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Copyright of Journal of Social Work (1672-4828) is the property of Journal of Social Work Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the effects of curcumin on the in vitro proliferation and apoptosis of mouse liver cancer Hepa1-6 cells. Methods Hepa1-6 cells in the logarithmic growth phase were divided into the control group, 10 µmol/L group, 20 µmol/L group and 40 µmol/L group, respectively, which were treated with 0, 10, 20, and 40 µmol/L of curcumin. Cell proliferation was assessed by the MTT assay, and apoptosis level was detected by FACS. Real-time quantitative PCR (RT-qPCR) was employed to detect the levels of apoptosis-related molecules Bcl-2, Caspase-3, Toll-like receptor 2 (TLR2), IFN-α, and IFN-β in Hepa1-6 cells. The secretion levels of IFN-α and IFN-β in the cell culture supernatant were determined using ELISA. Hepa1-6 cells were incubated with CD4+ T cells, CD8+ T cells and NK cells in the control group and 40 µmol/L curcumin group, respectively. FACS was used to detect the expression levels of CD69 in CD4+ T cells, CD8+ T cells and NK cells. Results The proliferation inhibition rates of Hepa1-6 cells in the 10, 20 and 40 µmol/L groups increased in a dose-dependent manner, and the inhibition rates were (36. 45 ± 2. 11) %, （46. 40 ± 2. 08) % and (82. 16 ± 3. 32) %, respectively. There was statistically significant difference in comparison with that of the control group (P<0. 05) . The apoptotic proportions of Hepa1-6 cells in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups were 10. 47%, 26. 66% and 49. 81%, respectively. And the difference was statistically significant in comparison with that of the control group (P<0. 01) . RT-qPCR results showed that the transcription levels of anti-apoptotic gene Bcl-2 in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups were (0. 77 ± 0. 06) times, （0. 44 ± 0. 06) times and (0. 25 ± 0. 08) times that of the control group, respectively, with statistically significant difference (all P<0. 01) . At the same time, the expression of proapoptotic gene Caspase-3 significantly increased, and the transcription levels of pro-apoptotic gene Caspase-3 in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups was (1. 73 ± 0. 31) times, （2. 52 ± 0. 45) times and (3. 25 ± 0. 20) times that of the control group, respectively, with statistically significant difference (all P<0. 01) . With the increase of curcumin concentrations, TLR2 transcription levels increased gradually. TLR2 transcription levels in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups were (3. 56 ± 0. 59) times, （4. 93 ± 0. 04) times and (6. 60 ± 0. 47) times that of the control group, respectively, with statistically significant difference (all P<0. 05) . In addition, the transcription levels of IFN-α in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups significantly increased, which were (4. 21 ± 0. 22), （5. 54 ± 0. 39) and (8. 05 ± 0. 93) times that of the control group, respectively, and there were statistically significant differences among these groups (all P<0. 05) . The transcription levels of IFN-β were (3. 08 ± 0. 51), （5. 31 ± 0. 55) and (8. 35 ± 0. 59) times that of the control group, and the difference was statistically significant (all P<0. 01) . For IFN-α, compared with the control group ［（36. 26 ± 6. 12) pg/mL］, the levels of IFN-α secreted by cells in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups were (57. 00 ± 8. 8), （82. 47 ± 4. 42), and (100. 37 ± 8. 99) pg/mL, respectively； the levels of IFN-α secreted by cells in the 10, 20, and 40 µmol/L groups were higher that that of the control group (all P<0. 01) . The levels of IFN-β secreted by the cells in the 10, 20, and 40µmol/L groups were (60. 67 ± 6. 81), （91. 33 ± 5. 51), and (144. 00 ± 10. 15) pg/mL, respectively, while that in the control group was (44. 67 ± 1. 15) pg/mL. The levels of IFN-β secreted by the cells in the 10, 20, and 40 µmol/L groups were higher than that in the control group (all P<0. 01) . In the control group, CD69 expression levels of CD4+ T cells, CD8+ T cells and NK cells were (24. 53 ± 1. 39) %, （23. 40 ± 2. 32) %, （32. 33 ± 3. 08) %, respectively. The CD69 expression levels of CD4+ T cells, CD8+ T cells and NK cells in the 40 µmol/L group were (39. 90 ± 3. 51) %, (31. 47 ± 3. 88) %, （50. 83 ± 4. 74) %, respectively. There were significant differences in CD69 levels of CD4+ T cells, CD8+ T cells and NK cells between control group and 40 µmol/L group (all P<0. 05) . Conclusion Curcumin promotes the secretion of type Ⅰ interferon by regulating the expression of TLR2, thus inhibits the proliferation of hepatocellular carcinoma cells, induces the apoptosis of hepatocellular carcinoma cells, as well as promotes the activation of immune cells. [ABSTRACT FROM AUTHOR]

