcellular localization revealed that CsSAMS1 was located in the chloroplast, CsSAMS2 and CsSAMS3 were located in the cytoplasm, and CsSAMS4 was located in the cytoskeleton. Expression of CsSAMS and lignin content detection of different tea varieties indicated that CsSAMS2, CsSAMS3 and CsSAMS4 might potentially regulate lignin content. In addition, Y2H results showed that CsSAMS4 formed homodimers with itself. In this study,the physicochemical properties of four CsSAMS members are identified and analyzed, and their functions are predicted. The expression patterns of CsSAMS genes in different tissue sites, under nitrogen and fluoride treatments, as well as the potential involvement of CsSAMS in lignin synthesis process, are clarified. [ABSTRACT FROM AUTHOR]

Our group screened out two genes (CSS0013384 and CSS0036305) related to the albino leaf color of Camellia sinensis Baijiguan through the transcriptome, in order to explore the expression patterns of CSS0013384 and CSS0036305 in albino tea plants interacting proteins. Using cultivar Baijiguan as material, the full-length cDNA sequences of CSS0013384 and CSS0036305 were cloned. Bioinformatics, yeast one-hybrid and yeast two-hybrid were used to analyze the protein physicochemical properties, the phylogenetic tree, the chromosome location, the gene structure, the protein structure, the protein regulation and interaction network, and gene expression pattern. Bioinformatics analysis showed that CSS0013384 and CSS0036305 belonged to the pentatricopeptide repeat protein (PPR) and chaperone (CPN60-like) families, respectively. The lengths of their protein coding sequence (CDS) was 1 893 bp and 1 752 bp, the number of encoded amino acids was 631 and 575, the protein mass was 71.87 kD and 60.79 kD, the isoelectric points were 8.93 and 6.21, the subcellular localization prediction results indicated that CSS0013384 was localized in chloroplast, and CSS0036305 was localized in mitochondria. The RT-qPCR results of the second leaf of Baijiguan under shading and restored light treatment and tea plant varieties with different leaf colors revealed that CSS0013384 and CSS0036305 were highly expressed in albino leaves. CSS0002807 belonged to the PIF transcription factor family, and the yeast one-hybrid results indicated that CSS0002807 bound to the CSS0013384 promoter. CSS0013384 and CSS0036305 may be involved in the development of chloroplast and mitochondria in albino tea leaves, and play an important role in the process of leaf albino. The results may provide a reference for further research on the mechanism of tea leaf albino. [ABSTRACT FROM AUTHOR]

To solve the problems of real-time and accuracy of fuel cell vehicle power distribution in current research, the off-line nonlinear programming combining online XGBoost algorithm was used to predict the fuel cell power in fuel cell vehicles. The power system model of fuel cell hybrid vehicles was constructed, and the typically mixed driving conditions of vehicles were obtained through cluster analysis. The optimal distribution ratio of fuel cells and lithium batteries under the working condition was calculated off-line by nonlinear programming algorithm. Taking the nonlinear programming calculation results as training data, the XGBoost algorithm was used to conduct the model training verification. The comparative calculation results show that through the proposed algorithm, the multi-objective consideration of the dynamic performance optimization of fuel cell hybrid system in the current off-line calculation is strengthened, and the accuracy of the online machine learning training data is improved. The proposed XGBoost algorithm can effectively expedite the calculation speed and avoid the over-fitting of the data to realize the accurate estimation of the power of fuel cell hybrid vehicle. [ABSTRACT FROM AUTHOR]

Objective To evaluate the efficacy and safety of neoadjuvant chemotherapy combined with programmed death-1 (PD-1) antibody in operable, borderline or potentially resectable locally advanced esophageal squamous cell carcinoma(ESCC) in the real world. Methods The study retrospectively analyzed 28 patients with operable or potentially resectable locally advanced ESCC patients treated with preoperative chemotherapy combined with PD-1 inhibitor in Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School from April 2020 to March 2021. According to the clinical TNM staging system of the 8th edition of the American Joint Committee on Cancer, there were 1, 15, 10, 1 and 1 case of stage Ⅱ, Ⅲ, ⅣA, ⅣB and unknown stage respectively. The treatment was two cycle of dual drug chemotherapy regimen including taxane plus platinum or fluorouracil combined with PD-1 antibody followed by tumor response assessment and surgery if the patient was eligible for resection. Results Of the 28 patients, 1, 2, 3 and 4 cycles of chemotherapy combined with PD-1 antibody treatment completed in 1, 21, 5, and 1 patient, respectively. Objective response rate (ORR) was 71.4% (20/28), and disease control rate (DCR) was 100% (28/28). The incidence of adverse events exceeding grade 3 levels was 21.4% (6/28), including 3 neutropenia, 1 leukopenia, 1 thrombocytopenia and 1 immune hepatitis. There was no treatment-related death. Of the 23 patients underwent surgery, R0 resection rate was 87.0% (20/23), 13 patients had down staged to the T1-2N0M0 I stage, the pCR rate was 17.3% (4/23), and the pCR rate of primary tumor was 21.7% (5/23). Four patients received definitive chemoradiotherapy. One patient rejected surgery and other treatment after achieved PR response. Conclusion Neoadjuvant chemotherapy combined PD-1 inhibitor is safe and has high efficacy in operable, borderline or potentially resectable locally advanced ESCC, and it is a promising regimen. [ABSTRACT FROM AUTHOR]

