Objective To investigate the application value of inflammatory indicators in the diagnosis and treatment of COPD patients, and to conduct the prediction of the invasive ventilation in the patients with acute and severe COPD. Methods One hundred cases of COPD admitted to the department of respiratory medicine of t he hospital from June 2018 to June 2019 were selected as the research subjects. Among them,50 cases we re in the stable stage(stable group ),50 cases were in the acute exacerbation stage ( critical group),and contemporaneous 50 persons undergoing the healthy physical examination in t he hospital were selected as the healthy physical examination group. The CRP and PCT levels were compared among 3 groups. Meanwhile NLR and PLR were calculated according to the blood routine results and compared among the three groups. pH,PaO2 and PaCO2 were compared between the non invasive breathing group and invasive breathing group in the patients of the critical group. The correlations between CRP, PCT, NLR and PLR with pH, PaO2 and PaCO2 were analyzed. Results There were statistically significant differences in CRP, PCT,NLR and PLR among the three groups(P < 0.05),moreover the levels of CRP,PCT,NLR and PLR in the critical group were significantly higher than those in the stable group and the healthy physical examination group. In addition,the levels of CRP,PCT, NLR and PLR in the stable group were significantly higher than those in the healthy physical examination group, and the differences were statistically significant (P < 0.05 ) . The levels of CRP, PCT, NLR and PLR in invasive breathing group we re significantly higher than those in the non invasive breathing group, while PaO2 was significantly lower than that in the non invasive breathing group, and the difference was statistically significant (P < 0.05). The 4 indicators of CRP,PCT, NLR and PLR were negatively cor related with pH and PaCO, ( P < 0.05), and positively correlated with PaO2 (P < 0.05) . Conclusion CRP, PCT, NLR and PLR can evaluate the disease status of COPD patients, and have a certain predictive value for the invasive respiratory therapy, which is worthy of clinical promotion and application. [ABSTRACT FROM AUTHOR]