Copyright of Water Conservancy & Electric Power Technology & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: A variety kinds of cells can secrete microvesicles because of their paracrine effect, and the smallest microvesicles are called exosomes. Initially, exosomes were recognized as the “metabolic waste” of normal cells. However, they can engage in the regulation of several signaling pathways by transporting special substances such as proteins, lipids, miRNA and ligands or just act as ligands. As one of the most promising therapies, mesenchymal stem cells-derived exosomes are widely used in the study of various diseases and have a significant role in secondary lymphedema. OBJECTIVE: To review the development and effect of mesenchymal stem cells derived exosomes on secondary lymphedma systematically, and summarize the deficiency of researches. METHODS: With the key words and “snowballing ways”, articles about rehabilitation of mesenchymal stem cells-derived exosomes on secondary lymphedma were searched in PubMed, Google Scholar, Embase, Scopus, Wiley, CNKI and Wanfang databases from 2005 to 2022. A total of 58 articles were included finally. RESULTS AND CONCLUSION: (1) Due to the low immunogenicity of mesenchymal stem cells-derived exosomes, they are widely used in tissue regeneration, visceral fibrosis and many other kinds of diseases. There are rich sources of them, the application of adipose, bone marrow, umbilical cord blood-derived exosomes are most frequent. (2) Mesenchymal stem cells-derived exosomes benefit secondary lymphedema in animal experiments. They can reduce the volume of edema by promoting lymphatic endothelial cell differentiation and reconstructing new lymphatic values. (3) Meanwhile, the exosomes can interact with macrophages and transforming growth factor β and other important factors to regulate the local inflammation as well as the process of fibrosis and fat deposition. However, the specific intervention machanisms are still incomplete. (4) Current researches focus on the animal experiments not touch upon clinical experiments. Besides, there are no clear conclusions about the optimal concentration, proper time and frequency of intervention, so more details and clinical researches are still worthy to be supplied in the future. [ABSTRACT FROM AUTHOR]

In the field of modern aviation the cockpit temperature is too high due to solar radiation heat avionics heat generation and aerodynamics heat of aircraft surface and the cooling capacity of the cockpit environmental control system ECS of Chinese fighter aircraft cannot meet the requirements of human thermal comfort. The long-term heat stress of flight personnel not only affects the operational efficiency but also becomes one of the important causes of plane crash. The improvement of cockpit environmental control system requires expensive cost and time and is restricted by a variety of factors. Developing individual cooling suits for pilots is a cost-effective way to solve the problem of heat stress. Therefore domestic and foreign scholars are developing individual cooling suits. A liquid-cooling vest for fighter pilots was developed to solve thermal stress problems in the scenarios of low altitude and high speed flights. Based on the garment ergonomics principle factors were considered from the perspectives of cooling technology selection design of the cooling capacity cooling cover selection basic properties of the surface and auxiliary materials parameters of the heat exchange tube loop number and arrangement clothing style and structure and other aspects. The sweating thermal manikin tests were used to analyze the parameters and arrangement of heat exchange tubes of the liquid-cooling vest. The experiment was carried out in the artificial climate room the ambient temperature was 34 ± 0. 2°C the relative humidity was 40 ± 5 % the skin temperature of the sweating thermal manikin was set at 34°C and the sweat volume was set at 800 mL / h.m² . Based on the four-loop design of the heat exchange tube circuit the influence of the inlet water temperature heat exchange tube layout density horizontal and vertical arrangement and pipe diameter on the cooling performance of the liquid cooling vest was explored. The experimental results of the sweating thermal manikin show that the lower the inlet water temperature is the greater heat loss and cooling power of the liquidcooling vests with different tube circuit designs are. Therefore the decrease of the inlet water temperature can significantly improve the cooling capacity of the liquid-cooling vests. The cooling effect of the liquid cooling vest is significantly affected by the layout density of heat exchange tubes. The cooling capacity of the liquid cooling vest with dense arrangement of heat exchange tubes is significantly better than that with parallel arrangement of heat exchange tubes. The heat exchange tube with a size of 3 × 5 mm or 4 × 6 mm has no significant effect on the cooling capacity while the cooling vest with a 3 × 5 mm heat exchange tube has slightly higher cooling capacity. The horizontal or vertical arrangement of the heat exchange tube has no significant effects on the liquid cooling vest while the liquid cooling vest with horizontal arrangement of the heat exchange tube exhibits better cooling ability. The liquid cooling vests with different heat exchange tube layouts have different cooling capacities at the same part of the human torso so the liquid cooling vests with the combination design of a heat exchange tube have better cooling effect. Specifically the cooling capacity of the liquid cooling vest with dense arrangement of heat exchange tubes is significantly better than that with parallel arrangement in all parts of the body. The liquid cooling vest with horizontal arrangement of heat exchange tubes has higher cooling capacity in the middle back and lower back and the liquid cooling vest with vertical arrangement of heat exchange tubes has better cooling capacity in the upper chest and waist. The liquid-cooling vest developed in this paper uses the combination design and four-loop of the heat exchange tube exhibits better cooling effect and can improve the thermal comfort of human body in high temperature environments. The research findings will enrich the practical research of liquid cooling equipment in the flight field and provide reference for the scientific design and application of liquid cooling clothing. [ABSTRACT FROM AUTHOR]