Promoting the construction of beautiful countryside to carry out zoning and grading of domestic waste disposal in rural areas and to improve the harmlessness of domestic waste disposal in rural areas is of great importance in this regard. 8 indicators (disposable income per capita, population density, garbage collection density, household waste generation per capita, distance from urban and county centres, road network density, topography fluctuation, land area) of 30 881 township units in China were proposed; a scientific and reasonable township identification index system was constructed; the spatial distribution pattern of townships in China was calculated by using spatial difference analysis, spatial autocorrelation analysis, spatial interpolation analysis; and the domestic waste disposal patterns of different types of townships in the eastern, central, western and northeastern of China were discussed. The results show that (1) according to the township classification, China’s townships can be divided into the urban-rural integration type, the intensive type, and the dispersed type of villagers; (2) in terms of spatial heterogeneity, the difference within the indices of townships in the eastern and central of China is relatively small, so the same waste treatment model are popularized; the township indices in the northeastern and western of China are very different, so the different types of domestic waste disposal should be popularized; (3) with respect to spatial correlation, the spatial agglomeration effect of the township index is evident at different scales in China, particularly the spatial correlation effect of “near-vermilion” in the eastern of China. Lastly, based on the spatial distribution characteristics of rural cities and towns, the selection of the rural domestic waste disposal model in different regions of China was summarized. [ABSTRACT FROM AUTHOR]

A large amount of waste slurry will be produced during slurry shield construction, and the traditional treatment method will lead to environmental pollution and land resource occupation. Based on the slurry shield engineering of Xinjizhou Water Supply Corridor Project in Nanjing Yangtze River, the feasibility of using waste slurry in shield construction as synchronous grouting material were discussed. The influence of slurry solid water ratio, bentonite substitution rate and waste slurry clay content on the performance of grouting materials were investigated. Furthermore, the influence of bentonite slurry and waste slurry on the performance of grouting materials were compared and analyzed. The results show that mortar can obtain shorter setting time, higher strength, smaller bleeding rate, lower volume shrinkage and poor fluidity, with the increase of slurry solid water ratio. Compared with newly prepared bentonite slurry, the mortar prepared by waste slurry can obtain better fluidity, but obtaining higher bleeding rate and lower strength at the same time. If the newly prepared bentonite slurry is partially replaced, the bleeding rate and strength of the mortar can be controlled, and the fluidity of the mortar can be greatly improved. The waste slurry clay content has little influence on performance of mortar, to some extent, it indicates that the mortar prepared by waste slurry produced in different stratum has similar properties, therefore, it is unnecessary to significantly adjust the proportioning of mortar with the change of construction stratum, which is convenient for engineering construction application. [ABSTRACT FROM AUTHOR]

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and vasculitis. T lymphocyte infiltration is the key to its pathogenesis. Th17 and Treg cells are homologous, and both are differentiated from initial CD4+T cells. Among them, Th17 cells promote inflammatory response, while Treg cells inhibit inflammatory response and maintain autoimmune tolerance. The occurrence of RA is closely related to the disorder of immune disease, the over-activation of immune cells, and the imbalance of the proportion of immune cell subsets. Th17/Treg imbalance exists in the entire RA disease process, ultimately leading to synovial inflammation, joint destruction, bone erosion, etc., aggravating the course of RA. Regulation of Th17/Treg balance is a target for the treatment of RA. This paper reviews the regulatory role of Th17/Treg imbalance in the occurrence and development of RA. [ABSTRACT FROM AUTHOR]

Whether the vertical tilt, horizontal verticality, and flatness of the end surface of immersed tube prefabricated end steel shell reach the design value is directly related to the sealing effect of the water tape crimping after the installation of the immersed tube, and the amount of immersed tube axis deviation. Due to the short reservation period of immersed tube prefabricated detection and the long post -processing time of the current immersed tube detection technology, it is also necessary to ensure that the vertical tile and horizontal verticality of the end surface are less than 依3mm, and the flatness of end surface is less than 依5 mm, which brings great challenges to the detection personnel. Based on the existing immersed tube detection technology, this paper has carried out in -depth analysis, introduced a multiplier multivariate linear regression method, and prepared a set of visualizing detection software for immersed tube, improve detection efficiency, shortened the detection cycle, and strictly controlled the vertical tilt, horizontal verticality and end surface flatness of the end steel shell. The practice of the Dalian Bay Subsea Tunnel construction project shows that the detection software is practical and can provide references for subsequent similar project detection. [ABSTRACT FROM AUTHOR]

【Objective】The present paper aimed to study the effects of optimized fan frequency and different tobacco density on the temperature difference in the curing barn, changes in tobacco leaves and the quality of cured tobacco, and further determine the applicability of optimized fan frequency in the curing process. 【Method】Two factors of fan frequency and smoke density were set to track the changes of the three smoke density during the process of optimizing the fan frequency and the quality of the cured tobacco during the whole process, and conduct a comparative analysis in combination with the conventional full process of 50 Hz. 【Result】In terms of temperature difference in the roasting barn, as the baking progresses, the temperature difference basically followed the change rule of the main water loss stage>the late stage>the main yellowing stage>the preheating stage, and the optimization of the fan frequency reduces the temperature difference in the roasting barn. In terms of tobacco leaf changes, the unevenness of leaf temperature was D2Y>D1Y>D3Y>D2C; L* value and b* value first increase and then decrease, L* values of D2C and D1Y were always higher than that of D2Y and D3Y; a* value gradually increased with the change of the state, and there was no obvious difference between different treatments; The overall contraction of the optimized fan frequency was good, and the water loss form of D2Y tobacco was the best. In terms of quality of cured tobacco leaves, compared with D2C, D1Y, D2Y and D3Y had significant differences in appearance quality, chemical composition, sensory evaluation and comprehensive score (P<0.05), and D2Y had the highest score. 【Conclusion】Optimizing the fan frequency can have a lower temperature difference in the curing barn under different loading densities, better tobacco leaf changes and higher quality of cured tobacco, which has strong applicability. [ABSTRACT FROM AUTHOR]

Objective: This study aims to observe the efficacy of dapagliflozin on patients with early diabetic kidney disease (DKD and the influence on expression of regulatory T cells (Tregs) and inflammatory factors. Methods: Forty-seven patients who developed DKD between August 2019 and December 2019 in the Affiliated Jiangning Hospital of Nanjing Medical University were enrolled. On the basis of the original hypoglycemic therapy, all patients were prescribed dapagliflozin 10 mg, qd, orally,for 4 weeks and kept diet and exercise mode unchanged. Fasting plasma glucose (FBG), glycated albumin (GA), urinary albumin creatinine ratio (UACR), 24-hour urinary protein and estimated glomerular filtration rate (eGFR) were compared between baseline and 4-week after prescription. The level of Tregs in peripheral blood detected by flow cytometry, the levels of interleukin (IL) -6, IL-1β, tumor necrosis factor (TNF)-β and IL-10 measured by ELISA were also compared. Adverse drug reactions were recorded. Results: After 4 weeks of dapagliflozin treatment, FBG [(8.96 ± 0.83 mmol/L) vs. (7.42 ± 0.67) mmol/L], GA [(18.47 ± 3.32) % vs. (15.49 ± 2.62) %], 24 h urine protein quantification [1.14 (0.29, 2.08) g/24 h vs. 0.28 (0.15,0.83) g/24 h], UACR[ 80 (45,150) mg/g vs. 40 (30,80) mg/g]and e GFR [(105.30 ± 36.01) mL/ (min·1.73 m²) vs. (92.07 ± 35.26) mL/ (min·1.73 m²) ]were significantly lower than baseline (P < 0.05) . However, after 8 weeks of treatment, the eGFR could return to the level before treatment [(104.88 ± 36.86) mL/(min · 1.73 m²) vs. (105.30 ± 36.01) mL/ (min·1.73 m²), P > 0.05]. Compared with baseline, the expression of Tregs was significantly up-regulated [(3.19 ± 0.74) % vs. (5.64 ± 0.93)%, P < 0.05], the pro-inflammatory factors IL-1β [(7.83 ± 1.39) ng/L vs. (4.57 ± 0.71) ng/L], TNF-β [(372.85 ± 6.79) ng/L vs. (227.62 ± 7.29) ng/L], IL-6 [(3.99 ± 0.47) ng/L vs. (2.59 ± 1.01) ng/L]was significantly down-regulated (P < 0.05),and the expression of the anti-inflammatory factor IL-10 was up-regulated [(0.03 ± 0.01) ng/mL vs. (0.05 ± 0.01) ng/mL, P < 0.05]. There were no adverse reactions such as hypoglycemia and ketosis, and 5 patients had asymptomatic urinary tract infection during the treatment period. Conclusion: Dapagliflozin may up-regulate the expression of Tregs to inhibit the inflammatory response and ultimately play a role in renal protection in DKD patients. [ABSTRACT FROM AUTHOR]

Grape coloring is an essential stage in the grape ripening process, which has a very important influence on the quality of grape berries. In this paper, nine-year-old grape variety Frey was used as the research object and the influences of a novel abscisic acid (ABA) functional analog, natenpac, on grape coloring and quality improvement in the field were studied. At the initial stage of fruit coloring, foliar spraying, root irrigation, and fruit soaking were carried out with 2, 5, and 10 mg/L natenpac, respectively, and clean water treatment as the blank control. By comparing the apparent changes, such as average transverse diameter, color, and single fruit weight, and internal quality changes, such as soluble solids, anthocyanin, and soluble sugar contents, the optimal application mode and concentration were determined. The results showed that natenpac could make Frey grape finish coloring 7-10 days earlier than the control by foliar spraying or root soaking modes, and contributed to significant increases in soluble solid content and coloring degree, and slight increases in the transverse diameter and single fruit weight of berries. The three treatment modes showed a great difference in efficacy. Root irrigation and foliar spraying were better than fruit soaking and 2 mg/L of foliar spraying was the best. This study clarified the best application mode and concentration of natenpac to Frey grape and provided the basis for guiding the field application of natenpac in grape coloring. [ABSTRACT FROM AUTHOR]

Objective To evaluate the effects of bony pelvic dimensions on operative difficulty of laparoscopic radical prostatectomy. Methods A retrospective case-control study was conducted. Clinical and imaging data of patients who underwent LRP in Tong ji Hospital, Tongji Medical College, Huazhong University of Science and Technology from March2017 to November 2020 were collected. The imaging parameters representing the size of pelvic entrance, middle pelvic space and depth of pelvis were measured at the sagittal and transverse positions of the pelvis by preoperative magnetic resonance imaging. The operative time and the classification of complications were used to evaluate the surgical difficulty. The Clavien-Dindo（CD） complication classification was used to classify the complications. Univariate and multivariate logistic regression were used to analyze the relationship between pelvic measurement parameters and postoperative complications, and multiple linear regression method was used to analyze the relationship between pelvic measurement parameters and operation time. Results A total of 377 LRP patients were included in the study, with an average operation time of 175（105-215） min.57 experienced postoperative complications, including Clavien grade I in 9（2.39%）, grade II in 17 cases（4.51%）, grade Ⅲ in29 cases（7.69%）, and grads IV in 2 cases（0.53%）. The multivariate regression analysis showed that Pelvic index to prostate volume ratio（PCI/PV）, middle pelvic transverse diameter to prostate volume ratio（ISD/PV）, and pelvic incidence Angle were independent risk factors for the risk of operative complications of LRP. Multiple linear regression analysis revealed that the incidence angle of pelvic cavity, pubic symphysis angle and the distance between prostatic apex and anterior promontory were correlated with the operation time. Conclusion PCI/PV, ISD/PV, pelvic incidence angle, pubic symphysis angle and pelvic depth are important parameters to indicate "difficult pelvis". Using the pelvic space dimension can accurately judge the pelvic space dimension, objectively evaluate the surgical risk, and assist urologist in formulating a personalized surgical plan before surgery. [ABSTRACT FROM AUTHOR]