Copyright of Engineering Science Research & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Science Research & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ovarian hyperstimulation syndrome (OHSS) is an iatric disease frequently occurred in patients with controlled ovarian hyperstimulation, but also can be observed in spontaneous ovulation cycles, especially those with multiple-pregnancy, hypothyroidism, polycystic ovary syndrome. The incidence of natural pregnancy complicated with OHSS is very low, which seriously affects the health of patients and even endangers their lives. This paper reported a case of spontaneous ovarian hyperstimulation syndrome (sOHSS) with ovarian rupture, and discussed the pathogenesis, clinical manifestations, complications, differential diagnosis and treatment of sOHSS, so as to provide a reference for clinical treatment. [ABSTRACT FROM AUTHOR]

Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Journal of Oral & Maxillofacial Surgery is the property of Shanghai Jiao Tong University, College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Signal Processing is the property of Journal of Signal Processing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the relationship between the levels of serum gastrin releasing peptide precursor (ProGRP), squamous cell carcinoma antigen (SccAg), human epididymal protein 4 (HE4) and the pathologicalcharacteristics of patients with non-small cell lung cancer (NSCLC), and analyze its clinical diagnostic value for NSCLC. Method: From September 2015 to February 2020, 110 patients with NSCLC (observation group) and 100 healthy volunteers (control group) who were received by our hospital were selected as the study subjects, and the serum ProGRP, SCCAg and HE4 levels were measured. The relationship between serum ProGRP, SCCAg, HE4 levels and clinicopathological parameters of patients with NSCLC were analyzed. Receiver operator characteristics curve (ROC) was used to analyze the value of ProGRP, SCCAg, HE4 and ProGRP, SCCAg, HE4 in the diagnosis of NSCLC. Results: The levels of ProGRP, SCCAg and HE4 in observation group were higher than those in control group (P<0.05). The serum ProGRP and SCCAg levels of patients with NSCLC with low and middle differentiation, TNM Ⅲ-Ⅳ staging and lymph node metastasis were higher than those of patients with NSCLC with high differentiation, TNM Ⅰ-Ⅱ staging and no lymph node metastasis (P<0.05). The serum HE4 levels of TNM Ⅲ-Ⅳ staging and lymph node metastasis were higher than those of TNM Ⅰ-Ⅱ and no lymph node metastasis (P<0.05). ROC analysis showed that the AUC of ProGRP, SCCAg, HE4, ProGRP + SCCAg + HE4 combined diagnosis of NSCLC was 0.834（95% CI: 0.779～0.888）, 0.584（95%CI: 0.507～0.662）, 0.743（95%CI: 0.675～0.811）, 0.947（95%CI: 0.910～0.984）respectively. Conclusion: The levels of ProGRP, SCCAg and HE4 in patients with NSCLC are significantly increased, levels of serum ProGRP and SCCAg are related to the degree of NSCLC differentiation, TNM staging and lymph node metastasis. Serum HE 4 levels are related to TNM stage and lymph node metastasis. The combined detection of ProGRP, SCCAg and HE4 is of high value for NSCLC diagnosis and can improve the accuracy of early diagnosis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Mine Automation is the property of Industry & Mine Automation Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

抑制RAS/RAF/MEK/ERK信号通路异常激活从而诱导细胞凋亡成为黑色素瘤的主要靶向治疗手段。MEK抑制剂可有效抑制肿瘤细胞增殖,但单药使用时不良反应较大。多项Ⅰ～Ⅲ期临床试验对MEK抑制剂的联合用药方案进行了探索。常见MEK抑制剂(曲美替尼、考比替尼、Binimetinib、Selumetinib)与BRAF抑制剂或免疫治疗药物(如PD-1,CTLA-4抑制剂)联合应用治疗黑色素瘤有助于提高疗效,延缓耐药,改善患者预后,减轻不良反应。未来将研究几种新的免疫治疗和靶向治疗组合,从而进一步改善晚期黑色素瘤患者的预后。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shanghai Physical Education Institute / Shanghai Tiyu Xueyuan Xuebao is the property of Shanghai Physical Education Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To summarize the experience of pharmaceutical care provided by clinical pharmacists in the treatment of renal injury associated with anti-neutrophil cytoplasmic antibody (ANCA ) vasculitis complicated with pulmonary infection. Methods: Through participation in the treatment of renal damage associated with ANCA vasculitis complicated with pulmonary infection and in consideration of vasculitis type and previous impact frequency and cumulative dosage of immunosuppressive agents. and also in view of the pulmonary infection and renal function of the patient. clinical pharmacists offered pharmaceutical care from the aspects of daily diet. rational use of diuretics. antibacterials. corticosteroids and immunosuppressive agents. Results: After several days of treatment. the patient conditions were greatly improved. with edema relieved. blood pressure returning to normal. urinary protein output obviously reduced. and no symptoms of pulmonary infection manifested. Above all. there was good compliance in the use of corticosteroids and immunosuppressive agents. Conclusion: For this type of patient , clinical pharmacists could offer comprehensive pharmaceutical care from the aspects of diet. rational use of diuretics and careful selection of antibacterials. corticosteroids and immunosuppressive agents. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)