In classical Western philosophy, prudence, justice, fortitude, and temperance constitute the four cardinal virtues. Fortitude, according to the interpretation of St. Thomas Aquinas, is rich in connotations. In particular, "firmness of mind" is the non-violent characteristic that points to the ultimate good. In Buddhist tradition, the virtue of vīrya has similar spiritual quality. In this article, we attempt to present the characteristic of vīrya as the Buddhist counterpart of fortitude using the wisdom of Sinicized Buddhism, particularly according to the discourse in the Doctrine of Mere-Conciousness (Vijñāpti-mātratā-siddhi). [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical effect of direct-acting antiviral agent (DAA) in the treatment of chronic hepatitis C (CHC) patients with thrombocytopenia and its effect on platelet count (PLT). Methods A retrospective analysis was performed for 83 CHC patients with thrombocytopenia (PLT < 150×109/L) who received the DAA treatment regimen without interferon for 12-24 weeks in Tianjin Third Central Hospital from April 2018 to March 2019, and the changes in virologic response, liver function parameters, PLT, and liver stiffness measurement (LSM) were evaluated at the end of treatment (EOT) and at week 12 after EOT. Quantitative data accord with normal distribution were compared by repeated measures ANOVA. Normal transformation was performed before the comparison between skewed data, then repeated measures ANOVA was carried out. A logistic regression analysis was used to investigate the predictive factors for PLT elevation, and the receiver operating characteristic (ROC) curve was plotted to analyze the value of LSM in predicting PLT elevation after treatment. Results Among the 83 CHC patients with thrombocytopenia, 61.4% had liver cirrhosis, and the rate of sustained virologic response at week 12 after the end of treatment (SVR12) was 98.8%. From baseline to EOT and SVR12, the patients had significant reductions in the serum levels of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, total bilirubin, and globin, a significant increase in the serum level of albumin, and a significant reduction in LSM (all P < 0.05). For all patients, PLT at EOT and SVR12 was significantly higher than that at baseline [EOT vs baseline: (110.4±44.6)×109/L vs (97.8±33.2)×109/L, P < 0.01; SVR12 vs baseline: (109.0±47.7)×109/L vs (97.8±33.2)×109/L, P < 0.01]. At SVR12, there were significant differences in the proportion of patients with liver cirrhosis, baseline LSM, and baseline white blood cell count between the PLT elevation group and the non-PLT elevation group (all P < 0.05). The multivariate logistic regression analysis showed that LSM was an independent predictive factor for significant PLT elevation after DAA treatment (odds ratio=0.929, 95% confidence interval: 0.864-0.999, P < 0.05). Baseline LSM had an area under the ROC curve of 0.644 in predicting PLT elevation, with a sensitivity of 81.0% and a specificity of 48.6% at a cut-off value of 20.15 kPa. The patients with PLT > 100×109/L at baseline had a greater increase in PLT(P < 0.05). Conclusion CHC patients with thrombocytopenia have significant improvements in liver function and LSM after receiving DAA treatment and obtaining SVR12, and baseline LSM is an independent predictive factor for PLT elevation. There is a significant increase in PLT from baseline to EOT and SVR12. [ABSTRACT FROM AUTHOR]

BACKGROUND: In osteoporosis patients, the stability of cervical spine after internal fixation is poor; the fracture healing process is slow; and the risk of refracture at the same site and other sites is significantly increased. Therefore, it is necessary to design a new method of anterior internal fixation to reduce complications and surgical revision rate. OBJECTIVE: To design a new fixation system for the treatment of cervical spondylosis with osteoporosis through the anterior pedicle approach using threedimensional (3D) finite element analysis and 3D printing technology, which is beneficial to improve the stability of the patient’s cervical spine after surgery METHODS: 3D CT data of 15 healthy cervical spine patients and 15 osteoporosis patients who were examined in the Department of Orthopedics, Affiliated Central Hospital of Shenyang Medical College from December 2017 to December 2019 were collected. The cervical spine models of 30 patients were constructed by 3D printing technology. A new nail plate internal fixation system was designed based on the pedicle positioning guide. 3D models were subjected to the vertebral pedicle fixation through the anterior approach guided by the localizer under external conditions. The prepared postoperative models were connected to the computer for finite element analysis and biomechanical analysis, and the best nail plate internal fixation system was designed based on the analysis results. RESULTS AND CONCLUSION: (1) 3D printing technology was used to successfully construct the cervical spine models of osteoporosis patients, as well as the anterior vertebral pedicle fixation and positioning guide and the anterior vertebral pedicle fixation nail plate system. (2) Finite element biomechanics analysis results showed that the bone mass of patients with severe osteoporosis was significantly higher than that of normal bone by torsional displacement and rotation angle. The addition of screws did not significantly improve the torsional deformation of the anterioposterior bending and the left and right bending. The addition of screws had a significant improvement in the deformation of the axial torsional load. (3) The results indicated that the trial designed a vertebral pedicle internal fixation nail plate system for the anterior cervical approach using 3D printing technology, confirming that 3D printing technology can successfully assist the cervical spine through anterior pedicle fixation for cervical spondylosis combined with osteoporosis. [ABSTRACT FROM AUTHOR]

Bladder cancer is a common malignant tumor in the urinary system, the incidence of the disease is increasing year by year, and the recurrence rate is relatively high. Early diagnosis and regular follow-up are the keys to ensure long-term survival of bladder cancer patients. The diagnosis of bladder cancer and follow-up of patients are usually performed by cystoscopy or urine exfoliation cytology. However, the former is more expensive and invasive. The latter has the characteristic of relatively low sensitivity and was limited by the subjective factors of the doctor, there is no urine biomarker that can replace traditional diagnostic methods. Bladder tumors have extensive heterogeneity, and different disease phenotypes have different molecular differences. Therefore, the introduction of urine biomarkers to diagnose the disease and assess the aggressiveness, risk of progression, likelihood of recurrence and prognosis of the disease has important clinical value. In this paper, the current status of urinary biomarkers in the diagnosis of bladder cancer is summarized, and the main research progress in this field is reviewed. [ABSTRACT FROM AUTHOR]

Type-reduction is the key block in general type-2 fuzzy logic systems. This paper compares and analyzes the sum operation in discrete enhanced Karnik-Mendel (EKM) algorithms and the integral operation in continuous enhanced Karnik-Mendel (CEKM) algorithms. Based on the alpharepresentation theory of general type-2 fuzzy sets, EKM algorithms are extended to perform the centroid type-reduction of general type-2 fuzzy logic systems. While computing the centroid type-reduced sets and the defuzzified values of general type-2 fuzzy logic systems, two computer simulation examples show that the calculation results of EKM algorithms can accurately approximate the CEKM algorithms, when the number of sampling of primary variables of centroid output GT2 FSs increases appropriately. [ABSTRACT FROM AUTHOR]

Under the background of global warming, extreme precipitation events occurred frequently in the Loess Plateau, which significantly affected the social economy and vegetation ecosystem. Studying the characteristics of extreme precipitation in the Loess Plateau and their influence on fractional vegetation cover ( FVC) could provide scientific support for ecological environment protection and regional sustainable development. Based on daily precipitation data from 64 meteorological stations and MODIS NDVI data in the Loess Plateau from 2000 to 2020, trend analysis and correlation analysis were used to analyze the spatiotemporal variation characteristics of extreme precipitation and FVC in the Loess Plateau, as well as the influence of extreme precipitation on FVC was discussed. The results show that the total precipitation PRCPTOT, moderate rain day R10mm, heavy rain day R20mm, heavy precipitation day R25mm ), and precipitation intensity SDII in the Loess Plateau increases significantly from 2000 to 2020 ( P < 0. 05 ) . The heavy rain increases mainly in the western and northern of the study area, but the southern area experiences drought. From 2000 to 2020, FVC generally shows a significant increasing trend (P < 0. 05),which mainly locates in the central and eastern of the study area, accounting for 32. 00% of the total study area. Only 4. 91% of the total area shows significantly decreasing trend, which mainly distributes in the southern of the study area. From 2000 to 2020, there is positive correlation between moderate rain day R10mm, heavy rain day R20mm, heavy precipitation day R25mm, precipitation intensity SDII and FVC in the Loess Plateau, which accounts for 22. 33%, 48. 19%, 14. 36%, and 24. 37% of the study area respectively, and mainly distributes in the central area. During the past 20 years, extreme precipitation and FVC increases simultaneously in the Loess Plateau, extreme precipitation shows a positive effect on vegetation ecological improvement. However, the time scale is also important for extreme precipitation research, that is, the effect of extreme precipitation on FVC may be weakened on short time scales. [ABSTRACT FROM AUTHOR]

In order to protect personal information in images, this paper proposed an adversarial image perturbations algorithm to combat deep neural network, which could mine and discover personal image knowledge. It transformed the problem of adversarial example generation into a multi-objective optimization problem with constraints. Considering the classification confidence of the neural network, the location of the perturbed pixels and the chromatic aberration, this paper obtained the adversarial examples iteratively by using the differential evolution algorithm. On MNIST and CIF AR-10 dataset, based on deep neural network LeN et and ResN et, the algorithm generated the experiment of adversarial examples. This paper compared and analyzed the success rate, number of perturbation pixels, optimization effects and spatial characteristics of the adversarial examples. The results show that the proposed algorithm still can effectively combat the deep neural network in the case of few disturbed pixels ( the average number of perturbation pixels is 5) . The algorithm significantly optimizes the location and chromatic aberration of the perturbed pixels, so as to protect personal information without destroying the original image. This study is helpful to balance the relationship between information technology dividend sharing and personal information security, and provides technical support for the research of adversarial examples generation and classification spatial features in deep neural networks. [ABSTRACT FROM AUTHOR]

Telomeres are special nuclear protein complexes located at the ends of chromosomes, whose highly conserved repetitive sequences and protein complexes form a protective ring structure to maintain the stability and integrity of linear chromosomes. Telomerase plays an important role in maintaining and regulating telomere length, cell immortality and aging by adding guanine-rich repetitive sequences. By studying the change trend of telomere length and telomerase activity of diseased cells, it can provide a theoretical reference for selecting telomerase as a marker for cancer treatment. This article reviews the structure and daily action mechanism of telomeres and telomerase, as well as their research progress in hepatocellular carcinoma, in order to help prevent, diagnose and treat malignant tumors and metabolic diseases. [ABSTRACT FROM AUTHOR]

In order to optimize the energy consumption of the natural gas dew point control system under meeting the requirement of dew point at the junction point, HYSYS model is used to establish steady simulation to perform the sensitivity analysis of the key parameters affecting the dew point,including feed gas pressure and temperature, TEG circulation flowrate, reboiler temperature, stripping gas flowrate and J-T valve front temperature, and the reasonable value range of the key parameters,then the value range of which is determined. On this basis, the process parameters are optimized by the optimizer module of HYSYS and the optimal combination of process parameters is obtained. In view of the phenomenon of natural gas reverse condensation, the product gas envelope is used to check dew point during transporting. The results show that the pressure-temperature curve along the pipeline is on the right side of the dew point line, which proves that the product gas is always transported in gas phase [ABSTRACT FROM AUTHOR]

Original sin and capital sins, which pertain to the evil of human conduct, form the fundamental structure of St. Thomas Aquinas' articulation of the theory of sins. Using the concepts of original sin and capital sins as the starting point, the article aims to introduce and analyze this fundamental structure as well as clarify ambiguities regarding capital sins such as pride / vainglory and sloth (spiritual apathy). [ABSTRACT FROM AUTHOR]

Objective: To explore the relationship between the levels of experiential avoidance and suicidal ideation among college students. Methods: A total of 4 633 students from seven comprehensive universities were selected. They were assessed with the Acceptance and Action Questionnaire, Second Edition (AAQ-Ⅱ) and the question "In the past 12 months, have you seriously considered suicide" to evaluate the level of experiential avoidance and last year suicidal ideation. Results: The reporting rate of last year suicidal ideation among college students was3. 89%, with higher rates in females than in males (4. 51 % vs. 3. 19%, P ＜0. 05). Multivariable logistic regression model for last year suicidal ideation among college students showed that moderateand high level of experiential avoidance, female gender, coming from urban, moderate and poor academic performance, not attending extracurricular activities, and smoking were all positively associated with suicidal ideation (OR=8. 18, 29. 69, 2. 51, 1. 55, 1. 82, 2. 74, 1. 59, 2. 57) . Conclusion: Moderate and high levels of experiential avoidance may be associated with suicidal ideation among college students. College students with moderate and high levels of experiential avoidance need to be focused on for suicidal ideation prevention. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of immunoglobulin combined with sodium creatine phosphate on myocardial remodeling and myocardial injury in children with viral myocarditis. Methods: Selected 143 cases of children with viral myocarditis who were treated in our hospital from January 2017 to December 2019, divided into two groups randomly. In the control group, sodium creatine phosphate was infused intravenously, 0.5~1.0 g each time, once a day for 14 days. The observation group combined with intravenous injection of human immunoglobulin at a dose of 1 g/(kg·d), once a day for 2 days. The changes of myocardial remodeling index and myocardial injury index were detected before and after treatment. Results: The effective rate of the observation group was significantly higher than control group (P<0.05). Before treatment, there was no significant difference in the levels of TGF β1, PINP, MMP2, ICTP and MMP9 between the two groups (P>0.05), after treatment, the levels of TGF β1, PINP, MMP2, ICTP and MMP9 in the two groups were significantly reduced (P<0.05), the levels of TGF β1, PINP, MMP2, ICTP and MMP9 in the observation group were significantly lower than those in the control group (P<0.05). Before treatment, there was no significant difference in the levels of MDA, CK-MB, BNP and cTnI between the two groups (P>0.05), after treatment, the levels of MDA, CK-MB, BNP and cTnI in the two groups were significantly reduced (P<0.05), the levels of MDA, CK-MB, BNP and cTnI in the observation group were significantly lower than those in the control group(P<0.05). Conclusion: Immunoglobulin combined with sodium creatine phosphate has a significant effect on children with viral myocarditis. It can effectively inhibit myocardial remodeling and reduce myocardial damage, which is worthy of promotion. [ABSTRACT FROM AUTHOR]

To solve the privilege escalation attacks on Android App, this paper proposed a formal privilege escalation attacks detection model based on Pi calculus. It used the extended Pi calculus to model the Android App and its runtime environment, and obtained a formal behavior model. By formalizing the privilege security policy as process expressions containing the IFTHEN rule and using the properties of Pi calculus to perform process calculus and migration, it constructed the detection model, and gave out the privilege escalation attacks detection method . The analysis and experiment results show that this method has linear time and space complexity, moreover, the existing privilege security policy can be easily applied on this model to ensure the accuracy of the model. Compared with other methods, the detection accuracy is improved without sacrificing the detection efficiency. [ABSTRACT FROM AUTHOR]

Objective: To investigate the expression and clinical significance of β-catenin (β-catenin), E-cadherin (E-cadherin) and matrix metalloproteinase-9 (MMP-9) in esophageal cancer. Methods: Immunohistochemical staining was used to detect the levels of β-catenin, E-cadherin and MMP-9 proteins in cancer and adjacent tissues of 60 patients with esophageal cancer, and the relationship between the expression level and clinicopathological characteristics was analyzed. All patients were followed up for 24 months, the survival of different levels of β-catenin, E-cadherin and MMP-9 were observed. The expression of β-Catenin, E-cadherin and MMP-9 in esophageal cancer were analyzed. Results: The positive rate of β-catenin and MMP-9 protein in esophageal cancer were higher than those in adjacent tissues, and the positive rate of E-cadherin protein was lower than that in adjacent tissues (P<0.05). The positive rates of β-catenin and MMP-9 protein in patients with moderately low differentiation, TNM stage III+IV, lymph node metastasis were higher than those in patients with high differentiation, clinical stage I+II and no lymph node metastasis, and the positive rates of E-cadherin protein were lower than those in patients with high differentiation, clinical stage I+II and no lymph node metastasis (P<0.05). Log_rank test showed that the survival rate of β-catenin (-), E-cadherin (+), MMP-9 (-) patients in cancer tissue were higher than those of β-catenin (+), E-cadherin (-), MMP-9 (-) patients (P<0.05). Spearman correlation analysis showed that the expression of β-catenin protein was negatively correlated with that of E-cadherin protein, and it was positively correlated with that of MMP-9 (P<0.05). The expression of MMP-9 protein was negatively correlated with the expression of E-cadherin protein (P<0.05). Conclusion: The abnormal high expression of β-catenin and MMP-9, and the abnormal low expression of E-cadherin in esophageal cancer patients, which are closely related to the tissue differentiation, TNM stage and lymph node metastasis, the detection of β-catenin, MMP-9 and E-cadherin expression situation are helpful to predict the survival prognosis of esophageal cancer patients. [ABSTRACT FROM AUTHOR]

In practical applications， the analysis of crack problems by the extended finite element method(XFEM) has the problems of highly ill-conditioned overall stiffness matrix， singularity of matrix， etc. The numerical simulation does not achieve the ideal requirement that the analysis result has nothing to do with meshing. The three-point bending beam test was selected based on the ABAQUS platform， and the discrete Freschet distance was introduced to evaluate the difference in crack development path with time history. The influence of the poor crack configuration related to meshing on the simulation results in the application of the standard XFEM was analyzed. The results show that the initial crack endpoint must be at the element boundary during numerical simulation to avoid weakening the components， and poor crack configuration will cause the distortion of the crack development path simulation， and the distortion will increase as the poor coefficient decreases. The poor coefficient u should be controlled within 0.25~1. The convergence and path accuracy can be improved by introducing viscous damping. [ABSTRACT FROM AUTHOR]

Extractive method extracts sentences from source text, which results in information redundancy. Generative method may generate non-source words, which results in grammatical problems and poor naturalness. BERT as a bidirectional Transformer model, which shows excellent performance in natural language understanding tasks. The application of text generation task remains to be explored. To address the above issues, this paper proposed a three-stage compound text summarization model based on pre-training( TSPT), which combining extractive method and generative method. The bidirectional contextual information word vectors generated by the pre-training of the source text are extracted from the sigmoid function to obtain sentence scores and extract key sentences. Finally, key sentences are rewritten as cloze filling tasks to generate final summarization. The experimental results show that it achieves high scores in CNN/ Daily Mail dataset. [ABSTRACT FROM AUTHOR]

To achieve efficient dispatching of agricultural machinery in China during the farming season and ensure the successful completion of farming operations, the precise scheduling of Beidou agricultural machinery was designed based on the combination of genetic algorithm and WiFi clustering algorithm. In the designed scheme，the soil moisture data was firstly collected according to the internet of things technology to predict in advance whether the field needed agricultural machinery. By Beidou satellite navigation， the job field and the agricultural machinery were located to obtain the position information, and the GIS technology was used to calculate the trajectory. Through the genetic algorithm， the iterative deduction of agricultural machinery and farmland in a region was simulated to screen out the optimal agricultural machinery scheduling. According to the schedule ， the farmer's operation needs were accurately and quickly solved. Under the no-signal environment, the agricultural machinery was positioned by the WiFi clustering algorithm to master the situation of agricultural machinery.The results show that the scheme is simple, easy to use, efficient, convenient and adaptable. It can help the local agricultural machinery stations to accurately dispatch agricultural machinery and improve the informationization and modernization level of Chinese agriculture to accelerate the process of agricultural modernization. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (HCC), characterized by insidious onset, rapid progression, and poor treatment outcome, is a common malignant tumor that seriously affects the health of people. Therefore, various academic research associations in China and globally have re leased a number of evidence-based medicine guidelines for liver cancer, focusing on the key issues in the screening, diagnosis, and treatment of HCC, and made constant updates to these guidelines. Clinicians are recommended to comprehend these guidelines with reference to their own specialties, so as to gain a better understanding of the advances in the field of liver cancer and further improve the prognosis of HCC patients. [ABSTRACT FROM AUTHOR]

目的总结新型冠状病毒肺炎(COVID-19)不同发病时间的胸部CT 影像学特点，以指导临床诊断及治疗。方法回顾性分析38 例经病毒核酸检测确诊的COVID-19 患者胸部CT 影像资料，即不同发病时间患者CT 影像上病灶的形态、数目、分布和随时间的变化特点。结果38 例 COVID-19 患者胸部CT 检查均发现肺部有不同程度的病变，以双肺散在、多发、肺野外周区及背侧分布、多肺叶受累为主。首次进行CT 检查分别为发病第 1 ~3 天21 例、4~6天12例、7~ 9 天4例、10天1例。 表现为磨玻璃样密度影( GGO) 35 例(92.1%），斑片状实变、亚实变11 例(28.9%） ，小叶间隔增厚20例(52.6%），纤维索条影2例(5. 3%）。随后CT 复查肺内GGO病变有逐渐减少，纤维索条影逐渐增多趋势。影像学表现病变演变存在相互交叉过程，发病第1~3 天病灶多为GGO，第4～6天、7 ~9天复查病变以进展为主，表现为GGO增多、增大、部分融合、实变、密度增高。发病第10天后病变以吸收减少为主，表现为病灶缩小、减少、密度变淡， 部分可见纤维索条影，后期病变吸收较前期减缓。纤维索条样影吸收消失2例。 胸腔少最积液1例。 结论COVID-19 患者胸部CT 基本病变主要表现为GGO、斑片状实变及亚实变、小叶间隔增厚。COVID-19患者胸部CT 显示，发病第4~9天，病变进展明显，表现为GGO增多、增大、密度增高，出现斑片状实变及亚实变，部分融合；第10~12天，病变吸收则逐渐占据优势， 表现为病灶缩小、数目 减少、密度减低， 边缘模糊，并出现纤维索条影；第13~15天病变开始明显吸收，表现为病灶进一步缩小、数目减少、密度减低。 [ABSTRACT FROM AUTHOR]

Bubbled-root irrigation is an efficient water saving technique for irrigation of fruit trees that has been used in China. It is a subsurface micro-irrigation technology that can directly deliver water and fertilizer to the crop root zone for local irrigation. This study reviewed the characteristics, application status of the bubbled-root irrigation technique and proposed its development directions. The structural characteristics, working principles, irrigation methods, layout, hydraulic performance, costs and operation management of bubbled-root irrigation technology were summarized. The advantages of bubbled-root irrigation compared with traditional micro-irrigation were discussed. In addition, the application effect of this technology in fields was reviewed. The problems and developmental direction were proposed. The bubbled-root irrigation was better than drip irrigation, micro-sprinkling irrigation, and underground seepage irrigation because it overcame the shortcoming of those irrigation technologies such as the emitter clogging, aging of pipelines and low water use efficiency for fruit trees. The bubbled-root irrigation in fruit trees could not only save water and labors but also improve water and fertilizer use efficiency. Compared to the drip irrigation, the bubbled-root irrigation could lower the cost by 2 030 Yuan/hm2 and increase the benefit by 2 480 Yuan/hm2. Because the pipelines were buried into the soils, the influence of operations on soil surface such as tillage was small and thus it facilitated the field management. Meanwhile, the soil moisture condition could be improved by inhibiting evaporation and preventing soils from hardening and cracking. The technique had high water use efficiency and could enhance the yield. However, it would face challenges such as less practices, irrigation system to be optimized, the performance of emitter to be optimized an so on. Attentions should paid to the following areas: 1) improving and optimizing the performance of the irrigation equipment; 2) improving the level of informatization and automation management of bubbled root irrigation on the basis of the existing technology; 3) improving the performance of irrigation devices; and 4) optimizing irrigation systems of typical fruit trees. The bubbled-root irrigation has been promoted and applied in the Loess Plateau in northern Shaanxi, China and has achieved remarkable results. The use of bubbled-root irrigation technology for jujube irrigation greatly saved water and fertilizer consumption, alleviated the pressure caused by the serious shortage of water resources in northern Shaanxi and effectively improved the water and fertilizer utilization rate. However, the promotion and application of this technology also had certain limitations. Future studies should test if the technique is suitable to the other areas since the soil types, topographic conditions and the types of fruit trees in the other regions may change. The review would provide valuable information for the cultivation of fruit trees with less water and high yield. [ABSTRACT FROM AUTHOR]

Aiming at the problem of lightweight design by laser beam welding for B-pillar，based on the B-pillar manufacturability analysis， the orthogonal test method was used. The safety analysis of the B-pillar under side collision，based on the maximum intrusion volume and in­trusion speed in the collision process，the safety comparison analysis was carried out. Under the premise of meeting the five-star standard of side collision，the scheme with the most weight loss was the optimal lightweight design. The profile tolerance，maximum thinning rate，and collision safety of the actual production B-pillar was analyzed. The results indicate that the position of the weld seam is finally selected from the bottom end of 380 mm is optimal. The final material combination is DP800/DP600，and the thickness is 1. 8 mm/1. 6 mm，the quality of the B-pillar is reduced from 4.449 kg to 3. 50 kg，and the weight loss is 21.3% . By adjusting the stamping process parameters，the B-pillar product is tested. The pass rate of the profile is 100%，and the maximum thinning rate is 21. 1%，which is in line with the requirements of the OEM. The side impact test shows that the strength meets the requirements and the simulation and experimental results are basically the same，and the error is within 4%，indicating the reliability of the analysis. [ABSTRACT FROM AUTHOR]

Using the outbreak of Nova Coronavirus which has overwhelmingly threatened humanity as an introduction, this article tries to analyze the idea of integral ecology and its core concept of ecological conversion in Pope Francis' second encyclical letter Laudato Si': On Care for Our Common Home (2015). The encyclical letter in question is interpreted in the context of contemporary eco-ethics and Catholic tradition, especially Thomist philosophy. [ABSTRACT FROM AUTHOR]

BACKGROUND: Sequencing of the human genome has found that gene mutation will lead to structural changes of intervertebral disc and increase the risk for degeneration.OBJECTIVE: To investigate the association of rs12077871, rs12722877, and rs7533552 polymorphisms in the COL9A2 gene with intervertebral disc degeneration by meta-analysis.METHODS: Databases of PubMed, Web of Science, CNKI and WanFang were searched for the articles addressing the association of rs12077871, rs12722877, and rs7533552 polymorphisms in the COL9A2 gene with intervertebral disc degeneration published before July2018. The quality of the included studies was evaluated according to the principle of STREGA, and 6 articles involving 2 874 participants were eligible for inclusion and exclusion criteria. Distribution characteristics of different alleles and genotypes in the intervertebral disc degeneration(case group) and non-intervertebral disc degeneration(control group) underwent meta-analysis on Stata 12.0 software.RESULTS AND CONCLUSION:(1) The results of meta-analysis showed that there was no significant differences association between the genotypes and allele frequency of rs12077871, rs12722877, and rs7533552 polymorphisms in COL9A2 gene and intervertebral disc degeneration.(2) Therefore, the rs12077871, rs12722877, and rs7533552 polymorphisms in COL9A2 gene are not associated with intervertebral disc degeneration in Asian. But, more high-quality multi-center and large-sampled case control studies are required to verify the conclusion. [ABSTRACT FROM AUTHOR]